Abstract：
:Huntington's disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human patients and mouse HD models suggest that disturbances of neuronal function in the neocortex play an important role in disease onset and progression. However, the precise nature and time course of cortical alterations in HD have remained elusive. Here, we use chronic in vivo two-photon calcium imaging to longitudinally monitor the activity of identified single neurons in layer 2/3 of the primary motor cortex in awake, behaving R6/2 transgenic HD mice and wildtype littermates. R6/2 mice show age-dependent changes in cortical network function, with an increase in activity that affects a large fraction of cells and occurs rather abruptly within one week, preceeding the onset of motor defects. Furthermore, quantitative proteomics demonstrate a pronounced downregulation of synaptic proteins in the cortex, and histological analyses in R6/2 mice and human HD autopsy cases reveal a reduction in perisomatic inhibitory synaptic contacts on layer 2/3 pyramidal cells. Taken together, our study provides a time-resolved description of cortical network dysfunction in behaving HD mice and points to disturbed excitation/inhibition balance as an important pathomechanism in HD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Burgold J,Schulz-Trieglaff EK,Voelkl K,Gutiérrez-Ángel S,Bader JM,Hosp F,Mann M,Arzberger T,Klein R,Liebscher S,Dudanova Idoi
10.1038/s41598-019-43024-wsubject
Has Abstractpub_date
2019-04-29 00:00:00pages
6634issue
1issn
2045-2322pii
10.1038/s41598-019-43024-wjournal_volume
9pub_type
杂志文章abstract：:Colloidal crystals composed of micro- or nano- colloids have been investigated in various fields such as photonics due to their unique optical properties. Binary colloidal crystals have an outstanding potential for fine-tuning material properties by changing the components, concentration, or size of colloids. Because ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12831-4
更新日期：2017-09-29 00:00:00
abstract：:Graphene aerogels (GAs) with high mechanical strength, tunable density and volume have been prepared only via soaking graphene hydrogels (GHs) in ammonia solution. The density and volume of the obtained GAs are controlled by adjusting the concentration of ammonia solution. Although volume of the GAs decreases with inc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05025
更新日期：2014-05-22 00:00:00
abstract：:We demonstrate the optical orbital angular momentum conservation during the transfer process from subwavelength plasmonic vortex lens (PVLs) to light and the generating process of surface plasmon polaritons (SPPs). Illuminating plasmonic vortex lenses with beams carrying optical orbital angular momentum, the SP vortic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03191
更新日期：2013-11-12 00:00:00
abstract：:Long-term supply of synthetic nitrogen (N) has the potential to affect the soil N processes. This study aimed to (i) establish N response curves to find the best balance between inputs and outputs of N over four ratoons; (ii) use 15N-labeled fertilizer to estimate the N recovery efficiency of fertilizer applied in the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75971-0
更新日期：2020-11-02 00:00:00
abstract：:The influence of the growth conditions of multilayer CdTe/ZnTe quantum dots (QDs) on Si substrate upon their carrier dynamics is studied using intensity integration and broadening photoluminescence. The unusual temperature dependence of the line broadening is explained using a model for interband transitions that invo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08267
更新日期：2015-02-05 00:00:00
abstract：:Biology is adapted to Earth's gravity force, and the long-term effects of varying gravity on the development of animals is unclear. Previously, we reported that high gravity, called hypergravity, increases defects in the development of motor neuron axons in the nematode Caenorhabditis elegans. Here, we show that a mut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78414-y
更新日期：2020-12-03 00:00:00
abstract：:The oxidative stress regulator Spx is ubiquitously found among Gram-positive bacteria. Previously, we reported identification of two Spx proteins in Streptococcus mutans - SpxA1 was the primary activator of oxidative stress genes whereas SpxA2 served a backup role. Here, we used RNA sequencing to uncover the scope of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16367-5
更新日期：2017-11-22 00:00:00
abstract：:Ice adhesion is mainly dictated by surface properties, and water wettability is frequently correlated with ice adhesion strength. However, these established correlations are limited to high ice adhesion and become invalid when the ice adhesion strength is low. Here we carried out an experimental study to explore the r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42181
更新日期：2017-02-07 00:00:00
abstract：:We aimed to predict molecular subtypes of breast cancer using radiomics signatures extracted from synthetic mammography reconstructed from digital breast tomosynthesis (DBT). A total of 365 patients with invasive breast cancer with three different molecular subtypes (luminal A + B, luminal; HER2-positive, HER2; triple...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78681-9
更新日期：2020-12-09 00:00:00
abstract：:Outbreaks involving the Asian genotype Chikungunya virus (CHIKV) caused over one million infections in the Americas recently. The outbreak was preceded by a major nationwide outbreak in the Philippines. We examined the phylogenetic and phylogeographic relationships of representative CHIKV isolates obtained from the 20...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12279
更新日期：2015-07-23 00:00:00
abstract：:High sensitivity magnetoelectric sensors with their electromechanical resonance frequencies < 200 kHz have been recently demonstrated using magnetostrictive/piezoelectric magnetoelectric heterostructures. In this work, we demonstrate a novel magnetoelectric nano-electromechanical systems (NEMS) resonator with an elect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01985
更新日期：2013-01-01 00:00:00
abstract：:Single-wall carbon nanotubes (SWCNTs) and Bi2Te3 nanoplates are very promising thermoelectric materials for energy harvesting. When these two materials are combined, the resulting nanocomposites exhibit high thermoelectric performance and excellent flexibility. However, simple mixing of these materials is not effectiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73808-4
更新日期：2020-10-12 00:00:00
abstract：:Surgical treatment of tendon lesions still yields unsatisfactory clinical outcomes. The use of bioresorbable scaffolds represents a way forward to improve tissue repair. Scaffolds for tendon reconstruction should have a structure mimicking that of the natural tendon, while providing adequate mechanical strength and st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35536-8
更新日期：2018-11-21 00:00:00
abstract：:The fundamental plasticity mechanisms in thin freestanding Zr65Ni35 metallic glass films are investigated in order to unravel the origin of an outstanding strength/ductility balance. The deformation process is homogenous until fracture with no evidence of catastrophic shear banding. The creep/relaxation behaviour of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49910-7
更新日期：2019-09-17 00:00:00
abstract：:Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35581
更新日期：2016-10-19 00:00:00
abstract：:This was a nine-year retrospective cohort study to investigate obstetric and perinatal outcomes in a cohort of adolescent girls with twin pregnancies from a major Australian tertiary centre in Brisbane, Australia. The adolescent cohort was aged <19 years and the control group was aged 20-24 years. The total study coho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37364-2
更新日期：2018-12-24 00:00:00
abstract：:Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle conformational differences, but the relationship between CCS and atomic structur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20012-0
更新日期：2018-01-26 00:00:00
abstract：:We report the results of a game-theoretic experiment with human players who solve problems of increasing complexity by cooperating in groups of increasing size. Our experimental environment is set up to make it complicated for players to use rational calculation for making the cooperative decisions. This environment i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41773-2
更新日期：2019-04-02 00:00:00
abstract：:α-Ketoglutarate (αKG) is a metabolite of the tricarboxylic acid cycle, important for biomass synthesis and a precursor for biotechnological products like 1,4-butanediol. In the eukaryote Saccharomyces cerevisiae αKG is present in different compartments. Compartmentation and (intra-)cellular transport could interfere w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69178-6
更新日期：2020-07-30 00:00:00
abstract：:Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76935-0
更新日期：2020-11-16 00:00:00
abstract：:Clinical differentiation between cystic lesions of endodontic and non-endodontic origin is of importance because correct diagnosis may affect treatment decision making. Most radicular cysts are treated with conservative approaches and, therefore, are not surgically removed. The objective of this study was to determine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71029-3
更新日期：2020-08-25 00:00:00
abstract：:In this paper, the annually average Defense Meteorological Satellite Program-Operational Linescan System (DMSP/OLS) night-time light data is first proposed as a surrogate indicator to mine and forecast the average housing prices in the inland capital cities of China. First, based on the time-series analysis of individ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64506-2
更新日期：2020-05-07 00:00:00
abstract：:The identification of the modes of action of bioactive compounds is a major challenge in chemical systems biology of diseases. Genome-wide expression profiling of transcriptional responses to compound treatment for human cell lines is a promising unbiased approach for the mode-of-action analysis. Here we developed a n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40164
更新日期：2017-01-10 00:00:00
abstract：:Caterpillars of the silk moth genus Hyalophora (Lepidoptera; Saturniidae) construct multilayered cocoons that function as overwintering housing during the pupal to adult developmental period. While all cocoons share the primary function of protecting the developing moth, cocoons spun by different Hyalophora silk moth ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62547-1
更新日期：2020-03-27 00:00:00
abstract：:The objective of this study was to evaluate the stimulatory effects of Bacillus amyloliquefaciens SQR9 on dendritic cells (DCs) and to verify its ability to enhance the immune response by modulating DC maturation. The results demonstrated that B. amyloliquefaciens SQR9 can adhere to the nasal epithelium and be taken u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21363
更新日期：2016-02-19 00:00:00
abstract：:The nucleotides guanosine tetraphosphate and pentaphosphate (together known as (p)ppGpp or magic spot) are produced in plant plastids from GDP/GTP and ATP by RelA-SpoT homologue (RSH) enzymes. In the model plant Arabidopsis (p)ppGpp regulates chloroplast transcription and translation to affect growth, and is also impl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54207-w
更新日期：2019-11-27 00:00:00
abstract：:The inter-relationship between subtropical western-central Pacific sea surface temperatures (STWCPSST), sea ice concentrations in the Beaufort Sea (SICBS), and the North Atlantic Oscillation (NAO) in summer are investigated over the period 1980-2016. It is shown that the Arctic response to the remote impact of the Pac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39896-7
更新日期：2019-03-05 00:00:00
abstract：:Melanoma is the most lethal cutaneous cancer. New drugs have recently appeared; however, not all patients obtain a benefit of these new drugs. For this reason, it is still necessary to characterize melanoma at molecular level. The aim of this study was to explore the molecular differences between melanoma tumor subtyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43512-z
更新日期：2019-05-10 00:00:00
abstract：:Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn -/- mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD. Interestingly, these mice are infertile but the mechanisms ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05993-8
更新日期：2017-08-07 00:00:00
abstract：:Social projection is the tendency to project one's own characteristics onto others. This phenomenon can potentially explain cooperation in prisoner's dilemma experiments and other social dilemmas. The social projection hypothesis has recently been formalized for symmetric games as co-action equilibrium and for general...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-19085-0
更新日期：2018-01-15 00:00:00
