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Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA) binds human erythrocytes independent of Duffy antigen status.

Abstract：

:Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections in Duffy-negative individuals, suggesting that the parasite may utilize alternative receptor-ligand pairs to complete the erythrocyte invasion. Here, we identified and characterized a novel parasite ligand, Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA), that bound human erythrocytes regardless of Duffy antigen status. PvGAMA was localized at the microneme in the mature schizont-stage parasites. The antibodies against PvGAMA fragments inhibited PvGAMA binding to erythrocytes in a dose-dependent manner. The erythrocyte-specific binding activities of PvGAMA were significantly reduced by chymotrypsin treatment. Thus, PvGAMA may be an adhesion molecule for the invasion of Duffy-positive and -negative human erythrocytes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Cheng Y,Lu F,Wang B,Li J,Han JH,Ito D,Kong DH,Jiang L,Wu J,Ha KS,Takashima E,Sattabongkot J,Cao J,Nyunt MH,Kyaw MP,Desai SA,Miller LH,Tsuboi T,Han ET

doi

10.1038/srep35581

subject

Has Abstract

pub_date

2016-10-19 00:00:00

pages

35581

issn

2045-2322

pii

srep35581

journal_volume

6

pub_type

杂志文章

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