Abstract：
:Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery.
journal_name
Sci Repjournal_title
Scientific reportsauthors
He X,Lin M,Sha B,Feng S,Shi X,Qu Z,Xu Fdoi
10.1038/srep12808subject
Has Abstractpub_date
2015-08-03 00:00:00pages
12808issn
2045-2322pii
srep12808journal_volume
5pub_type
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