Abstract：
:High frequency oscillations (HFOs) are bursts of neural activity in the range of 80 Hz or higher, recorded from intracranial electrodes during epileptiform discharges. HFOs are a proposed biomarker of epileptic brain tissue and may also be useful for seizure forecasting. Despite such clinical utility of HFOs, the spatial context and neuronal activity underlying these local field potential (LFP) events remains unclear. We sought to further understand the neuronal correlates of ictal high frequency LFPs using multielectrode array recordings in the human neocortex and mesial temporal lobe during rhythmic onset seizures. These multiscale recordings capture single cell, multiunit, and LFP activity from the human brain. We compare features of multiunit firing and high frequency LFP from microelectrodes and macroelectrodes during ictal discharges in both the seizure core and penumbra (spatial seizure domains defined by multiunit activity patterns). We report differences in spectral features, unit-local field potential coupling, and information theoretic characteristics of high frequency LFP before and after local seizure invasion. Furthermore, we tie these time-domain differences to spatial domains of seizures, showing that penumbral discharges are more broadly distributed and less useful for seizure localization. These results describe the neuronal and synaptic correlates of two types of pathological HFOs in humans and have important implications for clinical interpretation of rhythmic onset seizures.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Smith EH,Merricks EM,Liou JY,Casadei C,Melloni L,Thesen T,Friedman DJ,Doyle WK,Emerson RG,Goodman RR,McKhann GM 2nd,Sheth SA,Rolston JD,Schevon CAdoi
10.1038/s41598-020-76138-7subject
Has Abstractpub_date
2020-11-05 00:00:00pages
19166issue
1issn
2045-2322pii
10.1038/s41598-020-76138-7journal_volume
10pub_type
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