Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation.

abstract：:While designing the anti-inflammatory agents targeting cyclooxygenase-2 (COX-2), we first identified a water loop around the heme playing critical role in the enzyme catalysis. The results of molecular dynamic studies supported by the strong hydrogen-bonding equilibria of the participating atoms, radical stabilization...

journal_title：Scientific reports

authors： Kaur M,Kaur B,Kaur J,Kaur A,Bhatti R,Singh P

更新日期：2020-07-01 00:00:00

abstract：:Although poaching (illegal killing) is an important cause of death for large carnivores globally, the effect of lethal management policies on poaching is unknown for many populations. Two opposing hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunting') or increase it (...

journal_title：Scientific reports

authors： Santiago-Ávila FJ,Chappell RJ,Treves A

更新日期：2020-08-17 00:00:00

abstract：:We present experimental demonstrations of two-photon interference involving temporally separated photons within two types of interferometers: a Mach-Zehnder interferometer and a polarization-based Michelson interferometer. The two-photon states are probabilistically prepared in a symmetrically superposed state within ...

journal_title：Scientific reports

authors： Kim H,Lee SM,Moon HS

更新日期：2016-10-06 00:00:00

abstract：:A comprehensive analysis of heavy metal pollution was conducted in the representative limnetic ecosystems of eastern China, which are subject to rapid economic development and population growth. The results demonstrated that the average contents with standard deviations of Cd, Cr, Cu, Ni, Pb and Zn in the surface sedi...

journal_title：Scientific reports

authors： Tang W,Shan B,Zhang H,Zhang W,Zhao Y,Ding Y,Rong N,Zhu X

更新日期：2014-11-21 00:00:00

abstract：:All electronic, optoelectronic or photovoltaic applications of silicon depend on controlling majority charge carriers via doping with impurity atoms. Nanoscale silicon is omnipresent in fundamental research (quantum dots, nanowires) but also approached in future technology nodes of the microelectronics industry. In ge...

journal_title：Scientific reports

authors： König D,Hiller D,Gutsch S,Zacharias M,Smith S

更新日期：2017-04-20 00:00:00

abstract：:Individuals who have prior history of childhood traumatic experiences are at a high risk for a variety of psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether such individuals exhibit altered cortical functional networks during a behavioral inhibition task. One hundr...

journal_title：Scientific reports

authors： Kim S,Kim JS,Shim M,Im CH,Lee SH

更新日期：2018-07-04 00:00:00

abstract：:Although copy number variation (CNV) and presence-absence variation (PAV) have been discovered in selected gene families in most crop species, the global prevalence of these polymorphisms in most complex genomes is still unclear and their influence on quantitatively inherited agronomic traits is still largely unknown....

journal_title：Scientific reports

authors： Gabur I,Chawla HS,Lopisso DT,von Tiedemann A,Snowdon RJ,Obermeier C

更新日期：2020-03-05 00:00:00

abstract：:Exploration of genetic variant-to-gene relationships by quantitative trait loci such as expression QTLs is a frequently used tool in genome-wide association studies. However, the wide range of public QTL databases and the lack of batch annotation features complicate a comprehensive annotation of GWAS results. In this ...

journal_title：Scientific reports

authors： Munz M,Wohlers I,Simon E,Reinberger T,Busch H,Schaefer AS,Erdmann J

更新日期：2020-11-24 00:00:00

abstract：:Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted pr...

journal_title：Scientific reports

authors： Fu L,Huang M,Han B,Sun X,Sree KS,Appenroth KJ,Zhang J

更新日期：2017-06-08 00:00:00

abstract：:Cold atomic gases are perfect laboratories for realization of quantum simulators. In order to simulate solid state systems in the presence of magnetic fields special effort has to be made because atoms are charge neutral. There are different methods for realization of artificial magnetic fields, that is the creation o...

journal_title：Scientific reports

authors： Mochol M,Sacha K

更新日期：2015-01-08 00:00:00

abstract：:Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human diseases in biomedicine. Production of transgenic pigs, however, is a lengthy and inefficient process that hinders research using pig models. Recent application...

journal_title：Scientific reports

authors： Ruan J,Li H,Xu K,Wu T,Wei J,Zhou R,Liu Z,Mu Y,Yang S,Ouyang H,Chen-Tsai RY,Li K

更新日期：2015-09-18 00:00:00

abstract：:Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric ...

journal_title：Scientific reports

authors： Li Y,Liu Y,Liu J,Liu J,Tang H,Cao C,Zhao D,Ding Y

更新日期：2015-01-09 00:00:00

abstract：:Balance is a very important function that allows maintaining a stable stance needed for many daily life activities and for preventing falls. We investigated whether balance control could be improved by a placebo procedure consisting of verbal suggestion. Thirty healthy volunteers were randomized in two groups (placebo...

journal_title：Scientific reports

authors： Villa-Sánchez B,Emadi Andani M,Menegaldo G,Tinazzi M,Fiorio M

更新日期：2019-04-23 00:00:00

abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...

journal_title：Scientific reports

authors： Halim S,Gurudas S,Chandra S,Greenwood J,Sivaprasad S

更新日期：2020-10-05 00:00:00

abstract：:The Andaman day gecko (Phelsuma andamanensis) is endemic to the Andaman Archipelago, located ~ 6000 km away from Madagascar where the genus Phelsuma likely evolved. We complemented existing phylogenetic data with additional markers to show that this species consistently branches off early in the evolution of the genus...

journal_title：Scientific reports

authors： Mohan AV,Orozco-terWengel P,Shanker K,Vences M

更新日期：2020-07-16 00:00:00

abstract：:Patient-matched transcriptomic studies using tumour samples before and after treatment allow inter-patient heterogeneity to be controlled, but tend not to include an untreated comparison. Here, Illumina BeadArray technology was used to measure dynamic changes in gene expression from thirty-seven paired diagnostic core...

journal_title：Scientific reports

authors： Pearce DA,Arthur LM,Turnbull AK,Renshaw L,Sabine VS,Thomas JS,Bartlett JM,Dixon JM,Sims AH

更新日期：2016-07-07 00:00:00

abstract：:High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epit...

journal_title：Scientific reports

authors： Liu C,Lin J,Li L,Zhang Y,Chen W,Cao Z,Zuo H,Chen C,Kee K

更新日期：2015-01-07 00:00:00

abstract：:The International Institute of Tropical Agriculture maintains the world's largest collection of cowpea germplasm of over 15,000 accessions. A sub-set of 298 lines from the loosely composed mini core collection of 370 landraces were genotyped based on genotyping by sequencing (GBS). Ward's minimum variance hierarchical...

journal_title：Scientific reports

authors： Fatokun C,Girma G,Abberton M,Gedil M,Unachukwu N,Oyatomi O,Yusuf M,Rabbi I,Boukar O

更新日期：2018-10-30 00:00:00

abstract：:Anaerobic ammonium oxidation (anammox) bacteria significantly improve the efficiency and reduce cost of nitrogen removal in wastewater treatment plants. However, their slow growth and vulnerable activity limit the application of anammox technology. In this paper, the enhancement of biotin on the nitrogen removal activ...

journal_title：Scientific reports

authors： Li Q,Chen J,Liu GH,Xu X,Zhang Q,Wang Y,Yuan J,Li Y,Qi L,Wang H

更新日期：2021-01-21 00:00:00

abstract：:In this paper, we demonstrate and thoroughly analyze the activation volumetric properties of selected liquid crystals in the nematic and crystalline E phases in comparison with those reported for glass-forming liquids. In the analysis, we have employed and evaluated two entropic models (based on either total or config...

journal_title：Scientific reports

authors： Grzybowski A,Urban S,Mroz S,Paluch M

更新日期：2017-02-09 00:00:00

abstract：:Mouse models have contributed to the bulk of knowledge on Systemic Lupus Erythematosus (SLE). Nevertheless, substantial differences exist between human and mouse immune system. We aimed to establish and characterise a SLE model mediated by human immune system. Injection of pristane into immunodeficient mice reconstitu...

journal_title：Scientific reports

authors： Gunawan M,Her Z,Liu M,Tan SY,Chan XY,Tan WWS,Dharmaraaja S,Fan Y,Ong CB,Loh E,Chang KTE,Tan TC,Chan JKY,Chen Q

更新日期：2017-11-30 00:00:00

abstract：:Cadherin-related 23 (CDH23) is an adhesive protein important for hearing and vision, while CAMSAP3/Marshalin is a microtubule (MT) minus-end binding protein that regulates MT networks. Although both CDH23 and CAMSAP3/Marshalin are expressed in the organ of Corti, and carry several protein-protein interaction domains, ...

journal_title：Scientific reports

authors： Takahashi S,Mui VJ,Rosenberg SK,Homma K,Cheatham MA,Zheng J

更新日期：2016-06-28 00:00:00

abstract：:Tilapias (family Cichlidae) are of importance in aquaculture and fisheries. Hybridisation and introgression are common within tilapia genera but are difficult to analyse due to limited numbers of species-specific genetic markers. We tested the potential of double digested restriction-site associated DNA (ddRAD) sequen...

journal_title：Scientific reports

authors： Syaifudin M,Bekaert M,Taggart JB,Bartie KL,Wehner S,Palaiokostas C,Khan MGQ,Selly SC,Hulata G,D'Cotta H,Baroiller JF,McAndrew BJ,Penman DJ

更新日期：2019-09-10 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) and the transcription factor Stat3 play pivotal roles in the pathogenesis of psoriasis. CD147 is a transmembrane glycosylation protein that belongs to the immunoglo...

journal_title：Scientific reports

authors： Peng C,Zhang S,Lei L,Zhang X,Jia X,Luo Z,Huang X,Kuang Y,Zeng W,Su J,Chen X

更新日期：2017-03-08 00:00:00

abstract：:Incomplete or partial observations of network structures pose a serious challenge to theoretical and engineering studies of real networks. To remedy the missing links in real datasets, topology-based link prediction is introduced into the studies of various networks. Due to the complexity of network structures, the ac...

journal_title：Scientific reports

authors： Cao Z,Zhang Y,Guan J,Zhou S

更新日期：2018-09-06 00:00:00

abstract：:The impacts of flooding are expected to rise due to population increases, economic growth and climate change. Hence, understanding the physical and spatiotemporal characteristics of risk drivers (hazard, exposure and vulnerability) is required to develop effective flood mitigation measures. Here, the long-term trend i...

journal_title：Scientific reports

authors： Tanoue M,Hirabayashi Y,Ikeuchi H

更新日期：2016-10-26 00:00:00

abstract：:L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar KM for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of bacterial origin, immun...

journal_title：Scientific reports

authors： Rigouin C,Nguyen HA,Schalk AM,Lavie A

更新日期：2017-08-31 00:00:00

abstract：:Wolbachia, an endosymbiotic alpha-proteobacterium commonly found in insects, can inhibit the transmission of human pathogens by mosquitoes. Biocontrol programs are underway using Aedes aegypti mosquitoes trans-infected with a non-natural Wolbachia strain to reduce dengue virus transmission. Less is known about the imp...

journal_title：Scientific reports

authors： Straub TJ,Shaw WR,Marcenac P,Sawadogo SP,Dabiré RK,Diabaté A,Catteruccia F,Neafsey DE

更新日期：2020-08-14 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Nie H,Yan X,Huo Z,Jiang L,Chen P,Liu H,Ding J,Yang F

更新日期：2018-08-07 00:00:00

abstract：:Ionotropic activation of NMDA receptors (NMDARs) requires agonist glutamate and co-agonist glycine. Here we show that glycine enhances the activation of cell survival-promoting kinase Akt in cultured cortical neurons in which both the channel activity of NMDARs and the glycine receptors are pre-inhibited. The effect o...

journal_title：Scientific reports

authors： Hu R,Chen J,Lujan B,Lei R,Zhang M,Wang Z,Liao M,Li Z,Wan Y,Liu F,Feng H,Wan Q

更新日期：2016-10-03 00:00:00