当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms.

Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms.

Abstract：

:Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present stranded RNA-seq data generated directly from a small volume of blood from three Cambodian vivax malaria patients collected before treatment. Our analyses show surprising similarities of the parasite gene expression patterns across infections, despite extensive variations in parasite stage proportion. These similarities contrast with the unique gene expression patterns observed in sporozoites isolated from salivary glands of infected Colombian mosquitoes. Our analyses also indicate that more than 10% of P. vivax genes encode multiple, often undescribed, protein-coding sequences, potentially increasing the diversity of proteins synthesized by blood stage parasites. These data also greatly improve the annotations of P. vivax gene untranslated regions, providing an important resource for future studies of specific genes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kim A,Popovici J,Vantaux A,Samreth R,Bin S,Kim S,Roesch C,Liang L,Davies H,Felgner P,Herrera S,Arévalo-Herrera M,Ménard D,Serre D

doi

10.1038/s41598-017-07275-9

subject

Has Abstract

pub_date

2017-08-10 00:00:00

pages

7761

issue

1

issn

2045-2322

pii

10.1038/s41598-017-07275-9

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Ultrasound-Activated Piezoelectric Nanoparticles Inhibit Proliferation of Breast Cancer Cells.

    abstract：:A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. The innovative solution consists in a platform based on biocompatible piezoelectric nanoparticles able to target and remotely stimulate HER2-positive breast cancer cells. The anti-proliferative effects of the ultrasound...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24697-1

    authors： Marino A,Battaglini M,De Pasquale D,Degl'Innocenti A,Ciofani G

    更新日期：2018-04-19 00:00:00

  • Study on performance degradation and damage modes of thin-film photovoltaic cell subjected to particle impact.

    abstract：:It has been a key issue for photovoltaic (PV) cells to survive under mechanical impacts by tiny dust. In this paper, the performance degradation and the damage behavior of PV cells subjected to massive dust impact are investigated using laser-shock driven particle impact experiments and mechanical modeling. The result...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80879-w

    authors： Xiao K,Wu X,Song X,Yuan J,Bai W,Wu C,Huang C

    更新日期：2021-01-12 00:00:00

  • Blueprint for nanoscale NMR.

    abstract：:Nitrogen vacancy (NV) centers in diamond have been used as ultrasensitive magnetometers to perform nuclear magnetic resonance (NMR) spectroscopy of statistically polarized samples at 1-100 nm length scales. However, the spectral linewidth is typically limited to the kHz level, both by the NV sensor coherence time and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43404-2

    authors： Schwartz I,Rosskopf J,Schmitt S,Tratzmiller B,Chen Q,McGuinness LP,Jelezko F,Plenio MB

    更新日期：2019-05-06 00:00:00

  • L290P/V mutations increase ERK3's cytoplasmic localization and migration/invasion-promoting capability in cancer cells.

    abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15135-9

    authors： Alsaran H,Elkhadragy L,Shakya A,Long W

    更新日期：2017-11-03 00:00:00

  • Evaluating phenotype-driven approaches for genetic diagnoses from exomes in a clinical setting.

    abstract：:Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13841-y

    authors： Pengelly RJ,Alom T,Zhang Z,Hunt D,Ennis S,Collins A

    更新日期：2017-10-18 00:00:00

  • Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.

    abstract：:A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36692

    authors： Ottosson H,Nylén F,Sarker P,Miraglia E,Bergman P,Gudmundsson GH,Raqib R,Agerberth B,Strömberg R

    更新日期：2016-11-09 00:00:00

  • Increasing incidence and improving survival of oral tongue squamous cell carcinoma.

    abstract：:We evaluated changes in incidence, relative survival (RS), and conditional survival (CS) of head and neck squamous cell carcinoma (HNSCC), focusing on oral tongue squamous cell carcinoma (OTSCC). Data of 74 680 HNSCC patients from 1976 to 2015 were obtained from the Surveillance, Epidemiology, and End Results database...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64748-0

    authors： Kim YJ,Kim JH

    更新日期：2020-05-12 00:00:00

  • Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode.

    abstract：:Leptin has a central role in the maintenance of energy homeostasis, and its sensitivity is influenced by both the photoperiod and dietary polyphenols. The aim of this study was to investigate the effect of seasonal consumption of polyphenol-rich fruits on the hypothalamic leptin signaling system in non-obese and obese...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-31855-y

    authors： Ibars M,Aragonès G,Ardid-Ruiz A,Gibert-Ramos A,Arola-Arnal A,Suárez M,Bladé C

    更新日期：2018-09-11 00:00:00

  • Autophagy is required for proper meiosis of porcine oocytes maturing in vitro.

    abstract：:Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components; however, the contribution of autophagy during meiosis has not been studied in porcine oocytes maturing in vitro. In this study, we observed that the autophagy-related gene, LC3, was expressed in ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29872-y

    authors： Shen XH,Jin YX,Liang S,Kwon JW,Zhu JW,Lei L,Kim NH

    更新日期：2018-08-22 00:00:00

  • Increasing active biomass carbon may lead to a breakdown of mature forest equilibrium.

    abstract：:The finding that mature forest ecosystems increase carbon in woody tissues and mineral soils indicates that the original equilibriums are being pushed to a higher state. The final driving forces will probably be increasing CO2 and nitrogen deposition, global warming, and changes to precipitation patterns. However, whi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03681

    authors： Xiao Y,Zhou G,Zhang Q,Wang W,Liu S

    更新日期：2014-01-14 00:00:00

  • Role of RPTPβ/ζ in neuroinflammation and microglia-neuron communication.

    abstract：:Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76415-5

    authors： Fernández-Calle R,Galán-Llario M,Gramage E,Zapatería B,Vicente-Rodríguez M,Zapico JM,de Pascual-Teresa B,Ramos A,Ramos-Álvarez MP,Uribarri M,Ferrer-Alcón M,Herradón G

    更新日期：2020-11-20 00:00:00

  • Multiple and diverse structural changes affect the breakpoint regions of polymorphic inversions across the Drosophila genus.

    abstract：:Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36248

    authors： Puerma E,Orengo DJ,Aguadé M

    更新日期：2016-10-26 00:00:00

  • Energy Dissipation Pathways in Few-Layer MoS2 Nanoelectromechanical Systems.

    abstract：:Free standing, atomically thin transition metal dichalcogenides are a new class of ultralightweight nanoelectromechanical systems with potentially game-changing electro- and opto-mechanical properties, however, the energy dissipation pathways that fundamentally limit the performance of these systems is still poorly un...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05730-1

    authors： Matis BR,Houston BH,Baldwin JW

    更新日期：2017-07-18 00:00:00

  • The development of spontaneous facial responses to others' emotions in infancy: An EMG study.

    abstract：:Viewing facial expressions often evokes facial responses in the observer. These spontaneous facial reactions (SFRs) are believed to play an important role for social interactions. However, their developmental trajectory and the underlying neurocognitive mechanisms are still little understood. In the current study, 4- ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17556-y

    authors： Kaiser J,Crespo-Llado MM,Turati C,Geangu E

    更新日期：2017-12-13 00:00:00

  • Genomic signatures of local adaptation reveal source-sink dynamics in a high gene flow fish species.

    abstract：:Understanding source-sink dynamics is important for conservation management, particularly when climatic events alter species' distributions. Following a 2011 'marine heatwave' in Western Australia, we observed high recruitment of the endemic fisheries target species Choerodon rubescens, towards the cooler (southern) e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09224-y

    authors： Cure K,Thomas L,Hobbs JA,Fairclough DV,Kennington WJ

    更新日期：2017-08-17 00:00:00

  • Shock Synthesis of Five-component Icosahedral Quasicrystals.

    abstract：:Five-component icosahedral quasicrystals with compositions in the range Al68-73Fe11-16Cu10-12Cr1-4Ni1-2 were recently recovered after shocking metallic CuAl5 and (Mg0.75Fe0.25)2SiO4 olivine in a stainless steel 304 chamber, intended to replicate a natural shock that affected the Khatyrka meteorite. The iron in those q...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15771-1

    authors： Oppenheim J,Ma C,Hu J,Bindi L,Steinhardt PJ,Asimow PD

    更新日期：2017-11-15 00:00:00

  • Multi-omics dataset to decipher the complexity of drug resistance in diffuse large B-cell lymphoma.

    abstract：:The prognosis of patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains unsatisfactory and, despite major advances in genomic studies, the biological mechanisms underlying chemoresistance are still poorly understood. We conducted for the first time a large-scale differential multi-omics ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37273-4

    authors： Fornecker LM,Muller L,Bertrand F,Paul N,Pichot A,Herbrecht R,Chenard MP,Mauvieux L,Vallat L,Bahram S,Cianférani S,Carapito R,Carapito C

    更新日期：2019-01-29 00:00:00

  • Rearrangement of Actin Microfilaments in the Development of Olfactory Receptor Cells in Fish.

    abstract：:At present, it remains poorly understood how the olfactory neuron migrates through the thick neuroepithelium during its maturation from a stem cell and how it develops a specific sensitivity to environmental odorants after maturation. We investigated the cytochemical features associated with the development of olfacto...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22049-7

    authors： Klimenkov IV,Sudakov NP,Pastukhov MV,Svinov MM,Kositsyn NS

    更新日期：2018-02-27 00:00:00

  • SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin.

    abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32350

    authors： Carrasco-Garcia E,Lopez L,Aldaz P,Arevalo S,Aldaregia J,Egaña L,Bujanda L,Cheung M,Sampron N,Garcia I,Matheu A

    更新日期：2016-08-30 00:00:00

  • Active structural acoustic illusions.

    abstract：:We present active manipulation of the structural vibrations of an elastic body to generate an acoustic illusion. The resultant illusion misrepresents the nature, size and number of objects in the exterior acoustic domain. We demonstrate our technique, herein termed active structural acoustic illusion, using an elastic...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66398-8

    authors： Eggler D,Kessissoglou N

    更新日期：2020-06-17 00:00:00

  • PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2.

    abstract：:Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12916

    authors： Nagaoka T,Tabuchi K,Kishi M

    更新日期：2015-08-10 00:00:00

  • Crystal-Size Effects on Carbon Dioxide Capture of a Covalently Alkylamine-Tethered Metal-Organic Framework Constructed by a One-Step Self-Assembly.

    abstract：:To enhance the carbon dioxide (CO2) uptake of metal-organic frameworks (MOFs), amine functionalization of their pore surfaces has been studied extensively. In general, amine-functionalized MOFs have been synthesized via post-synthetic modifications. Herein, we introduce a one-step construction of a MOF ([(NiLethylamin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19337

    authors： Kim YK,Hyun SM,Lee JH,Kim TK,Moon D,Moon HR

    更新日期：2016-01-13 00:00:00

  • Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis.

    abstract：:Lysophospholipids (LPLs) are known to have potentially important roles in the initiation and maintenance of neuropathic pain in animal models. This study investigated the association between the clinical severity of lumbar spinal stenosis (LSS) and the cerebrospinal fluid (CSF) levels of LPLs, using human samples. We ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45742-7

    authors： Hayakawa K,Kurano M,Ohya J,Oichi T,Kano K,Nishikawa M,Uranbileg B,Kuwajima K,Sumitani M,Tanaka S,Aoki J,Yatomi Y,Chikuda H

    更新日期：2019-06-24 00:00:00

  • Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.

    abstract：:Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLC...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44653

    authors： Dinh TA,Vitucci EC,Wauthier E,Graham RP,Pitman WA,Oikawa T,Chen M,Silva GO,Greene KG,Torbenson MS,Reid LM,Sethupathy P

    更新日期：2017-03-17 00:00:00

  • Automated analysis of cell-matrix adhesions in 2D and 3D environments.

    abstract：:Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation, proliferation, survival, tissue morphogenesis, wound healing, and tumorigenesis. Adhesions are dynamic structures that are classically defined on two-dimensional (2D) s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08124

    authors： Broussard JA,Diggins NL,Hummel S,Georgescu W,Quaranta V,Webb DJ

    更新日期：2015-01-29 00:00:00

  • The Safety Limits Of An Extended Fast: Lessons from a Non-Model Organism.

    abstract：:While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state that links spontaneo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39008

    authors： Bertile F,Fouillen L,Wasselin T,Maes P,Le Maho Y,Van Dorsselaer A,Raclot T

    更新日期：2016-12-19 00:00:00

  • Structure and distribution of chalky deposits in the Pacific oyster using x-ray computed tomography (CT).

    abstract：:Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68726-4

    authors： Banker RMW,Sumner DY

    更新日期：2020-07-21 00:00:00

  • Spatial Characterization of Tumor Perfusion Properties from 3D DCE-US Perfusion Maps are Early Predictors of Cancer Treatment Response.

    abstract：:There is a need for noninvasive repeatable biomarkers to detect early cancer treatment response and spare non-responders unnecessary morbidities and costs. Here, we introduce three-dimensional (3D) dynamic contrast enhanced ultrasound (DCE-US) perfusion map characterization as inexpensive, bedside and longitudinal ind...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63810-1

    authors： El Kaffas A,Hoogi A,Zhou J,Durot I,Wang H,Rosenberg J,Tseng A,Sagreiya H,Akhbardeh A,Rubin DL,Kamaya A,Hristov D,Willmann JK

    更新日期：2020-04-24 00:00:00

  • Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP/PS1 mice modeling Alzheimer's disease.

    abstract：:Sleep, in addition to its brain restorative processes, plays an important role in memory transfer from its temporary store in the hippocampus to the more permanent storage in the neocortex. Alzheimer's disease (AD) affects memory and sleep. The aim of this study was to explore disturbances in global and local synchron...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41851-5

    authors： Zhurakovskaya E,Ishchenko I,Gureviciene I,Aliev R,Gröhn O,Tanila H

    更新日期：2019-03-29 00:00:00

  • Trait determinants of impulsive behavior: a comprehensive analysis of 188 rats.

    abstract：:Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the inf...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35537-7

    authors： Soares AR,Esteves M,Moreira PS,Cunha AM,Guimarães MR,Carvalho MM,Raposo-Lima C,Morgado P,Carvalho AF,Coimbra B,Melo A,Rodrigues AJ,Salgado AJ,Pêgo JM,Cerqueira JJ,Costa P,Sousa N,Almeida A,Leite-Almeida H

    更新日期：2018-12-05 00:00:00