Abstract：
:Impulsivity is a naturally occurring behavior that, when accentuated, can be found in a variety of neuropsychiatric disorders. The expression of trait impulsivity has been shown to change with a variety of factors, such as age and sex, but the existing literature does not reflect widespread consensus regarding the influence of modulating effects. We designed the present study to investigate, in a cohort of significant size (188 rats), the impact of four specific parameters, namely sex, age, strain and phase of estrous cycle, using the variable delay-to-signal (VDS) task. This cohort included (i) control animals from previous experiments; (ii) animals specifically raised for this study; and (iii) animals previously used for breeding purposes. Aging was associated with a general decrease in action impulsivity and an increase in delay tolerance. Females generally performed more impulsive actions than males but no differences were observed regarding delay intolerance. In terms of estrous cycle, no differences in impulsive behavior were observed and regarding strain, Wistar Han animals were, in general, more impulsive than Sprague-Dawley. In addition to further confirming, in a substantial study cohort, the decrease in impulsivity with age, we have demonstrated that both the strain and sex influences modulate different aspects of impulsive behavior manifestations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Soares AR,Esteves M,Moreira PS,Cunha AM,Guimarães MR,Carvalho MM,Raposo-Lima C,Morgado P,Carvalho AF,Coimbra B,Melo A,Rodrigues AJ,Salgado AJ,Pêgo JM,Cerqueira JJ,Costa P,Sousa N,Almeida A,Leite-Almeida Hdoi
10.1038/s41598-018-35537-7subject
Has Abstractpub_date
2018-12-05 00:00:00pages
17666issue
1issn
2045-2322pii
10.1038/s41598-018-35537-7journal_volume
8pub_type
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