Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.

abstract：:Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the SNV pattern differs ...

journal_title：Scientific reports

authors： Pan Y,Yan C,Hu Y,Fan Y,Pan Q,Wan Q,Torcivia-Rodriguez J,Mazumder R

更新日期：2017-02-08 00:00:00

abstract：:Viruses exploit host factors and environment for their efficient replication. The virus-host interaction mechanisms for achieving an optimal hepatitis B virus (HBV) replication have been largely unknown. Here, a single cell cloning revealed that HepAD38 cells, a widely-used HBV-inducible cell line, contain cell clones...

journal_title：Scientific reports

authors： Iwamoto M,Cai D,Sugiyama M,Suzuki R,Aizaki H,Ryo A,Ohtani N,Tanaka Y,Mizokami M,Wakita T,Guo H,Watashi K

更新日期：2017-09-06 00:00:00

abstract：:No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake...

journal_title：Scientific reports

authors： Wu QJ,Yang G,Zheng W,Li HL,Gao J,Wang J,Gao YT,Shu XO,Xiang YB

更新日期：2015-05-19 00:00:00

abstract：:In the paradigm of materials informatics for accelerated materials discovery, the choice of feature set (i.e. attributes that capture aspects of structure, chemistry and/or bonding) is critical. Ideally, the feature sets should provide a simple physical basis for extracting major structural and chemical trends and fur...

journal_title：Scientific reports

authors： Balachandran PV,Theiler J,Rondinelli JM,Lookman T

更新日期：2015-08-25 00:00:00

abstract：:The complete plastome sequences of six species were sequenced to better understand the evolutionary relationships and mutation patterns in the chloroplast genome of the genus Colobanthus. The length of the chloroplast genome sequences of C. acicularis, C. affinis, C. lycopodioides, C. nivicola, C. pulvinatus and C. su...

journal_title：Scientific reports

authors： Androsiuk P,Jastrzębski JP,Paukszto Ł,Makowczenko K,Okorski A,Pszczółkowska A,Chwedorzewska KJ,Górecki R,Giełwanowska I

更新日期：2020-07-13 00:00:00

abstract：:Understanding the genetic basis of phenotypic diversity is a challenge in contemporary biology. Domestication provides a model for unravelling aspects of the genetic basis of stress sensitivity. The ancestral Red Junglefowl (RJF) exhibits greater fear-related behaviour and a more pronounced HPA-axis reactivity than it...

journal_title：Scientific reports

authors： Fallahsharoudi A,de Kock N,Johnsson M,Ubhayasekera SJ,Bergquist J,Wright D,Jensen P

更新日期：2015-10-16 00:00:00

abstract：:Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat c...

journal_title：Scientific reports

authors： Zhang Y,Yang C,Wang W,Liu J,Liu Q,Huang F,Chu L,Gao H,Li C,Kong D,Liu Q,Liu J

更新日期：2016-02-15 00:00:00

abstract：:To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood under diurnally variable regimens including daily forays into deleterious temperatures. We sampled mature larva...

journal_title：Scientific reports

authors： Chou H,Jima DD,Funk DH,Jackson JK,Sweeney BW,Buchwalter DB

更新日期：2020-11-05 00:00:00

abstract：:Intrinsic disorder occurs when (part of) a protein remains unfolded during normal functioning. Intrinsically-disordered regions can contain segments that 'fold on binding' to another molecule. Here, we perform bioinformatical parsing of human 'folding-on-binding' (FB) proteins, into four subsets: Ordered regions, FB r...

journal_title：Scientific reports

authors： Narasumani M,Harrison PM

更新日期：2015-12-18 00:00:00

abstract：:Thermal perception is essential for the survival and daily activities of people. Thus, it is desirable to realize thermal feedback stimulation for improving the sense of realism in virtual reality (VR) for users. For thermal stimulus, conventional systems utilize liquid circulation with bulky external sources or therm...

journal_title：Scientific reports

authors： Kim SW,Kim SH,Kim CS,Yi K,Kim JS,Cho BJ,Cha Y

更新日期：2020-07-09 00:00:00

abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...

journal_title：Scientific reports

authors： Patra C,Kontarakis Z,Kaur H,Rayrikar A,Mukherjee D,Stainier DYR

更新日期：2017-06-02 00:00:00

abstract：:In this paper, a new strategy is reported for preparing a label-free β-trophin electrochemiluminescent (ECL) immunosensor with good specificity, reproducibility and stability. An aquagel polymer from the hydrolysis of (3-aminopropyl) trimethoxysilane acted as the linker to catch the Au nanoparticles (AuNPs) on the ind...

journal_title：Scientific reports

authors： Zheng L,Fang C,Yan J,Li H,Tu Y

更新日期：2017-09-11 00:00:00

abstract：:Harmful algal blooms caused by Phaeocystis globosa have resulted in staggering losses to coastal countries because of their world-wide distribution. Bacteria have been studied for years to control the blooms of harmful alga, however, the action mechanism of them against harmful algal cells is still not well defined. H...

journal_title：Scientific reports

authors： Guan C,Guo X,Li Y,Zhang H,Lei X,Cai G,Guo J,Yu Z,Zheng T

更新日期：2015-11-25 00:00:00

abstract：:We compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae for subsequent Miseq sequencing. Purification of DNA was based on matrix binding (silica or anion exchange resin) or differential precipitation (salting out), respectively. The choice of extraction kit had ...

journal_title：Scientific reports

authors： Becker L,Steglich M,Fuchs S,Werner G,Nübel U

更新日期：2016-06-17 00:00:00

abstract：:Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...

journal_title：Scientific reports

authors： Yan Q,Kumar P,Wang Y,Zhao Y,Lin H,Ran Q,An Z,Zhou W

更新日期：2020-10-09 00:00:00

abstract：:This report identifies mitochondrial DNA (mtDNA) as a target and active mediator that links low-level oxidative stress to inflammatory response in pulmonary epithelial cells. Extrusion of mtDNA into the bronchoalveolar lavage fluid occurs as an early event in mice subjected to cigarette smoke injury, concomitantly wit...

journal_title：Scientific reports

authors： Szczesny B,Marcatti M,Ahmad A,Montalbano M,Brunyánszki A,Bibli SI,Papapetropoulos A,Szabo C

更新日期：2018-01-17 00:00:00

abstract：:Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared...

journal_title：Scientific reports

authors： Workalemahu T,Grantz KL,Grewal J,Zhang C,Louis GMB,Tekola-Ayele F

更新日期：2018-05-08 00:00:00

abstract：:We study heat dissipation of a multi-wall carbon nanotube (MWCNT) device fabricated from two crossed nanotubes on a SiNx substrate under the influence of a constant (DC) electric bias. By monitoring the temperature of the substrate, we observe negligible Joule heating within the nanotube lattice itself and instead hea...

journal_title：Scientific reports

authors： Voskanian N,Olsson E,Cumings J

更新日期：2019-07-25 00:00:00

abstract：:The estrogenicity of parabens at human exposure levels has become a focus of concern due to the debate over whether the estrogenicity of parabens is strong enough to play a role in the increased incidence of breast cancer. In this study, the uterotrophic activities of methylparaben (MP) and ethylparaben (EP) at doses ...

journal_title：Scientific reports

authors： Sun L,Yu T,Guo J,Zhang Z,Hu Y,Xiao X,Sun Y,Xiao H,Li J,Zhu D,Sai L,Li J

更新日期：2016-04-28 00:00:00

abstract：:While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which causes long-lasting side effects. Identification of molecules contro...

journal_title：Scientific reports

authors： El Zawily A,McEwen E,Toosi B,Vizeacoumar FS,Freywald T,Vizeacoumar FJ,Freywald A

更新日期：2017-11-07 00:00:00

abstract：:Human umbilical cord mesenchymal stem cells (huMSCs) can treat primary ovarian insufficiency (POI) related to ovarian granulosa cell (OGC) apoptosis caused by cisplatin chemotherapy. Exosomes are a class of membranous vesicles with diameters of 30-200 nm that are constitutively released by eukaryotic cells. Exosomes m...

journal_title：Scientific reports

authors： Sun L,Li D,Song K,Wei J,Yao S,Li Z,Su X,Ju X,Chao L,Deng X,Kong B,Li L

更新日期：2017-05-31 00:00:00

abstract：:Stem cell therapy has long been considered a promising mode of treatment for many incurable diseases. Human mesenchymal stem cells (hMSCs) have provided the most promising results to date for regenerative medicine. Nevertheless, due to several obstacles such as difficulty in sourcing and characterizing hMSCs, they rem...

journal_title：Scientific reports

authors： Jeong GJ,Kang D,Kim AK,Han KH,Jeon HR,Kim DI

更新日期：2019-04-16 00:00:00

abstract：:Chinese liquor aroma components were characterized during the aging process using gas chromatography (GC). Principal component and cluster analysis (PCA, CA) were used to discriminate the Chinese liquor age which has a great economic value. Of a total of 21 major aroma components identified and quantified, 13 componen...

journal_title：Scientific reports

authors： Xu ML,Yu Y,Ramaswamy HS,Zhu SM

更新日期：2017-01-06 00:00:00

abstract：:The ability to respond appropriately to challenges is an important contributor to fitness. Variation in the regulation of glucocorticoid hormones, which mediate the phenotypic response to challenges, can therefore influence the ability to persist in a given environment. We compared stress responsiveness in four popula...

journal_title：Scientific reports

authors： Zimmer C,Taff CC,Ardia DR,Rose AP,Aborn DA,Johnson LS,Vitousek MN

更新日期：2020-08-13 00:00:00

abstract：:The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex formed between activated Sos and Ras at the point of the functional cycle where the nucleotide exchange is completed has not been described to date. Here we show th...

journal_title：Scientific reports

authors： Vo U,Vajpai N,Embrey KJ,Golovanov AP

更新日期：2016-07-14 00:00:00

abstract：:Recombination is crucial for biological evolution, which provides many new combinations of genetic diversity. Accurate identification of recombination spots is useful for DNA function study. To improve the prediction accuracy, researchers have proposed several computational methods for recombination spot identificatio...

journal_title：Scientific reports

authors： Wang R,Xu Y,Liu B

更新日期：2016-03-31 00:00:00

abstract：:Human and animal infections of Enterocytozoon bieneusi (E. bieneusi) have consistently been reported worldwide, garnering public attention; however, the molecular epidemiology of E. bieneusi in the giant panda remains limited. We surveyed captive giant pandas in China for the presence of E. bieneusi by using PCR and s...

journal_title：Scientific reports

authors： Li W,Zhong Z,Song Y,Gong C,Deng L,Cao Y,Zhou Z,Cao X,Tian Y,Li H,Feng F,Zhang Y,Wang C,Li C,Yang H,Huang X,Fu H,Geng Y,Ren Z,Wu K,Peng G

更新日期：2018-04-26 00:00:00

abstract：:In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...

journal_title：Scientific reports

authors： Ming NH,Ramesh S,Ramesh K

更新日期：2016-06-08 00:00:00

abstract：:Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and P...

journal_title：Scientific reports

authors： Liu J,Huang S,Su XZ,Song J,Lu F

更新日期：2016-08-24 00:00:00

abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...

journal_title：Scientific reports

authors： Wang Y,Jian Z,Zhao P,Xiao D,Chen J

更新日期：2016-07-06 00:00:00