Abstract：
:While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state that links spontaneous refeeding behaviour with fasting limits had been identified. Blood proteomics and physiological data reveal here that fasting-induced body protein depletion is not unsafe "per se". Indeed, incubating penguins only abandon their chick/egg to refeed when this state is associated with metabolic defects in glucose homeostasis/fatty acid utilization, insulin production and action, and possible renal dysfunctions. Our data illustrate how the field investigation of "exotic" models can be a unique source of information, with possible biomedical interest.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bertile F,Fouillen L,Wasselin T,Maes P,Le Maho Y,Van Dorsselaer A,Raclot Tdoi
10.1038/srep39008subject
Has Abstractpub_date
2016-12-19 00:00:00pages
39008issn
2045-2322pii
srep39008journal_volume
6pub_type
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