Author Correction: A large-scale RNA interference screen identifies genes that regulate autophagy at different stages.

abstract：:Irreversible electroporation (IRE) as a non-thermal tumor ablation technology has been studied for the treatment of pancreatic carcinoma and has shown a significant survival benefit. We discovered that moderate heating (MH) at 43 °C for 1-2 minutes significantly enhanced ex vivo IRE tumor ablation of Pan02 cells by 5....

journal_title：Scientific reports

authors： Edelblute CM,Hornef J,Burcus NI,Norman T,Beebe SJ,Schoenbach K,Heller R,Jiang C,Guo S

更新日期：2017-09-18 00:00:00

abstract：:The integrity of the corticospinal tract (CST) is significantly affected following basal ganglia haemorrhage. We aimed to assess the local features of CST and to effectively predict motor function by diffusion characteristics of CST in patients with motor injury following acute haemorrhage in the acute basal ganglia r...

journal_title：Scientific reports

authors： Li J,Wei XH,Liu YK,Chen LS,Zhu ZQ,Hou SY,Fang XK,Wang ZQ

更新日期：2020-10-01 00:00:00

abstract：:Air pollution has aroused significant public concern in China, therefore, long-term air-quality data with high temporal and spatial resolution are needed to understand the variations of air pollution in China. However, the yearly variations with high spatial resolution of air quality and six air pollutants are still u...

journal_title：Scientific reports

authors： Guo H,Gu X,Ma G,Shi S,Wang W,Zuo X,Zhang X

更新日期：2019-10-23 00:00:00

abstract：:Methylation of histone H3-lysine 9 (H3K9) and H3K27 by the methyltransferase G9a and polycomb repressive complex 2 (PRC2) inhibits transcription of target genes. A crosstalk between G9a and PRC2 via direct physical interaction has been shown recently. Here, we demonstrate an alternative mechanism by which G9a promotes...

journal_title：Scientific reports

authors： Pan MR,Hsu MC,Chen LT,Hung WC

更新日期：2015-12-21 00:00:00

abstract：:The chronic unpredictable stress (CUS) paradigm is extensively used in preclinical research. However, CUS exhibits translational inconsistencies, some of them resulting from the use of adult rodents, despite the evidence that vulnerability for many psychiatric disorders accumulates during early life. Here, we assessed...

journal_title：Scientific reports

authors： Sequeira-Cordero A,Salas-Bastos A,Fornaguera J,Brenes JC

更新日期：2019-11-22 00:00:00

abstract：:To compare the different features of necrotizing pneumonia (NP) and non-NP (NNP) caused by Mycoplasma pneumoniae pneumonia (MPP) with large pulmonary lesions, and explore the predictor for NP to differentiate from MPP. A retrospective study of MPP patients with large pulmonary lesions hospitalized from January 2008 to...

journal_title：Scientific reports

authors： Zhou Y,Hu M,Ye B,Chen Z,Zhang Y

更新日期：2020-11-04 00:00:00

abstract：:The COVID-19 pandemic caused by the SARS-CoV-2 requires a fast development of antiviral drugs. SARS-CoV-2 viral main protease (Mpro, also called 3C-like protease, 3CLpro) is a potential target for drug design. Crystal and co-crystal structures of the SARS-CoV-2 Mpro have been solved, enabling the rational design of in...

journal_title：Scientific reports

authors： Shitrit A,Zaidman D,Kalid O,Bloch I,Doron D,Yarnizky T,Buch I,Segev I,Ben-Zeev E,Segev E,Kobiler O

更新日期：2020-11-30 00:00:00

abstract：:Gyroviruses (GyVs) are small, single-stranded, circular DNA viruses in the genus Gyrovirus, which consists of the chicken anemia virus (CAV) prototype and nine other viral species. These different GyV species have been reported in chickens, humans, mice, and companion animals. To date, CAV has been identified in the f...

journal_title：Scientific reports

authors： Niu JT,Yi SS,Dong GY,Guo YB,Zhao YL,Huang HL,Wang K,Hu GX,Dong H

更新日期：2019-09-16 00:00:00

abstract：:The outstanding optoelectronics and photovoltaic properties of metal halide perovskites, including high carrier motilities, low carrier recombination rates, and the tunable spectral absorption range are attributed to the unique electronic properties of these materials. While DFT provides reliable structures and stabil...

journal_title：Scientific reports

authors： Tao SX,Cao X,Bobbert PA

更新日期：2017-10-30 00:00:00

abstract：:Using starch as the carbon precursor and different-sized ZnO naoparticles as the hard template, a series of porous carbon materials for electrochemical sensing were prepared. Experiments of scanning electron microscopy, transmission electron microscopy and Nitrogen adsorption-desorption isotherms reveal that the parti...

journal_title：Scientific reports

authors： Cheng Q,Ji L,Wu K,Zhang W

更新日期：2016-02-29 00:00:00

abstract：:The new-type electrolysis-integrated ecological floating beds (EEFBs) were set up to study their water removal ability due to the excellent water treatment capacity of electrolysis, this enhanced EEFBs were made of polyethylene filled with biochar substrate and in middle of the substrate placed the Mg-Al alloy served ...

journal_title：Scientific reports

authors： Yan C,Wang M,Ma T,Yang S,Kong M,Shen J,Yang L,Gao Y

更新日期：2020-05-06 00:00:00

abstract：:Taraxacum kok-saghyz (TKS) carries great potential as alternative natural rubber source. To better inform future breeding efforts with TKS and gain a deeper understanding of its genetic diversity, we utilized de novo sequencing to generate novel genomic simple sequence repeats markers (gSSRs). We utilized 25 gSSRs on ...

journal_title：Scientific reports

authors： Nowicki M,Zhao Y,Boggess SL,Fluess H,Payá-Milans M,Staton ME,Houston LC,Hadziabdic D,Trigiano RN

更新日期：2019-02-13 00:00:00

abstract：:Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little is known about HSP90 inhibition-mediated bladder cancer therapy. Here, we report a quantitative proteomic study that evaluates alte...

journal_title：Scientific reports

authors： Li QQ,Hao JJ,Zhang Z,Krane LS,Hammerich KH,Sanford T,Trepel JB,Neckers L,Agarwal PK

更新日期：2017-03-15 00:00:00

abstract：:We aimed to analyze the associations of bone mineral density (BMD) of femoral heads, age and gender, and compare the differences in BMD between fracture side and non-fracture side by "3D Spine Exam Analysis" module in QCT Pro software. In this study, we identified patients who had undergone quantitative computed tomog...

journal_title：Scientific reports

authors： Li X,Xu Y,Lin W,Fan Y

更新日期：2020-08-03 00:00:00

abstract：:Polypyrrole complex nitrogen-doped porous carbon matrix (PPy/N-PCM) was synthesized by a simple two-step method. Firstly, graphene oxide was prepared by the modified Hummers method. Secondly, Polypyrrole was compounded on the graphene oxide substrate, and the carbon matrix with a high specific surface area was obtaine...

journal_title：Scientific reports

authors： Feng M,Lu W,Zhou Y,Zhen R,He H,Wang Y,Li C

更新日期：2020-09-21 00:00:00

abstract：:The neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of Alzheimer's disease (AD). Here, we examined the effect of fisetin, a flavonol, on tau levels. Treatment of cortical cells or primary neurons with fisetin resulted in significant decreases in the levels of phosphorylated tau. I...

journal_title：Scientific reports

authors： Kim S,Choi KJ,Cho SJ,Yun SM,Jeon JP,Koh YH,Song J,Johnson GV,Jo C

更新日期：2016-04-26 00:00:00

abstract：:Nanomaterials are extensively studied in electrochemical energy storage and conversion systems because of their structural advantages. However, their volumetric energy density still needs improvement due to the high surface area, especially the carbon based nanocomposites. Constructing hierarchical micro-scaled materi...

journal_title：Scientific reports

authors： Liang S,Tan Q,Xiong W,Tang Y,Tan X,Huang L,Pan A,Cao G

更新日期：2016-09-21 00:00:00

abstract：:Hard carbon attracts wide attentions as the anode for high-energy rechargeable batteries due to its low cost and high theoretical capacities. However, the intrinsically disordered microstructure gives it poor electrical conductivity and unsatisfactory rate performance. Here we report a facile synthesis of N-doped grap...

journal_title：Scientific reports

authors： Wang N,Liu Q,Sun B,Gu J,Yu B,Zhang W,Zhang D

更新日期：2018-07-02 00:00:00

abstract：:Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense variant (c3818C > T; ...

journal_title：Scientific reports

authors： Peters C,Rosch RE,Hughes E,Ruben PC

更新日期：2016-09-01 00:00:00

abstract：:Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we dem...

journal_title：Scientific reports

authors： Uemura M,Nagasawa A,Terai K

更新日期：2016-06-07 00:00:00

abstract：:Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis. We detected PRL and PRLR in all GBM cell lines tested. PRLR activation or overexpression using plasmid tra...

journal_title：Scientific reports

authors： Asad AS,Nicola Candia AJ,Gonzalez N,Zuccato CF,Abt A,Orrillo SJ,Lastra Y,De Simone E,Boutillon F,Goffin V,Seilicovich A,Pisera DA,Ferraris MJ,Candolfi M

更新日期：2019-12-20 00:00:00

abstract：:Exotic pattern formation as a result of drying of an aqueous solution containing DNA and silica nanoparticles is reported. The pattern due to segregation was found to critically depend on the relative ratio of nanoparticles and DNA, as revealed by polarization microscopy, scanning electron microscopy, and fluorescence...

journal_title：Scientific reports

authors： Joksimovic R,Watanabe S,Riemer S,Gradzielski M,Yoshikawa K

更新日期：2014-01-13 00:00:00

abstract：:The transition energies and formation energies of N, C, F, Cl, and S as substitutional dopants in Ag3PO4 are studied using first-principles calculations based on the hybrid Hartree-Fock density functional, which correctly reproduces the band gap and thus provides the accurate defect states. Our results show that NO an...

journal_title：Scientific reports

authors： Huang Y,Ma T,Chen QY,Cao C,He Y

更新日期：2015-08-03 00:00:00

abstract：:Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...

journal_title：Scientific reports

authors： Jang TH,Lim IH,Kim CM,Choi JY,Kim EA,Lee TJ,Park HH

更新日期：2016-08-09 00:00:00

abstract：:A common belief is that, unlike today, ancient urban areas developed in a sustainable way within the environmental limits of local natural resources and the ecosystem's capacity to respond. This long-held paradigm is based on a weak knowledge of the processes underpinning the emergence of urban life and the rise of an...

journal_title：Scientific reports

authors： Kaniewski D,Van Campo E,Morhange C,Guiot J,Zviely D,Shaked I,Otto T,Artzy M

更新日期：2013-12-18 00:00:00

abstract：:The current theories of antimalarial mechanism of artemisinin are inadequate to fully explain the observed effects. In our study, "organism-like" formation of Schistosoma hemozoin granules by attaching to and utilizing erythrocytes to form new ones was observed. This indicates that heme iron is transferred from erythr...

journal_title：Scientific reports

authors： Sun J,Li C,Wang S

更新日期：2016-10-03 00:00:00

abstract：:Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+)  T cells that are activated by MHC I-mediated presen...

journal_title：Scientific reports

authors： Keller IE,Vosyka O,Takenaka S,Kloß A,Dahlmann B,Willems LI,Verdoes M,Overkleeft HS,Marcos E,Adnot S,Hauck SM,Ruppert C,Günther A,Herold S,Ohno S,Adler H,Eickelberg O,Meiners S

更新日期：2015-05-19 00:00:00

abstract：:We propose that a parallel coordinates plot can be used to study multidimensional data particularly to explore discovery of patterns across the variables. This can assist researchers from the health sciences to visualize their cohort data with interactive data analysis. The study used data from Mother and Child in the...

journal_title：Scientific reports

authors： Mitku AA,Zewotir T,North D,Naidoo RN

更新日期：2020-04-30 00:00:00

abstract：:Our goals was to evaluate how sentinel lymph node biopsy (SLNB) benefit neck management in patients with parotid cancer. Patients diagnosed with cN0 parotid cancer by preoperative fine needle puncture were prospectively enrolled. The neck status was evaluated by SLNB. If node metastasis was proved by SLNB, a neck diss...

journal_title：Scientific reports

authors： Pan W,Ba K,Niu X,Liu F,Fang Q

更新日期：2019-06-06 00:00:00

abstract：:Recent parallel studies clearly indicated that Merkel cells and the mechanosensitive piezo2 ion channel play critical roles in the light-touch somatosensation. Moreover, piezo2 was suggested to be a light-touch sensing ion channel without a role in pain sensing in mammals. However, biophysical characteristics of piezo...

journal_title：Scientific reports

authors： Shin KC,Park HJ,Kim JG,Lee IH,Cho H,Park C,Sung TS,Koh SD,Park SW,Bae YM

更新日期：2019-04-23 00:00:00