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Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging.

Abstract：

:Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD using mass spectrometry-based imaging. Nine human muscle biopsies from DMD patients and nine muscle biopsies from control individuals were subjected to untargeted MSI using matrix-assisted laser desorption/ionization Fourier-transform ion cyclotron resonance mass spectrometry. Both univariate and pattern recognition techniques have been used for data analysis. This study revealed significant changes in 34 keys metabolites. Seven metabolites were decreased in the Duchenne biopsies compared to control biopsies including adenosine triphosphate, and glycerophosphocholine. The other 27 metabolites were increased in the Duchenne biopsies, including sphingomyelin, phosphatidylcholines, phosphatidic acids and phosphatidylserines. Most of these dysregulated metabolites are tightly related to energy and phospholipid metabolism. This study revealed a deep metabolic remodelling in phospholipids and energy metabolism in DMD. This systems-based approach enabled exploring the metabolism in DMD in an unprecedented holistic and unbiased manner with hypothesis-free strategies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dabaj I,Ferey J,Marguet F,Gilard V,Basset C,Bahri Y,Brehin AC,Vanhulle C,Leturcq F,Marret S,Laquerrière A,Schmitz-Afonso I,Afonso C,Bekri S,Tebani A

doi

10.1038/s41598-021-81090-1

subject

Has Abstract

pub_date

2021-01-21 00:00:00

pages

1906

issue

1

issn

2045-2322

pii

10.1038/s41598-021-81090-1

journal_volume

11

pub_type

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