Abstract：
:Prostate cancer (PCa) is the most common malignancy and second leading cause of cancer-related deaths in American men. Proliferating cells have higher need for nutrients and oxygen, triggering angiogenesis that plays a critical role in tumor growth, progression and metastasis. Consequently, immense focus has converged onto inhibitors of angiogenesis in cancer treatment, such as Nintedanib, which has shown exceptional antitumor activity via inhibiting cell proliferation and the resulting tumor growth, primarily due to its combined action on tumor cells, endothelial cells and pericytes. Accordingly, here we assessed both in vitro and in vivo efficacy of Nintedanib in PCa. The results showed that Nintedanib decreased cell viability in both androgen dependent- and -independent PCa cells, together with a decrease in cell motility and invasiveness. Nintedanib also reduced the expression of significant genes responsible for cell cycle progression. PCa PC3 xenograft-carrying nude mice treated with Nintedanib showed significantly decreased tumor volume and cell proliferation alongside diminished levels of pro-angiogenic molecules and blood vessel densities. In conclusion, we report that Nintedanib has strong efficacy against PCa in pre-clinical models via modulation of various pathways, and that it could be employed as a promising new strategy to manage PCa clinically.
journal_name
Sci Repjournal_title
Scientific reportsauthors
da Silva RF,Dhar D,Raina K,Kumar D,Kant R,Cagnon VHA,Agarwal C,Agarwal Rdoi
10.1038/s41598-018-27831-1subject
Has Abstractpub_date
2018-06-22 00:00:00pages
9540issue
1issn
2045-2322pii
10.1038/s41598-018-27831-1journal_volume
8pub_type
杂志文章abstract：:Although oxide-based resistive switching memory (OxRAM) is one of the strong next-generation high capacity memory candidates, it has the critical disadvantage that deviations of resistance levels is too severe to be adopted as a high capacity memory device. More specifically, it is known that the larger on/off current...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35838-x
更新日期：2019-01-22 00:00:00
abstract：:Finger-oximeters are ubiquitously used for patient monitoring in hospitals worldwide. Recently, remote measurement of arterial blood oxygenation (SpO2) with a camera has been demonstrated. Both contact and remote measurements, however, require the subject to remain static for accurate SpO2 values. This is due to the u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38609
更新日期：2016-12-07 00:00:00
abstract：:ABX464 is a first-in-class, clinical-stage, small molecule for oral administration that has shown strong anti-inflammatory effects in the DSS-model for inflammatory bowel disease (IBD) and also prevents replication of the HIV virus. ABX464 which binds to cap binding complex (CBC) has demonstrated safety and efficacy i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37813-y
更新日期：2019-01-28 00:00:00
abstract：:We present a detailed study to resolve the discrepancy between the existing theoretically estimated oscillator strengths and the recently observed result from the X-ray free electron laser (XFEL) experiment performed at the Linac Coherent Light Source (LCLS) for the intensity ratio between two of the strongest emissio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43916-x
更新日期：2019-05-16 00:00:00
abstract：:Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20278-4
更新日期：2018-01-31 00:00:00
abstract：:Three-dimensional ion and particle concentrations under hydrodynamic focusing in a Y-shaped square microchannel are numerically simulated to clarify the decrease of the ion concentration along the flow direction within the focused particle stream. The simulation model is theoretically governed by the laminar flow and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82259-4
更新日期：2021-01-28 00:00:00
abstract：:Enoxacin and its bone-seeking bisphosphonate derivative, bis-enoxacin, have recently captured attention as potential therapeutic agents for the treatment of cancer and bone disease. No differences in growth or survival of 4T1 murine breast cancer cells were detected at a concentration of 50 µM of enoxacin or bis-enoxa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34698-9
更新日期：2018-11-01 00:00:00
abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65206-7
更新日期：2020-05-22 00:00:00
abstract：:In-stent restenosis (ISR) remains the leading problem encountered after percutaneous coronary intervention (PCI). Thiazolidinediones (TZDs) has been shown to be associated with reduced ISR and target lesion revascularization (TLR); however, the results are inconsistent, especially between rosiglitazone and pioglitazon...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-14873-0
更新日期：2017-10-31 00:00:00
abstract：:Fluid-feeding insects have evolved a unique strategy to distribute the labor between a liquid-acquisition device (proboscis) and a sucking pump. We theoretically examined physical constraints associated with coupling of the proboscis and sucking pump into a united functional organ. Classification of fluid feeders with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06391-w
更新日期：2017-07-26 00:00:00
abstract：:2D transition metal dichalcogenides (TMDs) have attracted a lot of attention recently for energy-efficient tunneling-field-effect transistor (TFET) applications due to their excellent gate control resulting from their atomically thin dimensions. However, most TMDs have bandgaps (Eg) and effective masses (m(*)) outside...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28515
更新日期：2016-06-27 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep31347. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46979
更新日期：2018-05-11 00:00:00
abstract：:There is a growing interest concerning the relevance of salivary cortisone levels in stress-related research. However, studies investigating morning patterns and day-to-day variability of cortisone versus cortisol levels are lacking. Cortisol and cortisone analysis by liquid chromatography-tandem mass spectroscopy (LC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55571-3
更新日期：2019-12-17 00:00:00
abstract：:Recently, a concept of digital metamaterials has been proposed to manipulate field distribution through proper spatial mixtures of digital metamaterial bits. Here, we present a design of 2-bit digitally-controlled coding metasurface that can effectively modulate the scattered electromagnetic wave and realize different...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42302
更新日期：2017-02-08 00:00:00
abstract：:Understanding the factors that enable mutualisms to evolve and to subsequently remain stable over time, is essential to fully understand patterns of global biodiversity and for evidence based conservation policy. Theoretically, spatial heterogeneity of mutualists, through increased likelihood of fidelity between coope...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/srep14826
更新日期：2015-10-05 00:00:00
abstract：:African black-footed cats (Felis nigripes) are endangered wild felids. One male and full-sibling female African black-footed cat developed vision deficits and mydriasis as early as 3 months of age. The diagnosis of early-onset progressive retinal atrophy (PRA) was supported by reduced direct and consensual pupillary l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43918
更新日期：2017-03-21 00:00:00
abstract：:Crystalline materials exhibit long-range ordered lattice unit, within which resides nonperiodic structural features called defects. These crystallographic defects play a vital role in determining the physical and mechanical properties of a wide range of material systems. While computer vision has demonstrated success ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49105-0
更新日期：2019-09-04 00:00:00
abstract：:Lipofectamine reagents are widely accepted as "gold-standard" for the safe delivery of exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based explanation of their superior efficacy has remained mostly elusive thus far. Here we apply a straightforward combination of live cell imaging, single-part...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25879
更新日期：2016-05-11 00:00:00
abstract：:Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04169
更新日期：2014-02-25 00:00:00
abstract：:The study of geomagnetic excursions is key for understanding the behavior of the magnetic field of the Earth. In this paper, we present the geomagnetic record in a 2.29-m-long continuous core sampled in a flowstone in Liguria (Italy) and dated to the Lower Brunhes. The cored flowstone developed from Marine Isotopic St...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38350-4
更新日期：2019-02-04 00:00:00
abstract：:Short flashes of blue light (bioluminescence) from dinoflagellates can reduce copepod grazing of light-emitting cells. Other protective strategies against grazing are toxicity, reduced cell chain length and altered swimming patterns in different phytoplankton. Both toxicity and bioluminescence capacity in dinoflagella...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13293-4
更新日期：2017-10-12 00:00:00
abstract：:MLC901, a traditional Chinese medicine containing a cocktail of active molecules, both reduces cerebral infarction and improves recovery in patients with ischemic stroke. The aim of this study was to evaluate the acute and long-term benefits of MLC901 in ischemic and reperfused mouse hearts. Ex vivo, under physiologic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14822-x
更新日期：2017-10-31 00:00:00
abstract：:Either hardness or toughness has been the core interest in scientific exploration and technological pursuit for a long time. However, it is still a big challenge to enhance the hardness and toughness at the same time, since the improvement of one side is always at the expense of the other one. Here, we have succeeded ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09807-9
更新日期：2017-08-24 00:00:00
abstract：:Use of 10,129 singleton SNPs of known genomic location in tetraploid cotton provided unique opportunities to characterize genome-wide diversity among 440 Gossypium hirsutum and 219 G. barbadense cultivars and landrace accessions of widespread origin. Using the SNPs distributed genome-wide, we examined genetic diversit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41285
更新日期：2017-01-27 00:00:00
abstract：:The association between blood urea nitrogen to creatinine ratio (UCR) and survival is uncertain in hemodialysis patients. We examined the influence of UCR on mortality and morbidity in hemodialysis patients. A total of 3,401 hemodialysis patients were prospectively followed for 4 years. The association between UCR wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14205-2
更新日期：2017-11-02 00:00:00
abstract：:Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36187-5
更新日期：2018-12-05 00:00:00
abstract：:Understanding how a species utilises its habitat, and the processes that give rise to its movements and patterns of space use, is critical for its conservation. Southern Ground-hornbills Bucorvus leadbeateri are listed as Endangered in South Africa, as a result of habitat loss and persecution. The National Species Rec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73236-4
更新日期：2020-10-01 00:00:00
abstract：:Cell division during the reproductive phase of the Streptomyces life-cycle requires tight coordination between synchronous formation of multiple septa and DNA segregation. One remarkable difference with most other bacterial systems is that cell division in Streptomyces is positively controlled by the recruitment of Ft...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25782-1
更新日期：2018-05-09 00:00:00
abstract：:We investigated the effects of different intraoperative eyeball fixation techniques (superior rectus muscle suture [MS] and traction suture at the corneal limbus [CS]), on intraocular pressure (IOP) and the incidence of ptosis after phacotrabeculectomy. Forty-one eyes with different glaucoma types which qualified for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79635-x
更新日期：2021-01-12 00:00:00
abstract：:Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. ace1 encodes the synaptic enzyme and ace2 has other essential actions in many insect species, such as Chilo suppressalis an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05360-7
更新日期：2017-07-10 00:00:00
