Abstract:
:Biocompatible surfaces hold key to a variety of biomedical problems that are directly related to the competition between host-tissue cell integration and bacterial colonisation. A saving solution to this is seen in the ability of cells to uniquely respond to physical cues on such surfaces thus prompting the search for cell-instructive nanoscale patterns. Here we introduce a generic rationale engineered into biocompatible, titanium, substrates to differentiate cell responses. The rationale is inspired by cicada wing surfaces that display bactericidal nanopillar patterns. The surfaces engineered in this study are titania (TiO2) nanowire arrays that are selectively bactericidal against motile bacteria, while capable of guiding mammalian cell proliferation according to the type of the array. The concept holds promise for clinically relevant materials capable of differential physico-mechanical responses to cellular adhesion.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Diu T,Faruqui N,Sjöström T,Lamarre B,Jenkinson HF,Su B,Ryadnov MGdoi
10.1038/srep07122subject
Has Abstractpub_date
2014-11-20 00:00:00pages
7122issn
2045-2322pii
srep07122journal_volume
4pub_type
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