Binding of mycotoxins to proteins involved in neuronal plasticity: a combined in silico/wet investigation.

Abstract:

:We have applied a combined computational procedure based on inverse and direct docking in order to identify putative protein targets of a panel of mycotoxins and xenobiotic compounds that can contaminate food and that are known to have several detrimental effects on human health. This procedure allowed us to identify a panel of human proteins as possible targets for aflatoxins, gliotoxin, ochratoxin A and deoxynivalenol. Steady-state fluorescence and microscale thermophoresis experiments allowed us to confirm the binding of some of these mycotoxins to acetylcholinesterase and X-linked neuroligin 4, two proteins involved in synapse activity and, particularly for the second protein, neuronal plasticity and development. Considering the possible involvement of X-linked neuroligin 4 in the etiopathogenesis of autism spectrum syndrome, this finding opens up a new avenue to explore the hypothetical role of these xenobiotic compounds in the onset of this pathology.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Scafuri B,Varriale A,Facchiano A,D'Auria S,Raggi ME,Marabotti A

doi

10.1038/s41598-017-15148-4

subject

Has Abstract

pub_date

2017-11-09 00:00:00

pages

15156

issue

1

issn

2045-2322

pii

10.1038/s41598-017-15148-4

journal_volume

7

pub_type

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