Abstract：
:Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their biologically active forms. "ICE-/-" or "Casp1-/-" mice generated using 129 embryonic stem cells carry a 129-associated inactivating passenger mutation on the caspase-11 locus, essentially making them deficient in both caspase-1 and caspase-11. The overlapping and unique functions of caspase-1 and caspase-11 are difficult to unravel without additional genetic tools. Here, we generated caspase-1-deficient mouse (Casp1Null) on the C57BL/6 J background that expressed caspase-11. Casp1Null cells did not release IL-1β and IL-18 in response to NLRC4 activators Salmonella Typhimurium and flagellin, canonical or non-canonical NLRP3 activators LPS and ATP, Escherichia coli, Citrobacter rodentium and transfection of LPS, AIM2 activators Francisella novicida, mouse cytomegalovirus and DNA, and the infectious agents Listeria monocytogenes and Aspergillus fumigatus. We further demonstrated that caspase-1 and caspase-11 differentially contributed to the host defense against A. fumigatus infection and to endotoxemia.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Man SM,Karki R,Briard B,Burton A,Gingras S,Pelletier S,Kanneganti TDdoi
10.1038/srep45126subject
Has Abstractpub_date
2017-03-27 00:00:00pages
45126issn
2045-2322pii
srep45126journal_volume
7pub_type
杂志文章abstract：:Users of social media often share their feelings or emotional states through their posts. In this study, we developed a deep learning model to identify a user's mental state based on his/her posting information. To this end, we collected posts from mental health communities in Reddit. By analyzing and learning posting...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68764-y
更新日期：2020-07-16 00:00:00
abstract：:Noisy galvanic vestibular stimulation (nGVS) delivered at imperceptible intensities can improve vestibular function in health and disease. Here we evaluated whether nGVS effects on vestibular function are only present during active stimulation or may exhibit relevant post-stimulation after-effects. Initially, nGVS amp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59374-9
更新日期：2020-02-13 00:00:00
abstract：:A three-dimensional multiscale modeling framework is developed to analyze the failure procedure of radially aligned zinc oxide (ZnO) enhanced single fiber composites (SFC) under tensile loading to understand the interfacial improvement between the fiber and the matrix. The model introduces four levels in the computati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56503-x
更新日期：2019-12-27 00:00:00
abstract：:Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Obje...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56264-7
更新日期：2019-12-23 00:00:00
abstract：:Measurements of volcanic tephra fallout deposits provide useful information about the magnitude and intensity of explosive volcanic eruptions and potential for remobilization of deposits as dangerous volcanic flows. However, gathering information in the vicinity of erupting craters is extremely dangerous, and moreover...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71902-1
更新日期：2020-09-09 00:00:00
abstract：:Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35302
更新日期：2016-10-12 00:00:00
abstract：:In an era of climate change, biological invasions by alien species represent one of the main anthropogenic drivers of global environmental change. The present study, using an ensemble modelling approach, has mapped current and future global distribution of the invasive Leucanthemum vulgare (Ox-eye Daisy) and predicted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47859-1
更新日期：2019-08-06 00:00:00
abstract：:Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses revealed that geneti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76600-6
更新日期：2020-11-09 00:00:00
abstract：:Misfolding of translated proteins occurs in all domains of life. In most cells, misfolded proteins coalesce in discrete aggregates at distinct cellular locations. In many bacteria, including mycobacteria, protein aggregates are located at the cellular pole. Yet the mechanism by which aggregates are sorted to the mycob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51132-w
更新日期：2019-10-10 00:00:00
abstract：:Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27106
更新日期：2016-06-03 00:00:00
abstract：:While previous studies separately demonstrate EEG spectral modulations during speech preparation and ERP responses to the listened speech, it is unclear whether these responses are related on a trial-by-trial basis between a speaker and listener. In order to determine whether these responses are related in real-time, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31038-9
更新日期：2018-08-27 00:00:00
abstract：:Recently, structural colour formation and light control by accumulated guanine crystals were reported. However, the relationship between light interference by guanine platelets and light intensity in an individual platelet must be examined further. This study presents experimental evidence that the guanine crystal pla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34866-x
更新日期：2018-11-19 00:00:00
abstract：:Exposure to affective stimuli could enhance perception and facilitate attention via increasing alertness, vigilance, and by decreasing attentional thresholds. However, evidence on the impact of affective sounds on perception and attention is scant. Here, a novel aspect of affective facilitation of attention is studied...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09975-8
更新日期：2017-09-04 00:00:00
abstract：:Recent reports on direct reprogramming of cancer cells (iPCs) which results in reduced tumorigenic potential has attributed the importance of epigenetics in tumorigenesis, but lacked genome-wide analysis. Here we describe successful generation of iPCs from non-small cell lung cancer (NSCLC) cell lines. Following repro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00592
更新日期：2012-01-01 00:00:00
abstract：:In bacteria, the SecA ATPase provides the driving force for protein secretion via the SecYEG translocon. While the dynamic interplay between SecA and SecYEG in translocation is widely appreciated, it is not clear how SecA associates with the translocon in the crowded cellular environment. We use super-resolution micro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81081-2
更新日期：2021-01-14 00:00:00
abstract：:Asymmetric cell division is a ubiquitous feature during the development of higher organisms. Asymmetry is achieved by differential localization or activities of biological molecules such as proteins, and coding and non-coding RNAs. Here, we present subcellular transcriptomic and proteomic analyses along the animal-veg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26592-1
更新日期：2018-05-29 00:00:00
abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12720
更新日期：2015-07-30 00:00:00
abstract：:A major unresolved question in understanding visually guided locomotion in humans is whether actions are driven solely by the immediately available optical information (model-free online control mechanisms), or whether internal models have a role in anticipating the future path. We designed two experiments to investig...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44723-0
更新日期：2019-06-06 00:00:00
abstract：:High-grade gliomas are the most aggressive malignant brain tumors. Accurate pre-operative prognosis for this cohort can lead to better treatment planning. Conventional survival prediction based on clinical information is subjective and could be inaccurate. Recent radiomics studies have shown better prognosis by using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37387-9
更新日期：2019-01-31 00:00:00
abstract：:The anatomic and functional combinations of cusps and lophs (ridges) define the tooth shape of rodent molars, which distinguishes species. The species-specific cusp patterns result from the spatiotemporal induction of enamel knots (EKs), which require precisely controlled cellular behavior to control the epithelial in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37828
更新日期：2016-11-28 00:00:00
abstract：:When searching a target in a natural scene, it has been shown that both the target's visual properties and similarity to the background influence whether and how fast humans are able to find it. So far, it was unclear whether searchers adjust the dynamics of their eye movements (e.g., fixation durations, saccade ampli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37548-w
更新日期：2019-02-07 00:00:00
abstract：:The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufacturer's manual, and so...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13116-6
更新日期：2017-10-23 00:00:00
abstract：:Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03424-2
更新日期：2017-06-19 00:00:00
abstract：:IFI16 and AIM2 are important DNA sensors in antiviral immunity. To characterize these two molecules in a woodchuck model, which is widely used to study hepatitis B virus (HBV) infection, we cloned and analyzed the complete coding sequences (CDSs) of woodchuck IFI16 and AIM2, and found that AIM2 was highly conserved in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28776
更新日期：2016-06-29 00:00:00
abstract：:Biomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to reduce remodeling and restore cardiac function in recent preclinical studies. While the effect of biomaterial injection in reducing mechanical wall stress has been recently demonstrated, the influence of biomaterials on the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69900-4
更新日期：2020-07-31 00:00:00
abstract：:Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of envi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44305-0
更新日期：2019-05-24 00:00:00
abstract：:TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79145-w
更新日期：2021-01-14 00:00:00
abstract：:Hematopoietic stem/progenitor cells (HSPC) in zebrafish emerge from the aortic hemogenic endothelium (HE) and migrate towards the caudal hematopoietic tissue (CHT), where they expand and differentiate during definitive hematopoiesis. Phospholipase C gamma 1 (Plcγ1) has been implicated for hematopoiesis in vivo and in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36338-8
更新日期：2019-01-21 00:00:00
abstract：:Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28179
更新日期：2016-06-15 00:00:00
abstract：:Spiny mice of the genus Acomys display several unique physiological traits, including menstruation and scar-free wound healing; characteristics that are exceedingly rare in mammals, and of considerable interest to the scientific community. These unique attributes, and the potential for spiny mice to accurately model h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09334-7
更新日期：2017-08-21 00:00:00
