Abstract：
:There is a need for noninvasive repeatable biomarkers to detect early cancer treatment response and spare non-responders unnecessary morbidities and costs. Here, we introduce three-dimensional (3D) dynamic contrast enhanced ultrasound (DCE-US) perfusion map characterization as inexpensive, bedside and longitudinal indicator of tumor perfusion for prediction of vascular changes and therapy response. More specifically, we developed computational tools to generate perfusion maps in 3D of tumor blood flow, and identified repeatable quantitative features to use in machine-learning models to capture subtle multi-parametric perfusion properties, including heterogeneity. Models were developed and trained in mice data and tested in a separate mouse cohort, as well as early validation clinical data consisting of patients receiving therapy for liver metastases. Models had excellent (ROC-AUC > 0.9) prediction of response in pre-clinical data, as well as proof-of-concept clinical data. Significant correlations with histological assessments of tumor vasculature were noted (Spearman R > 0.70) in pre-clinical data. Our approach can identify responders based on early perfusion changes, using perfusion properties correlated to gold-standard vascular properties.
journal_name
Sci Repjournal_title
Scientific reportsauthors
El Kaffas A,Hoogi A,Zhou J,Durot I,Wang H,Rosenberg J,Tseng A,Sagreiya H,Akhbardeh A,Rubin DL,Kamaya A,Hristov D,Willmann JKdoi
10.1038/s41598-020-63810-1subject
Has Abstractpub_date
2020-04-24 00:00:00pages
6996issue
1issn
2045-2322pii
10.1038/s41598-020-63810-1journal_volume
10pub_type
杂志文章abstract：:Bacterial proteins exported to the cell surface play key cellular functions. However, despite the interest to study the localisation of surface proteins such as adhesins, transporters or hydrolases, monitoring their dynamics in live imaging remains challenging, due to the limited availability of fluorescent probes rem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72498-2
更新日期：2020-09-25 00:00:00
abstract：:Herein, by growing mono dispersed gold nanoparticles (MNPAu) on the surface of polystyrene (PS)/nanogold (Au) core-shell composites (PS@Au), we successfully synthesized a micron-sized gold cage (2.6-10.7 μm), referred to as PS@Au@MNPAu for the first time. The new micron-gold cage materials exhibit broadband absorption...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72831-9
更新日期：2020-10-06 00:00:00
abstract：:Cooperating gene mutations are typically required to transform normal cells enabling growth in soft agar or in immunodeficient mice. For example, mutations in Kras and transformation-related protein 53 (Trp53) are known to transform a variety of mesenchymal and epithelial cells in vitro and in vivo. Identifying other ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53572-w
更新日期：2019-11-20 00:00:00
abstract：:Dynamical polarization of nuclear spin ensembles is of central importance for magnetic resonance studies, precision sensing and for applications in quantum information theory. Here we propose a scheme to generate long-lived singlet pairs in an unpolarized nuclear spin ensemble which is dipolar coupled to the electron ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00603-z
更新日期：2017-04-03 00:00:00
abstract：:Rangelands play a critical role in the global carbon cycle. However, the eco-physiological mechanisms associated with the effects of grazing on leaf photosynthesis and soil respiration remain poorly understood. To examine the impacts of grazing on leaf photosynthesis and soil respiration, we measured the photosyntheti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30087
更新日期：2016-07-25 00:00:00
abstract：:Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking advantage of the metabolic flexibility of TNBC MDA-MB-231 cells to generate subpopulations with glycolytic or oxidative p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31367-9
更新日期：2018-09-04 00:00:00
abstract：:Mucociliary clearance is a biomechanical mechanism of airway protection. It consists of the active transport along the bronchial tree of the mucus, a fluid propelled by the coordinated beating of a myriad of cilia on the epithelial surface of the respiratory tract. The physics of mucus transport is poorly understood b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20882-4
更新日期：2018-02-05 00:00:00
abstract：:Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) stress is associated with acute lung injury (ALI), we hypothesized that CIRP causes ALI via induction of ER stress. To test this hypothesis, we st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41363
更新日期：2017-01-27 00:00:00
abstract：:The continuous search for natural products that attenuate age-related losses has increasingly gained notice; among them, those applicable for skin care have drawn significant attention. The bioester generated from the Chenopodium quinoa's oil is a natural-origin ingredient described to produce replenishing skin effect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76325-6
更新日期：2020-11-10 00:00:00
abstract：:The mechanisms of pattern formation during embryonic development remain poorly understood. Embryonic stem cells in culture self-organise to form spatial patterns of gene expression upon geometrical confinement indicating that patterning is an emergent phenomenon that results from the many interactions between the cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73228-4
更新日期：2020-10-01 00:00:00
abstract：:The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33123-5
更新日期：2018-10-19 00:00:00
abstract：:13C-labeled glucose combined with chromatography and mass spectrometry enables us to decipher the percentage of lactate generated from various metabolic pathways. We showed that lactate derived from glycolysis, pentose phosphate pathway, Krebs cycle, and other sources accounted for 82-90%, 6.0-11%, 0.67-1.8% and 1.5-7...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08277-3
更新日期：2017-08-16 00:00:00
abstract：:We propose a method to simulate spin models in trapped ions using a digital-analog approach, consisting in a suitable gate decomposition in terms of analog blocks and digital steps. In this way, we show that the quantum dynamics of an enhanced variety of spin models could be implemented with substantially less number ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30534
更新日期：2016-07-29 00:00:00
abstract：:In sensory systems, a range of computational rules are presumed to be implemented by neuronal subpopulations with different tuning functions. For instance, in primate cortical area MT, different classes of direction-selective cells have been identified and related either to motion integration, segmentation or transpar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11373-z
更新日期：2017-09-12 00:00:00
abstract：:Cenozoic climate cooling at the advent of the Eocene-Oligocene transition (EOT), ~33.7 Ma ago, was stamped in the ocean by a series of climatic events albeit the impact of this global climatic transition on terrestrial environments is still fragmentary. Yet archival constraints on Late Eocene atmospheric circulation a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07766-9
更新日期：2017-08-10 00:00:00
abstract：:Adaptation to systematic visual distortions is well-documented but there is little evidence of similar adaptation to radical changes in audition. We use a pseudophone to transpose the sound streams arriving at the left and right ears, evaluating the perceptual effects it provokes and the possibility of learning to loc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61332-4
更新日期：2020-03-12 00:00:00
abstract：:In this paper we applied transfer learning techniques for image recognition, automatic categorization, and labeling of nanoscience images obtained by scanning electron microscope (SEM). Roughly 20,000 SEM images were manually classified into 10 categories to form a labeled training set, which can be used as a referenc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13565-z
更新日期：2017-10-16 00:00:00
abstract：:Coral reefs across the world's oceans are in the midst of the longest bleaching event on record (from 2014 to at least 2016). As many of the world's reefs are remote, there is limited information on how past thermal conditions have influenced reef composition and current stress responses. Using satellite temperature d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38402
更新日期：2016-12-06 00:00:00
abstract：:Peritrichs are a major group of ciliates with worldwide distribution. Yet, its internal phylogeny remains unresolved owing to limited sampling. Additionally, ecological distributions of peritrichs are poorly known. We performed substantially expanded phylogenetic analyses of peritrichs that incorporated SSU rDNA seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21695
更新日期：2016-02-16 00:00:00
abstract：:CIC-DUX4 sarcoma (CDS) is a group of rare, mesenchymal, small round cell tumours that harbour the unique CIC-DUX4 translocation, which causes aberrant gene expression. CDS exhibits an aggressive course and poor clinical outcome, thus novel therapeutic approaches are needed for CDS treatment. Although patient-derived c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04967-0
更新日期：2017-07-05 00:00:00
abstract：:Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51270-1
更新日期：2019-10-10 00:00:00
abstract：:DNA-directed RNA polymerase II (pol II) is composed of ten core and two dissociable subunits. The dissociable subcomplex is a heterodimer of Rpb4/Polr2d and Rpb7/Polr2g, which are encoded by RPB4/polr2d and RPB7/polr2g genes, respectively. Functional studies of Rpb4/Polr2d in yeast have revealed that Rpb4 plays a role...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70110-1
更新日期：2020-08-06 00:00:00
abstract：:Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70813-5
更新日期：2020-08-13 00:00:00
abstract：:Ecosystem functions are regulated by compositional and functional traits of bacterial communities, shaped by stochastic and deterministic processes. Biogeographical studies have revealed microbial community taxonomy in a given ecosystem to change alongside varying environmental characteristics. Considering that stable...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40315-0
更新日期：2019-03-06 00:00:00
abstract：:A synergetic approach of employing smooth mesoporous TiO2 microsphere (SμS-TiO2)-nanoparticulate TiO2 (np-TiO2) composite photoanode, and size and defect controlled CdSe quantum dots (QD) to achieve high efficiency (η) in a modified Grätzel solar cell, quantum dot sensitized whisperonic solar cells (QDSWSC), is report...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27969-y
更新日期：2018-06-26 00:00:00
abstract：:Are musicians better able to understand speech in noise than non-musicians? Recent findings have produced contradictory results. Here we addressed this question by asking musicians and non-musicians to understand target sentences masked by other sentences presented from different spatial locations, the classical 'cock...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11628
更新日期：2015-06-26 00:00:00
abstract：:Infection of humans with Chlamydia trachomatis, a bacterial pathogen with a unique intracellular replication cycle, may cause a variety of clinical manifestations. These are linked to various serovars of the pathogen; trachoma to serovars A-C, oculogenital infections to serovars D-K, and lymphogranuloma venereum to se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54886-5
更新日期：2019-12-04 00:00:00
abstract：:Coherent, optically dressed media composed of two-level molecular systems without inversion symmetry are considered as all-optically tunable sources of coherent radiation in the microwave domain. A theoretical model and a numerical toolbox are developed to confirm the main finding: the generation of low-frequency radi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74569-w
更新日期：2020-10-19 00:00:00
abstract：:In this paper, phosphorene nanoribbons (PNRs) are theoretically studied using a multiscale simulation flow from the ab initio level to the tight binding (TB) level. The scaling effects of both armchair PNRs (aPNRs) and zigzag PNRs (zPNRs) from material properties to device properties are explored. The much larger effe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38009
更新日期：2016-11-29 00:00:00
abstract：:Although the initial formulation of modern concepts of adaptive radiation arose from consideration of the fossil data, rigorous attempts to identify this phenomenon in the fossil record are largely uncommon. Here I focus on direct evidence of the diet (through tooth-wear patterns) and ecologically-relevant traits of o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29803
更新日期：2016-07-13 00:00:00
