Independent Emergence of the Cosmopolitan Asian Chikungunya Virus, Philippines 2012.

abstract：:Some previous studies have indicated that valproate (VPA) might change the pharmacokinetics and enhance the effects of propofol. We evaluated whether clinical VPA therapy affected the propofol blood level, the protein-unbound free propofol level, and/or the anesthetic effects of propofol in the clinical setting. The s...

journal_title：Scientific reports

authors： Kodama M,Higuchi H,Ishii-Maruhama M,Nakano M,Honda-Wakasugi Y,Maeda S,Miyawaki T

更新日期：2020-01-31 00:00:00

abstract：:Daily sunlight exposure damages the epidermal basement membrane (BM) and disrupts epidermal homeostasis. Inter-follicular epidermal stem cells (IFE-SCs) regulate epidermal proliferation and differentiation, which supports epidermal homeostasis. Here, we examine how photoaging affects the function of IFE-SCs and we ide...

journal_title：Scientific reports

authors： Iriyama S,Yasuda M,Nishikawa S,Takai E,Hosoi J,Amano S

更新日期：2020-07-28 00:00:00

abstract：:Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that κ opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly inhibited human umbilical vein endothelial cell (HUVEC) migration and tube ...

journal_title：Scientific reports

authors： Yamamizu K,Furuta S,Hamada Y,Yamashita A,Kuzumaki N,Narita M,Doi K,Katayama S,Nagase H,Yamashita JK,Narita M

更新日期：2013-11-14 00:00:00

abstract：:Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (α-GalCer) or vehicle once a week for four weeks. In the α-GalC...

journal_title：Scientific reports

authors： Uchida T,Nakashima H,Yamagata A,Ito S,Ishikiriyama T,Nakashima M,Seki S,Kumagai H,Oshima N

更新日期：2018-05-29 00:00:00

abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...

journal_title：Scientific reports

authors： Takahashi M,Okimura Y,Iguchi G,Nishizawa H,Yamamoto M,Suda K,Kitazawa R,Fujimoto W,Takahashi K,Zolotaryov FN,Hong KS,Kiyonari H,Abe T,Kaji H,Kitazawa S,Kasuga M,Chihara K,Takahashi Y

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to investigate whether a novel physiologically relevant marker, InsuTAG (fasting insulin × fasting triglycerides) can predict insulin resistance (IR) and metabolic syndrome (MetS). Data of 618 participants from the Retirement Health and Lifestyle Study (RHLS) were evaluated for the current st...

journal_title：Scientific reports

authors： Thota RN,Abbott KA,Ferguson JJA,Veysey M,Lucock M,Niblett S,King K,Garg ML

更新日期：2017-11-09 00:00:00

abstract：:Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage dysplasia, but the ...

journal_title：Scientific reports

authors： Wang C,Xu CX,Alippe Y,Qu C,Xiao J,Schipani E,Civitelli R,Abu-Amer Y,Mbalaviele G

更新日期：2017-07-07 00:00:00

abstract：:Cetacean strandings (CS) have been reported in increasing numbers in coastal areas worldwide. Although the causes of these strandings are unknown, a number of anthropogenic and environmental factors have been suggested. This paper aims to characterize CS patterns and describe their fine-scale spatiotemporal dynamics. ...

journal_title：Scientific reports

authors： Alvarado-Rybak M,Toro F,Escobar-Dodero J,Kinsley AC,Sepúlveda MA,Capella J,Azat C,Cortés-Hinojosa G,Zimin-Veselkoff N,Mardones FO

更新日期：2020-06-11 00:00:00

abstract：:Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...

journal_title：Scientific reports

authors： Guerra S,Peressotti A,Peressotti F,Bulgheroni M,Baccinelli W,D'Amico E,Gómez A,Massaccesi S,Ceccarini F,Castiello U

更新日期：2019-11-12 00:00:00

abstract：:Fertilisation datasets collected from field experiments (n = 21) in tea-producing areas from 2016 to 2018 were used to build a quantitative evaluation of the fertility of tropical soils (QUEFTS) model to estimate nutrient uptake of tea plants, and to investigate relationships between tea yield and nutrient accumulatio...

journal_title：Scientific reports

authors： Tang S,Liu Y,Zheng N,Li Y,Ma Q,Xiao H,Zhou X,Xu X,Jiang T,He P,Wu L

更新日期：2020-02-04 00:00:00

abstract：:Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). ...

journal_title：Scientific reports

authors： Christian P,Tumphart S,Ehmann HMA,Riegler H,Coclite AM,Werzer O

更新日期：2018-05-08 00:00:00

abstract：:The associations of 18F-THK5351 tau positron emission tomography (PET) findings with core domains of progressive supranuclear palsy (PSP) and its diagnostic certainty have yet to be fully elucidated. The 18F-THK5351 PET patterns of 17 patients with PSP (68.9 ± 6.5 years; 8 women) were compared with those observed in 2...

journal_title：Scientific reports

authors： Hsu JL,Chen SH,Hsiao IT,Lu CS,Yen TC,Okamura N,Lin KJ,Weng YH

更新日期：2020-11-10 00:00:00

abstract：:A histoanatomical context is imperative in an analysis of gene expression in a cell in a tissue to elucidate physiological function of the cell. In this study, we made technical advances in fluorescence laser microdissection (LMD) in combination with the absolute quantification of small amounts of mRNAs from a region ...

journal_title：Scientific reports

authors： Yoshioka W,Endo N,Kurashige A,Haijima A,Endo T,Shibata T,Nishiyama R,Kakeyama M,Tohyama C

更新日期：2012-01-01 00:00:00

abstract：:Recently, mesoporous carbon nitride (MCN) has aroused extensive interest for its potential applications in organocatalysis, photo- and electrochemistry and CO2 capture. However, further surface functionalization of MCN for advanced nanomaterials and catalysis still remains very challenging. Here we show that acidic ca...

journal_title：Scientific reports

authors： Zhong L,Anand C,Lakhi KS,Lawrence G,Vinu A

更新日期：2015-08-05 00:00:00

abstract：:The use of entomopathogenic fungi for biocontrol of plant pests is recently receiving an increased interest due to the need of reducing the impact of agricultural practices on the environment. Biocontrol efficacy could be improved by co-inoculation of different microorganisms. However, interactions between the fungal ...

journal_title：Scientific reports

authors： Canfora L,Abu-Samra N,Tartanus M,Łabanowska BH,Benedetti A,Pinzari F,Malusà E

更新日期：2017-10-12 00:00:00

abstract：:Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell...

journal_title：Scientific reports

authors： Mandon M,Huet S,Dubreil E,Fessard V,Le Hégarat L

更新日期：2019-07-22 00:00:00

abstract：:We study stochastic particle systems made up of heterogeneous units. We introduce a general framework suitable to analytically study this kind of systems and apply it to two particular models of interest in economy and epidemiology. We show that particle heterogeneity can enhance or decrease the size of the collective...

journal_title：Scientific reports

authors： Lafuerza LF,Toral R

更新日期：2013-01-01 00:00:00

abstract：:The fine-tuning of gene expression contributes to both basic science and applications. Here, we develop a novel gene expression technology termed CRITGI (CRISPR/Transposon gene integration). CRITGI uses CRISPR/Cas9 to integrate multiple copies of the plasmid pTy1 into Ty1 loci, budding yeast retrotransposons. The pTy1...

journal_title：Scientific reports

authors： Hanasaki M,Masumoto H

更新日期：2019-10-25 00:00:00

abstract：:The green bacterial biosynthesis of lead sulfide nanocrystallites by L-cysteine-desulfurizing bacterium Lysinibacillus sphaericus SH72 was demonstrated in this work. Nanocrystals formed by this bacterial method were characterized using the mineralogical and morphological approaches. The results revealed that the micro...

journal_title：Scientific reports

authors： Wei S,Guo C,Wang L,Xu J,Dong H

更新日期：2021-01-13 00:00:00

abstract：:During the late Eocene, the Earth's climate experienced several transient temperature fluctuations including the Vonhof cooling event (C16n.1n; ~35.8 Ma) hitherto known mainly from the southern oceans. Here we reconstruct sea-surface temperatures (SST) and provide δ18O and δ13C foraminiferal records for the late Eocen...

journal_title：Scientific reports

authors： Śliwińska KK,Thomsen E,Schouten S,Schoon PL,Heilmann-Clausen C

更新日期：2019-03-14 00:00:00

abstract：:Human epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological types of EC. This study investigated the accuracy of human epididymis...

journal_title：Scientific reports

authors： Liu J,Han L,Jiao Z

更新日期：2021-01-12 00:00:00

abstract：:Iron oxide nanoparticles have attracted a great deal of research interest and have been widely used in bioscience and clinical research including as contrast agents for magnetic resonance imaging, hyperthermia and magnetic field assisted radionuclide therapy. It is therefore important to develop methods, which can pro...

journal_title：Scientific reports

authors： Erofeev A,Gorelkin P,Garanina A,Alova A,Efremova M,Vorobyeva N,Edwards C,Korchev Y,Majouga A

更新日期：2018-05-10 00:00:00

abstract：:Medial arterial calcification (MAC) is a common outcome in diabetes and chronic kidney disease (CKD). It occurs as linear mineral deposits along the degraded elastin lamellae and is responsible for increased aortic stiffness and subsequent cardiovascular events. Current treatments for calcification, particularly in CK...

journal_title：Scientific reports

authors： Karamched SR,Nosoudi N,Moreland HE,Chowdhury A,Vyavahare NR

更新日期：2019-02-22 00:00:00

abstract：:We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under differe...

journal_title：Scientific reports

authors： Tyler WJ,Boasso AM,Mortimore HM,Silva RS,Charlesworth JD,Marlin MA,Aebersold K,Aven L,Wetmore DZ,Pal SK

更新日期：2015-09-10 00:00:00

abstract：:MicroRNA is responsible for the fine-tuning of fundamental cellular activities and human disease development. The altered availability of microRNAs, target mRNAs, and other types of endogenous RNAs competing for microRNA interactions reflects the dynamic and conditional property of microRNA-mediated gene regulation th...

journal_title：Scientific reports

authors： Shu J,Silva BVRE,Gao T,Xu Z,Cui J

更新日期：2017-10-17 00:00:00

abstract：:West Nile virus (WNV) is a mosquito-borne flavivirus which has caused repeated outbreaks in humans in southern and central Europe, but thus far not in northern Europe. The main mosquito vector for WNV, Culex pipiens, consists of two behaviourally distinct biotypes, pipiens and molestus, which can form hybrids. Differe...

journal_title：Scientific reports

authors： Vogels CBF,Hartemink N,Koenraadt CJM

更新日期：2017-07-10 00:00:00

abstract：:A biochemical reaction model clarifies for the first time how cold atmospheric plasmas (CAPs) affect mitochondrial redox homeostasis and energy metabolism. Fundamental mitochondrial functions in pyruvic acid oxidation, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation involving the respiratory chain (RC...

journal_title：Scientific reports

authors： Murakami T

更新日期：2019-11-20 00:00:00

abstract：:Noise-induced hearing loss (NIHL) is a common health concern with significant social, psychological, and cognitive implications. Moderate levels of acoustic overstimulation associated with tinnitus and impaired speech perception cause cochlear synaptopathy, characterized physiologically by reduction in wave I of the s...

journal_title：Scientific reports

authors： Rouse SL,Matthews IR,Li J,Sherr EH,Chan DK

更新日期：2020-10-22 00:00:00

abstract：:The indirect interactions between insect vectors, such as whiteflies, and the viruses they transmit, such as begomoviruses, via host plants may produce a range of outcome depending on the species/strain of each of the three organisms involved, and the mechanisms underlying the variations are not well understood. Here,...

journal_title：Scientific reports

authors： Sun YC,Pan LL,Ying FZ,Li P,Wang XW,Liu SS

更新日期：2017-04-03 00:00:00

abstract：:The global left ventricular (LV) contractility index, dσ*/dtmax measures the maximal rate of change in pressure-normalized LV wall stress. We aim to describe the trend of dσ*/dtmax in differing severity of aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) and the association of dσ*/dtmax wi...

journal_title：Scientific reports

authors： Sim HW,Ngiam NJ,Zhong L,Tan BY,Low LY,Djohan AH,Boey E,Kong WKF,Tan RS,Poh KK

更新日期：2020-04-30 00:00:00