Abstract:
:During the late Eocene, the Earth's climate experienced several transient temperature fluctuations including the Vonhof cooling event (C16n.1n; ~35.8 Ma) hitherto known mainly from the southern oceans. Here we reconstruct sea-surface temperatures (SST) and provide δ18O and δ13C foraminiferal records for the late Eocene and earliest Oligocene in the North Sea Basin. Our data reveal two main perturbations: (1), an abrupt brief cooling of ~4.5 °C dated to ~35.8 Ma and synchronous with the Vonhof cooling, which thus may be a global event, and (2) a gradual nearly 10 °C temperature fall starting at 36.1 Ma and culminating near the Eocene-Oligocene transition at ~33.9 Ma. The late Priabonian temperature trend in the North Sea shows some resemblance IODP Site U1404 from the North Atlantic, offshore Newfoundland; and is in contrast to the more abrupt change observed in the deep-sea δ18O records from the southern oceans. The cooling in the North Sea is large compared to the pattern seen in the North Atlantic record. This difference may be influenced by a late Eocene closure of the warm gateways connecting the North Sea with the Atlantic and Tethys oceans.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Śliwińska KK,Thomsen E,Schouten S,Schoon PL,Heilmann-Clausen Cdoi
10.1038/s41598-019-41013-7subject
Has Abstractpub_date
2019-03-14 00:00:00pages
4458issue
1issn
2045-2322pii
10.1038/s41598-019-41013-7journal_volume
9pub_type
杂志文章abstract::As the world's oceans are currently threatened by anthropogenic pollution and climate change, coral breeding has become an important conservation method, since it can limit marine organisms' exposure to sub-optimal environment conditions. However, the aquarium environment is inherently different from the ocean, and th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33341-x
更新日期:2018-10-11 00:00:00
abstract::It is well known that tumour-associated macrophages (TAMs) play an important role in tumour development by modulating the tumour microenvironment, and targeting of protumour activation or the M2 polarization of TAMs is expected to be an effective therapy for cancer patients. We previously demonstrated that onionin A (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29588
更新日期:2016-07-12 00:00:00
abstract::The potential angiogenic effect of roxarsone, a feed additive widely used to promote animal growth worldwide, was demonstrated recently. We explored the mechanism of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in roxarsone promotion of rat vascular endothelial cells (ECs) and B16F10 mouse xenogr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53870-3
更新日期:2019-11-22 00:00:00
abstract::Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-si...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00357-8
更新日期:2017-03-21 00:00:00
abstract::NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myris...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-44379-w
更新日期:2019-05-28 00:00:00
abstract::Swarming bacteria are an example of a complex, active biological system, where high cell density and super-diffusive cell mobility confer survival advantages to the group as a whole. Previous studies on the dynamics of the swarm have been limited to easily observable regions at the advancing edge of the swarm where ce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34192-2
更新日期:2018-10-25 00:00:00
abstract::Traditionally, dynamic atomic force microscopy (AFM) techniques are based on the analysis of the quasi-steady state response of the cantilever deflection in terms of Fourier analysis. Here we describe a technique that instead exploits the often disregarded transient response of the cantilever through a relatively mode...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49104-1
更新日期:2019-09-03 00:00:00
abstract::Sweet potato leaf curl virus (SPLCV) causes yield losses in sweet potato cultivation. Diagnostic techniques such as serological detection have been developed because these plant viruses are difficult to treat. Serological assays have been used extensively with recombinant antibodies such as whole immunoglobulin or sin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64996-0
更新日期:2020-05-15 00:00:00
abstract::Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 201...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36235
更新日期:2016-11-08 00:00:00
abstract::Most people with diabetes suffer some deterioration of the feet. Diabetic foot syndrome causes ulceration in about 15% of cases and such deterioration leads to amputation in about 2.5% of diabetic patients, diminishing their quality of life and generating extraordinary costs for patients and public health systems. Cur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42124
更新日期:2017-02-06 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58753-6
更新日期:2020-01-29 00:00:00
abstract::Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42932-1
更新日期:2019-04-23 00:00:00
abstract::The present study aimed to explore a new source of montmorillonite and to develop an extraction and purification protocol for its isolation from raw clay samples acquired from the Koh-e-Suleiman mountain range in Pakistan. The process involved the collection of raw clay from the source, identification and quantificati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57511-y
更新日期:2020-01-17 00:00:00
abstract::The dispensing of tiny droplets is a basic and crucial process in a myriad of applications, such as DNA/protein microarray, cell cultures, chemical synthesis of microparticles, and digital microfluidics. This work systematically demonstrates droplet dispensing into immiscible fluids through electric charge concentrati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31901
更新日期:2016-08-18 00:00:00
abstract::In 1842 Charles Darwin claimed that vertical growth on a subsiding foundation caused fringing reefs to transform into barrier reefs then atolls. Yet historically no transition between reef types has been discovered and they are widely considered to develop independently from antecedent foundations during glacio-eustat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04997
更新日期:2014-05-21 00:00:00
abstract::Ergothioneine (ERG), a unique thiol compound, is suggested to function as an antioxidant and cytoprotectant. Despite several recent attempts to produce ERG using various organisms, its yield was still very low and the costs remained high. Since the level of ERG produced depends strictly on the availability of three di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38382-w
更新日期:2019-02-13 00:00:00
abstract::Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35004
更新日期:2016-10-07 00:00:00
abstract::Encapsulation is essential to protect the air-sensitive components of organic light-emitting diodes (OLEDs) such as active layers and cathode electrodes. In this study, hybrid zirconium inorganic/organic nanolaminates were fabricated using remote plasma enhanced atomic layer deposition (PEALD) and molecular layer depo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40061
更新日期:2017-01-06 00:00:00
abstract::This work provides new insights into the dynamics of silica nanoparticle-based removal of organic fluids (here oil) from naturally occurring porous media. We have used 4D (time-resolved 3D) imaging at pore-scale using X-ray computed micro-tomography (μCT) technique. The captured 3D tomographic time-series data reveal ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29569-2
更新日期:2018-07-24 00:00:00
abstract::We have designed a versatile and sensitive liquid chromatographic (LC) system, featuring a monolithic trap column and a very narrow (10 μm ID) fused silica open tubular liquid chromatography (OTLC) separation column functionalized with C18-groups, for separating a wide range of molecules (from small metabolites to int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37507
更新日期:2016-11-29 00:00:00
abstract::Acute traumatic intraparenchymal hematoma (tICH) expansion is a devastating neurological complication that is associated with poor outcome after cerebral contusion. This study aimed to develop and validate a novel noncontrast computed tomography (CT) (NCCT) multihematoma fuzzy sign to predict acute tICH expansion. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81685-8
更新日期:2021-01-21 00:00:00
abstract::Degradation of the biologically potent octapeptide angiotensin Ang II-(1-8) is mediated by the activities of several peptidases. The conversion of Ang II to the septapeptide Ang-(1-7) is of particular interest as the latter also confers organ protection. The conversion is catalyzed by angiotensin-converting enzyme 2 a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45473
更新日期:2017-04-05 00:00:00
abstract::The freshwater crustacean Daphnia is known for its ability to develop inducible morphological defences that thwart predators. These defences are developed only in the presence of predators and are realized as morphological shape alterations e.g. 'neckteeth' in D. pulex and 'crests' in D. longicephala. Both are discuss...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09649-5
更新日期:2017-08-29 00:00:00
abstract::The largest tsunamis are generated by seafloor uplift resulting from rupture of offshore subduction-zone megathrusts. The rupture of the shallowest part of a megathrust often produces unexpected outsize tsunami relative to their seismic magnitude. These are so called 'tsunami earthquakes', which are difficult to ident...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68097-w
更新日期:2020-07-06 00:00:00
abstract::The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06997-0
更新日期:2017-07-26 00:00:00
abstract::The introduced oriental shrimp Palaemon macrodactylus has recently become widespread in temperate estuaries worldwide. However, this recent worldwide spread outside of its native range arises after a previous introduction to the US Pacific coast, where it was restricted for more than 30 years. Using a phylogeographic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05808
更新日期:2014-07-24 00:00:00
abstract::Plant genomes encode several classes of small regulatory RNAs (sRNAs) that play critical roles in both development and stress responses. Panax notoginseng (Burk.) F.H. Chen (P. notoginseng) is an important traditional Chinese herbal medicinal plant species for its haemostatic effects. Therefore, the root yield of P. n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09670-8
更新日期:2017-08-25 00:00:00
abstract::The purpose of this study was the preparation, characterization and application of high-performance activated carbons (ACs) derived from oily sludge through chemical activation by KOH. The produced ACs were characterized using iodine number, N2 adsorption-desorption, Fourier-transform infrared spectroscopy (FTIR) and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55794-4
更新日期:2019-12-18 00:00:00
abstract::Repetitive traumatic brain injury (TBI) has been linked to late life development of chronic traumatic encephalopathy (CTE), a neurodegenerative disorder histopathologically characterized by perivascular tangles of hyperphosphorylated tau at the depth of sulci to later widespread neurofibrillary pathology. Although tau...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40678-4
更新日期:2019-03-07 00:00:00
abstract::Although the glucose lowering effect of dipeptidyl peptidase-4 (DPP4) inhibitors is well established, several potential serious acute safety concerns have been raised including acute kidney injury, respiratory tract infections, and acute pancreatitis. Using the UK-based Clinical Practice Research Datalink (CPRD), we i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33483-y
更新日期:2018-10-11 00:00:00