Abstract:
:Most people with diabetes suffer some deterioration of the feet. Diabetic foot syndrome causes ulceration in about 15% of cases and such deterioration leads to amputation in about 2.5% of diabetic patients, diminishing their quality of life and generating extraordinary costs for patients and public health systems. Currently, there is no objective method for the detection of diabetic foot syndrome in its early stages. We propose terahertz imaging as a method for the evaluation of such deterioration. This screening method could aid the prevention and medical treatment of this condition in the future.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hernandez-Cardoso GG,Rojas-Landeros SC,Alfaro-Gomez M,Hernandez-Serrano AI,Salas-Gutierrez I,Lemus-Bedolla E,Castillo-Guzman AR,Lopez-Lemus HL,Castro-Camus Edoi
10.1038/srep42124subject
Has Abstractpub_date
2017-02-06 00:00:00pages
42124issn
2045-2322pii
srep42124journal_volume
7pub_type
杂志文章abstract::Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48151-y
更新日期:2019-08-13 00:00:00
abstract::Repeated cycles of post-remission high-dose cytarabine (Ara-C) have been suggested to improve survival in core binding factor (CBF) acute myeloid leukaemia (AML). High-dose Ara-C used for induction regimens has also been reported to be associated with increased treatment-related mortality (TRM). Few data are available...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57414-y
更新日期:2020-01-20 00:00:00
abstract::Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability assay (PAMPA), Transwell models and metabolic inhibitors were us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06199-8
更新日期:2017-07-19 00:00:00
abstract::To characterize the molecular mechanisms underlying life-stage transitions in Phytophthora infestans, we initiated a chemical genetics approach by screening for a stage-specific inhibitor of morphological development from microbial culture extracts prepared mostly from actinomycetes from soil in Japan. Of the more tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79326-7
更新日期:2020-12-18 00:00:00
abstract::Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79393-w
更新日期:2021-01-13 00:00:00
abstract::Botulinum-toxin A (BoNT/A) is used for a wide range of conditions. Intramuscular administration of BoNT/A inhibits the release of acetylcholine at the neuromuscular junction from presynaptic motor neurons causing muscle-paralysis. The aim of the present study was to investigate the effect of high dose intramuscular Bo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14997-3
更新日期:2017-11-07 00:00:00
abstract::In biological tissues, radiation causes the formation of reactive oxygen species (ROS), some of which lead to sequential oxidation of certain protein cysteine residues. Resultant cysteinyl radicals are subject to post-translational modification through S-glutathionylation. The present clinical trial was designed to de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50288-9
更新日期:2019-09-24 00:00:00
abstract::The association between cervical lymph node metastasis (LNM) and ultrasonographic features as well as BRAFV600E mutations in patients with papillary thyroid carcinoma (PTC) remained controversial. This study investigated the association between LNM and ultrasonographic features as well as BRAFV600E mutation in Chinese...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36171-z
更新日期:2019-01-11 00:00:00
abstract::The oxidative stress regulator Spx is ubiquitously found among Gram-positive bacteria. Previously, we reported identification of two Spx proteins in Streptococcus mutans - SpxA1 was the primary activator of oxidative stress genes whereas SpxA2 served a backup role. Here, we used RNA sequencing to uncover the scope of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16367-5
更新日期:2017-11-22 00:00:00
abstract::Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel therapeutic target is the Transient Receptor Potential A1 channel (TRPA1), an ion channel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38852-9
更新日期:2019-02-20 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60910-w
更新日期:2020-02-28 00:00:00
abstract::We investigated whether dogs remember their spontaneous past actions relying on episodic-like memory. Dogs were trained to repeat a small set of actions upon request. Then we tested them on their ability to repeat other actions produced by themselves, including actions performed spontaneously in everyday situations. D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67302-0
更新日期:2020-06-26 00:00:00
abstract::The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29103-4
更新日期:2018-07-16 00:00:00
abstract::Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung diseases, shaping t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29768
更新日期:2016-07-19 00:00:00
abstract::The mechanism whereby lactic acid bacteria extend the lifespan of Caenorhabditis elegans has previously been elucidated. However, the role of Weissella species has yet not been studied. We show that Weissella koreensis and Weissella cibaria significantly (p < 0.05) extend the lifespan of C. elegans compared with Esche...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17128
更新日期:2015-11-25 00:00:00
abstract::Ge-monopnictides (GeAs) plays critical role in high-tech industry, especially in the field of advanced optical devices and infrared. As a secondary material, coal fly ash could be further recycled to retrieve germanium and prepare GeAs material with high added values. Hence, the aim of this paper is to propose a one-p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03398-1
更新日期:2017-06-16 00:00:00
abstract::Laser-Stimulated Fluorescence (LSF) is used to identify fully fledged feathering in the hatchling enantiornithine bird specimen MPCM-LH-26189, supporting precocial nesting behavior in this extinct group. The LSF results include the detection of a long pennaceous wing feather as well as cover feathers around the body. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41423-7
更新日期:2019-03-21 00:00:00
abstract::Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver diseases (NAFLD) and obesity. However, the role of ATF4 in animal model systems is poorly understood. To investi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16587-9
更新日期:2017-11-27 00:00:00
abstract::The oceanic connection between the coastal variability along the southwestern African coasts and the linear equatorial dynamics at subseasonal time-scales (<120 days) is examined using a variety of model outputs, ranging from linear to general circulation models. We focus on the equatorially-forced fast and weakly dis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41847-1
更新日期:2019-03-28 00:00:00
abstract::Invasive alien species represent one of the major factors of global loss of biodiversity and disruption of natural ecosystems. The small Indian mongoose, Urva auropunctata, is considered one of the wild carnivore species with the greatest negative impact on global biodiversity. Understanding of the factors underpinnin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64502-6
更新日期:2020-05-04 00:00:00
abstract::Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this study we analysed the expression of both transcription factors usin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15977-3
更新日期:2017-11-20 00:00:00
abstract::The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59658-0
更新日期:2020-02-20 00:00:00
abstract::Confinement of the electron gas along one of the spatial directions opens an avenue for studying fundamentals of quantum transport along the side of numerous practical electronic applications, with high-electron-mobility transistors being a prominent example. A heterojunction of two materials with dissimilar electroni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03880-w
更新日期:2017-06-28 00:00:00
abstract::Compact silicon integrated lasers are of significant interest for various applications. We present a detailed investigation for realizing sub-mm long on-chip laser structures operating at λ = 1.533 µm on the silicon-on-insulator photonic platform by combining a multi-segment silicon waveguide structure and a recently ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67722-y
更新日期:2020-07-02 00:00:00
abstract::The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele freq...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41580-9
更新日期:2019-03-26 00:00:00
abstract::Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11486-5
更新日期:2017-09-07 00:00:00
abstract::Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and grap...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76495-3
更新日期:2020-12-04 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24178-5
更新日期:2018-04-17 00:00:00
abstract::As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38106-0
更新日期:2019-03-14 00:00:00
abstract::This corrects the article DOI: 10.1038/srep44797. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep46843
更新日期:2017-06-16 00:00:00