A double-blind randomized clinical trial of high frequency rTMS over the DLPFC on nicotine dependence, anxiety and depression.

Abstract:

:High frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dorsolateral prefrontal cortex (L-DLPFC) is a widely applied treatment protocol for chronic smoking and major depressive disorder. However, no previous study has measured the effects of rTMS on both nicotine consumption and anxiety/depression in the same volunteers despite the relationship between them. The aim of this work was to evaluate the efficacy of 10 daily sessions of HF-rTMS over the L-DLPFC in chronic cigarette smokers' addiction and investigate the possible beneficial effects of this treatment procedure on symptoms of depression and anxiety in the same subjects. The study included 40 treatment-seeking nicotine-dependent cigarette smokers. Onset/duration of smoking, number of cigarettes/day, Fagerstrom Test of Nicotine Dependence (FTND), Tobacco Craving Questionnaire-Short Form (TCQ-SF), Hamilton depression and anxiety scales (HAM-D and HAM-A) were recorded. Participants were randomly assigned to the active or the sham treatment group. Those in the active group received 10 trains of 20 Hz stimulation, at 80% of the resting motor threshold (rMT) for 10 consecutive working days over L-DLPFC. Participants were reassessed immediately after treatment, and then 3 months later using all rating scales. There were no differences between active and sham groups at baseline. The cigarette consumption/day, and scores on FTND, and TCQ decreased significantly in both groups (p = 0.0001 for each) immediately after treatment. However, improvement persisted to 3 months in the active group but not in the sham group. Moreover, there was a significant reduction in HAM-D and HAM-A scores immediately after treatment in the active but not the sham group. Subjects with a longer history of smoking had a lower percent improvement in FTND (p = 0.005). Our findings revealed that HF-rTMS over L-DLPCF for 10 days reduced cigarette consumption, craving, dependence, and improved associated symptoms of anxiety and depression.ClinicalTrials.gov Identifier: NCT03264755 registered at 29/08/2017.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Abdelrahman AA,Noaman M,Fawzy M,Moheb A,Karim AA,Khedr EM

doi

10.1038/s41598-020-80927-5

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

1640

issue

1

issn

2045-2322

pii

10.1038/s41598-020-80927-5

journal_volume

11

pub_type

杂志文章
  • Selective spatial attention modulates bottom-up informational masking of speech.

    abstract::To hear out a conversation against other talkers listeners overcome energetic and informational masking. Largely attributed to top-down processes, information masking has also been demonstrated using unintelligible speech and amplitude-modulated maskers suggesting bottom-up processes. We examined the role of speech-li...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08662

    authors: Carlile S,Corkhill C

    更新日期:2015-03-02 00:00:00

  • Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats.

    abstract::Recent work reveals that the extinction of conditioned fear depends upon the interval between conditioning and extinction. Extinction training that takes place within minutes to hours after fear conditioning fails to produce a long-term extinction memory, a phenomenon known as the immediate extinction deficit (IED). N...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46010-4

    authors: Totty MS,Payne MR,Maren S

    更新日期:2019-07-01 00:00:00

  • Reciprocal association between depression and peptic ulcers: Two longitudinal follow-up studies using a national sample cohort.

    abstract::This study was aimed to explore the bidirectional association between depression and peptic ulcers. The ≥20-year-old participants of the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013 were included in the study. In study I, 30,306 depression patients were 1:4 matched with 121,224 con...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58783-0

    authors: Kim SY,Min C,Oh DJ,Choi HG

    更新日期:2020-02-04 00:00:00

  • Quaternary functionalized mesoporous adsorbents for ultra-high kinetics of CO2 capture from air.

    abstract::Obstacles to widespread deployments of direct air capture of CO2 (DAC) lie in high material and energy costs. By grafting quaternary ammonium (QA) functional group to mesoporous polymers with high surface area, a unique DAC adsorbent with moisture swing adsorption (MSA) ability and ultra-high kinetics was developed in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77477-1

    authors: Wang T,Wang X,Hou C,Liu J

    更新日期:2020-12-08 00:00:00

  • Measuring Tumor Mutational Burden (TMB) in Plasma from mCRPC Patients Using Two Commercial NGS Assays.

    abstract::Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA (ctDNA) found in plasma is attractive in tissue-constrained indications. We compared the performance of two plasma-based commercial TMB assays including the effec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37128-y

    authors: Qiu P,Poehlein CH,Marton MJ,Laterza OF,Levitan D

    更新日期:2019-01-14 00:00:00

  • Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation.

    abstract::The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulato...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41904-9

    authors: Wang DG,Wang S,Huang B,Liu F

    更新日期:2019-04-10 00:00:00

  • Wild specimens of sand fly phlebotomine Lutzomyia evansi, vector of leishmaniasis, show high abundance of Methylobacterium and natural carriage of Wolbachia and Cardinium types in the midgut microbiome.

    abstract::Phlebotomine sand flies are remarkable vectors of several etiologic agents (virus, bacterial, trypanosomatid Leishmania), posing a heavy health burden for human populations mainly located at developing countries. Their intestinal microbiota is involved in a wide range of biological and physiological processes, and cou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53769-z

    authors: Vivero RJ,Villegas-Plazas M,Cadavid-Restrepo GE,Herrera CXM,Uribe SI,Junca H

    更新日期:2019-11-28 00:00:00

  • Online flow cytometry reveals microbial dynamics influenced by concurrent natural and operational events in groundwater used for drinking water treatment.

    abstract::Detailed measurements of physical, chemical and biological dynamics in groundwater are key to understanding the important processes in place and their influence on water quality - particularly when used for drinking water. Measuring temporal bacterial dynamics at high frequency is challenging due to the limitations in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38462

    authors: Besmer MD,Epting J,Page RM,Sigrist JA,Huggenberger P,Hammes F

    更新日期:2016-12-07 00:00:00

  • Discovery of a new Theileria sp. closely related to Theileria annulata in cattle from Sri Lanka.

    abstract::Theileria annulata is a haemoprotozoan parasite that causes a cancer-like illness known as tropical theileriosis in cattle. In the course of analyzing the genetic diversity of T. annulata in Sri Lanka, we observed that merozoite-piroplasm surface antigen (tams1) and surface protein (tasp)-like gene sequences obtained ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52512-y

    authors: Sivakumar T,Fujita S,Tuvshintulga B,Kothalawala H,Silva SSP,Yokoyama N

    更新日期:2019-11-06 00:00:00

  • Fast and high-accuracy localization for three-dimensional single-particle tracking.

    abstract::We report a non-iterative localization algorithm that utilizes the scaling of a three-dimensional (3D) image in the axial direction and focuses on evaluating the radial symmetry center of the scaled image to achieve the desired single-particle localization. Using this approach, we analyzed simulated 3D particle images...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02462

    authors: Liu SL,Li J,Zhang ZL,Wang ZG,Tian ZQ,Wang GP,Pang DW

    更新日期:2013-01-01 00:00:00

  • Signaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology.

    abstract::Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer's disease (AD) and is directly correlated with the cognitive decline typical of this pathology. The p75 neurotrophin receptor (p75NTR) binds amyloid-β oligomers in the nM range. While it was sh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70153-4

    authors: Patnaik A,Zagrebelsky M,Korte M,Holz A

    更新日期:2020-08-07 00:00:00

  • Spectral variation of fluorescence lifetime near single metal nanoparticles.

    abstract::We explore the spectral dependence of fluorescence enhancement and the associated lifetime modification of fluorescent molecules coupled to single metal nanoparticles. Fluorescence lifetime imaging microscopy and single-particle dark-field spectroscopy are combined to correlate the dependence of fluorescence lifetime ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21349

    authors: Li J,Krasavin AV,Webster L,Segovia P,Zayats AV,Richards D

    更新日期:2016-02-15 00:00:00

  • Prevalence, awareness, treatment, and control of hypertension and their determinants: Results from the first cohort of non-communicable diseases in a Kurdish settlement.

    abstract::Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48232-y

    authors: Rajati F,Hamzeh B,Pasdar Y,Safari R,Moradinazar M,Shakiba E,Bazargan-Hejazi S,Karim H,Najafi F

    更新日期:2019-08-27 00:00:00

  • Sensitive detection of copper ions via ion-responsive fluorescence quenching of engineered porous silicon nanoparticles.

    abstract::Heavy metal pollution has been a problem since the advent of modern transportation, which despite efforts to curb emissions, continues to play a critical role in environmental pollution. Copper ions (Cu2+), in particular, are one of the more prevalent metals that have widespread detrimental ramifications. From this pe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35565

    authors: Hwang J,Hwang MP,Choi M,Seo Y,Jo Y,Son J,Hong J,Choi J

    更新日期:2016-10-18 00:00:00

  • A New Strategy of Lithography Based on Phase Separation of Polymer Blends.

    abstract::Herein, we propose a new strategy of maskless lithographic approach to fabricate micro/nano-porous structures by phase separation of polystyrene (PS)/Polyethylene glycol (PEG) immiscible polymer blend. Its simple process only involves a spin coating of polymer blend followed by a development with deionized water rinse...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15947

    authors: Guo X,Liu L,Zhuang Z,Chen X,Ni M,Li Y,Cui Y,Zhan P,Yuan C,Ge H,Wang Z,Chen Y

    更新日期:2015-10-30 00:00:00

  • 6-Amidopyrene as a label-assisted laser desorption/ionization (LA-LDI) enhancing tag: development of photoaffinity pyrene derivative.

    abstract::Pyrene-conjugated compounds are detected by label-assisted laser desorption/ionization mass spectrometry (LA-LDI MS) without matrixes. We found that 6-amidopyrene derivatives were highly detectable by the LDI MS instrument equipped with a 355 nm laser. In a certain case of a 6-amidopyrene derivative, a molecular ion p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep17853

    authors: Yoneda K,Hu Y,Kita M,Kigoshi H

    更新日期:2015-12-15 00:00:00

  • Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients.

    abstract::The loss of retinal pericytes (RPCs) is a hallmark of early stage diabetic retinopathy (DR), but the mechanism underlying RPC death is unclear. Although it was postulated in previous studies using bovine RPCs that autoantibodies against RPCs might develop and induce RPC death, it is unknown whether autoantibodies agai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20341

    authors: Zhang L,Li Y,Payne J,Srivastava S,Fan X,Fung J,Li X,Kern TS,Lin F

    更新日期:2016-02-03 00:00:00

  • Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis.

    abstract::Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves show...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07972-5

    authors: Lei Z,Fu S,Yang B,Liu Q,Ahmed S,Xu L,Xiong J,Cao J,Qiu Y

    更新日期:2017-08-08 00:00:00

  • Ultrafast Volumetric Optoacoustic Imaging of Whole Isolated Beating Mouse Heart.

    abstract::The Langendorff-perfused heart technique has become the model of choice for multiparametric optical mapping of cardiac function and electrophysiology. However, photon scattering in tissues represents a significant drawback of the optical imaging approach, fundamentally limiting its mapping capacity to the heart surfac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32317-1

    authors: Lin HA,Déan-Ben XL,Reiss M,Schöttle V,Wahl-Schott CA,Efimov IR,Razansky D

    更新日期:2018-09-20 00:00:00

  • Near-infrared roll-off-free electroluminescence from highly stable diketopyrrolopyrrole light emitting diodes.

    abstract::Organic light emitting diodes (OLEDs) operating in the near-infrared spectral region are gaining growing relevance for emerging photonic technologies, such as lab-on-chip platforms for medical diagnostics, flexible self-medicated pads for photodynamic therapy, night vision and plastic-based telecommunications. The ach...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34096

    authors: Sassi M,Buccheri N,Rooney M,Botta C,Bruni F,Giovanella U,Brovelli S,Beverina L

    更新日期:2016-09-28 00:00:00

  • Bioluminescent imaging of vaccinia virus infection in immunocompetent and immunodeficient rats as a model for human smallpox.

    abstract::Due to the increasing concern of using smallpox virus as biological weapons for terrorist attack, there is renewed interest in studying the pathogenesis of human smallpox and development of new therapies. Animal models are highly demanded for efficacy and safety examination of new vaccines and therapeutic drugs. Here,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11397

    authors: Liu Q,Fan C,Zhou S,Guo Y,Zuo Q,Ma J,Liu S,Wu X,Peng Z,Fan T,Guo C,Shen Y,Huang W,Li B,He Z,Wang Y

    更新日期:2015-08-03 00:00:00

  • Sensitivity to near-future CO2 conditions in marine crabs depends on their compensatory capacities for salinity change.

    abstract::Marine crabs inhabit shallow coastal/estuarine habitats particularly sensitive to climate change, and yet we know very little about the diversity of their responses to environmental change. We report the effects of a rarely studied, but increasingly prevalent, combination of environmental factors, that of near-future ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34089-0

    authors: Whiteley NM,Suckling CC,Ciotti BJ,Brown J,McCarthy ID,Gimenez L,Hauton C

    更新日期:2018-10-23 00:00:00

  • Vibrational density of states and thermodynamics at the nanoscale: the 3D-2D transition in gold nanostructures.

    abstract::Surface enhanced Raman scattering (SERS) is generally and widely used to enhance the vibrational fingerprint of molecules located at the vicinity of noble metal nanoparticles. In this work, SERS is originally used to enhance the own vibrational density of states (VDOS) of nude and isolated gold nanoparticles. This off...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39164

    authors: Carles R,Benzo P,Pécassou B,Bonafos C

    更新日期:2016-12-16 00:00:00

  • Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins.

    abstract::Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escheric...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51969-1

    authors: Denkovskienė E,Paškevičius Š,Misiūnas A,Stočkūnaitė B,Starkevič U,Vitkauskienė A,Hahn-Löbmann S,Schulz S,Giritch A,Gleba Y,Ražanskienė A

    更新日期:2019-10-28 00:00:00

  • Retinal involvement and ocular findings in COVID-19 pneumonia patients.

    abstract::Changes in immune and coagulation systems and possible viral spread through the blood-brain barrier have been described in SARS-CoV-2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A cross-sectional study was conducted on 46 patients a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74446-6

    authors: Pirraglia MP,Ceccarelli G,Cerini A,Visioli G,d'Ettorre G,Mastroianni CM,Pugliese F,Lambiase A,Gharbiya M

    更新日期:2020-10-15 00:00:00

  • Comparison between conventional and chemomechanical approaches for the removal of carious dentin: an in vitro study.

    abstract::The present study aimed to evaluate the efficiency, effectiveness, and biocompatibility of two agents used for the chemomechanical removal of carious dentin. Sixty extracted carious human teeth were treated with a conventional bur (CBG) or chemomechanical agents - Papacarie Duo (PG) and Brix 3000 (BG). Treatment effic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65159-x

    authors: Santos TML,Bresciani E,Matos FS,Camargo SEA,Hidalgo APT,Rivera LML,Bernardino ÍM,Paranhos LR

    更新日期:2020-05-15 00:00:00

  • Tai Chi Chuan and Baduanjin practice modulates functional connectivity of the cognitive control network in older adults.

    abstract::Cognitive impairment is one of the most common problem saffecting older adults. In this study, we investigated whether Tai Chi Chuan and Baduanjin practice can modulate mental control functionand the resting state functional connectivity (rsFC) of the cognitive control network in older adults. Participants in the two ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41581

    authors: Tao J,Chen X,Egorova N,Liu J,Xue X,Wang Q,Zheng G,Li M,Hong W,Sun S,Chen L,Kong J

    更新日期:2017-02-07 00:00:00

  • The Impact of a Severe Drought on Dust Lifting in California's Owens Lake Area.

    abstract::Mineral dust aerosols are responsible for some of the largest sources of uncertainties in our current understanding of climate change. Here we show that a severe drought is having a significant impact in one of largest sources of mineral dust aerosols of the U.S., the Owens Lake area in California's southwest. Measure...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01829-7

    authors: Borlina CS,Rennó NO

    更新日期:2017-05-11 00:00:00

  • Species-Specific Marker Discovery in Tilapia.

    abstract::Tilapias (family Cichlidae) are of importance in aquaculture and fisheries. Hybridisation and introgression are common within tilapia genera but are difficult to analyse due to limited numbers of species-specific genetic markers. We tested the potential of double digested restriction-site associated DNA (ddRAD) sequen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48339-2

    authors: Syaifudin M,Bekaert M,Taggart JB,Bartie KL,Wehner S,Palaiokostas C,Khan MGQ,Selly SC,Hulata G,D'Cotta H,Baroiller JF,McAndrew BJ,Penman DJ

    更新日期:2019-09-10 00:00:00

  • A Framework for Modeling Flood Depth Using a Hybrid of Hydraulics and Machine Learning.

    abstract::Solving river engineering problems typically requires river flow characterization, including the prediction of flow depth, flow velocity, and flood extent. Hydraulic models use governing equations of the flow in motion (conservation of mass and momentum principles) to predict the flow characteristics. However, solving...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65232-5

    authors: Hosseiny H,Nazari F,Smith V,Nataraj C

    更新日期:2020-05-19 00:00:00