Abstract：
:We report the development of on-chip fluorescence switching system based on DNA strand displacement and DNA hybridization for the construction of a rewritable and randomly accessible data storage device. In this study, the feasibility and potential effectiveness of our proposed system was evaluated with a series of wet experiments involving 40 bits (5 bytes) of data encoding a 5-charactered text (KRIBB). Also, a flexible data rewriting function was achieved by converting fluorescence signals between "ON" and "OFF" through DNA strand displacement and hybridization events. In addition, the proposed system was successfully validated on a microfluidic chip which could further facilitate the encoding and decoding process of data. To the best of our knowledge, this is the first report on the use of DNA hybridization and DNA strand displacement in the field of data storage devices. Taken together, our results demonstrated that DNA-based fluorescence switching could be applicable to construct a rewritable and randomly accessible data storage device through controllable DNA manipulations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nguyen HH,Park J,Hwang S,Kwon OS,Lee CS,Shin YB,Ha TH,Kim Mdoi
10.1038/s41598-017-16535-7subject
Has Abstractpub_date
2018-01-10 00:00:00pages
337issue
1issn
2045-2322pii
10.1038/s41598-017-16535-7journal_volume
8pub_type
杂志文章abstract：:The programmed induction of meiotic DNA double-strand breaks (DSBs) by the evolutionarily conserved SPO-11 protein, which is structurally related to archaeal Topo VIA topoisomerases, triggers meiotic recombination. Identification of several meiosis-specific factors that are required for SPO-11-mediated DSB formation r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02641-z
更新日期：2017-05-24 00:00:00
abstract：:Genes with similar roles in the cell cluster on chromosomes, thus benefiting from coordinated regulation. This allows gene function to be inferred by transferring annotations from genomic neighbors, following the guilt-by-association principle. We performed a systematic search for co-occurrence of >1000 gene functions...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55984-0
更新日期：2019-12-20 00:00:00
abstract：:Sexual segregation in foraging occurs in many animal species, resulting in the partitioning of resources and reduction of competition between males and females, yet the patterns and drivers of such segregation are still poorly understood. We studied the foraging movements (GPS-tracking), habitat use (habitat modelling...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02854-2
更新日期：2017-06-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) have various functions, making a significant contribution to tissue repair. On the other hand, the viability and function of MSCs are not lasting after an in vivo transplant, and the therapeutic effects of MSCs are limited. Although various chemical modification methods have been applied ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17166-8
更新日期：2017-12-05 00:00:00
abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10068-9
更新日期：2017-08-29 00:00:00
abstract：:Metastasis causes approximately 90% of breast cancer-related deaths in women. Previously, we have demonstrated that 2-dodecyl-6-methoxycyclohexa-2,5-diene- 1,4-dione (DMDD) remarkably inhibited the growth of human breast cancer cells with little toxicity. In this study, we investigated the toxicity and efficacy of DMD...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07162-3
更新日期：2017-07-27 00:00:00
abstract：:Nucleic acid amplification tests have become a common method for diagnosis of STIs due to their improved sensitivity over immunoassays and traditional culture-based methods. Isothermal nucleic acid amplification methods offer significant advantages over polymerase chain reaction (PCR) because they do not require sophi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20487
更新日期：2016-02-03 00:00:00
abstract：:Tropical Pacific variability (TPV) heavily influences global climate, but much is still unknown about its drivers. We examine the impact of South Pacific variability on the modes of TPV: the El Niño-Southern Oscillation (ENSO) and the Interdecadal Pacific Oscillation (IPO). We conduct idealised coupled experiments in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52805-2
更新日期：2019-12-04 00:00:00
abstract：:Previous studies have suggested that microRNA-107 (miR-107) regulates cell migration in tumor and promotes Hypoxia Inducible Factor 1α (HIF1α) regulated angiogenesis under hypoxia. We found that miR-107 was strongly expressed in ischemic boundary zone (IBZ) after permanent middle cerebral artery occlusion (pMCAO) in r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13316
更新日期：2015-08-21 00:00:00
abstract：:Wound dressings with silver have been shown to be cytotoxic in vitro. However, the extrapolation of this cytotoxicity to clinical settings is unclear. We applied dressings with various forms of silver on porcine skin ex vivo and investigated silver penetration and DNA damage. We assessed antimicrobial efficacy, cytoto...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72249-3
更新日期：2020-09-16 00:00:00
abstract：:This study introduces a new chemical carving technique as an alternative to existing lithography and etching techniques. Chemical carving incorporates the concept of scanning probe lithography and metal-assisted chemical etching (MaCE). A catalyst-coated probe mechanically scans a Si substrate in a solution, and the S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70407-1
更新日期：2020-08-07 00:00:00
abstract：:A spontaneous exchange bias (SEB) discovered by Wang et al. [Phys. Rev. Lett. 106 (2011) 077203.] after zero-field cooling (ZFC) has attracted recent attention due to its interesting physics. In this letter, we report a giant SEB tuned by Sb-doping in Ni50Mn38Ga12-xSbx Heusler alloys. Such an SEB was switched on below...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30801
更新日期：2016-08-01 00:00:00
abstract：:Combining the advantages of structured random measurement matrix and chaotic structure, this paper introduces a color image encryption algorithm based on a structural chaotic measurement matrix and random phase mask. The Chebyshev chaotic sequence is used in the algorithm to generate the flip permutation matrix, the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75562-z
更新日期：2020-10-29 00:00:00
abstract：:Shikimate is a key intermediate in the synthesis of neuraminidase inhibitors. Compared with traditional methods, microbial production of shikimate has the advantages of environmental friendliness, low cost, feed stock renewability, and product selectivity and diversity. Despite these advantages, shikimate kinase I and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29745
更新日期：2016-07-13 00:00:00
abstract：:The availability of engineered biological tissues holds great potential for both clinical applications and basic research in a life science laboratory. A prototype standalone perfusion/compression bioreactor system was proposed to address the osteogenic commitment of stem cells seeded onboard of 3D chitosan-graphene (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53319-7
更新日期：2019-11-14 00:00:00
abstract：:Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be a potent target in combating drug-resistant bacteria. In silico methodologies including...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10618-1
更新日期：2017-09-14 00:00:00
abstract：:Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05969-8
更新日期：2017-07-24 00:00:00
abstract：:SARS-CoV-2 can transmit efficiently in humans, but it is less clear which other mammals are at risk of being infected. SARS-CoV-2 encodes a Spike (S) protein that binds to human ACE2 receptor to mediate cell entry. A species with a human-like ACE2 receptor could therefore be at risk of being infected by SARS-CoV-2. We...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80573-x
更新日期：2021-01-18 00:00:00
abstract：:Paclitaxel drug coated balloons (DCBs) should provide optimal drug transfer exclusively to the target tissue. The aim of this study was to evaluate the particle loss by handling during angioplasty. A robotic arm was developed for systematic and reproducible drug abrasion experiments. The contact force on eight differe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74227-1
更新日期：2020-10-14 00:00:00
abstract：:The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81777-5
更新日期：2021-01-27 00:00:00
abstract：:Epigenetics alternation of non-genetic variation and genome-wide association study proven allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development. We analyzed promoter DNA methylation array to evaluate the associated with increased susceptibility to T2D (30 cases, 10 controls) and fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71336-9
更新日期：2020-09-30 00:00:00
abstract：:Honeybees (Apis mellifera L.), which unquestionably play an economically important role in pollination and agricultural production, are at risk of decline. To study changes in gene expression in insects upon exposure to pesticides or other external stimuli, appropriate reference genes are required for data normalizati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73125-w
更新日期：2020-09-30 00:00:00
abstract：:In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy resistance. To promote nose-to-brain transport, we designed siRNA targeting G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01279-1
更新日期：2017-04-27 00:00:00
abstract：:The evolution of cooperation is a fundamental problem in biology, especially for non-relatives, where indirect fitness benefits cannot counter within-group inequalities. Multilevel selection models show how cooperation can evolve if it generates a group-level advantage, even when cooperators are disadvantaged within t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29828
更新日期：2016-07-28 00:00:00
abstract：:Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39345-5
更新日期：2019-02-22 00:00:00
abstract：:Natural competence for genetic transformation refers to the natural ability of various bacteria to take up exogenous DNA from their surroundings and to incorporate internalized genetic information into their genomes. By promoting bacterial diversification and adaptability, this process represents a major driving force...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47423-x
更新日期：2019-07-30 00:00:00
abstract：:Looking for single molecule electronic devices, we have investigated the charge transport properties of individual tetra-phenylporphyrin molecules on different substrates by ultrahigh-vacuum scanning tunneling microscopy and spectroscopy and by first-principles calculations. The tetra-phenylporphyrins with a Co atom (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08350
更新日期：2015-02-10 00:00:00
abstract：:Across the planet the biogeographic distribution of human cultural diversity tends to correlate positively with biodiversity. In this paper we focus on the biogeographic distribution of mammal species and human cultural diversity. We show that not only are these forms of diversity similarly distributed in space, but t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76658-2
更新日期：2020-11-12 00:00:00
abstract：:Absolute numbers of lymphocytes are decreased in uninfected infants born to HIV-1-infected women (HIV-1-exposed). Although the exact mechanism is unknown, fetal exposure to maternal HIV-1-infection could prime the immune system and affect T cell trafficking. We compared the expression of chemokine receptors on cord bl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06690
更新日期：2014-10-24 00:00:00
abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50057-8
更新日期：2019-09-20 00:00:00
