Abstract:
:Bone metastasis of breast cancer cells is a major concern, as it causes increased morbidity and mortality in patients. Bone tissue-derived CXCL12 preferentially recruits breast cancer cells expressing CXCR4 to bone metastatic sites. Thus, understanding how CXCR4 expression is regulated in breast cancer cells could suggest approaches to decrease bone metastasis of breast tumor cells. Here, we show that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) increases responsiveness of breast cancer cells to CXCL12 by promoting up-regulation of CXCR4 in those cells. In addition, we used a xenograft mouse model established by intracardiac injection of tumor cells to show that ANGPTL2 knockdown in breast cancer cells attenuates tumor cell responsiveness to CXCL12 by decreasing CXCR4 expression in those cells, thereby decreasing bone metastasis. Finally, we found that ANGPTL2 and CXCR4 expression levels within primary tumor tissues from breast cancer patients are positively correlated. We conclude that tumor cell-derived ANGPTL2 may increase bone metastasis by enhancing breast tumor cell responsiveness to CXCL12 signaling through up-regulation of tumor cell CXCR4 expression. These findings may suggest novel therapeutic approaches to treat metastatic breast cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Masuda T,Endo M,Yamamoto Y,Odagiri H,Kadomatsu T,Nakamura T,Tanoue H,Ito H,Yugami M,Miyata K,Morinaga J,Horiguchi H,Motokawa I,Terada K,Morioka MS,Manabe I,Iwase H,Mizuta H,Oike Ydoi
10.1038/srep09170subject
Has Abstractpub_date
2015-03-16 00:00:00pages
9170issn
2045-2322pii
srep09170journal_volume
5pub_type
杂志文章abstract::Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68100-4
更新日期:2020-07-06 00:00:00
abstract::Homocysteine (Hcy) has been shown to have a neurotoxic effect on ischemic brain cells; however, the underlying mechanisms remain incompletely understood. Here, we examined whether Hcy treatment influences mitochondria injury, oxidative stress, and mitochondrial STAT3 (mitoStat3) expression in rat ischemic brain. Our r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07112-z
更新日期:2017-07-31 00:00:00
abstract::Transcriptome analysis by RNA-seq technology allows novel insights into gene expression and regulatory networks in health and disease. To better understand the molecular basis of renal fibrosis, we performed RNA-seq analysis in the Unilateral Ureteric Obstruction (UUO) mouse model. We analysed sham operated, 2- and 8-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26235
更新日期:2016-05-18 00:00:00
abstract::Floating macrophytes, including water hyacinth (Eichhornia crassipes), are dominant invasive organisms in tropical aquatic systems, and they may play an important role in modifying the gas exchange between water and the atmosphere. However, these systems are underrepresented in global datasets of greenhouse gas (GHG) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20424
更新日期:2016-02-05 00:00:00
abstract::The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibrob...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28952-3
更新日期:2018-07-13 00:00:00
abstract::It is well known that the Gobi Desert is the dominant source area of the Badain Jaran Desert (BJD) and the Chinese Loess Plateau (CLP). However, due to the absence of quantitative analyses, there are nearly no exact assessments of its actual contribution. Combinations of field investigations, wind tunnel experiments, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37635-y
更新日期:2019-01-30 00:00:00
abstract::Measuring toxicity is one of the main steps in drug development. Hence, there is a high demand for computational models to predict the toxicity effects of the potential drugs. In this study, we used a dataset, which consists of four toxicity effects:mutagenic, tumorigenic, irritant and reproductive effects. The propos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38660
更新日期:2016-12-09 00:00:00
abstract::Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by the destruction of interlobular biliary ductules, which progressively leads to cholestasis, hepatic fibrosis, cirrhosis, and eventually liver failure. Several mouse models have been used to clarify the pathogenesis of PBC and are general...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15661-6
更新日期:2017-11-10 00:00:00
abstract::According to the Source Monitoring Framework, the origin of a memory is remembered through the retrieval of specific features (e.g. perceptive, sensitive, affective signals). In two source discrimination tasks, we studied the ability of cuttlefish to remember the modality in which an item had been presented several ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62335-x
更新日期:2020-03-25 00:00:00
abstract::The pharmacokinetic compatibility of short-acting CDRI candidate antimalarial trioxane derivative, 99-411, was tested with long-acting prescription antimalarials, lumefantrine and piperaquine. LC-ESI-MS/MS methods were validated for simultaneous bioanalysis of lumefantrine and 99-411 and of piperaquine and 99-411 comb...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17264
更新日期:2015-11-25 00:00:00
abstract::A good high rate supercapacitor performance requires a fine control of morphological (surface area and pore size distribution) and electrical properties of the electrode materials. Polyaniline (PANI) is an interesting material in supercapacitor context because it stores energy Faradaically. However in conventional ino...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21002
更新日期:2016-02-12 00:00:00
abstract::Hallucinogens induce the head-twitch response (HTR), a rapid reciprocal head movement, in mice. Although head twitches are usually identified by direct observation, they can also be assessed using a head-mounted magnet and a magnetometer. Procedures have been developed to automate the analysis of magnetometer recordin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65264-x
更新日期:2020-05-20 00:00:00
abstract::To evaluate and improve datasets of anthropogenic land cover change used in local and global climate models, great efforts were made to reconstruct historical land use, including the LandCover 6k project which dedicated to reconstructing human land use over the past 10,000 years. In this study, we utilized historical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31807-6
更新日期:2018-09-10 00:00:00
abstract::Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in bra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25213-1
更新日期:2018-04-30 00:00:00
abstract::The overlap between pain and reward processing pathways leds researchers to hypothesize that there are interactions between them in the human brain. Two hypotheses have been proposed. The "competition hypothesis" posits that reward can reduce pain-related neural activity and vice versa. The "salience hypothesis" sugge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26426
更新日期:2016-05-19 00:00:00
abstract::Small RNA-Seq is a common means to interrogate the small RNA'ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identifying and quantifying the small RNA'ome constituent components. For example, small RNAs in the circulatory syst...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61495-0
更新日期:2020-03-12 00:00:00
abstract::Human platelet antigens (HPAs) are membranous glycoproteins considered as alloantigens due to their polymorphisms. HPA-incompatibility in multiple pregnancies or blood transfusion can induce the development of alloantibodies leading to thrombocytopenia. The frequency of HPAs varies among populations, so that deep know...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64469-4
更新日期:2020-05-04 00:00:00
abstract::Geothermal waters from the Semi, Dagejia and Kawu hot springs in the Shiquanhe-Yarlung Zangbo geothermal field of southern Tibet (China) are highly enriched in rare alkali metals (RAM). However, the enrichment mechanism is still hotly debated. Here, we report the first silicon isotope data of these geothermal waters t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44249-5
更新日期:2019-05-27 00:00:00
abstract::The most consistent sex differences in cognition are found for spatial ability, in which males, on average, outperform females. Utilizing a twin design, two studies have shown that females with male co-twins perform better than females with female co-twins on a mental rotation task. According to the Twin Testosterone ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31704-y
更新日期:2018-09-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-53132-2
更新日期:2019-11-08 00:00:00
abstract::Single-wall carbon nanotubes (SWCNTs) and Bi2Te3 nanoplates are very promising thermoelectric materials for energy harvesting. When these two materials are combined, the resulting nanocomposites exhibit high thermoelectric performance and excellent flexibility. However, simple mixing of these materials is not effectiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73808-4
更新日期:2020-10-12 00:00:00
abstract::Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05423-9
更新日期:2017-07-12 00:00:00
abstract::Tea plant is a typical fluorine (F) accumulator. F concentration in mature tea leaves is several hundred times higher than that in normal field crops. Long-term consumption of teas with high level F will increase the risks of dental and skeletal fluorosis. The mechanism of F accumulation in tea stands unclear. RNA-Seq...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08587-6
更新日期:2017-08-29 00:00:00
abstract::Pigeon pea is an important legume infested by a plethora of insect pests amongst which gram pod borer Helicoverpa armigera is very prominent. Imparting resistance to this insect herbivore is of global importance in attaining food security. Expression of insecticidal crystal proteins (ICP) in diverse crops has led to i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26358-9
更新日期:2018-06-11 00:00:00
abstract::Glass is an ultraviscous liquid that ceases to flow on a laboratory timescale but continues to relax on a geological timescale. Quintessentially, it has become hopeless for humans to explore the equilibrium behavior of glass, although the technology of glass making witness a remarkable advance. In this work, we propos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43091
更新日期:2017-02-22 00:00:00
abstract::We aimed to investigate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in evaluating blunt abdominal trauma for patients presenting to the emergency department. Electronic search of Scopus and Pubmed was performed from inception to September 2016. Human studies investigating the diagnostic accuracy of ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-04779-2
更新日期:2017-06-30 00:00:00
abstract::Supercontinuum generation in Kerr media has become a staple of nonlinear optics. It has been celebrated for advancing the understanding of soliton propagation as well as its many applications in a broad range of fields. Coherent spectral broadening of laser light is now commonly performed in laboratories and used in c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34344-4
更新日期:2018-11-21 00:00:00
abstract::Interactions of high-frequency radio waves (RF) with biological tissues are currently being investigated as a therapeutic platform for non-invasive cancer hyperthermia therapy. RF delivers thermal energy into tissues, which increases intra-tumoral drug perfusion and blood-flow. Herein, we describe an optical-based met...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43961
更新日期:2017-03-13 00:00:00
abstract::Jellyfish locomotion and orientation have been studied in the past both in the laboratory, testing mostly small jellyfish, and in the field, where it was impossible to control the seawater currents. Utilizing an outdoor water flume, we tested the locomotion of jellyfish when swimming against and with currents of up to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56311-3
更新日期:2019-12-30 00:00:00
abstract::Luteinizing hormone (LH) is one of the main pituitary hormones that regulate ovulation, however its role has not been studied in giant panda. In this study, we developed an ELISA method for the detection of panda urinary LH. We analyzed urinary hormones of 24 female pandas during 36 breeding periods, we found females ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40749
更新日期:2017-01-16 00:00:00