Abstract：
:Interactions of high-frequency radio waves (RF) with biological tissues are currently being investigated as a therapeutic platform for non-invasive cancer hyperthermia therapy. RF delivers thermal energy into tissues, which increases intra-tumoral drug perfusion and blood-flow. Herein, we describe an optical-based method to optimize the short-term treatment schedules of drug and hyperthermia administration in a 4T1 breast cancer model via RF, with the aim of maximizing drug localization and homogenous distribution within the tumor microenvironment. This method, based on the analysis of fluorescent dyes localized into the tumor, is more time, cost and resource efficient, when compared to current analytical methods for tumor-targeting drug analysis such as HPLC and LC-MS. Alexa-Albumin 647 nm fluorphore was chosen as a surrogate for nab-paclitaxel based on its similar molecular weight and albumin driven pharmacokinetics. We found that RF hyperthermia induced a 30-40% increase in Alexa-Albumin into the tumor micro-environment 24 h after treatment when compared to non-heat treated mice. Additionally, we showed that the RF method of delivering hyperthermia to tumors was more localized and uniform across the tumor mass when compared to other methods of heating. Lastly, we provided insight into some of the factors that influence the delivery of RF hyperthermia to tumors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ware MJ,Krzykawska-Serda M,Chak-Shing Ho J,Newton J,Suki S,Law J,Nguyen L,Keshishian V,Serda M,Taylor K,Curley SA,Corr SJdoi
10.1038/srep43961subject
Has Abstractpub_date
2017-03-13 00:00:00pages
43961issn
2045-2322pii
srep43961journal_volume
7pub_type
杂志文章abstract：:Recent studies have established that single nucleotide polymorphisms are sufficient to build accurate predictive models of gene expression. Gamazon, et al., found that gene expression values predicted from cis neighborhood SNPs show statistical association with disease status. In this work, we remove the cis neighborh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39360
更新日期：2016-12-20 00:00:00
abstract：:Because of the unique climate characteristics, the runoff law in mid-temperate zone is very different from other regions in spring. Accurate runoff simulation and forecasting is of great importance to spring flood control and efficient use of water resources. Baishan reservoir is located in the upper Second Songhua Ri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35282-x
更新日期：2018-11-16 00:00:00
abstract：:Vanadium doped ZnO (VZO) thin films were grown by RF magnetron sputtering, starting from a ZnO:V ceramic target. The crystal structure, chemical composition, electric and piezoelectric properties of the films were investigated either on the as-grown thin films or after a post-deposition rapid thermal annealing (RTA) t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41957
更新日期：2017-02-06 00:00:00
abstract：:The mechanisms contributing to collective attention in humans remain unclear. Research indicates that pedestrians utilise the gaze direction of others nearby to acquire environmentally relevant information, but it is not known which, if any, additional social cues influence this transmission. Extending upon previous f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05794
更新日期：2014-07-23 00:00:00
abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42360-1
更新日期：2019-04-17 00:00:00
abstract：:In the present study rice straw (R, control) was mixed with Cowdung (C), Azolla (A) and cellulolytic fungus Aspergillus terreus (F) in different combinations viz. RC, RA, RF, RCF, RCA, RFA and RCFA and subjected to aerobic composting (Acom) and vermicomposting (Vcom - with Eisenia fetida). It was found that addition o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37880-1
更新日期：2019-02-04 00:00:00
abstract：:Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19265-6
更新日期：2018-01-17 00:00:00
abstract：:Long Terminal Repeats (LTRs) are nearly identical DNA sequences found at either end of Human Endogenous Retroviruses (HERVs). The high sequence similarity that exists among different LTRs suggests they could be substrate of ectopic gene conversion events. To understand the extent to which gene conversion occurs and to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28710
更新日期：2016-06-27 00:00:00
abstract：:The environmental fate of the herbicide fenoxaprop-ethyl (FE) in water, sediment and water-sediment microcosm was studied and degradation products fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA) and 6-chloro-2,3-dihydrobenzoxazol-2-one (CDHB) were monitored. FE, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26797
更新日期：2016-05-26 00:00:00
abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two different algorithms. METHODS:In a case-control study of CAH patients ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65897-y
更新日期：2020-06-01 00:00:00
abstract：:Phlebotonics' effects were evaluated to reduce time-to-stop bleeding and anal irritation in 130 patients who complained of hemorrhoidal disease (HD); bleeding and pain after hemorrhoidectomy (31 patients) and hemorrhoidal thrombosis (34 patients) in the short time. Sixty patients were randomized to receive the routine...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64772-0
更新日期：2020-05-14 00:00:00
abstract：:We report a method to promote photoluminescence emission in graphene materials by enhancing carrier scattering instead of directly modifying band structure in multilayer reduced graphene oxide (rGO) nanospheres. We intentionally curl graphene layers to form nanospheres by reducing graphene oxide with spherical polymer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02315
更新日期：2013-01-01 00:00:00
abstract：:The microgravity environment during space flight imposes numerous adverse effects on animal and microbial physiology. It is unclear, however, how microgravity impacts those cellular interactions between mutualistic microbes and their hosts. Here, we used the symbiosis between the host squid Euprymna scolopes and its l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01340
更新日期：2013-01-01 00:00:00
abstract：:Alumina toughened zirconia (ATZ) and zirconia toughened alumina (ZTA) are currently the materials of choice to meet the need for tough, strong, and bioinert ceramics for medical devices. However, the mechanical properties of ZrO2/Al2O3 dispersion ceramics could be considerably increased by reducing the corresponding g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20589
更新日期：2016-02-05 00:00:00
abstract：:Silver nanowires (AgNWs) networks are promising candidates for the replacement of indium tin oxide (ITO). However, the surface roughness of the AgNWs network is still too high for its application in optoelectronic devices. In this work, we have reduced the surface roughness of the AgNWs networks to 6.4 nm, compared to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45392
更新日期：2017-03-28 00:00:00
abstract：:Hookworms are one of the most prevalent and important parasites, infecting ~500 million people worldwide. Hookworm disease is among the leading causes of iron-deficiency anemia in the developing world and is associated with significant growth stunting and malnutrition. In humans, hookworms appear to impair memory and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44301-4
更新日期：2019-05-27 00:00:00
abstract：:Biclustering algorithms, which aim to provide an effective and efficient way to analyze gene expression data by finding a group of genes with trend-preserving expression patterns under certain conditions, have been widely developed since Morgan et al. pioneered a work about partitioning a data matrix into submatrices ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23466
更新日期：2016-03-22 00:00:00
abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01432-w
更新日期：2017-05-03 00:00:00
abstract：:Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the pathogenesis of inflammatory bowel disease. However, the role of CH25H in experimental colitis remains unknown. Dextran sulfate sodium (DSS)-induced coliti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71198-1
更新日期：2020-08-28 00:00:00
abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10034-5
更新日期：2017-08-25 00:00:00
abstract：:In this work we study theoretically and experimentally the multi-particle structure of the so-called type-II quantum dots with spatially separated electrons and holes. Our calculations based on customarily developed full configuration interaction ap- proach reveal that exciton complexes containing holes interacting wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45568
更新日期：2017-03-30 00:00:00
abstract：:Using the Ermakov-Lewis invariants appearing in KvN mechanics, the time-dependent frequency harmonic oscillator is studied. The analysis builds upon the operational dynamical model, from which it is possible to infer quantum or classical dynamics; thus, the mathematical structure governing the evolution will be the sa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26759-w
更新日期：2018-05-30 00:00:00
abstract：:Age-related macular degeneration (AMD) is a chronic degenerative disease of the retina. Recent reports have highlighted the potential role of mucosal surface microbes in the pathogenesis of AMD. In this case-control study, the composition of the nasal and oral microbiota in newly diagnosed neovascular age-related macu...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-60674-3
更新日期：2020-03-02 00:00:00
abstract：:Due to the two dimensional confinement of electrons in a monolayer of 2D materials, the properties of monolayer can be controlled by electrical field formed on the monolayer surface. F4TCNQ was evaporated on MoS2 and WS2 monolayer forming dipoles between strong acceptor, F4TCNQ, and monolayers of MoS2 or WS2. The stro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24105
更新日期：2016-04-07 00:00:00
abstract：:Pain is a highly unpleasant sensory and emotional experience, and no objective diagnosis test exists to assess it. In clinical practice there are two main methods for the estimation of pain, a patient's self-report and clinical judgement. However, these methods are highly subjective and the need of biomarkers to measu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42098-w
更新日期：2019-04-04 00:00:00
abstract：:Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 201...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36235
更新日期：2016-11-08 00:00:00
abstract：:Applying a circular economy approach, this research explores the use of cheese whey permeate (CWP), by-product of whey ultrafiltration, as cheap substrate for the production of bacterial cellulose (BC) and Sakacin-A, to be used in an antimicrobial packaging material. BC from the acetic acid bacterium Komagataeibacter ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78430-y
更新日期：2020-12-07 00:00:00
abstract：:Principal research on energy from thermonuclear fusion uses Deuterium-Tritium plasmas magnetically trapped in toroidal devices. As major scientific problem for an economic (i.e., really feasible) reactor, we must understand how to lead strongly heated plasmas to sustain a high fusion gain while large fraction of curre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27996-9
更新日期：2018-07-09 00:00:00
abstract：:The possibility of producing transgenic cloned buffalos by nuclear transfer of fetal fibroblasts expressing enhanced green fluorescent protein (EGFP) was explored in this study. When buffalo fetal fibroblasts (BFFs) isolated from a male buffalo fetus were transfected with pEGFP-N1 (EGFP is driven by CMV and Neo is dri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25120-5
更新日期：2018-05-03 00:00:00
abstract：:Urbanization is associated with dramatic increases in noise and light pollution, which affect animal behaviour, physiology and fitness. However, few studies have examined these stressors simultaneously. Moreover, effects of urbanization during early-life may be detrimental but are largely unknown. In developing great ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02940-5
更新日期：2017-06-05 00:00:00
