Evidence of extensive non-allelic gene conversion among LTR elements in the human genome.

abstract：:Individuals differ in their level of general anxiety as well as in their level of anxiety towards specific activities, such as mathematics and spatial tasks. Both specific anxieties correlate moderately with general anxiety, but the aetiology of their association remains unexplored. Moreover, the factor structure of s...

journal_title：Scientific reports

authors： Malanchini M,Rimfeld K,Shakeshaft NG,Rodic M,Schofield K,Selzam S,Dale PS,Petrill SA,Kovas Y

更新日期：2017-02-21 00:00:00

abstract：:Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivor...

journal_title：Scientific reports

authors： Gouin A,Bretaudeau A,Nam K,Gimenez S,Aury JM,Duvic B,Hilliou F,Durand N,Montagné N,Darboux I,Kuwar S,Chertemps T,Siaussat D,Bretschneider A,Moné Y,Ahn SJ,Hänniger S,Grenet AG,Neunemann D,Maumus F,Luyten I,Labadi

更新日期：2017-09-25 00:00:00

abstract：:The liver has a variety of functions for maintaining homeostasis, and hepatocytes play a major role. In contrast with the high regenerative capacity of mature hepatocytes (MHs) in vivo, they have not been successfully expanded ex vivo. Here we demonstrate that CD44-positive cells sorted from small hepatocyte (SH) colo...

journal_title：Scientific reports

authors： Ishii M,Kino J,Ichinohe N,Tanimizu N,Ninomiya T,Suzuki H,Mizuguchi T,Hirata K,Mitaka T

更新日期：2017-04-11 00:00:00

abstract：:Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophys...

journal_title：Scientific reports

authors： Yang NN,Shi H,Yu G,Wang CM,Zhu C,Yang Y,Yuan XL,Tang M,Wang ZL,Gegen T,He Q,Tang K,Lan L,Wu GY,Tang ZX

更新日期：2016-05-10 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:Single epitaxially-grown semiconductor quantum dots have great potential as single photon sources for photonic quantum technologies, though in practice devices often exhibit nonideal behavior. Here, we demonstrate that amplitude modulation can improve the performance of quantum-dot-based sources. Starting with a brigh...

journal_title：Scientific reports

authors： Ates S,Agha I,Gulinatti A,Rech I,Badolato A,Srinivasan K

更新日期：2013-01-01 00:00:00

abstract：:The plasmonic waveguide made of uniform corrugated metallic strip can support and guide spoof surface plasmon polaritons (SSPPs) with high confinements. Here, we propose periodically-modulated plasmonic waveguide composed of non-uniform corrugated metallic strip to convert SSPPs to radiating waves, in which the main b...

journal_title：Scientific reports

authors： Kong GS,Ma HF,Cai BG,Cui TJ

更新日期：2016-07-12 00:00:00

abstract：:Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse...

journal_title：Scientific reports

authors： Jeong H,Sim HJ,Song EK,Lee H,Ha SC,Jun Y,Park TJ,Lee C

更新日期：2016-02-09 00:00:00

abstract：:Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]...

journal_title：Scientific reports

authors： Real CI,Werner M,Paul A,Gerken G,Schlaak JF,Vaillant A,Broering R

更新日期：2017-03-08 00:00:00

abstract：:Sodefrin, a decapeptide isolated from the male dorsal gland of the Japanese fire belly newt Cynops pyrrhogaster, was the first peptide pheromone identified from a vertebrate. The fire belly salamander and sodefrin have become a model for sex pheromone investigation in aquatically courting salamanders ever since. Subse...

journal_title：Scientific reports

authors： Van Bocxlaer I,Maex M,Treer D,Janssenswillen S,Janssens R,Vandebergh W,Proost P,Bossuyt F

更新日期：2016-03-03 00:00:00

abstract：:High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced v...

journal_title：Scientific reports

authors： Kishimoto S,Maruhashi T,Kajikawa M,Matsui S,Hashimoto H,Takaeko Y,Harada T,Yamaji T,Han Y,Kihara Y,Chayama K,Goto C,Yusoff FM,Nakashima A,Higashi Y

更新日期：2020-07-10 00:00:00

abstract：:In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...

journal_title：Scientific reports

authors： Mohammadi I,Shahrabi T,Mahdavian M,Izadi M

更新日期：2020-03-19 00:00:00

abstract：:Bacterial vaginosis (BV) is associated with HIV acquisition and adverse pregnancy outcomes. Recurrence after metronidazole treatment is high. HIV-negative, non-pregnant Rwandan BV patients were randomized to four groups (n = 17/group) after seven-day oral metronidazole treatment: behavioral counseling only (control), ...

journal_title：Scientific reports

authors： van de Wijgert JHHM,Verwijs MC,Agaba SK,Bronowski C,Mwambarangwe L,Uwineza M,Lievens E,Nivoliez A,Ravel J,Darby AC

更新日期：2020-03-03 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential therapy for many chronic inflammatory diseases due to their regenerative, immunologic and anti-inflammatory properties. The two-way dialogue between MSCs and macrophages is crucial to tissue regeneration and repair. Previous research demonstrated that murine adipose-der...

journal_title：Scientific reports

authors： Souza-Moreira L,Soares VC,Dias SDSG,Bozza PT

更新日期：2019-12-30 00:00:00

abstract：:In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...

journal_title：Scientific reports

authors： Tsai SB,Ma H

更新日期：2018-11-09 00:00:00

abstract：:The progression of pulmonary fibrosis (PF) entails a complex network of interactions between multiple classes of molecules and cells, which are closely related to the vagus nerve. Stimulation of the vagus nerve increases fibrogenic cytokines in humans, therefore, activation of the nerve may promote PF. The hypothesis ...

journal_title：Scientific reports

authors： Song N,Liu J,Shaheen S,Du L,Proctor M,Roman J,Yu J

更新日期：2015-08-20 00:00:00

abstract：:The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease modeling and drug screening approaches. To circumvent the risk of random integration into the host genome caused by retroviruses, non-integra...

journal_title：Scientific reports

authors： Diecke S,Lu J,Lee J,Termglinchan V,Kooreman NG,Burridge PW,Ebert AD,Churko JM,Sharma A,Kay MA,Wu JC

更新日期：2015-01-28 00:00:00

abstract：:Kinase inhibitors are often used as cancer targeting agents for their ability to prevent the activation of cell growth and proliferation signals. Cardiotoxic effects have been identified for some marketed kinase inhibitors that were not detected during clinical trials. We hypothesize that more predictive cardiac funct...

journal_title：Scientific reports

authors： Conant G,Ahadian S,Zhao Y,Radisic M

更新日期：2017-09-18 00:00:00

abstract：:Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve as potential source for cancer biomarkers. As an attract...

journal_title：Scientific reports

authors： Sun Y,Xia Z,Shang Z,Sun K,Niu X,Qian L,Fan LY,Cao CX,Xiao H

更新日期：2016-04-19 00:00:00

abstract：:Migration and interactions of immune cells are routinely studied by time-lapse microscopy of in vitro migration and confrontation assays. To objectively quantify the dynamic behavior of cells, software tools for automated cell tracking can be applied. However, many existing tracking algorithms recognize only rather sh...

journal_title：Scientific reports

authors： Al-Zaben N,Medyukhina A,Dietrich S,Marolda A,Hünniger K,Kurzai O,Figge MT

更新日期：2019-03-01 00:00:00

abstract：:The ability of radial glial progenitors (RGPs) to generate cortical neurons is determined by local extracellular factors and signaling pathways intrinsic to RGPs. Here we find that GPR157, an orphan G protein-coupled receptor, localizes to RGPs' primary cilia exposed to the cerebrospinal fluid (CSF). GPR157 couples wi...

journal_title：Scientific reports

authors： Takeo Y,Kurabayashi N,Nguyen MD,Sanada K

更新日期：2016-05-04 00:00:00

abstract：:A multi-agent Parrondo's model based on complex networks is used in the current study. For Parrondo's game A, the individual interaction can be categorized into five types of behavioral patterns: the Matthew effect, harmony, cooperation, poor-competition-rich-cooperation and a random mode. The parameter space of Parro...

journal_title：Scientific reports

authors： Ye Y,Cheong KH,Cen YW,Xie NG

更新日期：2016-11-15 00:00:00

abstract：:Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD risk are inconsistent. To quantify the effect of temperature on HFMD incidence, Wuhan was chosen as the study site because of its high temperature variability and high HFMD incidence. Daily serie...

journal_title：Scientific reports

authors： Huang J,Chen S,Wu Y,Tong Y,Wang L,Zhu M,Hu S,Guan X,Wei S

更新日期：2018-01-31 00:00:00

abstract：:A novel and facile two-step strategy has been designed to prepare high performance bi-transition-metals (Fe- and Mo-) carbide supported on nitrogen-doped graphene (FeMo-NG) as electrocatalysts for oxygen reduction reactions (ORR). The as-synthesized FeMo carbide -NG catalysts exhibit excellent electrocatalytic activit...

journal_title：Scientific reports

authors： Chen M,Liu J,Zhou W,Lin J,Shen Z

更新日期：2015-05-22 00:00:00

abstract：:The incidence and mortality of primary liver cancer are very high and resection of tumor is the most crucial treatment for it. We aimed to assess the efficacy and safety of combined use of transversus abdominis plane (TAP) block and laryngeal mask airway (LMA) during implementing Enhanced Recovery After Surgery (ERAS)...

journal_title：Scientific reports

authors： Huang HM,Chen RX,Zhu LM,Zhao WS,Ye XJ,Luo JW,Lu FD,Zhang L,Yang XY,Yuan Y,Cao J

更新日期：2020-09-10 00:00:00

abstract：:There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological ...

journal_title：Scientific reports

authors： Lutz W,Schwartz B,Hofmann SG,Fisher AJ,Husen K,Rubel JA

更新日期：2018-05-18 00:00:00

abstract：:Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown. The GluN2C-containing NMDARs exhibit unique biophysical properties and expression pattern, and lower expression of GluN2C subunit has been reporte...

journal_title：Scientific reports

authors： Gupta SC,Ravikrishnan A,Liu J,Mao Z,Pavuluri R,Hillman BG,Gandhi PJ,Stairs DJ,Li M,Ugale RR,Monaghan DT,Dravid SM

更新日期：2016-12-06 00:00:00

abstract：:Prenatal skeletal muscle development genetically determines postnatal muscle characteristics such as growth and meat quality in pigs. However, the molecular mechanisms underlying prenatal skeletal muscle development remain unclear. Here, we performed the first genome-wide analysis of chimeric RNAs, single nuclear poly...

journal_title：Scientific reports

authors： Yang Y,Tang Z,Fan X,Xu K,Mu Y,Zhou R,Li K

更新日期：2016-06-29 00:00:00

abstract：:Core-shell nanoparticles often exhibit improved catalytic properties due to the lattice strain created in these core-shell particles. Herein, we demonstrate the synthesis of core-shell Au@Pd nanoparticles from their core-shell Au@Ag/Pd parents. This strategy begins with the preparation of core-shell Au@Ag nanoparticle...

journal_title：Scientific reports

authors： Chen D,Li C,Liu H,Ye F,Yang J

更新日期：2015-07-06 00:00:00

abstract：:Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies....

journal_title：Scientific reports

authors： Liu C,Zhao Y,He W,Wang W,Chen Y,Zhang S,Ma Y,Gohda J,Ishida T,Walter TS,Owens RJ,Stuart DI,Ren J,Gao B

更新日期：2015-09-28 00:00:00