Abstract:
:There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological treatment for mood or anxiety disorders were assessed using Ecological Momentary Assessments four times a day for two weeks before treatment (3,248 measurements). Multilevel vector autoregressive models were employed to compute dynamic symptom networks. Intake variables and network parameters (centrality measures) were used as predictors for dropout using machine-learning algorithms. Networks for patients differed significantly between completers and dropouts. Among intake variables, initial impairment and sex predicted dropout explaining 6% of the variance. The network analysis identified four additional predictors: Expected force of being excited, outstrength of experiencing social support, betweenness of feeling nervous, and instrength of being active. The final model with the two intake and four network variables explained 32% of variance in dropout and identified 47 out of 58 patients correctly. The findings indicate that patients' dynamic network structures may improve the prediction of dropout. When implemented in routine care, such prediction models could identify patients at risk for attrition and inform personalized treatment recommendations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lutz W,Schwartz B,Hofmann SG,Fisher AJ,Husen K,Rubel JAdoi
10.1038/s41598-018-25953-0subject
Has Abstractpub_date
2018-05-18 00:00:00pages
7819issue
1issn
2045-2322pii
10.1038/s41598-018-25953-0journal_volume
8pub_type
杂志文章abstract::Lignosus rhinocerotis (Tiger milk mushroom) is an important folk medicine for indigenous peoples in Southeast Asia. We previously reported its de novo assembled 34.3 Mb genome encoding a repertoire of proteins including a putative bioactive fungal immunomodulatory protein. Here we report the cDNA of this new member (F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30010
更新日期:2016-07-27 00:00:00
abstract::Repeated blood pressure (BP) measurements allow better control of hypertension. Current measurements rely on cuff-based devices. The aim of the present study was to compare BP measurements using a novel cuff-less photoplethysmography-based device to a standard sphygmomanometer device. Males and females were recruited ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73172-3
更新日期:2020-09-30 00:00:00
abstract::The purpose of this study was the preparation, characterization and application of high-performance activated carbons (ACs) derived from oily sludge through chemical activation by KOH. The produced ACs were characterized using iodine number, N2 adsorption-desorption, Fourier-transform infrared spectroscopy (FTIR) and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55794-4
更新日期:2019-12-18 00:00:00
abstract::Cardiac fibroblasts are present throughout the myocardium and are enriched in the microenvironment surrounding the ventricular conduction system (VCS). Several forms of arrhythmias are linked to VCS abnormalities, but it is still unclear whether VCS malformations are cardiomyocyte autonomous or could be linked to cros...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73159-0
更新日期:2020-09-30 00:00:00
abstract::HIV-1 Tat protein is released from HIV-1-infected cells and can enter non-permissive cells including neurons. Tat disrupts neuronal homeostasis and may contribute to the neuropathogenesis in people living with HIV (PLWH). The use of cocaine by PLWH exacerbates neuronal dysfunction. Here, we examined the mechanisms by ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34539-9
更新日期:2018-11-02 00:00:00
abstract::Little is known regarding the interplays between the mechanical and molecular bases for vein graft restenosis. We elucidated the stenosis initiation using a high-frequency ultrasonic (HFU) echogenicity platform and estimated the endothelium yield stress from von-Mises stress computation to predict the damage locations...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22147
更新日期:2016-02-26 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-75277-1
更新日期:2020-10-20 00:00:00
abstract::When making choices between smaller, sooner rewards and larger, later ones, people tend to discount future outcomes. Individual differences in temporal discounting in older adults have been associated with episodic memory abilities and entorhinal cortical thickness. The cause of this association between better memory ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63373-1
更新日期:2020-04-14 00:00:00
abstract::In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71768-3
更新日期:2020-09-07 00:00:00
abstract::Despite being a cardinal experimental model, the induction of cirrhosis in rats by repeated exposure to carbon tetrachloride (CCl4) has low reproducibility. Here, we compared two models of cirrhosis induced by orogastric administration of CCl4 once (CCl4-1xWk) or twice a week (CCl4-2xWk) for 12 weeks in male Sprague-D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27427-9
更新日期:2018-06-15 00:00:00
abstract::We investigated the clinical characteristics of cilioretinal arteries (CAs) and cilioretinal veins (CVs) in eyes with pathologic myopia. Ninety-five eyes with pathologic myopia and CAs were studied. The retrobulbar vessels from which the CAs originated were identified by indocyanine green angiography (ICGA). The resul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38616-5
更新日期:2019-02-21 00:00:00
abstract::Nonstructural protein 1 (NS1) is secreted by dengue virus in the first days of infection and acts as an excellent dengue biomarker. Here, the direct electrical detection of NS1 from dengue type 2 virus has been achieved by the measurement of variations in open circuit potential (OCP) between a reference electrode and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07865
更新日期:2015-01-19 00:00:00
abstract::Developing effective treatment strategies for neurodegenerative diseases require an understanding of the underlying cellular pathways that lead to neuronal vulnerability and progressive degeneration. To date, numerous mutations in 147 distinct genes are identified to be "associated" with, "modifier" or "causative" of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32902-4
更新日期:2018-10-03 00:00:00
abstract::This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68975-3
更新日期:2020-07-20 00:00:00
abstract::The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the -10 promoter element and the transcription start site of the regu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27780-9
更新日期:2018-06-21 00:00:00
abstract::High-quality, 25 nm octahedral-shaped Fe3O4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe3O4-Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29618-w
更新日期:2018-07-26 00:00:00
abstract::Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40026
更新日期:2017-01-05 00:00:00
abstract::Development of highly efficient and potential material for toxic p-nitrophenol is an important design for sensitive detection of hazardous species from ecology and environment. Here it is developed, an efficient as well as selective of p-nitrophenol using binary material by electrochemical performances, including good...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55891-4
更新日期:2019-12-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-48219-9
更新日期:2019-08-15 00:00:00
abstract::Phosphoinositides play important roles in numerous intracellular membrane pathways. Little is known about the regulation or function of these lipids in rod photoreceptor cells, which have highly active membrane dynamics. Using new assays with femtomole sensitivity, we determined that whereas levels of phosphatidylinos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26978
更新日期:2016-06-01 00:00:00
abstract::Caterpillars have long been used as models for studying animal defence. Their impressive armour, including flamboyant warning colours, poisonous spines, irritating sprays, and mimicry of plant parts, snakes and bird droppings, has been extensively documented. But research has mainly focused on visual and chemical disp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31469
更新日期:2016-08-11 00:00:00
abstract::Genetic polymorphisms in drug metabolizing enzymes and drug transporters may affect irinotecan toxicity. Although genetic polymorphisms have been shown to influence the irinotecan toxicity, data are limited in Thai population. Thus, the aim of this study was to assess the allele and genotype frequencies and the relati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70351-0
更新日期:2020-08-10 00:00:00
abstract::The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are perfor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46065
更新日期:2017-04-05 00:00:00
abstract::To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21523-6
更新日期:2018-02-21 00:00:00
abstract::Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate replication initiation and progression. The checkpoint kinase ATR...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25238-6
更新日期:2018-05-02 00:00:00
abstract::Willow (Salix spp.) seeds are able to tolerate desiccation, but differ from typical orthodox seeds in that they lose viability in a few days at room temperature, and in that the chloroplasts in embryo tissues do not dedifferentiate during maturation drying, thus retaining chlorophyll and maintaining intact their thyla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35476-3
更新日期:2018-11-21 00:00:00
abstract::We show a hybrid structure consisting of Si film with photonic crystal surface and random triangular gold grooves reflector at the bottom, which is capable of realizing efficient, broad-band, wide-angle optical absorption. It is numerically demonstrated that the enhanced absorption in a broad wavelength range (0.3-9.9...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12794
更新日期:2015-08-04 00:00:00
abstract::DNA methylation is an important epigenetic mark that regulates gene expression. Dnmt1 plays an important role in maintaining DNA methylation patterns on daughter DNA strands. Studies have shed light into the functional role of Dnmt1 regulation in the hematopoietic and epidermal systems. Here we show that Dnmt1 is requ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35355
更新日期:2016-10-18 00:00:00
abstract::Humans are host to a multitude of microorganisms that rapidly populate the body at birth, subject to a complex interplay that is dependent on host genetics, lifestyle, and environment. The host-associated microbiome, including the oral microbiome, presents itself in a complex ecosystem important to health and disease....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64747-1
更新日期:2020-05-14 00:00:00
abstract::The current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse eff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80099-2
更新日期:2021-01-13 00:00:00