Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS.

Abstract:

:Developing effective treatment strategies for neurodegenerative diseases require an understanding of the underlying cellular pathways that lead to neuronal vulnerability and progressive degeneration. To date, numerous mutations in 147 distinct genes are identified to be "associated" with, "modifier" or "causative" of amyotrophic lateral sclerosis (ALS). Protein products of these genes and their interactions helped determine the protein landscape of ALS, and revealed upstream modulators, key canonical pathways, interactome domains and novel therapeutic targets. Our analysis originates from known human mutations and circles back to human, revealing increased PPARG and PPARGC1A expression in the Betz cells of sALS patients and patients with TDP43 pathology, and emphasizes the importance of lipid homeostasis. Downregulation of YWHAZ, a 14-3-3 protein, and cytoplasmic accumulation of ZFYVE27 especially in diseased Betz cells of ALS patients reinforce the idea that perturbed protein communications, interactome defects, and altered converging pathways will reveal novel therapeutic targets in ALS.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dervishi I,Gozutok O,Murnan K,Gautam M,Heller D,Bigio E,Ozdinler PH

doi

10.1038/s41598-018-32902-4

subject

Has Abstract

pub_date

2018-10-03 00:00:00

pages

14732

issue

1

issn

2045-2322

pii

10.1038/s41598-018-32902-4

journal_volume

8

pub_type

杂志文章
  • Precisely dating the Frasnian-Famennian boundary: implications for the cause of the Late Devonian mass extinction.

    abstract::The Frasnian-Famennian boundary records one of the most catastrophic mass extinctions of the Phanerozoic Eon. Several possible causes for this extinction have been suggested, including extra-terrestrial impacts and large-scale volcanism. However, linking the extinction with these potential causes is hindered by the la...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27847-7

    authors: Percival LME,Davies JHFL,Schaltegger U,De Vleeschouwer D,Da Silva AC,Föllmi KB

    更新日期:2018-06-22 00:00:00

  • Aberrant expression of miR-153 is associated with overexpression of hypoxia-inducible factor-1α in refractory epilepsy.

    abstract::Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32091

    authors: Li Y,Huang C,Feng P,Jiang Y,Wang W,Zhou D,Chen L

    更新日期:2016-08-24 00:00:00

  • Global patterns of insect diversification: towards a reconciliation of fossil and molecular evidence?

    abstract::Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to major past environmental changes, such as the Cretaceous Terrestrial Revolution, or the development of major key innovations, such as wings or co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19208

    authors: Condamine FL,Clapham ME,Kergoat GJ

    更新日期:2016-01-18 00:00:00

  • Transformation of nonencapsulated Streptococcus pneumoniae during systemic infection.

    abstract::Streptococcus pneumoniae (pneumococcus) is a principal cause of bacterial middle ear infections, pneumonia, and meningitis. Capsule-targeted pneumococcal vaccines have likely contributed to increased carriage of nonencapsulated S. pneumoniae (NESp). Some NESp lineages are associated with highly efficient DNA uptake an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75988-5

    authors: Bradshaw JL,Rafiqullah IM,Robinson DA,McDaniel LS

    更新日期:2020-11-03 00:00:00

  • microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.

    abstract::microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we rep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02535

    authors: Leucci E,Patella F,Waage J,Holmstrøm K,Lindow M,Porse B,Kauppinen S,Lund AH

    更新日期:2013-01-01 00:00:00

  • An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro.

    abstract::Influenza virus remains an emerging virus and causes pandemics with high levels of fatality. After screening different plant extracts with potential anti-influenza activity, a water extract of Taxodium distichum stems (TDSWex) showed excellent activity against influenza viruses. The EC50 of TDSWex was 0.051 ± 0.024 mg...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36015

    authors: Hsieh CF,Chen YL,Lin CF,Ho JY,Huang CH,Chiu CH,Hsieh PW,Horng JT

    更新日期:2016-10-31 00:00:00

  • Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.

    abstract::Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31668

    authors: Mulvaney JF,Thompkins C,Noda T,Nishimura K,Sun WW,Lin SY,Coffin A,Dabdoub A

    更新日期:2016-08-23 00:00:00

  • SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma.

    abstract::Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20113

    authors: Fukazawa T,Guo M,Ishida N,Yamatsuji T,Takaoka M,Yokota E,Haisa M,Miyake N,Ikeda T,Okui T,Takigawa N,Maeda Y,Naomoto Y

    更新日期:2016-02-05 00:00:00

  • Variation in leaf morphological, stomatal, and anatomical traits and their relationships in temperate and subtropical forests.

    abstract::Leaf functional traits have attracted the attention of ecologists for several decades, but few studies have systematically assessed leaf morphological traits (termed "economic traits"), stomatal (termed "hydraulic"), and anatomical traits of entire forest communities, thus it is unclear whether their relationships are...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42335-2

    authors: Liu C,Li Y,Xu L,Chen Z,He N

    更新日期:2019-04-09 00:00:00

  • Potential for high yield with increased seedling density and decreased N fertilizer application under seedling-throwing rice cultivation.

    abstract::Fertilizer application for rice production has increased significantly in southern China to raise yields, but has led to problems with lodging, quality decline and environmental pollution. Therefore, research on fertilizer-saving cultivation technologies for high-yielding rice is necessary. A two-factor experiment was...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36978-w

    authors: Liu Y,Li C,Fang B,Fang Y,Chen K,Zhang Y,Zhang H

    更新日期:2019-01-24 00:00:00

  • Multistability of the Brain Network for Self-other Processing.

    abstract::Early fMRI studies suggested that brain areas processing self-related and other-related information were highly overlapping. Hypothesising functional localisation of the cortex, researchers have tried to locate "self-specific" and "other-specific" regions within these overlapping areas by subtracting suspected confoun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43313

    authors: Chen YA,Huang TR

    更新日期:2017-03-03 00:00:00

  • Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies.

    abstract::Epidemiological studies support a protective role of lycopene against stroke occurrence or mortality, but the results have been conflicting. We conducted a meta-analysis to assess the relationship between dietary or circulating lycopene and stroke risk (including stroke occurrence or mortality). Relevant papers were c...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep05031

    authors: Li X,Xu J

    更新日期:2014-05-22 00:00:00

  • Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.

    abstract::Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by coordinating the bal...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16173

    authors: Mukai S,Yabuta N,Yoshida K,Okamoto A,Miura D,Furuta Y,Abe T,Nojima H

    更新日期:2015-11-04 00:00:00

  • Differentiation of malignant cervical lymphadenopathy by dual-energy CT: a preliminary analysis.

    abstract::The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31020

    authors: Yang L,Luo D,Li L,Zhao Y,Lin M,Guo W,Zhou C

    更新日期:2016-08-08 00:00:00

  • A prospective, randomised study of the effect of fixation sutures during phacotrabeculectomy on intraocular pressure and incidence of ptosis.

    abstract::We investigated the effects of different intraoperative eyeball fixation techniques (superior rectus muscle suture [MS] and traction suture at the corneal limbus [CS]), on intraocular pressure (IOP) and the incidence of ptosis after phacotrabeculectomy. Forty-one eyes with different glaucoma types which qualified for ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79635-x

    authors: Konopińska J,Lisowski Ł,Mariak Z,Wojnar M,Obuchowska I,Rękas M

    更新日期:2021-01-12 00:00:00

  • Heat Transfer Enhancement During Water and Hydrocarbon Condensation on Lubricant Infused Surfaces.

    abstract::Vapor condensation is routinely used as an effective means of transferring heat or separating fluids. Dropwise condensation, where discrete droplets form on the condenser surface, offers a potential improvement in heat transfer of up to an order of magnitude compared to filmwise condensation, where a liquid film cover...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18955-x

    authors: Preston DJ,Lu Z,Song Y,Zhao Y,Wilke KL,Antao DS,Louis M,Wang EN

    更新日期:2018-01-11 00:00:00

  • Estimation of the ion-trap assisted electrical loads and resulting BBR shift.

    abstract::Capacitive, inductive and resistive loads of an ion-trap system, which can be modelled as LCR circuits, are important to know for building a high accuracy experiment. Accurate estimation of these loads is necessary for delivering the desired radio frequency (RF) signal to an ion trap via an RF resonator. Of particular...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35234-5

    authors: Sharma L,Roy A,Panja S,Ojha VN,De S

    更新日期:2018-11-15 00:00:00

  • Multiaxial Lenticular Stress-Strain Relationship of Native Myocardium is Preserved by Infarct-Induced Natural Heart Regeneration in Neonatal Mice.

    abstract::Neonatal mice exhibit natural heart regeneration after myocardial infarction (MI) on postnatal day 1 (P1), but this ability is lost by postnatal day 7 (P7). Cardiac biomechanics intricately affect long-term heart function, but whether regenerated cardiac muscle is biomechanically similar to native myocardium remains u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63324-w

    authors: Wang H,Bennett-Kennett R,Paulsen MJ,Hironaka CE,Thakore AD,Farry JM,Eskandari A,Lucian HJ,Shin HS,Wu MA,Imbrie-Moore AM,Steele AN,Stapleton LM,Zhu Y,Dauskardt RH,Woo YJ

    更新日期:2020-04-30 00:00:00

  • A convolutional neural network-based system to prevent patient misidentification in FDG-PET examinations.

    abstract::Patient misidentification in imaging examinations has become a serious problem in clinical settings. Such misidentification could be prevented if patient characteristics such as sex, age, and body weight could be predicted based on an image of the patient, with an alert issued when a mismatch between the predicted and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43656-y

    authors: Kawauchi K,Hirata K,Katoh C,Ichikawa S,Manabe O,Kobayashi K,Watanabe S,Furuya S,Shiga T

    更新日期:2019-05-10 00:00:00

  • Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study.

    abstract::Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based coh...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48065-9

    authors: Jess T,Morgen CS,Harpsøe MC,Sørensen TIA,Ajslev TA,Antvorskov JC,Allin KH

    更新日期:2019-08-08 00:00:00

  • Objective Assessment of Cerebellar Ataxia: A Comprehensive and Refined Approach.

    abstract::Parametric analysis of Cerebellar Ataxia (CA) could be of immense value compared to its subjective clinical assessments. This study focuses on a comprehensive scheme for objective assessment of CA through the instrumented versions of 9 commonly used neurological tests in 5 domains- speech, upper limb, lower limb, gait...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65303-7

    authors: Kashyap B,Phan D,Pathirana PN,Horne M,Power L,Szmulewicz D

    更新日期:2020-06-11 00:00:00

  • OCT Amplitude and Speckle Statistics of Discrete Random Media.

    abstract::Speckle, amplitude fluctuations in optical coherence tomography (OCT) images, contains information on sub-resolution structural properties of the imaged sample. Speckle statistics could therefore be utilized in the characterization of biological tissues. However, a rigorous theoretical framework relating OCT speckle s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14115-3

    authors: Almasian M,van Leeuwen TG,Faber DJ

    更新日期:2017-11-01 00:00:00

  • Relating quantum coherence and correlations with entropy-based measures.

    abstract::Quantum coherence and quantum correlations are important quantum resources for quantum computation and quantum information. In this paper, using entropy-based measures, we investigate the relationships between quantum correlated coherence, which is the coherence between subsystems, and two main kinds of quantum correl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09332-9

    authors: Wang XL,Yue QL,Yu CH,Gao F,Qin SJ

    更新日期:2017-09-21 00:00:00

  • MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a.

    abstract::Nonalcoholic fibrosing steatohepatitis is a uniform process throughout nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) have been suggested to modulate cellular processes in liver diseases. However, the functional role of miRNAs in nonalcoholic fibrosing steatohepatitis is largely unclear. In this study, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16163

    authors: Du J,Niu X,Wang Y,Kong L,Wang R,Zhang Y,Zhao S,Nan Y

    更新日期:2015-11-05 00:00:00

  • Skeletal muscle cutoff values for sarcopenia diagnosis using T10 to L5 measurements in a healthy US population.

    abstract::Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' valu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29825-5

    authors: Derstine BA,Holcombe SA,Ross BE,Wang NC,Su GL,Wang SC

    更新日期:2018-07-27 00:00:00

  • PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease.

    abstract::Alcoholic liver disease (ALD) causes significant morbidity and mortality, and pharmacological treatment options are limited. In this study, we evaluated the PCSK9 inhibitor alirocumab, a monoclonal antibody that robustly reduces low-density lipoprotein cholesterol (LDL-C), for the treatment of ALD using a rat model of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53603-6

    authors: Lee JS,Mukhopadhyay P,Matyas C,Trojnar E,Paloczi J,Yang YR,Blank BA,Savage C,Sorokin AV,Mehta NN,Vendruscolo JCM,Koob GF,Vendruscolo LF,Pacher P,Lohoff FW

    更新日期:2019-11-20 00:00:00

  • 3D Porous Graphene Based Aerogel for Electromagnetic Applications.

    abstract::Lightweight multifunctional electromagnetic (EM) absorbing materials with outstanding thermal properties, chemical resistance and mechanical stability are crucial for space, aerospace and electronic devices and packaging. Therefore, 3D porous graphene aerogels are attracting ever growing interest. In this paper we pre...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52230-5

    authors: Cheraghi Bidsorkhi H,D'Aloia AG,Tamburrano A,De Bellis G,Delfini A,Ballirano P,Sarto MS

    更新日期:2019-10-31 00:00:00

  • Male mice with large inversions or deletions of X-chromosome palindrome arms are fertile and express their associated genes during post-meiosis.

    abstract::Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27360-x

    authors: Kruger AN,Ellison Q,Brogley MA,Gerlinger ER,Mueller JL

    更新日期:2018-06-12 00:00:00

  • Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging.

    abstract::Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood. The aim of this study is to investigate the metabolic changes in DMD u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81090-1

    authors: Dabaj I,Ferey J,Marguet F,Gilard V,Basset C,Bahri Y,Brehin AC,Vanhulle C,Leturcq F,Marret S,Laquerrière A,Schmitz-Afonso I,Afonso C,Bekri S,Tebani A

    更新日期:2021-01-21 00:00:00

  • Stress loading history of earthquake faults influenced by fault/shear zone geometry and Coulomb pre-stress.

    abstract::Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69681-w

    authors: Sgambato C,Faure Walker JP,Mildon ZK,Roberts GP

    更新日期:2020-07-29 00:00:00