Abstract：
:Developing effective treatment strategies for neurodegenerative diseases require an understanding of the underlying cellular pathways that lead to neuronal vulnerability and progressive degeneration. To date, numerous mutations in 147 distinct genes are identified to be "associated" with, "modifier" or "causative" of amyotrophic lateral sclerosis (ALS). Protein products of these genes and their interactions helped determine the protein landscape of ALS, and revealed upstream modulators, key canonical pathways, interactome domains and novel therapeutic targets. Our analysis originates from known human mutations and circles back to human, revealing increased PPARG and PPARGC1A expression in the Betz cells of sALS patients and patients with TDP43 pathology, and emphasizes the importance of lipid homeostasis. Downregulation of YWHAZ, a 14-3-3 protein, and cytoplasmic accumulation of ZFYVE27 especially in diseased Betz cells of ALS patients reinforce the idea that perturbed protein communications, interactome defects, and altered converging pathways will reveal novel therapeutic targets in ALS.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dervishi I,Gozutok O,Murnan K,Gautam M,Heller D,Bigio E,Ozdinler PHdoi
10.1038/s41598-018-32902-4subject
Has Abstractpub_date
2018-10-03 00:00:00pages
14732issue
1issn
2045-2322pii
10.1038/s41598-018-32902-4journal_volume
8pub_type
杂志文章abstract：:Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38165-3
更新日期：2019-02-04 00:00:00
abstract：:SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41912
更新日期：2017-02-02 00:00:00
abstract：:This study aimed to develop a cationic nanosuspension of chitosan (CS) and methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) for ocular delivery of diclofenac (DIC). MPEG-PCL-CS block polymer was synthesized by covalent coupling of MPEG-PCL with CS. The critical micelle concentration of the MPEG-PCL-CS blo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11337
更新日期：2015-06-12 00:00:00
abstract：:Tissue fibrosis underlies the majority of human mortality to date with close to half of all reported deaths having a fibrotic etiology. The progression of fibrosis is very complex and reputed irreversible once established. Although some preventive options are being reported, therapeutic options are still scarce and in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67514-4
更新日期：2020-06-30 00:00:00
abstract：:Laser-driven ultrafast electron emission offers the possibility of manipulation and control of coherent electron motion in ultrashort spatiotemporal scales. Here, an analytical solution is constructed for the highly nonlinear electron emission from a dc biased metal surface illuminated by a single frequency laser, by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19894
更新日期：2016-01-28 00:00:00
abstract：:Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB response after low IR doses is of particular interest but its examination requires the analysis of high cell numbers. Here, we present an a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35660-5
更新日期：2018-11-23 00:00:00
abstract：:Electrically pumped GaAsBi/GaAs quantum well lasers are a promising new class of near-infrared devices where, by use of the unusual band structure properties of GaAsBi alloys, it is possible to suppress the dominant energy-consuming Auger recombination and inter-valence band absorption loss mechanisms, which greatly i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28863
更新日期：2016-07-01 00:00:00
abstract：:In arid and semiarid regions, low precipitation rates lead to soil salinity problems, which may limit plant establishment, growth, and survival. Herein, we investigated the NaCl stress effect on chlorophyll fluorescence, photosynthetic-pigments, movement and chloroplasts ultrastructure in chlorenchyma cells of Opuntia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08744-x
更新日期：2017-08-17 00:00:00
abstract：:The prognostic relevance of strokes in different locations is debated. For example, insular strokes have been associated with increased mortality, but this association could reflect their greater severity. In two independent cohorts of patients with supratentorial ischemic stroke (n = 90 and 105), we studied the progn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27883-3
更新日期：2018-06-22 00:00:00
abstract：:We adopted a vision-based tracking system for augmented reality (AR), and evaluated whether it helped surgeons to localize the recurrent laryngeal nerve (RLN) during robotic thyroid surgery. We constructed an AR image of the trachea, common carotid artery, and RLN using CT images. During surgery, an AR image of the tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65439-6
更新日期：2020-05-21 00:00:00
abstract：:This study investigated the effects of 4 aeration levels (varied by injection of air to the soil through subsurface irrigation lines) at two subsurface irrigation line depths (15 and 40 cm) on plant growth, yield and nutritional quality of greenhouse tomato. In all experiments, fruit number, width and length, yield, v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39307
更新日期：2016-12-20 00:00:00
abstract：:Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27633
更新日期：2016-06-08 00:00:00
abstract：:Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61828-z
更新日期：2020-03-17 00:00:00
abstract：:Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34894
更新日期：2016-10-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-60467-8
更新日期：2020-02-27 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-59303-w
更新日期：2020-02-06 00:00:00
abstract：:DNA methylation may be involved in development of type 1 diabetes (T1D), but previous epigenome-wide association studies were conducted among cases with clinically diagnosed diabetes. Using multiple pre-disease peripheral blood samples on the Illumina 450 K and EPIC platforms, we investigated longitudinal methylation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60758-0
更新日期：2020-02-28 00:00:00
abstract：:Deleterious mutations in patchd1 domain containing 1 (PTCHD1) gene have been identified in patients with intellectual disability and/or autism spectrum disorder (ASD). To clarify the causal relationship between Ptchd1 deficiency and behavioral defects relevant to neurodevelopmental disorders, we generated global Ptchd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49781-y
更新日期：2019-09-12 00:00:00
abstract：:The Sinorhizobium meliloti (S. meliloti) strain CCNWSX0020 displayed tolerance to high levels exposures of multiple metals and growth promotion of legume plants grown in metal-contaminated soil. However, the mechanism of metal-resistant strain remains unknown. We used five P1B-ATPases deletions by designating as ∆copA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29355
更新日期：2016-07-05 00:00:00
abstract：:The Martian outflow channels comprise some of the largest known channels in the Solar System. Remote-sensing investigations indicate that cataclysmic floods likely excavated the channels ~3.4 Ga. Previous studies show that, in the southern circum-Chryse region, their flooding pathways include hundreds of kilometers of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39632-1
更新日期：2019-02-25 00:00:00
abstract：:As an analytic pipeline for quantitative imaging feature extraction and analysis, radiomics has grown rapidly in the past decade. On the other hand, recent advances in deep learning and transfer learning have shown significant potential in the quantitative medical imaging field, raising the research question of whethe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-80998-y
更新日期：2021-01-14 00:00:00
abstract：:Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion protei...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03486-2
更新日期：2017-06-09 00:00:00
abstract：:In this paper, we study a system with two interacting qubits described by the Heisenberg model with dissipative terms, and analyze decay dynamics and the steady-state of geometric quantum discords. Our results indicate that we can ignore the interaction force in the z-direction and adjust the parameters to change the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67698-9
更新日期：2020-07-02 00:00:00
abstract：:A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate the development of neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth, predicts adverse neurodevelopmental outcome eighteen months after neonatal encephalopa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70131-w
更新日期：2020-08-04 00:00:00
abstract：:Craniofacial muscles drive critical functions in the head, including speech, feeding and expression. Compared with their counterparts in trunk and limbs, craniofacial muscles are of distinct embryonic origins, which might consequently lead to different growth patterns and regenerative potential. In this study, rat lev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28917-6
更新日期：2018-07-13 00:00:00
abstract：:Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-syste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22749-0
更新日期：2018-03-14 00:00:00
abstract：:Adult hippocampal neurogenesis is associated with learning and affective behavioural regulation. Its diverse functionality is segregated along the septotemporal axis from the dorsal to ventral hippocampus. However, features distinguishing immature neurons in these regions have yet to be characterized. Additionally, al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30467
更新日期：2016-07-29 00:00:00
abstract：:The biological function of sterol glucosides (SGs), the most abundant sterol derivatives in higher plants, remains uncertain. In an effort to improve our understanding of these membrane lipids we examined phenotypes exhibited by the roots of Arabidopsis (Arabidopsis thaliana) lines carrying insertions in the UDP-Glc:s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05925-6
更新日期：2017-07-18 00:00:00
abstract：:Robot-assisted laparoscopic radical prostatectomy (RALRP) is a minimally invasive procedure; however, some amount of surgical trauma that can trigger systemic inflammation remains. Moreover, pneumoperitoneum during RALRP induces ischemia-reperfusion injury (IRI). Propofol, an anesthetic, is known to have anti-inflamma...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-41708-x
更新日期：2019-03-27 00:00:00
abstract：:Vertically aligned radial-junction solar cell designs offer potential improvements over planar geometries, as carrier generation occurs close to the junction for all absorption depths, but most production methods still require a single crystal substrate. Here, we report on the fabrication of such solar cells from poly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06283
更新日期：2014-09-04 00:00:00
