Abstract：
:The current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse effects. Anterior segment optical coherence tomography angiography (AS-OCTA) is a non-invasive tool that has been shown to successfully delineate CV. However, there are no previous studies that have reported if AS-OCTA can determine CV stage and activity. We used an established CV model in rabbits to examine serial AS-OCTA scans of CV development and regression following treatment with anti-vascular endothelial growth factor. We compared AS-OCTA derived vascular measurements to that of ICGA determined vessel leakage and CV staging. Our results showed that AS-OCTA vessel densities and vessel branch area significantly correlated with the severity of CV based on ICGA (all p ≤ 0.05). We also found that AS-OCTA vessel densities correlated with ICGA vessel leakage time, following an inverse linear relationship (r2 = - 0.726, p < 0.01). Changes in aqueous levels of CXCL-12 and PIGF cytokines significantly correlated with AS-OCTA vessel densities (r2 = 0.736 and r2 = 0.731 respectively, all p < 0.05). In summary, we found that AS-OCTA derived vessel parameters may be useful for assessing CV severity, while vessel density correlates with CV activity and leakage. Thus, our pilot animal model study suggests that AS-OCTA may be a useful non-invasive imaging tool to provide objective assessment of CV to examine progression or response in treatment, which requires confirmation in clinical studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ong HS,Tey KY,Ke M,Tan B,Chua J,Schmetterer L,Mehta JS,Ang Mdoi
10.1038/s41598-020-80099-2subject
Has Abstractpub_date
2021-01-13 00:00:00pages
1212issue
1issn
2045-2322pii
10.1038/s41598-020-80099-2journal_volume
11pub_type
杂志文章abstract：:Subsea hypersaline anoxic brine pools are among the most extreme habitable environments on Earth that offer clues to life on other planets. Brine is toxic to macrofauna as remotely operated vehicles commonly observe dead and preserved remains in brine pools. While brine pools are often assumed to be stable stratified ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36781-7
更新日期：2019-01-15 00:00:00
abstract：:Nucleotide-binding domain and leucine-rich-repeat-containing family member X1 (NLRX1), located in mitochondria, can recognize cytoplasmic pattern recognition receptors and is tightly related to reactive oxygen species (ROS) production, mitochondrial function, apoptosis and inflammation. The present study was designed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44311
更新日期：2017-03-13 00:00:00
abstract：:The recent Paris UNFCCC climate meeting discussed the possibility of limiting global warming to 2 °C since pre-industrial times, or possibly even 1.5 °C, which would require major future emissions reductions. However, even if climate is stabilised at current atmospheric greenhouse gas (GHG) concentrations, those warmi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30294
更新日期：2016-07-27 00:00:00
abstract：:We aimed to analyze the associations of bone mineral density (BMD) of femoral heads, age and gender, and compare the differences in BMD between fracture side and non-fracture side by "3D Spine Exam Analysis" module in QCT Pro software. In this study, we identified patients who had undergone quantitative computed tomog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70144-5
更新日期：2020-08-03 00:00:00
abstract：:Schistosomes, unlike malaria parasites, are in their diploid stage when targeted by the human immune system. Diploids can be either homozygous or heterozygous. The difference has profound significance for developing immunity and yet has not previously been addressed. We examined the implications of zygosity on immunit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00346
更新日期：2012-01-01 00:00:00
abstract：:The high neutron detection efficiency, good gamma-ray discrimination and non-toxicity of 3He made of proportional counters filled with this gas the obvious choice for neutron detection, particularly in radiation portal monitors (RPM), used to control the illicit transport of nuclear material, of which neutron detector...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41699
更新日期：2017-02-09 00:00:00
abstract：:To pattern electrical metal contacts, electron beam lithography or photolithography are commonly utilized, and these processes require polymer resists with solvents. During the patterning process the graphene surface is exposed to chemicals, and the residue on the graphene surface was unable to be completely removed b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25050
更新日期：2016-05-12 00:00:00
abstract：:Doubly curved nanofiber-reinforced optically transparent composites with low thermal expansion of 15 ppm/k are prepared by hot pressing vacuum-filtered Pickering emulsions of hydrophobic acrylic resin monomer, hydrophilic chitin nanofibers and water. The coalescence of acrylic monomer droplets in the emulsion is preve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16421
更新日期：2015-11-10 00:00:00
abstract：:Chimpanzees (Pan troglodytes), one of humankinds' closest living relatives, are known to hunt and consume the meat of various animal taxa. Although some researchers have presented indirect evidence that chimpanzees may also prey on tortoises, until now, direct observations of this behaviour did not exist. Here, we pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43301-8
更新日期：2019-05-23 00:00:00
abstract：:Why lightning sometimes has multiple discharges to ground is an unanswered question. Recently, the observation of small plasma structures on positive leaders re-ignited the search. These small plasma structures were observed as pulsing radio sources along the positive leader length and were named "needles". Needles ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74597-6
更新日期：2020-10-15 00:00:00
abstract：:The expanding distribution of African swine fever (ASF) is threatening the pig industry worldwide. Most outbreaks occur in backyard and small-scale herds, where poor farmers often attempt to limit the disease's economic consequences by the emergency sale of their pigs. The risk of African swine fever virus (ASFV) rele...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17074
更新日期：2015-11-27 00:00:00
abstract：:The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38239
更新日期：2016-12-05 00:00:00
abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11713-z
更新日期：2017-09-12 00:00:00
abstract：:Biofilms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli and Listeria innocua biofilms. Both technologies were efficient in controlling...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81977-z
更新日期：2021-01-27 00:00:00
abstract：:Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The achieved percentage of expected low-density lipoprotein-cholesterol (LDL-C) reduction (primary variable) and achieveme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75901-0
更新日期：2020-11-09 00:00:00
abstract：:Cyanobacteria are photosynthetic prokaryotes that make major contributions to the production of the oxygen in the Earth atmosphere. The photosynthetic machinery in cyanobacterial cells is housed in flattened membrane structures called thylakoids. The structural organization of cyanobacterial cells and the arrangement ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19627
更新日期：2016-01-21 00:00:00
abstract：:Alumina toughened zirconia (ATZ) and zirconia toughened alumina (ZTA) are currently the materials of choice to meet the need for tough, strong, and bioinert ceramics for medical devices. However, the mechanical properties of ZrO2/Al2O3 dispersion ceramics could be considerably increased by reducing the corresponding g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20589
更新日期：2016-02-05 00:00:00
abstract：:The present study examined different types of neurological signs in patients with first-episode schizophrenia and their relationships with neurocognitive functions. Both cross-sectional and longitudinal designs were adopted with the use of the abridged Cambridge Neurological Inventory which comprises items capturing m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11850
更新日期：2015-07-02 00:00:00
abstract：:Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions-it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22077
更新日期：2016-02-25 00:00:00
abstract：:Trees produce pollen during specific times of the year. Pollen can induce pollinosis, a type of allergic rhinitis, in humans. In Japan, allergenic pollen is mainly dispersed from February to May. Using data collected at 120 observation sites managed by the Japanese Ministry of the Environment, we studied the annual pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47870-6
更新日期：2019-08-07 00:00:00
abstract：:NOTCH plays a pivotal role during normal development and in congenital disorders and cancer. γ-secretase inhibitors are commonly used to probe NOTCH function, but also block processing of numerous other proteins. We discovered a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46948-5
更新日期：2019-07-25 00:00:00
abstract：:We investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 female...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-22913-6
更新日期：2018-03-23 00:00:00
abstract：:Root damage due to aluminum (Al) toxicity restricts crop production on acidic soils, which are extensive in the tropics. The sorghum root Al-activated citrate transporter, SbMATE, underlies the Al tolerance locus, AltSB, and increases grain yield under Al toxicity. Here, AltSB loci associated with Al tolerance were co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27817-z
更新日期：2018-07-04 00:00:00
abstract：:IgE, forming an immune complex with small proteins, can enhance the specific antibody and CD4(+) T cell responses in vivo. The effects require the presence of CD23 (Fcε-receptor II)(+) B cells, which capture IgE-complexed antigens (Ag) in the circulation and transport them to splenic B cell follicles. In addition, als...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28290
更新日期：2016-06-16 00:00:00
abstract：:Intuition and insight can be deployed on the same continuum. Intuition is the unconscious ability to create links between information; insight is a process by which a sudden comprehension and resolution of a situation arises (i.e. euréka). In the present study, real and virtual environments were used to trigger intuit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81532-w
更新日期：2021-01-21 00:00:00
abstract：:Zebrafish is a popular and favorable model organism for cardiovascular research, with an increasing number of studies implementing functional assays in the adult stage. For example, the application of electrocardiography (ECG) in adult zebrafish has emerged as an important tool for cardiac pathophysiology, toxicity, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33577-7
更新日期：2018-10-30 00:00:00
abstract：:Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery. As human pluripotent stem cell-derived cardiomyocytes remain functionally fetal-type, close monitoring of electrophysiological maturation is critical for their furthe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43210
更新日期：2017-03-07 00:00:00
abstract：:Detecting communities or clusters in a real-world, networked system is of considerable interest in various fields such as sociology, biology, physics, engineering science, and interdisciplinary subjects, with significant efforts devoted in recent years. Many existing algorithms are only designed to identify the compos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24017
更新日期：2016-04-07 00:00:00
abstract：:The Expanded Susceptibility to Smoking Index (ESSI) is based on the combination of susceptibility to smoking and curiosity about smoking. The ESSI can identify young people who are at risk of starting to smoke cigarettes and related products. The objective of this study was to analyse the ESSI results and to examine f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81723-5
更新日期：2021-01-21 00:00:00
abstract：:Improving spatial accessibility to hospitals is a major task for health care systems which can be facilitated using recent methodological improvements of spatial accessibility measures. We used the integrated floating catchment area (iFCA) method to analyze spatial accessibility of general inpatient care (internal med...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76212-0
更新日期：2020-11-05 00:00:00
