Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system.

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Passari AK,Mishra VK,Singh G,Singh P,Kumar B,Gupta VK,Sarma RK,Saikia R,Donovan AO,Singh BP

更新日期：2018-03-12 00:00:00

abstract：:Biomass waste products from green algae have recently been given new life, as these polysaccharides have potential applications in industry, agriculture, and medicine. One such polysaccharide group called ulvans displays many different, potentially useful properties that arise from their structural versatility. Hence,...

journal_title：Scientific reports

authors： Melcher RL,Neumann M,Fuenzalida Werner JP,Gröhn F,Moerschbacher BM

更新日期：2017-03-22 00:00:00

abstract：:Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense against polymicrobial s...

journal_title：Scientific reports

authors： Itakura J,Sato M,Ito T,Mino M,Fushimi S,Takahashi S,Yoshimura T,Matsukawa A

更新日期：2017-10-09 00:00:00

abstract：:Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate replication initiation and progression. The checkpoint kinase ATR...

journal_title：Scientific reports

authors： Bøe CA,Håland TW,Boye E,Syljuåsen RG,Grallert B

更新日期：2018-05-02 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...

journal_title：Scientific reports

authors： Li Z,Mao R,Teng D,Hao Y,Chen H,Wang X,Wang X,Yang N,Wang J

更新日期：2017-09-21 00:00:00

abstract：:Balloon whisk-like and flower-like SiOx tubes with well-dispersed Sn and joining countless SiOx loops together induce intense luminescence characteristics in substrate materials. Our synthetic technique called "direct substrate growth" is based on pre-contamination of the surroundings without the intended catalyst and...

journal_title：Scientific reports

authors： Jin C,Hwang SJ,Cho MS,Choi SW,Na HG,Park S,Park S,Noh Y,Jeong H,Lee D

更新日期：2016-08-01 00:00:00

abstract：:Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...

journal_title：Scientific reports

authors： Raabe CA,Voss R,Kummerfeld DM,Brosius J,Galiveti CR,Wolters A,Seggewiss J,Huge A,Skryabin BV,Rozhdestvensky TS

更新日期：2019-03-12 00:00:00

abstract：:We delineate the four principal surface plasmon polariton coupling and interaction mechanisms in subwavelength gratings, and demonstrate their significant roles in shaping the optical response of plasmonic gratings. Within the framework of width-graded metal-insulator-metal nano-gratings, electromagnetic field confine...

journal_title：Scientific reports

authors： Shayegannia M,Montazeri AO,Dixon K,Prinja R,Kazemi-Zanjani N,Kherani NP

更新日期：2021-01-12 00:00:00

abstract：:The role of non-bilayer lipids and non-lamellar lipid phases in biological membranes is an enigmatic problem of membrane biology. Non-bilayer lipids are present in large amounts in all membranes; in energy-converting membranes they constitute about half of their total lipid content-yet their functional state is a bila...

journal_title：Scientific reports

authors： Dlouhý O,Kurasová I,Karlický V,Javornik U,Šket P,Petrova NZ,Krumova SB,Plavec J,Ughy B,Špunda V,Garab G

更新日期：2020-07-20 00:00:00

abstract：:Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patien...

journal_title：Scientific reports

authors： Tang YJ,Wang JL,Xie KG,Lan CG

更新日期：2016-10-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Wada Y,Nithichanon A,Nobusawa E,Moise L,Martin WD,Yamamoto N,Terahara K,Hagiwara H,Odagiri T,Tashiro M,Lertmemongkolchai G,Takeyama H,De Groot AS,Ato M,Takahashi Y

更新日期：2019-10-08 00:00:00

abstract：:Recently, a concept of digital metamaterials has been proposed to manipulate field distribution through proper spatial mixtures of digital metamaterial bits. Here, we present a design of 2-bit digitally-controlled coding metasurface that can effectively modulate the scattered electromagnetic wave and realize different...

journal_title：Scientific reports

authors： Huang C,Sun B,Pan W,Cui J,Wu X,Luo X

更新日期：2017-02-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Zhang X,Shen Q,Lei Z,Wang Q,Zheng J,Jia Z

更新日期：2020-03-06 00:00:00

abstract：:The mitochondrial genome almost exclusively encodes a handful of transmembrane constituents of the oxidative phosphorylation (OXPHOS) system. Coordinated expression of these genes ensures the correct stoichiometry of the system's components. Translation initiation in mitochondria is assisted by two general initiation ...

journal_title：Scientific reports

authors： Kuzmenko A,Derbikova K,Salvatori R,Tankov S,Atkinson GC,Tenson T,Ott M,Kamenski P,Hauryliuk V

更新日期：2016-01-05 00:00:00

abstract：:Oral microbiome dysbiosis has been associated with various local and systemic human diseases such as dental caries, periodontal disease, obesity, and cardiovascular disease. Bacterial composition may be affected by age, oral health, diet, and geography, although information about the natural variation found in the gen...

journal_title：Scientific reports

authors： Burcham ZM,Garneau NL,Comstock SS,Tucker RM,Knight R,Metcalf JL,Genetics of Taste Lab Citizen Scientists.

更新日期：2020-02-07 00:00:00

abstract：:CD4+latency-associated peptide (LAP)+ T cells are a newly discovered T cell subset with suppressive function on immune responses. In this study, we investigate the role of CD4+LAP+ T cells on mice corneal allograft survival by down-regulating their expression using anti-LAP mAb. We show that a blockage of LAP leads to...

journal_title：Scientific reports

authors： Li S,Lu H,Sella R,Zhang W,Dong H,Guo C,Afshari NA,Pan Z,Jie Y

更新日期：2018-05-22 00:00:00

abstract：:MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3'untranslated regions of its target genes. Machine learning based miRNA target prediction algorithms first extract a set of features from potential binding sites (PBSs) in the mRNA and then train a classifier to distinguish targets from no...

journal_title：Scientific reports

authors： Bandyopadhyay S,Ghosh D,Mitra R,Zhao Z

更新日期：2015-01-23 00:00:00

abstract：:An important safety concern on cell-based gene therapy is that few methods have been available to control the proliferation and functioning of therapeutic protein-expressing cells after transplantation. We previously reported that the proliferation and functioning of the cells transfected with herpes simplex virus thy...

journal_title：Scientific reports

authors： Tsujimura M,Kusamori K,Katsumi H,Sakane T,Yamamoto A,Nishikawa M

更新日期：2019-12-11 00:00:00

abstract：:Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...

journal_title：Scientific reports

authors： Glennon EKK,Megawati D,Torrevillas BK,Ssewanyana I,Huang L,Aweeka F,Greenhouse B,Adams LG,Luckhart S

更新日期：2018-06-11 00:00:00

abstract：:Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water sample...

journal_title：Scientific reports

authors： Ido A,Hiromori Y,Meng L,Usuda H,Nagase H,Yang M,Hu J,Nakanishi T

更新日期：2017-04-12 00:00:00

abstract：:Cover cropping is proposed to enhance soil microbial diversity and activity, with cover crop type affecting microbial groups in different ways. We compared fungal community compositions of bulk soils differing by cover crop treatment, season, and edaphic properties in the third year of an organic, conventionally tille...

journal_title：Scientific reports

authors： Cloutier ML,Murrell E,Barbercheck M,Kaye J,Finney D,García-González I,Bruns MA

更新日期：2020-04-10 00:00:00

abstract：:Microorganisms associated with plants are highly diverse and can produce a large number of secondary metabolites, with antimicrobial, anti-parasitic and cytotoxic activities. We are particularly interested in exploring endophytes from medicinal plants found in the Pantanal, a unique and widely unexplored wetland in Br...

journal_title：Scientific reports

authors： Savi DC,Shaaban KA,Gos FMWR,Ponomareva LV,Thorson JS,Glienke C,Rohr J

更新日期：2018-02-15 00:00:00

abstract：:Malaria surveillance data provide opportunity to develop forecasting models. Seasonal variability in environmental factors correlate with malaria transmission, thus the identification of transmission patterns is useful in developing prediction models. However, with changing seasonal transmission patterns, either due t...

journal_title：Scientific reports

authors： Sewe MO,Tozan Y,Ahlm C,Rocklöv J

更新日期：2017-06-01 00:00:00

abstract：:High-altitude-adapted ectotherms can escape competition from dominant species by tolerating low temperatures at cooler elevations, but climate change is eroding such advantages. Studies evaluating broad-scale impacts of global change for high-altitude organisms often overlook the mitigating role of biotic factors. Yet...

journal_title：Scientific reports

authors： Muluvhahothe MM,Joseph GS,Seymour CL,Munyai TC,Foord SH

更新日期：2021-01-08 00:00:00

abstract：:Ti3+ species are highly unstable in air owing to their facile oxidation into Ti4+ species, and thus they cannot concentrate in the surface layer of TiO2 but are mainly present in its bulk. We report generation of abundant and stable Ti3+ species in the surface layer of TiO2 by boron doping for efficient utilization of...

journal_title：Scientific reports

authors： Feng N,Liu F,Huang M,Zheng A,Wang Q,Chen T,Cao G,Xu J,Fan J,Deng F

更新日期：2016-10-06 00:00:00

abstract：:Despite a large body of evidence showing the pandemic of chronic kidney disease, the impact of pre-operative kidney function on the risk of post-operative pulmonary complications (PPCs) is not well known. We used multivariable logistic regression analyses with 3-level hierarchical adjustments to identify the associati...

journal_title：Scientific reports

authors： Shimomura A,Obi Y,Fazl Alizadeh R,Li S,Nguyen NT,Stamos MJ,Kalantar-Zadeh K,Ichii H

更新日期：2017-07-26 00:00:00

abstract：:Seed number per pod (SNPP) is one of the major yield components and breeding targets in rapeseed that shows great variation and is invaluable for genetic improvement. To elucidate the genetic architecture and uncover the mechanism of SNPP, we identified five quantitative trait loci (QTLs) using the BnaZNRIL population...

journal_title：Scientific reports

authors： Yang Y,Shi J,Wang X,Liu G,Wang H

更新日期：2016-04-12 00:00:00

abstract：:We report on the synthesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) - (EtO)3Si(CH2)nN = CHPhX where n = 3 or 11 and X = 4-CF3, 3,5-CF3, 3-F-4-CF3, 4-F, or 2,3,4,5,6-F, and explore their rectification behavior in relation to their molecular structure. The electrical proper...

journal_title：Scientific reports

authors： Lamport ZA,Broadnax AD,Harrison D,Barth KJ,Mendenhall L,Hamilton CT,Guthold M,Thonhauser T,Welker ME,Jurchescu OD

更新日期：2016-11-29 00:00:00

abstract：:Autonomic modulation and cardiorespiratory variables are influenced by numerous factors, including anthropometric variables. We investigated autonomic recovery following aerobic exercise in healthy men with different waist-stature ratio (WSR) values. The study was conducted with 52 healthy men aged 18 to 30 years, div...

journal_title：Scientific reports

authors： Fontes AMGG,de Oliveira LS,Vanderlei FM,Garner DM,Valenti VE

更新日期：2018-10-31 00:00:00

abstract：:Science, being a social enterprise, is subject to fragmentation into groups that focus on specialized areas or topics. Often new advances occur through cross-fertilization of ideas between sub-fields that otherwise have little overlap as they study dissimilar phenomena using different techniques. Thus to explore the n...

journal_title：Scientific reports

authors： Pan RK,Sinha S,Kaski K,Saramäki J

更新日期：2012-01-01 00:00:00