Author Correction: Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.

abstract：:The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospect...

journal_title：Scientific reports

authors： Brewer A,Cormican P,Lim JJ,Chapwanya A,O'Farrelly C,Meade KG

更新日期：2020-10-26 00:00:00

abstract：:Due to the potentially detrimental consequences of low performance in basic functional tasks, individuals are expected to improve performance with age and show the most marked changes during early stages of life. Soaring-gliding birds use rising-air columns (thermals) to reduce energy expenditure allocated to flight. ...

journal_title：Scientific reports

authors： Harel R,Horvitz N,Nathan R

更新日期：2016-06-13 00:00:00

abstract：:The Internet of Things (IoT), as a cutting-edge integrated cross-technology, promises to informationize people's daily lives, while being threatened by continuous challenges of eavesdropping and tampering. The emerging quantum cryptography, harnessing the random nature of quantum mechanics, may also enable uncondition...

journal_title：Scientific reports

authors： Pang XL,Qiao LF,Sun K,Liu Y,Yang AL,Jin XM

更新日期：2019-04-09 00:00:00

abstract：:Adverse events during the prenatal and early postnatal period of life are associated with development of cardiovascular disease in adulthood. Prenatal exposure to excess testosterone (T) in sheep induces adverse reproductive and metabolic programming leading to polycystic ovarian syndrome, insulin resistance and hyper...

journal_title：Scientific reports

authors： Vyas AK,Hoang V,Padmanabhan V,Gilbreath E,Mietelka KA

更新日期：2016-06-22 00:00:00

abstract：:Production of reactive nitrogen species (NO) is a key step in the immune response following infections. NO induces lesions to bacterial DNA, thus limiting bacterial growth within hosts. Using two pathogenic bacteria, Bacillus cereus and Shigella flexneri, we show that the DNA-repair protein Mfd (Mutation-Frequency-Dec...

journal_title：Scientific reports

authors： Guillemet E,Leréec A,Tran SL,Royer C,Barbosa I,Sansonetti P,Lereclus D,Ramarao N

更新日期：2016-07-20 00:00:00

abstract：:Stryphnodendron adstringens is a medicinal plant belonging to the Leguminosae family, and it is commonly found in the southeastern savannas, endemic to the Cerrado biome. The goal of this study was to assemble and annotate the chloroplast genome of S. adstringens and to compare it with previously known genomes of the ...

journal_title：Scientific reports

authors： Souza UJB,Nunes R,Targueta CP,Diniz-Filho JAF,Telles MPC

更新日期：2019-10-02 00:00:00

abstract：:Myosin phosphatase (MP) holoenzyme is a protein phosphatase-1 (PP1) type Ser/Thr specific enzyme that consists of a PP1 catalytic (PP1c) and a myosin phosphatase target subunit-1 (MYPT1). MYPT1 is an ubiquitously expressed isoform and it targets PP1c to its substrates. We identified the protein arginine methyltransfer...

journal_title：Scientific reports

authors： Sipos A,Iván J,Bécsi B,Darula Z,Tamás I,Horváth D,Medzihradszky KF,Erdődi F,Lontay B

更新日期：2017-01-11 00:00:00

abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...

journal_title：Scientific reports

authors： Yuan X,Gao K,Yuan F,Wang P,Zhang Y

更新日期：2015-06-10 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Li R,Tun HM,Jahan M,Zhang Z,Kumar A,Dilantha Fernando WG,Farenhorst A,Khafipour E

更新日期：2018-11-22 00:00:00

abstract：:Increased p66Shc expression has been associated with diabetic nephropathy (DN). However, whether p66Shc can serve as a potential biomarker for tubular oxidative injury in DN is unknown. We measured the expression of p66Shc in peripheral blood monocytes (PBMs) and renal biopsy tissues from DN patients and then analysed...

journal_title：Scientific reports

authors： Xu X,Zhu X,Ma M,Han Y,Hu C,Yuan S,Yang Y,Xiao L,Liu F,Kanwar YS,Sun L

更新日期：2016-07-05 00:00:00

abstract：:During pregnancy several maternal adaptations occur in order to support the growing fetus which are further exacerbated by gestational diabetes mellitus (GDM). Previously we developed a mouse model of GDM, however we did not evaluate alterations to energy and fat metabolism. We have also shown that alterations in lipi...

journal_title：Scientific reports

authors： Pennington KA,Dong Y,Ruano SH,van der Walt N,Sangi-Haghpeykar H,Yallampalli C

更新日期：2020-11-30 00:00:00

abstract：:We have investigated the use of fluorescent molecular rotors as probes for detection of p53 binding to DNA. These are a class of fluorophores that undergo twisted intramolecular charge transfer (TICT). They are non-fluorescent in a freely rotating conformation and experience a fluorescence increase when restricted in ...

journal_title：Scientific reports

authors： Goh WL,Lee MY,Lim TX,Chua JS,Brenner S,Ghadessy FJ,Teo YN

更新日期：2018-08-28 00:00:00

abstract：:The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient genome-editing, we optimized a workflow for the CRISPR/Cas9 system in th...

journal_title：Scientific reports

authors： Jacobs EZ,Warrier S,Volders PJ,D'haene E,Van Lombergen E,Vantomme L,Van der Jeught M,Heindryckx B,Menten B,Vergult S

更新日期：2017-11-30 00:00:00

abstract：:Self-assembly of biological molecules on solid materials is central to the "bottom-up" approach to directly integrate biology with electronics. Inspired by biology, exquisite biomolecular nanoarchitectures have been formed on solid surfaces. We demonstrate that a combinatorially-selected dodecapeptide and its variants...

journal_title：Scientific reports

authors： Hayamizu Y,So CR,Dag S,Page TS,Starkebaum D,Sarikaya M

更新日期：2016-09-22 00:00:00

abstract：:Ti-24Nb-4Zr-8Sn (Ti2448), a new β-type Ti alloy, consists of nontoxic elements and exhibits a low uniaxial tensile elastic modulus of approximately 45 GPa for biomedical implant applications. Nevertheless, the bio-corrosion resistance and biocompatibility of Ti2448 alloys must be improved for long-term clinical use. I...

journal_title：Scientific reports

authors： Liu CF,Lee TH,Liu JF,Hou WT,Li SJ,Hao YL,Pan H,Huang HH

更新日期：2018-04-26 00:00:00

abstract：:Two-photon (2P) microscopy is a powerful tool for imaging and exploring label-free biological tissues at high resolution. Although this type of microscopy has been demonstrated in ex vivo ocular tissues of both humans and animal models, imaging the human eye in vivo has always been challenging. This work presents a no...

journal_title：Scientific reports

authors： Ávila FJ,Gambín A,Artal P,Bueno JM

更新日期：2019-07-12 00:00:00

abstract：:Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat c...

journal_title：Scientific reports

authors： Zhang Y,Yang C,Wang W,Liu J,Liu Q,Huang F,Chu L,Gao H,Li C,Kong D,Liu Q,Liu J

更新日期：2016-02-15 00:00:00

abstract：:Magnetic materials have found wide application ranging from electronics and memories to medicine. Essential to these advances is the control of the magnetic order. To date, most room-temperature applications have a fixed magnetic moment whose orientation is manipulated for functionality. Here we demonstrate an iron-ox...

journal_title：Scientific reports

authors： Lin AL,Rodrigues JN,Su C,Milletari M,Loh KP,Wu T,Chen W,Neto AH,Adam S,Wee AT

更新日期：2015-06-23 00:00:00

abstract：:Clinical data have been equivocal and controversial as to the benefits to the brain and cognition of hormone therapy (HT) in postmenopausal women. Recent reevaluation of the role of estrogens proposed that HT may effectively prevent the deleterious effects of aging on cognition, and reduces the risks of dementia, incl...

journal_title：Scientific reports

authors： Girard R,Météreau E,Thomas J,Pugeat M,Qu C,Dreher JC

更新日期：2017-03-21 00:00:00

abstract：:Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specific modification of p...

journal_title：Scientific reports

authors： Sur S,Qiao Y,Fries A,O'Meally RN,Cole RN,Kinzler KW,Vogelstein B,Zhou S

更新日期：2015-12-17 00:00:00

abstract：:For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NL...

journal_title：Scientific reports

authors： Liu C,Li L,Lu WS,Du H,Yan LN,Yang JY,Wen TF,Zeng GJ,Jiang L,Yang J

更新日期：2017-10-24 00:00:00

abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...

journal_title：Scientific reports

authors： Hatakeyama H,Nakamura Y,Konaka T,Nishida S,Kriangwanich W,Uematsu K,Tsuchida S

更新日期：2020-05-22 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease. This disease is characterized by an excessive accumulation of extracellular matrix deposition that modify normal lung physiology. Up to date, there are not efficient therapeutic tools to fight IPF. Glucagon-like peptide-1 receptor (...

journal_title：Scientific reports

authors： Fandiño J,Toba L,González-Matías LC,Diz-Chaves Y,Mallo F

更新日期：2020-10-22 00:00:00

abstract：:Sugarcane (Saccharum spp.) is a globally important crop for sugar and bioenergy production. Its highly polyploid, complex genome has hindered progress in understanding its molecular structure. Flow cytometric sorting and analysis has been used in other important crops with large genomes to dissect the genome into comp...

journal_title：Scientific reports

authors： Metcalfe CJ,Li J,Giorgi D,Doležel J,Piperidis N,Aitken KS

更新日期：2019-12-18 00:00:00

abstract：:Cell motility requires the precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation. LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellular leading edge of motile cells and suppresses FAK. We sought to understand how LKB1 coordinates these...

journal_title：Scientific reports

authors： Wilkinson S,Hou Y,Zoine JT,Saltz J,Zhang C,Chen Z,Cooper LA,Marcus AI

更新日期：2017-01-19 00:00:00

abstract：:In recent years, macrophages have been shown to be tremendously plastic in both in vitro and in vivo settings; however, it remains unclear whether macrophages retain any persistent memory of past polarization states which may then impact their future repolarization to new states. Here, we perform deep transcriptomic p...

journal_title：Scientific reports

authors： Liu SX,Gustafson HH,Jackson DL,Pun SH,Trapnell C

更新日期：2020-07-23 00:00:00

abstract：:Mal11 catalyzes proton-coupled maltose transport across the plasma membrane of Saccharomyces cerevisiae. We used structure-based design of mutants and a kinetic analysis of maltose transport to determine the energy coupling mechanism of transport. We find that wildtype Mal11 is extremely well coupled and allows yeast ...

journal_title：Scientific reports

authors： Henderson R,Poolman B

更新日期：2017-10-30 00:00:00

abstract：:Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...

journal_title：Scientific reports

authors： Otto L,Budde K,Kastenmüller G,Kaul A,Völker U,Völzke H,Adamski J,Kühn JP,Krumsiek J,Artati A,Nauck M,Friedrich N,Pietzner M

更新日期：2020-01-30 00:00:00

abstract：:Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability (W-CIN) we down-regulated the spindle assembly checkpoint component BUB1 and the mitotic cohesin SMC1A, and...

journal_title：Scientific reports

authors： Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna C

更新日期：2016-10-12 00:00:00

abstract：:Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-determined states chan...

journal_title：Scientific reports

authors： Mondal S,Johnston JM,Wang H,Khelashvili G,Filizola M,Weinstein H

更新日期：2013-10-09 00:00:00