Abstract:
:We investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 females). Blood glucose, HbA1c, lipid profile and Nrf2 levels were determined along with circulatory cytokines in study subjects. The data were adjusted with confounding factors such as age and sex using multiple logistic regression analysis. We found that Th1/Th2 and oxidative stress markers were significantly elevated, whereas Nrf2 and its downstream targets were decreased in peripheral blood mononuclear cells (PBMCs) of DM subjects when compared with control. The circulatory levels of Nrf2 showed a positive correlation with Th2 cytokines and negative correlation to Th1 cytokines. Further, the impaired insulin secretion in pancreatic β-cells observed due to cytokine stress has been restored by activation of Nrf2 as assessed by glucose-stimulated insulin secretion (GSIS). This study identifies Nrf2 plays a central role in skewing Th1 and Th2 dominance in the progression of diabetes.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sireesh D,Dhamodharan U,Ezhilarasi K,Vijay V,Ramkumar KMdoi
10.1038/s41598-018-22913-6subject
Has Abstractpub_date
2018-03-23 00:00:00pages
5126issue
1issn
2045-2322pii
10.1038/s41598-018-22913-6journal_volume
8pub_type
临床试验,杂志文章abstract::We propose a method for dual-channel near-field manipulations by designing isotropic but inhomogeneous metasurfaces. As example, we present a dual-channel near-field focusing metasurface device. When the device is driven by surface waves from different channels on the metasurface, the near fields will be focused at th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15853
更新日期:2015-11-03 00:00:00
abstract::Sixty norovirus outbreaks that occurred in Pudong District, Shanghai in 2017 and affected 959 people were summarised. Of the outbreaks, 29 (48.3%), 27 (45.0%), and 4 (6.7%) occurred in kindergartens, primary schools, and middle schools, respectively. Although the total number of outbreaks peaked in March (13/60, 21.7%...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33724-0
更新日期:2018-10-15 00:00:00
abstract::Potato (Solanum tuberosum) is an important staple crop worldwide, it has been cultivated in the Andean Altiplano under low-input farming practices at high altitudes and under harsh environment for centuries. We analyzed secondary metabolite (SM) gene diversity encoded in the potato rhizosphere microbiome during plant ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02314-x
更新日期:2017-05-24 00:00:00
abstract::Bast fibres are long extraxylary cells which mechanically support the phloem and they are divided into xylan- and gelatinous-type, depending on the composition of their secondary cell walls. The former, typical of jute/kenaf bast fibres, are characterized by the presence of xylan and a high degree of lignification, wh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05200-8
更新日期:2017-07-10 00:00:00
abstract::The G protein-coupled receptor opsin is a phospholipid scramblase that facilitates rapid transbilayer phospholipid exchange in liposomes. The mechanism by which opsin scrambles lipids is unknown. It has been proposed that lipid translocation may occur at protein-protein interfaces of opsin dimers. To test this possibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16842-z
更新日期:2017-12-01 00:00:00
abstract::Common genetic risk variants for colorectal cancer (CRC) have been identified at approximately 40 loci by genome-wide association studies (GWAS). We investigated the association of these risk variants by age at onset of CRC using case-only and case-control analysis. A total of 1,962 CRC cases and 2,668 controls from t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40644
更新日期:2017-01-13 00:00:00
abstract::The growing interest in engineered tumor models prompted us to devise a method for the non-invasive assessment of such models. Here, we report on bioluminescence imaging (BLI) for the assessment of engineered tumor models in the fertilized chicken egg, i.e, chick chorioallantoic membrane (CAM) assay. One prostate canc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04572-1
更新日期:2017-07-10 00:00:00
abstract::Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68247-0
更新日期:2020-07-09 00:00:00
abstract::Because of the unique selection rule, hyper-Raman scattering (HRS) can provide spectral information that linear Raman and infrared spectroscopy cannot obtain. However, the weak signal is the key bottleneck that restricts the application of HRS technique in study of the molecular structure, surface or interface behavio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30331-x
更新日期:2018-08-08 00:00:00
abstract::Bee-pollinated plants face a dilemma in that bees both passively transport pollen grains among conspecific flowers and actively collect pollen to feed their larvae. Therefore, mechanisms that reduce pollen collection by bees have evolved in melittophilous plants. Malvaceae pollen is uncollectable for corbiculate bees ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41262-6
更新日期:2019-03-18 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-59906-3
更新日期:2020-02-13 00:00:00
abstract::Accurate detection of accelerometer non-wear time is crucial for calculating physical activity summary statistics. In this study, we evaluated three epoch-based non-wear algorithms (Hecht, Troiano, and Choi) and one raw-based algorithm (Hees). In addition, we performed a sensitivity analysis to provide insight into th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62821-2
更新日期:2020-04-03 00:00:00
abstract::Nearly half of the world's population obtains its daily calories from rice grains, which lack or have insufficient levels of essential micronutrients. The deficiency of micronutrients vital for normal growth is a global health problem, and iron, zinc and vitamin A deficiencies are the most prevalent ones. We developed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07198-5
更新日期:2017-07-31 00:00:00
abstract::Controlled quantum teleportation involves a third party as a controller for the teleportation of state. Here, we present the novel protocols for controlling teleportation of the arbitrary two-qubit and three-qubit states through five-qubit and seven-qubit cluster states respectively. In these schemes, Alice sends the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70446-8
更新日期:2020-08-12 00:00:00
abstract::Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05384-z
更新日期:2017-07-11 00:00:00
abstract::Triboelectric charging is common in desert sandstorms and dust devils on Earth; however, it remains poorly understood. Here we show a charging mechanism of sands with the adsorbed water on micro-porous surface in wind-blown sand based on the fact that water content is universal but usually a minor component in most pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01337
更新日期:2013-01-01 00:00:00
abstract::The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcript...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26170-5
更新日期:2018-05-21 00:00:00
abstract::Injury to the external branch of the superior laryngeal nerve (eSLN) can cause a hoarse or weak voice with dysergia of the cricothyroid. The present study provided the topographic information of the eSLN in the Asian and verified anatomical validity of the landmarks previously recruited to localize the eSLN. Thirty sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15070-9
更新日期:2017-11-02 00:00:00
abstract::Hand, foot, and mouth disease (HFMD), predominantly occurs among infants and children. Previous studies have shown that suitable, stable temperatures favor HFMD virus reproduction; however, temperature fluctuations also affect virus transmission, and there are, so far, no studies concerning the association between suc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59265-z
更新日期:2020-02-13 00:00:00
abstract::Nitric oxide (NO) produced by endothelial cells in response to cytokines displays anti-inflammatory activity by preventing the adherence, migration and activation of neutrophils. The molecular mechanism by which NO operates at the blood-endothelium interface to exert anti-inflammatory properties is largely unknown. He...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16342-0
更新日期:2017-11-23 00:00:00
abstract::The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca. We investigated developmental Gbx-expression in representatives of both molluscan sis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05605-5
更新日期:2017-07-14 00:00:00
abstract::This study aimed to explore the effects of radiochemotherapy on the neurocognitive function of patients with high-grade gliomas (HGG). The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), event-related potential P300 (ERP-P300), and specific MRI parameters were compared, and the associations...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42321-8
更新日期:2019-04-12 00:00:00
abstract::In this report, we investigate the stabilization of saddle fixed points in coupled oscillators where individual oscillators exhibit the saddle fixed points. The coupled oscillators may have two structurally different types of suppressed states, namely amplitude death and oscillation death. The stabilization of saddle ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45909
更新日期:2017-04-05 00:00:00
abstract::Fire ants are widely studied, invasive and venomous arthropod pests. There is significant biomedical interest in immunotherapy against fire ant stings. However, mainly due to practical reasons, the physiological effects of envenomation has remained poorly characterized. The present study takes advantage of a recently-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32327-z
更新日期:2018-09-26 00:00:00
abstract::Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D+CD4+ T cells contribute to the decreased Treg cells remains unclear. In the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01379-y
更新日期:2017-04-28 00:00:00
abstract::Cutaneous allodynia (CA) is a pain in response to non-nociceptive stimulation and a marker of central sensitisation. Probable migraine (PM) is a migraine subtype that fulfils all but one criterion of migraine. Headache intensity and the disability of individuals with PM are similar or lower than individuals with migra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82080-z
更新日期:2021-01-28 00:00:00
abstract::A retrospective immunohistochemical study was designed to investigate the frequency of concomitant traditional infectious disease pathogens in puppies that died suddenly and review the aspects of associated pathogenesis. Fifteen puppies were evaluated; the pathology reports and histopathologic slides of these animals ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31540-0
更新日期:2018-09-07 00:00:00
abstract::Determining the success of eradication of an invasive species requires a way to decide when its risk of reoccurrence has become acceptably low. In Japan, the area populated by the Argentine ant, Linepithema humile (Mayr), is expanding, and eradication via chemical treatment is ongoing at various locations. One such pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03516-z
更新日期:2017-06-13 00:00:00
abstract::Micropyles in insects are small openings that allow sperm entry into, and the number was usually decreased on unfertilized and (or) undeveloped eggs. However, reports showed that Harmonia axyridis, a reproductive success model, deposited similar number of micropyles on undeveloped and developing eggs. Thus, it was con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49249-z
更新日期:2019-09-04 00:00:00
abstract::Networks are mathematical structures that are universally used to describe a large variety of complex systems such as the brain or the Internet. Characterizing the geometrical properties of these networks has become increasingly relevant for routing problems, inference and data mining. In real growing networks, topolo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10073
更新日期:2015-05-18 00:00:00