Abstract:
:Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown. The GluN2C-containing NMDARs exhibit unique biophysical properties and expression pattern, and lower expression of GluN2C subunit has been reported in postmortem brains from schizophrenia patients. We found that loss of GluN2C subunit leads to a shift in cortical excitatory-inhibitory balance towards greater inhibition. Specifically, pyramidal neurons in the medial prefrontal cortex (mPFC) of GluN2C knockout mice have reduced mEPSC frequency and dendritic spine density and a contrasting higher frequency of mIPSCs. In addition a greater number of perisomatic GAD67 puncta was observed suggesting a potential increase in parvalbumin interneuron inputs. At a network level the GluN2C knockout mice were found to have a more robust increase in power of oscillations in response to NMDAR blocker MK-801. Furthermore, GluN2C heterozygous and knockout mice exhibited abnormalities in cognition and sensorimotor gating. Our results demonstrate that loss of GluN2C subunit leads to cortical excitatory-inhibitory imbalance and abnormal neuronal oscillations associated with neurodevelopmental disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gupta SC,Ravikrishnan A,Liu J,Mao Z,Pavuluri R,Hillman BG,Gandhi PJ,Stairs DJ,Li M,Ugale RR,Monaghan DT,Dravid SMdoi
10.1038/srep38321subject
Has Abstractpub_date
2016-12-06 00:00:00pages
38321issn
2045-2322pii
srep38321journal_volume
6pub_type
杂志文章abstract::The systematics of Oriental freshwater mussels (Bivalvia: Unionidae) is poorly known. Here, we present an integrative revision of the genus Trapezoideus Simpson, 1900 to further understanding of freshwater mussel diversity in the region. We demonstrate that Trapezoideus as currently circumscribed is non-monophyletic, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39365-1
更新日期:2019-03-11 00:00:00
abstract::During our research, we explored a novel way to represent subwavelength imaging and derived a transmission equation to explicate the FP (Fabry-Pérot) resonance phenomena. Subsequently, using analysis and observation, we performed deep-subwavelength imaging. Both numerically and experimentally, imaging with super-resol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67409-4
更新日期:2020-07-01 00:00:00
abstract::The Saccharomyces cerevisiae kinesin-5 Cin8 performs essential mitotic functions in spindle assembly and anaphase B spindle elongation. Recent work has shown that Cin8 is a bi-directional motor which moves towards the minus-end of microtubules (MTs) under high ionic strength (IS) conditions and changes directionality ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25597
更新日期:2016-05-24 00:00:00
abstract::Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota N...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19754-8
更新日期:2018-01-19 00:00:00
abstract::Ancient human remains of paleopathological interest typically contain highly degraded DNA in which pathogenic taxa are often minority components, making sequence-based metagenomic characterization costly. Microarrays may hold a potential solution to these challenges, offering a rapid, affordable, and highly informativ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04245
更新日期:2014-03-06 00:00:00
abstract::Mesenchymal stromal cells (MSC) are used in cell therapies, however cellular senescence increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes. The determination of cellular senescence is time consuming and logistically intensive. Here, we propose the use of endogenous autofluoresc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38546-2
更新日期:2019-02-14 00:00:00
abstract::SIRT1, the NAD+-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity are controlled. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37578
更新日期:2016-11-24 00:00:00
abstract::We report a new family with autosomal dominant inheritance of a late onset rapidly progressive leukodystrophy in which exome sequencing has revealed a novel mutation p.R782G in the Colony-Stimulating Factor 1 Receptor gene (CSF1R). Neuropathology of two affected family members showed cerebral white matter degeneration...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10042
更新日期:2015-05-15 00:00:00
abstract::Approximately 0.5-1.4% of natal males and 0.2-0.3% of natal females meet DSM-5 criteria for gender dysphoria, with many of these individuals self-describing as transgender men or women. Despite recent improvements both in social acceptance of transgender individuals as well as access to gender affirming therapy, progr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53500-y
更新日期:2019-12-27 00:00:00
abstract::H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how chronic inflammation triggers gastric carcinogenesis is still not clear. In this study, neutrophils and relative markers in gastric cancer development were examined with immunohistochemistry and fluo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29762
更新日期:2016-07-14 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors with low survival rates and the leading cause of death in neurofibromatosis type 1 (NF1) patients under 40 years old. Surgical resection is the standard of care for MPNSTs, but is often incomplete and can generate loss of function, necessitating t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37035
更新日期:2016-11-11 00:00:00
abstract::Geochemical discrimination has recently been recognised as a potentially useful proxy for identifying tsunami deposits in addition to classical proxies such as sedimentological and micropalaeontological evidence. However, difficulties remain because it is unclear which elements best discriminate between tsunami and no...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07077
更新日期:2014-11-17 00:00:00
abstract::We aimed to analyze the associations of bone mineral density (BMD) of femoral heads, age and gender, and compare the differences in BMD between fracture side and non-fracture side by "3D Spine Exam Analysis" module in QCT Pro software. In this study, we identified patients who had undergone quantitative computed tomog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70144-5
更新日期:2020-08-03 00:00:00
abstract::The high metabolic activity associated with endurance flights and intense fuelling of migrant birds may produce large quantities of reactive oxygen species, which cause oxidative damage. Yet it remains unknown how long-lived birds prepare for oxidative challenges prior to extreme flights. We combined blood measurement...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54057-6
更新日期:2019-11-26 00:00:00
abstract::Hybrid cells of Nicotiana suaveolens x N. tabacum grow normally at 36 °C, but immediately express lethality due to probable autoimmune response when transferred from 36 to 28 °C. Our recent study showed that the temperature-sensitive lethality of these hybrid cells occurs through autolytic programmed cell death (PCD)....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46619-5
更新日期:2019-07-15 00:00:00
abstract::Spatially-resolved neutron powder diffraction with a gauge volume of 2 × 2 × 20 mm(3) has been applied as an in situ method to probe the lithium concentration in the graphite anode of different Li-ion cells of 18650-type in charged state. Structural studies performed in combination with electrochemical measurements an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18380
更新日期:2015-12-18 00:00:00
abstract::Histamine is an important neurotransmitter that contributes to various processes, including the sleep-wake cycle, learning, memory, and stress responses. Its actions are mediated through histamine H1-H4 receptors. Gene knockout and pharmacological studies have revealed the importance of H1 receptors in learning and me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52623-6
更新日期:2019-11-11 00:00:00
abstract::Information concerning the pathogenic role of honey bee viruses in invasive species are still scarce. The aim of this investigation was to assess the presence of several honey bee viruses, such as Black Queen Cell Virus (BQCV), Kashmir Bee Virus (KBV), Slow Paralysis Virus (SPV), Sac Brood Virus (SBV), Israeli Acute P...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46565-2
更新日期:2019-07-12 00:00:00
abstract::Hatching out from the zona pellucida (ZP) is a crucial step for blastocyst implantation and development. However, it is still unknown whether the location of the hatching site relative to the inner cell mass (ICM) affects embryo implantation and foetal development. Here, we classified hatching blastocysts into three c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59424-2
更新日期:2020-02-12 00:00:00
abstract::Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52295-2
更新日期:2019-10-31 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-23329-y
更新日期:2018-03-19 00:00:00
abstract::Pain is a highly unpleasant sensory and emotional experience, and no objective diagnosis test exists to assess it. In clinical practice there are two main methods for the estimation of pain, a patient's self-report and clinical judgement. However, these methods are highly subjective and the need of biomarkers to measu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42098-w
更新日期:2019-04-04 00:00:00
abstract::Analysis of the developing proteome has been complicated by a lack of tools that can be easily employed to label and identify newly synthesized proteins within complex biological mixtures. Here, we demonstrate that the methionine analogs azidohomoalanine and homopropargylglycine can be globally incorporated into the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32377
更新日期:2016-08-30 00:00:00
abstract::The Serra Gaúcha region is the most important temperate fruit-producing area in southern Brazil. Despite mealybugs (Hemiptera: Pseudococcidae) infesting several host plants in the region, there is a lack of information about the composition of species damaging different crops. A survey of mealybug species associated w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15983-5
更新日期:2017-11-16 00:00:00
abstract::Theoretical and experimental work has demonstrated that excitatory (E) and inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron to network levels, has a fundamental role in proper brain function and its impairment has been linked to numerous brai...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68165-1
更新日期:2020-07-09 00:00:00
abstract::FAS rs2234767 (-1377 G>A), rs1800682 (-670 A>G) and FASLG rs763110 (-844 C>T) promoter polymorphisms can influence transcriptional activities of the genes and thus multiple tumors susceptibility. To investigate their association with risk of colorectal cancer (CRC), the three SNPs were genotyped in 878 cases and 884 c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19229
更新日期:2016-01-13 00:00:00
abstract::Understanding the factors that enable mutualisms to evolve and to subsequently remain stable over time, is essential to fully understand patterns of global biodiversity and for evidence based conservation policy. Theoretically, spatial heterogeneity of mutualists, through increased likelihood of fidelity between coope...
journal_title:Scientific reports
pub_type: 杂志文章,评审
doi:10.1038/srep14826
更新日期:2015-10-05 00:00:00
abstract::Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11304-y
更新日期:2017-09-14 00:00:00
abstract::Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G1 monoclonal antibody lost more than half of its ADCC activity after heat stress at 40 °C for 4 months. Size-exclusion and ion-exchange chromatography were used t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57184-2
更新日期:2020-01-15 00:00:00
abstract::Lattice dynamics and elasticity for the high-temperature ε phase (body-centered cubic; bcc) of plutonium is predicted utilizing first-principles electronic structure coupled with a self-consistent phonon method that takes phonon-phonon interaction and strong anharmonicity into account. These predictions establish the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01034-6
更新日期:2017-04-25 00:00:00