Abstract：
:Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophysiological experiments. First, osthole clearly remitted the scratching behaviors of mice induced with histamine, HTMT, and VUF8430. Second, in cultured dorsal root ganglion (DRG) neurons, osthole showed a dose-dependent inhibitory effect to histamine. On the same neurons, osthole also decreased the response to capsaicin and histamine. In further tests, the capsaicin-induced inward currents were inhibited by osthole. These results revealed that osthole inhibited histamine-dependent itch by modulating TRPV1 activity. This study will be helpful in understanding how osthole exerts anti-pruritus effects and suggests that osthole may be a useful treatment medicine for histamine-dependent itch.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yang NN,Shi H,Yu G,Wang CM,Zhu C,Yang Y,Yuan XL,Tang M,Wang ZL,Gegen T,He Q,Tang K,Lan L,Wu GY,Tang ZXdoi
10.1038/srep25657subject
Has Abstractpub_date
2016-05-10 00:00:00pages
25657issn
2045-2322pii
srep25657journal_volume
6pub_type
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