Gastric cancer depends on aldehyde dehydrogenase 3A1 for fatty acid oxidation.

abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...

journal_title：Scientific reports

authors： Takahashi M,Okimura Y,Iguchi G,Nishizawa H,Yamamoto M,Suda K,Kitazawa R,Fujimoto W,Takahashi K,Zolotaryov FN,Hong KS,Kiyonari H,Abe T,Kaji H,Kitazawa S,Kasuga M,Chihara K,Takahashi Y

更新日期：2011-01-01 00:00:00

abstract：:Bony defects are a common problem in musculoskeletal surgery. Replacement with autologous bone grafts is limited by availability of transplant material. Sterilized cancellous bone, while being osteoconductive, has limited osteoinductivity. Nanofiber scaffolds are currently used for several purposes due to their capabi...

journal_title：Scientific reports

authors： Schüttler KF,Bauhofer MW,Ketter V,Giese K,Eschbach DA,Yenigün M,Fuchs-Winkelmann S,Paletta JRJ

更新日期：2020-06-12 00:00:00

abstract：:Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...

journal_title：Scientific reports

authors： Gharooi Ahangar O,Javanrouh N,Daneshpour MS,Barzin M,Valizadeh M,Azizi F,Hosseinpanah F

更新日期：2020-08-12 00:00:00

abstract：:Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzyme...

journal_title：Scientific reports

authors： Dhinaut J,Balourdet A,Teixeira M,Chogne M,Moret Y

更新日期：2017-09-29 00:00:00

abstract：:Carbon quantum dots (C-QDs) are becoming a desirable alternative to metal-based QDs and dye probes owing to their high biocompatibility, low toxicity, ease of preparation, and unique photophysical properties. Herein, we describe fluorescence bioimaging of zebrafish using C-QDs as probe in terms of the preparation of C...

journal_title：Scientific reports

authors： Kang YF,Li YH,Fang YW,Xu Y,Wei XM,Yin XB

更新日期：2015-07-02 00:00:00

abstract：:ZnO, aside from TiO2, has been considered as a promising material for purification and disinfection of water and air, and remediation of hazardous waste, owing to its high activity, environment-friendly feature and lower cost. However, their poor visible light utilization greatly limited their practical applications. ...

journal_title：Scientific reports

authors： Zhang X,Qin J,Xue Y,Yu P,Zhang B,Wang L,Liu R

更新日期：2014-04-04 00:00:00

abstract：:In adipose tissue, agonists of the β3-adrenergic receptor (ADRB3) regulate lipolysis, lipid oxidation, and thermogenesis. The deficiency in the thermogenesis induced by neuroblast differentiation-associated protein AHNAK in white adipose tissue (WAT) of mice fed a high-fat diet suggests that AHNAK may stimulate energy...

journal_title：Scientific reports

authors： Shin JH,Lee SH,Kim YN,Kim IY,Kim YJ,Kyeong DS,Lim HJ,Cho SY,Choi J,Wi YJ,Choi JH,Yoon YS,Bae YS,Seong JK

更新日期：2016-03-18 00:00:00

abstract：:Cell division during the reproductive phase of the Streptomyces life-cycle requires tight coordination between synchronous formation of multiple septa and DNA segregation. One remarkable difference with most other bacterial systems is that cell division in Streptomyces is positively controlled by the recruitment of Ft...

journal_title：Scientific reports

authors： Zhang L,Willemse J,Hoskisson PA,van Wezel GP

更新日期：2018-05-09 00:00:00

abstract：:We introduce QuEST, the Quantum Exact Simulation Toolkit, and compare it to ProjectQ, qHipster and a recent distributed implementation of Quantum++. QuEST is the first open source, hybrid multithreaded and distributed, GPU accelerated simulator of universal quantum circuits. Embodied as a C library, it is designed so ...

journal_title：Scientific reports

authors： Jones T,Brown A,Bush I,Benjamin SC

更新日期：2019-07-24 00:00:00

abstract：:Recent studies have established that single nucleotide polymorphisms are sufficient to build accurate predictive models of gene expression. Gamazon, et al., found that gene expression values predicted from cis neighborhood SNPs show statistical association with disease status. In this work, we remove the cis neighborh...

journal_title：Scientific reports

authors： Vervier K,Michaelson JJ

更新日期：2016-12-20 00:00:00

abstract：:The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited success in meeting these multiple challenges. In this study, we applied a systematic approach, using model simulation and data from two groups o...

journal_title：Scientific reports

authors： Meng Q,Wang H,Yan P,Pan J,Lu D,Cui Z,Zhang F,Chen X

更新日期：2017-02-03 00:00:00

abstract：:Soil fauna are critical for ecosystem function and sensitive to the changes of soil fertility. The effects of fertilization on soil fauna communities, however, remain poorly understood. We examined the effects of fertilization form and quantity on the abundance, diversity and composition of soil fauna across an age-se...

journal_title：Scientific reports

authors： Wang S,Chen HY,Tan Y,Fan H,Ruan H

更新日期：2016-02-09 00:00:00

abstract：:MDN1/Rea1, as an AAA-type ATPase, is predicted to be the largest protein involved in pre-ribosome maturation in most organisms. However, its function in plant growth and development is poorly understood. Here, we characterized a novel Arabidopsis mutant, dwarf &short root (dsr) 1, which shows pleiotropic developmental...

journal_title：Scientific reports

authors： Li PC,Yu SW,Li K,Huang JG,Wang XJ,Zheng CC

更新日期：2016-11-08 00:00:00

abstract：:Surface hydrophobicity of silicon with sound durability under mechanical abrasion is highly desirable for practical needs. However, the reported micro-pyramid/nanowires structures suffer from the saturation characteristics of contact angle at around 132 degree, which impede the promotions toward reaching the state of ...

journal_title：Scientific reports

authors： Hsiao M,Chen KY,Chen CY

更新日期：2019-02-07 00:00:00

abstract：:Hypertension and diabetes mellitus (DM) have become major public health issues, and previous studies have shown that there is an association between hypertension and DM. However, there is a lack of detailed information about this association. This study aimed to explore how different blood pressure (BP) levels were as...

journal_title：Scientific reports

authors： Lv Y,Yao Y,Ye J,Guo X,Dou J,Shen L,Zhang A,Xue Z,Yu Y,Jin L

更新日期：2018-05-21 00:00:00

abstract：:Methylation of histone H3 lysine 4 (H3K4) is catalyzed by the multi-component COMPASS or COMPASS-like complex, which is highly conserved from yeast to human, and plays essential roles in gene expression and transcription, cell cycle progression, and DNA repair. Here we present a cryo-EM map of the complete S. cerevisi...

journal_title：Scientific reports

authors： Wang Y,Ding Z,Liu X,Bao Y,Huang M,Wong CCL,Hong X,Cong Y

更新日期：2018-11-27 00:00:00

abstract：:In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype is still poorly unde...

journal_title：Scientific reports

authors： Shiau DJ,Kuo WT,Davuluri GVN,Shieh CC,Tsai PJ,Chen CC,Lin YS,Wu YZ,Hsiao YP,Chang CP

更新日期：2020-08-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Qiao Y,Berg AL,Wang P,Ge Y,Quan S,Zhou S,Wang H,Liu Z,Gong R

更新日期：2020-09-21 00:00:00

abstract：:High-altitude retinopathy is initiated by hypobaric hypoxia and characterized by retinal functional changes, but the precise cellular and molecular mechanisms that mediate this dysfunction remain unclear. The aim of our investigation is to determine the protective efficacy of hesperidin (HSD) on the hypobaric hypoxia-...

journal_title：Scientific reports

authors： Xin X,Li Y,Liu H

更新日期：2020-11-10 00:00:00

abstract：:Antimicrobial peptides (AMPs) are an important part of the human innate immune system for protection against bacterial infections, however the AMPs display varying degrees of activity against Staphylococcus aureus. Previously, we showed that inactivation of the ATP synthase sensitizes S. aureus towards the AMP antibio...

journal_title：Scientific reports

authors： Liu L,Beck C,Nøhr-Meldgaard K,Peschel A,Kretschmer D,Ingmer H,Vestergaard M

更新日期：2020-07-09 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Chiba S,Wakabayashi T,Tachi Y,Takaki N,Terashima A,Okumura S,Yoshida T

更新日期：2017-12-05 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an EBV-associated epithelial malignancy prevalent in southern China. Presence of treatment-resistant cancer stem cells (CSC) may associate with tumor relapse and metastasis in NPC. ICG-001 is a specific CBP/β-catenin antagonist that can block CBP/β-catenin-mediated transcription of st...

journal_title：Scientific reports

authors： Chan KC,Chan LS,Ip JC,Lo C,Yip TT,Ngan RK,Wong RN,Lo KW,Ng WT,Lee AW,Tsao GS,Kahn M,Lung ML,Mak NK

更新日期：2015-04-21 00:00:00

abstract：:The trace addition of rare earth (RE) elements in Mg alloys can modify the extrusion texture, leading to the formation of RE texture and thus improved formability. The interrupted extrusion experiment as well as electron back-scatter diffraction (EBSD) characterization was conducted in Mg-1.5Zn-0.5Gd (wt.%) alloy to u...

journal_title：Scientific reports

authors： Jiang MG,Xu C,Yan H,Lu SH,Nakata T,Lao CS,Chen RS,Kamado S,Han EH

更新日期：2018-11-14 00:00:00

abstract：:A unique combination of useful properties in boron-carbide, such as extreme hardness, excellent fracture toughness, a low density, a high melting point, thermoelectricity, semi-conducting behavior, catalytic activity and a remarkably good chemical stability, makes it an ideal material for a wide range of technological...

journal_title：Scientific reports

authors： Mondal S,Bykova E,Dey S,Ali SI,Dubrovinskaia N,Dubrovinsky L,Parakhonskiy G,van Smaalen S

更新日期：2016-01-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

更新日期：2020-02-28 00:00:00

abstract：:Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces sensation in a different modality, provides a unique opportunity to study how multimodal information is represented in the human brain. We investigated how pitch classes (do, re, mi, etc.) are associated with the three d...

journal_title：Scientific reports

authors： Itoh K,Sakata H,Kwee IL,Nakada T

更新日期：2017-12-19 00:00:00

abstract：:Light modulates global features of the important human pathogen Acinetobacter baumannii lifestyle including metabolism, tolerance to antibiotics and virulence, most of which depend on the short BLUF-type photoreceptor BlsA. In this work, we show that the ability to circumvent iron deficiency is also modulated by light...

journal_title：Scientific reports

authors： Tuttobene MR,Cribb P,Mussi MA

更新日期：2018-05-16 00:00:00

abstract：:Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commerc...

journal_title：Scientific reports

authors： Nagai K,Horita N,Yamamoto M,Tsukahara T,Nagakura H,Tashiro K,Shibata Y,Watanabe H,Nakashima K,Ushio R,Ikeda M,Narita A,Kanai A,Sato T,Kaneko T

更新日期：2016-12-13 00:00:00

abstract：:Heteroplasmy is the existence of more than one mitochondrial DNA (mtDNA) variant within a cell. The evolutionary mechanisms of heteroplasmy are not fully understood, despite being a very common phenomenon. Here we combined heteroplasmy measurements using high throughput sequencing on green turtles (Chelonia mydas) wit...

journal_title：Scientific reports

authors： Tikochinski Y,Carreras C,Tikochinski G,Vilaça ST

更新日期：2020-01-14 00:00:00

abstract：:The mouse (Mus musculus) is an extensively used model of human disease and responses to stresses such as ionizing radiation. As part of our work developing gene expression biomarkers of radiation exposure, dose, and injury, we have found many genes are either up-regulated (e.g. CDKN1A, MDM2, BBC3, and CCNG1) or down-r...

journal_title：Scientific reports

authors： Ghandhi SA,Smilenov L,Shuryak I,Pujol-Canadell M,Amundson SA

更新日期：2019-12-19 00:00:00