Abstract:
:Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzymes and the consumption of dietary antioxidants, including carotenoids such as astaxanthin. Astaxanthin currently raises considerable interest as a powerful antioxidant and for its potential in alleviating age-related diseases. Current in vitro and short-term in vivo studies provide promising results about immune-stimulating and antioxidant properties of astaxanthin. However, to what extent dietary supplementation with astaxanthin can prevent long-term adverse effects of immunopathology on longevity is unknown so far. Here, using the mealworm beetle, Tenebrio molitor, as biological model we tested the effect of lifetime dietary supplementation with astaxanthin on longevity when exposed to early life inflammation. While supplementation with astaxanthin was found to lessen immunopathology cost on larval survival and insect longevity, it was also found to reduce immunity, growth rate and the survival of non immune-challenged larvae. This study therefore reveals that astaxanthin prevents immunopathology through an immune depressive effect and can have adverse consequences on growth.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dhinaut J,Balourdet A,Teixeira M,Chogne M,Moret Ydoi
10.1038/s41598-017-12769-7subject
Has Abstractpub_date
2017-09-29 00:00:00pages
12429issue
1issn
2045-2322pii
10.1038/s41598-017-12769-7journal_volume
7pub_type
杂志文章abstract::Natural sensory signals have nonlinear structures dynamically composed of the carrier frequencies and the variation of the amplitude (i.e., envelope). How the human brain processes the envelope information is still poorly understood, largely due to the conventional analysis failing to quantify it directly. Here, we us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53286-z
更新日期:2019-11-15 00:00:00
abstract::Often ignored and regarded as mere transcriptional noise, long noncoding RNAs (lncRNAs) are starting to be considered key regulators of gene expression across the Eukarya domain of life. In the model diatom Phaeodactylum tricornutum, we have previously reported the occurrence of 1,510 intergenic lncRNAs (lincRNAs), ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71002-0
更新日期:2020-08-24 00:00:00
abstract::Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/srep08466
更新日期:2015-02-16 00:00:00
abstract::The tibial tuberosity-trochlear groove (TT-TG) distance is a radiographic measurement that is used to quantify malalignment of the patellofemoral joint (PFJ) in cross-sectional imaging. There is an ongoing debate about the impact of the TT-TG-distance on lateral patellar instability and the initiating of cartilage deg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72299-7
更新日期:2020-09-18 00:00:00
abstract::The damping properties and specifically the bend losses of polymer optical fibres (POFs) have so far only been documented by experimental work, investigating bending parameters such as bending radius, length, and distance of the bends. Even though damping mechanisms and causes are well-known, no simple, generally vali...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68568-0
更新日期:2020-07-17 00:00:00
abstract::MicroRNAs (miRNAs) play an important role in guiding development and maintaining function of the human heart. Dysregulation of miRNAs has been linked to various congenital heart diseases including Tetralogy of Fallot (TOF), which represents the most common cyanotic heart malformation in humans. Several studies have id...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55570-4
更新日期:2019-12-13 00:00:00
abstract::One of the main azole-resistance mechanisms in Candida pathogens is the upregulation of drug efflux pumps, which compromises the efficacy of azoles and results in treatment failure. The combination of azole-antifungal agents with efflux pump inhibitors represents a promising strategy to combat fungal infection. High-t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33687
更新日期:2016-09-21 00:00:00
abstract::Engineered protein scaffolds are an alternative to monoclonal antibodies in research and drug design due to their small size, ease of production, versatility, and specificity for chosen targets. One key consideration when engineering such proteins is retaining the original scaffold structure and stability upon inserti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45565-6
更新日期:2019-06-21 00:00:00
abstract::Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep15460
更新日期:2015-10-21 00:00:00
abstract::Dumbbell probe (DP) attracts increasing interests in rolling circle amplification (RCA). A universal DP production method through cleavage-ligation of hairpin was proposed and optimized. The production is characterized by restriction endonuclease (RE)-induced cleavage ends ligation. It has the advantage of phosphoryla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29229
更新日期:2016-07-07 00:00:00
abstract::Although nearly one fifth of all human cancers have an infectious aetiology, the causes for the majority of cancers remain unexplained. Despite the enormous data output from high-throughput shotgun sequencing, viral DNA in a clinical sample typically constitutes a proportion of host DNA that is too small to be detecte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13201
更新日期:2015-08-19 00:00:00
abstract::A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00648
更新日期:2012-01-01 00:00:00
abstract::The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02408
更新日期:2013-01-01 00:00:00
abstract::The incidence and mortality of primary liver cancer are very high and resection of tumor is the most crucial treatment for it. We aimed to assess the efficacy and safety of combined use of transversus abdominis plane (TAP) block and laryngeal mask airway (LMA) during implementing Enhanced Recovery After Surgery (ERAS)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71477-x
更新日期:2020-09-10 00:00:00
abstract::The aim of this study was to investigate rheumatoid arthritis (RA), and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study investigated patients with a recorded diagnosis of RA (N = 6114), an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05110
更新日期:2014-06-05 00:00:00
abstract::Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32411
更新日期:2016-08-30 00:00:00
abstract::This corrects the article DOI: 10.1038/srep41699. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46942
更新日期:2018-02-12 00:00:00
abstract::To appraise the content and pollution level of cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni) and lead (Pb) in bus stop dusts, representative samples (n = 53) were collected from the city of Qingyang in Gansu province, NW China. The Cd, As, Hg, Ni, and Pb contents and physicochemical properties (particle size, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30452-3
更新日期:2018-08-22 00:00:00
abstract::We performed a systematic investigation on the dynamic behavior of conduction filaments (CFs) in WO₃-x-based devices. It was found that the electric forming produced an electric structure consisted of a conductive channel (virtual cathode) started from cathode and an insulating band surrounding anode. Both the virtual...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04058
更新日期:2014-02-11 00:00:00
abstract::During inflammatory response, blood leukocytes adhere to the endothelium. This process involves numerous adhesion molecules, including a transmembrane chemokine, CX3CL1, which behaves as a molecular cluster. How this cluster assembles and whether this association has a functional role remain unknown. The analysis of C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65988-w
更新日期:2020-06-03 00:00:00
abstract::Qinghai Lake is a major migrating bird breeding site that has experienced several recent highly pathogenic avian influenza virus (HPAIV) epizootics. From 2006 to 2009 we studied Qinghai's wild birds and pikas for evidence of AIV infections. We sampled 941 healthy wild animals and isolated seventeen H7N2 viruses (eight...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30974
更新日期:2016-08-24 00:00:00
abstract::Chronic hepatitis B infection remains a serious public health issue worldwide. Hepatitis B virus (HBV) reactivation is commonly reported in patients receiving anticancer therapy, immunosuppressive therapy, or organ and tissue transplantation. However, the precise mechanisms underlying chemotherapeutic agent-related HB...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21847-3
更新日期:2018-02-22 00:00:00
abstract::Several cobalt-based Heusler alloys have been predicted to exhibit Weyl Semimetal behavior due to time reversal symmetry breaking. Co2TiGe is one of the predicted ferromagnetic Weyl semimetals. In this work, we report weak localization and small anomalous Hall conductivity in half-metallic Co2TiGe thin films grown by ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39037-0
更新日期:2019-03-04 00:00:00
abstract::The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 200...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08498-6
更新日期:2017-08-15 00:00:00
abstract::Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73264-0
更新日期:2020-10-01 00:00:00
abstract::Oysters are unusual among bivalves in that they possess chambers, often filled with soft, chalky calcite, that are irregularly scattered throughout the shell. Because the function of these so-called chalky deposits is still unclear, evaluating the growth and distribution of chalk is important for elucidating the ecolo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68726-4
更新日期:2020-07-21 00:00:00
abstract::The development of well-organized structures with high luminescent properties in the solid and aggregated states is of both scientific and technological interest due to their applications in nanotechnology. In this paper we described the synthesis of amphiphilic and dumbbell shaped AIE-active tetraphenylethylene (TPE)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42898
更新日期:2017-02-23 00:00:00
abstract::Cd3As2 has long been known as a high-mobility semiconductor. The recent finding of a topological semimetal state in this compound has demanded growth of epitaxial films with high crystallinity and controlled thickness. Here we report the structural characterisation of Cd3As2 films grown on SrTiO3 substrates by solid-p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20758-7
更新日期:2018-02-02 00:00:00
abstract::Individuals who are well integrated into society have greater access to resources and tend to live longer. Why some individuals are socially isolated and others are not is therefore puzzling from an evolutionary perspective. Answering this question requires establishing the mix of intrinsic and contextual factors that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18104-4
更新日期:2017-12-19 00:00:00
abstract::Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22926-1
更新日期:2018-03-20 00:00:00