Kinase inhibitor screening using artificial neural networks and engineered cardiac biowires.

abstract：:Food and beverage consumption has a great impact on the environment, although there is a lack of information concerning the whole diet. The environmental impact of 153 Italian adults (51 omnivores, 51 ovo-lacto-vegetarians, 51 vegans) and the inter-individual variability within dietary groups were assessed in a real-l...

journal_title：Scientific reports

authors： Rosi A,Mena P,Pellegrini N,Turroni S,Neviani E,Ferrocino I,Di Cagno R,Ruini L,Ciati R,Angelino D,Maddock J,Gobbetti M,Brighenti F,Del Rio D,Scazzina F

更新日期：2017-07-21 00:00:00

abstract：:Dielectric Discharge Barrier (DBD) plasma actuators are considered as one of the best active electro-hydrodynamic control devices, and are considered by many contemporary researchers. Here a simple electrostatic model, which is improved by authors, and uses the Maxwell's and the Navier-Stokes equations, is proposed fo...

journal_title：Scientific reports

authors： Omidi J,Mazaheri K

更新日期：2020-11-02 00:00:00

abstract：:Recent studies have shown that ionic direct current (iDC) can modulate the vestibular system in-vivo, with potential benefits over conventional pulsed stimulation. In this study, the effects of iDC stimulation on vestibular nerve fiber firing rate was investigated using loose-patch nerve fiber recordings in the acutel...

journal_title：Scientific reports

authors： Manca M,Glowatzki E,Roberts DC,Fridman GY,Aplin FP

更新日期：2019-12-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Blanco Alvarez S,Brisbois J,Melinte S,Kramer RBG,Silhanek AV

更新日期：2020-02-27 00:00:00

abstract：:The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2'-pyrrolo[2,1-a]isoquinolines] in good yields and with high diastereoselectivity. The similar reaction of N-cyanomethylisoquinolinium c...

journal_title：Scientific reports

authors： Sun J,Shen GL,Huang Y,Yan CG

更新日期：2017-01-20 00:00:00

abstract：:Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson's disease pathology. However, the significance of PREP protein for aSyn aggregation and toxicity is not known. We studied this in vivo by using PREP knock-out mice with viral ve...

journal_title：Scientific reports

authors： Svarcbahs R,Julku UH,Norrbacka S,Myöhänen TT

更新日期：2018-01-24 00:00:00

abstract：:This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...

journal_title：Scientific reports

authors： Morshed MN,Pervez MN,Behary N,Bouazizi N,Guan J,Nierstrasz VA

更新日期：2020-09-30 00:00:00

abstract：:The human sweet taste receptor (T1R2) monomer-a member of the G-protein coupled receptor family that detects a wide variety of chemically and structurally diverse sweet tasting molecules, is known to pose a significant threat to human health. Protein that lack crystal structure is a challenge in structure-based protei...

journal_title：Scientific reports

authors： Arodola OA,Kanchi S,Hloma P,Bisetty K,Asiri AM,Inamuddin

更新日期：2020-10-27 00:00:00

abstract：:Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...

journal_title：Scientific reports

authors： Yan Q,Kumar P,Wang Y,Zhao Y,Lin H,Ran Q,An Z,Zhou W

更新日期：2020-10-09 00:00:00

abstract：:It is well known that collective migrations of oxygen vacancies in oxide is the key principle of resistance change in oxide-based resistive memory (OxRAM). The practical usefulness of OxRAM mainly arises from the fact that these oxygen vacancy migrations take place at relatively low operating voltages. The activation ...

journal_title：Scientific reports

authors： Hur JH

更新日期：2019-11-19 00:00:00

abstract：:Triple-doped (Yb(3+)/Er(3+)/Tm(3+)) KMnF3 nanocubes with uniform sizes of 250 nm were synthesized by a facile hydrothermal route using the oleic acid as the capping agent. It was found that these nanocubes can simultaneously exhibited four-color (blue, green, red and NIR) upconversion emissions under a single 980 nm n...

journal_title：Scientific reports

authors： Wang H,Hong X,Han R,Shi J,Liu Z,Liu S,Wang Y,Gan Y

更新日期：2015-11-26 00:00:00

abstract：:Measurement-based quantum computing is one of the most promising quantum computing models. Although various universal resource states have been proposed so far, it was open whether only two Pauli bases are enough for both of universal measurement-based quantum computing and its verification. In this paper, we construc...

journal_title：Scientific reports

authors： Takeuchi Y,Morimae T,Hayashi M

更新日期：2019-09-19 00:00:00

abstract：:Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the human immunodeficiency virus type 1 (HIV-1) infection and has been considered as an important therapeutic target for AIDS. CXCR4 mediates viral entry i...

journal_title：Scientific reports

authors： Hou P,Chen S,Wang S,Yu X,Chen Y,Jiang M,Zhuang K,Ho W,Hou W,Huang J,Guo D

更新日期：2015-10-20 00:00:00

abstract：:We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...

journal_title：Scientific reports

authors： Liu S,Wang Y,Liao C,Wang Y,He J,Fu C,Yang K,Bai Z,Zhang F

更新日期：2017-04-11 00:00:00

abstract：:Bioactive nanosilicates are emerging prominent next generation biomaterials due to their intrinsic functional properties such as advanced biochemical and biophysical cues. Recent studies show interesting dose-dependent effect of fluoride ions on the stem cells. Despite of interesting properties of fluoride ions as wel...

journal_title：Scientific reports

authors： Veernala I,Giri J,Pradhan A,Polley P,Singh R,Yadava SK

更新日期：2019-01-29 00:00:00

abstract：:The ideal strategy for hair cell regeneration is promoting residual supporting cell proliferation followed by induction of hair cell differentiation. In this study, cultured neonatal mouse organs of Corti were treated with neomycin to eliminate hair cells followed by incubation with recombined adenovirus expressing Pa...

journal_title：Scientific reports

authors： Chen Y,Yu H,Zhang Y,Li W,Lu N,Ni W,He Y,Li J,Sun S,Wang Z,Li H

更新日期：2013-10-21 00:00:00

abstract：:Both genetic and environmental factors are suggested to influence overweight and obesity risks. Although individual loci and genes have been frequently shown to be associated with body mass index (BMI), the overall interaction of these genes and their role in BMI remains underexplored. Data were collected in 90 health...

journal_title：Scientific reports

authors： Joseph PV,Jaime-Lara RB,Wang Y,Xiang L,Henderson WA

更新日期：2019-05-15 00:00:00

abstract：:We have quantitatively evaluated the macular and peripapillary microvascular changes in eyes with chiasmal compression caused by brain tumors compared with healthy control eyes using optical coherence tomography angiography (OCT-A) and correlated them with other ocular parameters. This cross-sectional study involved t...

journal_title：Scientific reports

authors： Lee GI,Park KA,Oh SY,Kong DS

更新日期：2020-02-07 00:00:00

abstract：:Small amphipods (Halice sp. MT-2017) with body length <1 cm were collected from the Challenger Deep (~10,920 m below sea level). The divergence time of their lineage was approximately 109 Mya, making this group ancient compared to others under study. The mitochondrial genome of Halice sp. shared the usual gene compone...

journal_title：Scientific reports

authors： Li JY,Zeng C,Yan GY,He LS

更新日期：2019-02-22 00:00:00

abstract：:The biological functions of nitric oxide (NO) depend on its concentration, and excessive levels of NO induce various harmful situations known as nitrosative stress. Therefore, organisms possess many kinds of strategies to regulate the intracellular NO concentration and/or to detoxify excess NO. Here, we used genetic s...

journal_title：Scientific reports

authors： Anam K,Nasuno R,Takagi H

更新日期：2020-04-07 00:00:00

abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

journal_title：Scientific reports

authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

更新日期：2020-12-01 00:00:00

abstract：:Long-term all-cause mortality and dependency after complex surgical procedures have not been assessed in the framework of value-based medicine. The aim of this study was to investigate the postoperative and long-term outcomes after surgical procedures lasting for more than six hours. Retrospective cohort study of pati...

journal_title：Scientific reports

authors： Cornellà N,Sancho J,Sitges-Serra A

更新日期：2017-08-23 00:00:00

abstract：:A growing bacterium typically divides into two genetically identical and morphologically similar sister cells and eventually gives rise to a clonal population. Nevertheless, significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting heterogeneity in cellular behavior often ensuri...

journal_title：Scientific reports

authors： Govers SK,Adam A,Blockeel H,Aertsen A

更新日期：2017-08-16 00:00:00

abstract：:Application of acute kidney injury (AKI) biomarkers with consideration of nonrenal conditions and systemic severity has not been sufficiently determined. Herein, urinary neutrophil gelatinase-associated lipocalin (NGAL), L-type fatty acid-binding protein (L-FABP) and nonrenal disorders, including inflammation, hypoper...

journal_title：Scientific reports

authors： Asada T,Isshiki R,Hayase N,Sumida M,Inokuchi R,Noiri E,Nangaku M,Yahagi N,Doi K

更新日期：2016-09-08 00:00:00

abstract：:Chimpanzees (Pan troglodytes), one of humankinds' closest living relatives, are known to hunt and consume the meat of various animal taxa. Although some researchers have presented indirect evidence that chimpanzees may also prey on tortoises, until now, direct observations of this behaviour did not exist. Here, we pro...

journal_title：Scientific reports

authors： Pika S,Klein H,Bunel S,Baas P,Théleste E,Deschner T

更新日期：2019-05-23 00:00:00

abstract：:The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...

journal_title：Scientific reports

authors： Roos J,Enlund E,Funcke JB,Tews D,Holzmann K,Debatin KM,Wabitsch M,Fischer-Posovszky P

更新日期：2016-12-06 00:00:00

abstract：:Solving river engineering problems typically requires river flow characterization, including the prediction of flow depth, flow velocity, and flood extent. Hydraulic models use governing equations of the flow in motion (conservation of mass and momentum principles) to predict the flow characteristics. However, solving...

journal_title：Scientific reports

authors： Hosseiny H,Nazari F,Smith V,Nataraj C

更新日期：2020-05-19 00:00:00

abstract：:Manual anthropometrics are used extensively in medical practice and epidemiological studies to assess an individual's health. However, traditional techniques reduce the complicated shape of human bodies to a series of simple size measurements and derived health indices, such as the body mass index (BMI), the waist-hip...

journal_title：Scientific reports

authors： Thelwell M,Chiu CY,Bullas A,Hart J,Wheat J,Choppin S

更新日期：2020-07-22 00:00:00

abstract：:Features from Electrovestibulography (EVestG) recordings have been used to classify and measure the severity of both persistent post-concussion syndrome (PCS) and major depressive disorder. Herein, we examined the effect of comorbid depression on the detection of persistent PCS using EVestG. To validate our previously...

journal_title：Scientific reports

authors： Suleiman A,Lithgow B,Mansouri B,Moussavi Z

更新日期：2018-09-27 00:00:00

abstract：:The ability to process time on the scale of milliseconds and seconds is essential for behaviour. A growing number of studies have started to focus on brain dynamics as a mechanism for temporal encoding. Although there is growing evidence in favour of this view from computational and in vitro studies, there is still a ...

journal_title：Scientific reports

authors： Bueno FD,Morita VC,de Camargo RY,Reyes MB,Caetano MS,Cravo AM

更新日期：2017-04-10 00:00:00