Cotransfection of Pax2 and Math1 promote in situ cochlear hair cell regeneration after neomycin insult.

abstract：:Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discover the genetic determinants of BPH risk. Understanding the biological ...

journal_title：Scientific reports

authors： Hellwege JN,Stallings S,Torstenson ES,Carroll R,Borthwick KM,Brilliant MH,Crosslin D,Gordon A,Hripcsak G,Jarvik GP,Linneman JG,Devi P,Peissig PL,Sleiman PAM,Hakonarson H,Ritchie MD,Verma SS,Shang N,Denny JC,Roden DM

更新日期：2019-04-15 00:00:00

abstract：:Pedobacter schmidteae sp. nov. strain EGT (Collection de Souches de l'Unité des Rickettsie CSUR P6417 = Colección Española de Cultivos Tipo CECT 9771) is a new Pedobacter species isolated from the planarian Schmidtea mediterranea. Schmidtea mediterranea are flatworms living in freshwater and exhibiting an unusual abil...

journal_title：Scientific reports

authors： Kangale LJ,Raoult D,Ghigo E,Fournier PE

更新日期：2020-04-09 00:00:00

abstract：:We study the capillary retraction of a Newtonian semi-infinite liquid filament through analytical methods. We derive a long-time asymptotic-state expansion for the filament profile using a one-dimensional free-surface slender cylindrical flow model based on the three-dimensional axisymmetric Navier-Stokes equations. T...

journal_title：Scientific reports

authors： Contò FP,Marín JF,Antkowiak A,Castrejón-Pita JR,Gordillo L

更新日期：2019-10-29 00:00:00

abstract：:Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...

journal_title：Scientific reports

authors： Sugiyama MG,Armstrong SM,Wang C,Hwang D,Leong-Poi H,Advani A,Advani S,Zhang H,Szaszi K,Tabuchi A,Kuebler WM,Van Slyke P,Dumont DJ,Lee WL

更新日期：2015-06-05 00:00:00

abstract：:Stromal capillary sheath cells in human spleens strongly express CD271, the low affinity nerve growth factor receptor p75. Serial sections of a representative adult human spleen were double-stained for CD271 versus smooth muscle alpha actin (SMA) plus CD34 to visualise capillary sheaths, the arterial tree and endothel...

journal_title：Scientific reports

authors： Steiniger BS,Wilhelmi V,Berthold M,Guthe M,Lobachev O

更新日期：2018-10-24 00:00:00

abstract：:Controlled quantum teleportation involves a third party as a controller for the teleportation of state. Here, we present the novel protocols for controlling teleportation of the arbitrary two-qubit and three-qubit states through five-qubit and seven-qubit cluster states respectively. In these schemes, Alice sends the ...

journal_title：Scientific reports

authors： Kumar A,Haddadi S,Pourkarimi MR,Behera BK,Panigrahi PK

更新日期：2020-08-12 00:00:00

abstract：:For isotropic fluids, classical nucleation theory predicts the nucleation rate, barrier height and critical droplet size by ac- counting for the competition between bulk energy and interfacial tension. The nucleation process in liquid crystals is less understood. We numerically investigate nucleation in monolayered ne...

journal_title：Scientific reports

authors： Bhattacharjee AK

更新日期：2017-01-05 00:00:00

abstract：:CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and ...

journal_title：Scientific reports

authors： Wu G,Sun Y,Wang K,Chen Z,Wang X,Chang F,Li T,Feng P,Xia Z

更新日期：2016-07-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Xue Q,Li X,Gu Y,Wang X,Wang M,Tian J,Duan X,Gao H,Ji X,Yan X,Dong W,Fang Q,Zhang X

更新日期：2020-05-08 00:00:00

abstract：:Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of subst...

journal_title：Scientific reports

authors： Castaings L,Caquot A,Loubet S,Curie C

更新日期：2016-11-16 00:00:00

abstract：:We propose and demonstrate an on-chip optofluidic device allowing active oscillatory microrheological measurements with sub-μL sample volume, low cost and high flexibility. Thanks to the use of this optofluidic microrheometer it is possible to measure the viscoelastic properties of complex fluids in the frequency rang...

journal_title：Scientific reports

authors： Vitali V,Nava G,Zanchetta G,Bragheri F,Crespi A,Osellame R,Bellini T,Cristiani I,Minzioni P

更新日期：2020-04-02 00:00:00

abstract：:Neurofeedback is a strong direct training method for brain function, wherein brain activity patterns are measured and displayed as feedback, and trainees try to stabilize the feedback signal onto certain desirable states to regulate their own mental states. Here, we introduce a novel neurofeedback method, using the mi...

journal_title：Scientific reports

authors： Chang M,Iizuka H,Naruse Y,Ando H,Maeda T

更新日期：2014-10-24 00:00:00

abstract：:The ratio of ω-6 to ω-3 polyunsaturated fatty acids (PUFAs) appears to be critical in the regulation of various pathophysiological processes and to maintain cellular homeostasis. While a high proportion of dietary intake of ω-6 PUFAs is associated with various inflammatory disorders, higher intake of ω-3 PUFAs is know...

journal_title：Scientific reports

authors： Kumar N,Gupta G,Anilkumar K,Fatima N,Karnati R,Reddy GV,Giri PV,Reddanna P

更新日期：2016-08-18 00:00:00

abstract：:Plants perceive and respond to volatile signals in their environment. Herbivore-infested plants release volatile organic compounds (VOCs) which can initiate systemic defense reactions within the plant and contribute to plant-plant communication. Here, for Ipomoea batatas (sweet potato) leaves we show that among variou...

journal_title：Scientific reports

authors： Meents AK,Chen SP,Reichelt M,Lu HH,Bartram S,Yeh KW,Mithöfer A

更新日期：2019-11-22 00:00:00

abstract：:Optogenetic tools have opened a rich experimental landscape for understanding neural function and disease. Here, we present the first validation of eight optogenetic constructs driven by recombinant adeno-associated virus (AAV) vectors and a WGA-Cre based dual injection strategy for projection targeting in a widely-us...

journal_title：Scientific reports

authors： O'Shea DJ,Kalanithi P,Ferenczi EA,Hsueh B,Chandrasekaran C,Goo W,Diester I,Ramakrishnan C,Kaufman MT,Ryu SI,Yeom KW,Deisseroth K,Shenoy KV

更新日期：2018-04-30 00:00:00

abstract：:Small RNA-Seq is a common means to interrogate the small RNA'ome or the full spectrum of small RNAs (<200 nucleotide length) of a biological system. A pivotal problem in NGS based small RNA analysis is identifying and quantifying the small RNA'ome constituent components. For example, small RNAs in the circulatory syst...

journal_title：Scientific reports

authors： Li J,Kho AT,Chase RP,Pantano L,Farnam L,Amr SS,Tantisira KG

更新日期：2020-03-12 00:00:00

abstract：:Feedback information is essential for us to adapt appropriately to the environment. The feedback-related negativity (FRN), a frontocentral negative deflection after the delivery of feedback, has been found to be larger for outcomes that are worse than expected, and it reflects a reward prediction error derived from th...

journal_title：Scientific reports

authors： Gu Y,Hu X,Pan W,Yang C,Wang L,Li Y,Chen A

更新日期：2016-10-03 00:00:00

abstract：:The aim of this prospective study was to compare surgical outcomes of slanted bilateral lateral rectus (LR) recession for intermittent exotropia (IXT) with convergence insufficiency (CI) according to their response to preoperative monocular occlusion. This prospective study included 55 children who underwent slanted b...

journal_title：Scientific reports

authors： Chun BY,Oh JH,Choi HJ

更新日期：2020-04-29 00:00:00

abstract：:Effects of fertilisation and other management techniques on a weed community were evaluated during wheat growth in a rice-wheat cropping system. Fertiliser treatments were C0 (C means chemical, C0 means zero chemical fertiliser.), CN (N fertiliser), CNK (N plus K fertiliser), CNPK (N plus P and K fertiliser), CNP (N p...

journal_title：Scientific reports

authors： Jiang M,Liu T,Huang N,Shen X,Shen M,Dai Q

更新日期：2018-03-05 00:00:00

abstract：:The root system displays a remarkable plasticity that enables plants to adapt to changing environmental conditions. This plasticity is tightly linked to the activity of root apical meristems (RAMs) and to the formation of lateral roots, both controlled by related hormonal crosstalks. In Arabidopsis thaliana, gibberell...

journal_title：Scientific reports

authors： Fonouni-Farde C,Miassod A,Laffont C,Morin H,Bendahmane A,Diet A,Frugier F

更新日期：2019-02-20 00:00:00

abstract：:The mobilities of electrons and holes determine the applicability of any semiconductor, but their individual measurement remains a major challenge. Here, we show that time-resolved terahertz spectroscopy (TRTS) can distinguish the mobilities of minority and majority charge carriers independently of the doping-type and...

journal_title：Scientific reports

authors： Hempel H,Hages CJ,Eichberger R,Repins I,Unold T

更新日期：2018-09-27 00:00:00

abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

journal_title：Scientific reports

authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

更新日期：2020-12-01 00:00:00

abstract：:Diarrheagenic Escherichia coli (DEC) causes human diarrhea symptom in both healthy and immunocompromised individuals. An auto-microfluidic thin-film chip (AMTC) instrument integrating one-step multiplex PCR (mPCR) with reverse dot blot hybridization (RDBH) was developed for high-throughput detection of DEC. The novel ...

journal_title：Scientific reports

authors： Yun Z,Zeng L,Huang W,Wu Q,Fan Y,Zheng S,Peng L,Han J,Huang Y,Zhou H,Chen H

更新日期：2018-08-27 00:00:00

abstract：:Support from human genetics increases the probability of success in drug development. However, few examples exist of successful genomically-driven drug repositioning. Given that a Mendelian form of severe enterocolitis is due to up-regulation of the interleukin-18 (IL18) signaling pathway, and pharmacologic inhibition...

journal_title：Scientific reports

authors： Mokry LE,Zhou S,Guo C,Scott RA,Devey L,Langenberg C,Wareham N,Waterworth D,Cardon L,Sanseau P,Davey Smith G,Richards JB

更新日期：2019-06-28 00:00:00

abstract：:Performing everyday actions requires fine postural control, which is a major focus of functional rehabilitation programs. Among the various range of training methods likely to improve balance and postural stability, motor imagery practice (MIP) yielded promising results. Transcranial direct current stimulation (tDCS) ...

journal_title：Scientific reports

authors： Saruco E,Di Rienzo F,Nunez-Nagy S,Rubio-Gonzalez MA,Jackson PL,Collet C,Saimpont A,Guillot A

更新日期：2017-03-28 00:00:00

abstract：:The molecular mechanisms behind aneurysmal subarachnoid haemorrhage (aSAH) are still poorly understood. Expression patterns of miRNAs may help elucidate the post-transcriptional gene expression in aSAH. Here, we evaluate the global miRNAs expression profile (miRnome) of patients with aSAH to identify potential biomark...

journal_title：Scientific reports

authors： Lopes KP,Vinasco-Sandoval T,Vialle RA,Paschoal FM Jr,Bastos VAPA,Bor-Seng-Shu E,Teixeira MJ,Yamada ES,Pinto P,Vidal AF,Ribeiro-Dos-Santos A,Moreira F,Santos S,Paschoal EHA,Ribeiro-Dos-Santos Â

更新日期：2018-06-08 00:00:00

abstract：:Pharmacological activities of some natural products diminish and even disappear after purification. In this study, we explored the mechanisms underlying the decrease of acute oral toxicity of Coptidis Rhizoma extract after purification. The water solubility, in vitro absorption, and plasma exposure of berberine (the m...

journal_title：Scientific reports

authors： Ma BL,Yin C,Zhang BK,Dai Y,Jia YQ,Yang Y,Li Q,Shi R,Wang TM,Wu JS,Li YY,Lin G,Ma YM

更新日期：2016-01-29 00:00:00

abstract：:Organic-inorganic halide perovskite nanocrystals or quantum dots (PQDs) are excellent candidates for optoelectronic applications, such as lasers, solar cells, light emitting diodes, and single photon sources. However, the potential applications of PQDs can expand once the photoluminescence, and in particular, the blin...

journal_title：Scientific reports

authors： Trinh CT,Minh DN,Ahn KJ,Kang Y,Lee KG

更新日期：2020-02-07 00:00:00

abstract：:The exponential growth in knowledge has resulted in a better understanding of the lactation process in a wide variety of animals. However, the underlying genetic mechanisms are not yet clearly known. In order to identify the mechanisms involved in the lactation process, various mehods, including meta-analysis, weighte...

journal_title：Scientific reports

authors： Farhadian M,Rafat SA,Panahi B,Mayack C

更新日期：2021-01-27 00:00:00

abstract：:Inbreeding can depress individuals' fitness traits and reduce population viability. However, studies that directly translate inbreeding depression on fitness traits into consequences for population viability, and further, into consequences for management choices, are lacking. Here, we estimated impacts of inbreeding d...

journal_title：Scientific reports

authors： Trask AE,Ferrie GM,Wang J,Newland S,Canessa S,Moehrenschlager A,Laut M,Duenas LB,Ewen JG

更新日期：2021-01-12 00:00:00