Formation of diverse polycyclic spirooxindoles via three-component reaction of isoquinolinium salts, isatins and malononitrile.

abstract：:Intravitreal anti-vascular endothelial growth factor (VEGF) agents have revolutionized the treatment of retinopathy of prematurity (ROP); however, there are concerns regarding the potential systemic complications caused by those treatments. This study aimed to determine the serum concentrations of cytokines in infants...

journal_title：Scientific reports

authors： Cheng Y,Zhu X,Linghu D,Xu Y,Liang J

更新日期：2020-07-29 00:00:00

abstract：:Third permanent molars (M3s) are the last tooth to form but have not been used to estimate age at dental maturation in early fossil hominins because direct histological evidence for the timing of their growth has been lacking. We investigated an isolated maxillary M3 (SK 835) from the 1.5 to 1.8-million-year-old (Mya)...

journal_title：Scientific reports

authors： Dean C,Zanolli C,Le Cabec A,Tawane M,Garrevoet J,Mazurier A,Macchiarelli R

更新日期：2020-11-04 00:00:00

abstract：:We explore two small molecules containing arms of dicyano-n-hexylrhodanine and diathiafulvalene wings terminated with benzothiadiazole linker, denoted as BAF-4CN and BAF-2HDT, respectively, as small molecule non-fullerene acceptors (SMNFAs) in organic solar cells. The proposed materials are mixed with a low band gap p...

journal_title：Scientific reports

authors： Datt R,Suman,Bagui A,Siddiqui A,Sharma R,Gupta V,Yoo S,Kumar S,Singh SP

更新日期：2019-06-12 00:00:00

abstract：:Vlasouliolides A-D (1-4), four rare sesquiterpene lactone dimers, were isolated from Vladimiria souliei. The common structural characteristic of 1-4 is the C32 skeleton comprising two sesquiterpene lactone units linked by a C11-C13' single bond with one acetyl connected to the C-13 position of one of the two sesquiter...

journal_title：Scientific reports

authors： Chen LP,Wu GZ,Zhang JP,Ye J,Liu QX,Shen YH,Li HL,Zhang WD

更新日期：2017-03-03 00:00:00

abstract：:The synthesis and subsequent genomic integration of DNA that is complementary to the genomes of non-retroviral RNA viruses are rarely observed. However, upon infection of various human cell lines and primary fibroblasts with the vesicular stomatitis virus (VSV), we detected DNA complementary to the VSV RNA. The VSV DN...

journal_title：Scientific reports

authors： Shimizu A,Nakatani Y,Nakamura T,Jinno-Oue A,Ishikawa O,Boeke JD,Takeuchi Y,Hoshino H

更新日期：2014-05-30 00:00:00

abstract：:Combined inhibition of BRAF and MEK1/2 (CIBM) improves therapeutic efficacy of BRAF-mutant melanoma. However, drug resistance to CIBM is inevitable and the drug resistance mechanisms still remain to be elucidated. Here, we show that BMK1 pathway contributes to the drug resistance to CIBM. Considering that ERK1/2 pathw...

journal_title：Scientific reports

authors： Song C,Wang L,Xu Q,Wang K,Xie D,Yu Z,Jiang K,Liao L,Yates JR,Lee JD,Yang Q

更新日期：2017-04-07 00:00:00

abstract：:The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated...

journal_title：Scientific reports

authors： Freyvert Y,Yong NA,Morikawa E,Zdunowski S,Sarino ME,Gerasimenko Y,Edgerton VR,Lu DC

更新日期：2018-10-19 00:00:00

abstract：:The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of proteoglycans and glycoproteins, to mediate cell contraction during the myogenic response. We, therefore, attempted to elucidate the signal ...

journal_title：Scientific reports

authors： Kang H,Liu J,Sun A,Liu X,Fan Y,Deng X

更新日期：2017-02-13 00:00:00

abstract：:The mechanism whereby lactic acid bacteria extend the lifespan of Caenorhabditis elegans has previously been elucidated. However, the role of Weissella species has yet not been studied. We show that Weissella koreensis and Weissella cibaria significantly (p < 0.05) extend the lifespan of C. elegans compared with Esche...

journal_title：Scientific reports

authors： Lee J,Kwon G,Lim YH

更新日期：2015-11-25 00:00:00

abstract：:Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...

journal_title：Scientific reports

authors： Qin YS,Han XL,Song KK,Tian YH,Peng CX,Wang L,Sun BA,Wang G,Kaban I,Eckert J

更新日期：2017-02-13 00:00:00

abstract：:We here develop a three-dimensional DMF (3D DMF) platform with patterned electrodes submerged in an oil medium to provide fundamental solutions to the technical limitations of 2D DMF platforms and water-air systems. 3D droplet manipulation on patterned electrodes is demonstrated by programmably controlling electrical ...

journal_title：Scientific reports

authors： Hong J,Kim YK,Won DJ,Kim J,Lee SJ

更新日期：2015-06-02 00:00:00

abstract：:Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanoma...

journal_title：Scientific reports

authors： Broza YY,Zuri L,Haick H

更新日期：2014-04-09 00:00:00

abstract：:The prion protein (PrP) evolved from the subbranch of ZIP metal ion transporters comprising ZIPs 5, 6 and 10, raising the prospect that the study of these ZIPs may reveal insights relevant for understanding the function of PrP. Building on data which suggested PrP and ZIP6 are critical during epithelial-to-mesenchymal...

journal_title：Scientific reports

authors： Brethour D,Mehrabian M,Williams D,Wang X,Ghodrati F,Ehsani S,Rubie EA,Woodgett JR,Sevalle J,Xi Z,Rogaeva E,Schmitt-Ulms G

更新日期：2017-01-18 00:00:00

abstract：:The development of artificial intelligence has led researchers to study the ethical principles that should guide machine behavior. The challenge in building machine morality based on people's moral decisions, however, is accounting for the biases in human moral decision-making. In seven studies, this paper investigate...

journal_title：Scientific reports

authors： Frank DA,Chrysochou P,Mitkidis P,Ariely D

更新日期：2019-09-11 00:00:00

abstract：:Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucid...

journal_title：Scientific reports

authors： Mizuno Y,Shimada S,Akiyama Y,Watanabe S,Aida T,Ogawa K,Ono H,Mitsunori Y,Ban D,Kudo A,Arii S,Yamaoka S,Tanabe M,Tanaka S

更新日期：2018-01-08 00:00:00

abstract：:Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in C...

journal_title：Scientific reports

authors： Guo C,Li Y,Huai Y,Rao CY,Lai S,Mu D,Yin W,Yu H,Nie S

更新日期：2018-11-21 00:00:00

abstract：:A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...

journal_title：Scientific reports

authors： Liu M,Hoffman J,Wang J,Zhang J,Nelson-Cheeseman B,Bhattacharya A

更新日期：2013-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： El-Zahar ER,Rashad AM,Saad W,Seddek LF

更新日期：2020-09-24 00:00:00

abstract：:To investigate the mechanism underlying AT1-AA-induced retinopathy in severe preeclampsia by measuring the positive rate and titer of AT1-AA in plasma from women with severe preeclampsia and normal pregnant women to see whether AT1-AA titer was correlated with the grade of retinopathy. A preeclampsia rat model was als...

journal_title：Scientific reports

authors： Liu F,Wang Y,Wang X,Zheng Y,Jin Z,Zhi J

更新日期：2016-07-06 00:00:00

abstract：:Receptor-mediated endocytosis is an essential process in signalling pathways for activation of intracellular signalling cascades. One example is the Wnt signalling pathway that seems to depend on endocytosis of the ligand-receptor complex for initiation of Wnt signal transduction. To date, the roles of different endoc...

journal_title：Scientific reports

authors： Bandmann V,Mirsanaye AS,Schäfer J,Thiel G,Holstein T,Mikosch-Wersching M

更新日期：2019-09-10 00:00:00

abstract：:The Serra Gaúcha region is the most important temperate fruit-producing area in southern Brazil. Despite mealybugs (Hemiptera: Pseudococcidae) infesting several host plants in the region, there is a lack of information about the composition of species damaging different crops. A survey of mealybug species associated w...

journal_title：Scientific reports

authors： Pacheco da Silva VC,Kaydan MB,Malausa T,Germain JF,Palero F,Botton M

更新日期：2017-11-16 00:00:00

abstract：:Anthropogenic radionuclides contaminate a range of environments as a result of nuclear activities, for example, leakage from waste storage tanks/ponds (e.g. Hanford, USA or Sellafield sites, UK) or as a result of large scale nuclear accidents (e.g. Chernobyl, Ukraine or Fukushima, Japan). One of the most widely applie...

journal_title：Scientific reports

authors： Handley-Sidhu S,Mullan TK,Grail Q,Albadarneh M,Ohnuki T,Macaskie LE

更新日期：2016-03-18 00:00:00

abstract：:Few-layered transition metal dichalcogenides (TMDs) are known as true two-dimensional materials, with excellent semiconducting properties and strong light-matter interaction. Thus, TMDs are attractive materials for semitransparent and flexible solar cells for use in various applications. Hoewver, despite the recent pr...

journal_title：Scientific reports

authors： Akama T,Okita W,Nagai R,Li C,Kaneko T,Kato T

更新日期：2017-09-20 00:00:00

abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...

journal_title：Scientific reports

authors： Tao CW,Yen TJ,Huang TY

更新日期：2020-03-24 00:00:00

abstract：:Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...

journal_title：Scientific reports

authors： Zheng M,Qu D,Wang H,Sun Z,Liu X,Chen J,Li C,Li X,Chen Z

更新日期：2016-06-29 00:00:00

abstract：:Recent studies suggest that spatial training can maintain associative memory capacity in Tg2576 mice, but it is not known whether the beneficial effects can be inherited from the trained fathers to their offspring. Here, we exposed male wild-type and male 3XTg Alzheimer disease (AD) mice (3-m old) respectively to spat...

journal_title：Scientific reports

authors： Zhang S,Li X,Wang Z,Liu Y,Gao Y,Tan L,Liu E,Zhou Q,Xu C,Wang X,Liu G,Chen H,Wang JZ

更新日期：2017-05-08 00:00:00

abstract：:In 2018, the World Health Organization identified the Zika virus (ZIKV) as a pathogen that should be prioritized for public health research due to its epidemic potential. In this study, whole-genome sequencing (WGS) of travel-acquired ZIKV infections was used to examine the limitations of phylogenetic analysis. WGS an...

journal_title：Scientific reports

authors： Kamelian K,Montoya V,Olmstead A,Dong W,Harrigan R,Morshed M,Joy JB

更新日期：2019-11-11 00:00:00

abstract：:Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were evaluated for foreign g...

journal_title：Scientific reports

authors： Chai YR,Ge MM,Wei TT,Jia YL,Guo X,Wang TY

更新日期：2018-04-27 00:00:00

abstract：:As part of efforts to reduce pressure on the Amazon and other biomes, one approach considered by Brazilian authorities and scientists is more intensive use of the soils of the interior of the northeast of the country, which are generally sandy, with low contents of organic matter and low water holding capacity and are...

journal_title：Scientific reports

authors： Batista EMCC,Shultz J,Matos TTS,Fornari MR,Ferreira TM,Szpoganicz B,de Freitas RA,Mangrich AS

更新日期：2018-07-16 00:00:00

abstract：:Adhesion is a significant concern after surgery. Many researchers studied the anti-adhesive effect of statin, of which results were inconsistent. Thus, we purposed to perform a systematic review and meta-analysis to evaluate the effect of statins on postoperative adhesion in an experimental study. A comprehensive sear...

journal_title：Scientific reports

authors： Choi GJ,Park HK,Kim DS,Lee D,Kang H

更新日期：2018-10-03 00:00:00