Abstract:
:The triethylamine promoted three-component reaction of N-(4-nitrobenzyl), N-ethoxycarbonylmethylisoquinolinium bromide, isatins and malononitrile in ethanol afforded spiro[indoline-3,2'-pyrrolo[2,1-a]isoquinolines] in good yields and with high diastereoselectivity. The similar reaction of N-cyanomethylisoquinolinium chloride mainly gave complex indolo[2″,3″:2',3']pyrrolo[3',4':4,5]pyrrolo[2,1-a]isoquinoline derivatives. However, the three-component reaction of N-cyanomethylisoquinolinium chloride, isatins and ethyl cyanoacetate mainly resulted in functionalized spiro[indoline-3,8'-pyrido[2',3':4,5]pyrrolo[2,1-a]isoquinolines].
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sun J,Shen GL,Huang Y,Yan CGdoi
10.1038/srep41024subject
Has Abstractpub_date
2017-01-20 00:00:00pages
41024issn
2045-2322pii
srep41024journal_volume
7pub_type
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