Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.

abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

journal_title：Scientific reports

authors： Wang L,Zhuang X,Zhuang G,Jing C

更新日期：2016-12-14 00:00:00

abstract：:FMS-like tyrosine kinase 3 (FLT3) is a key driver of acute myeloid leukemia (AML). Several tyrosine kinase inhibitors (TKIs) targeting FLT3 have been evaluated clinically, but their effects are limited when used in monotherapy due to the emergence of drug-resistance. Thus, a better understanding of drug-resistance pat...

journal_title：Scientific reports

authors： Morales ML,Arenas A,Ortiz-Ruiz A,Leivas A,Rapado I,Rodríguez-García A,Castro N,Zagorac I,Quintela-Fandino M,Gómez-López G,Gallardo M,Ayala R,Linares M,Martínez-López J

更新日期：2019-12-09 00:00:00

abstract：:Electron ptychography has seen a recent surge of interest for phase sensitive imaging at atomic or near-atomic resolution. However, applications are so far mainly limited to radiation-hard samples, because the required doses are too high for imaging biological samples at high resolution. We propose the use of non-conv...

journal_title：Scientific reports

authors： Pelz PM,Qiu WX,Bücker R,Kassier G,Miller RJD

更新日期：2017-08-29 00:00:00

abstract：:Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive f...

journal_title：Scientific reports

authors： Zhang B,Han M,Tan S,De Yang F,Tan Y,Jiang S,Zhang X,Huang XF

更新日期：2017-09-19 00:00:00

abstract：:Although re-sequencing of gene panels and mRNA expression profiling are now firmly established in clinical laboratories, in-depth proteome analysis has remained a niche technology, better suited for studying model systems rather than challenging materials such as clinical trial samples. To address this limitation, we ...

journal_title：Scientific reports

authors： Hughes CS,McConechy MK,Cochrane DR,Nazeran T,Karnezis AN,Huntsman DG,Morin GB

更新日期：2016-10-07 00:00:00

abstract：:For nearly a century, researchers have tried to understand the swimming of aquatic animals in terms of a balance between the forward thrust from swimming movements and drag on the body. Prior approaches have failed to provide a separation of these two forces for undulatory swimmers such as lamprey and eels, where most...

journal_title：Scientific reports

authors： Bale R,Shirgaonkar AA,Neveln ID,Bhalla AP,MacIver MA,Patankar NA

更新日期：2014-12-10 00:00:00

abstract：:The Mongol invasion of Eastern Europe, and especially its sudden withdrawal from Hungary in 1242 CE, has generated much speculation and an array of controversial theories. None of them, however, considered multifaceted environmental drivers and the coupled analysis of historical reports and natural archives. Here we i...

journal_title：Scientific reports

authors： Büntgen U,Di Cosmo N

更新日期：2016-05-26 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Dawson G,Campbell K,Hashemi J,Lippmann SJ,Smith V,Carpenter K,Egger H,Espinosa S,Vermeer S,Baker J,Sapiro G

更新日期：2020-01-14 00:00:00

abstract：:Fire-induced permafrost degradation is well documented in boreal forests, but the role of fires in initiating thermokarst development in Arctic tundra is less well understood. Here we show that Arctic tundra fires may induce widespread thaw subsidence of permafrost terrain in the first seven years following the distur...

journal_title：Scientific reports

authors： Jones BM,Grosse G,Arp CD,Miller E,Liu L,Hayes DJ,Larsen CF

更新日期：2015-10-29 00:00:00

abstract：:Developed through evolution, brain neural system self-organizes into an economical and dynamic network structure with the modulation of repetitive neuronal firing activities through synaptic plasticity. These highly variable electric activities inevitably produce a spontaneous magnetic field, which also significantly ...

journal_title：Scientific reports

authors： Wang R,Fan Y,Wu Y

更新日期：2019-07-04 00:00:00

abstract：:Parkinson's disease (PD) is an incapacitating neurodegenerative disease. Patients with PD and their caregivers may have interactive effects on each other's psychological well-being. This study aimed to assess the dyadic dynamics of resilience, fatigue, and suicidal ideation on the depression severity of PD patients an...

journal_title：Scientific reports

authors： Lee Y,Chiou YJ,Hung CF,Chang YY,Chen YF,Lin TK,Wang LJ

更新日期：2021-01-13 00:00:00

abstract：:Bee pollination is an indispensable component of global food production and plays a crucial role in sustainable agriculture. The worldwide decline of bee populations, including wild pollinators, poses a threat to this system. However, most studies to date are situated in temperate regions where Apini and Bombini are v...

journal_title：Scientific reports

authors： Nunes-Silva P,Piot N,Meeus I,Blochtein B,Smagghe G

更新日期：2016-09-02 00:00:00

abstract：:RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...

journal_title：Scientific reports

authors： Komatsu Y,Tanaka C,Komorizono R,Tomonaga K

更新日期：2020-04-03 00:00:00

abstract：:Interactions between diverse species that coexist in nature are of utmost interest in the field of ecology. Recent theoretical studies have shown that spatiality plays a key role in maintaining complex systems with multiple differing species. In these models, however, organisms move among habitats randomly, implying t...

journal_title：Scientific reports

authors： Mougi A

更新日期：2019-09-02 00:00:00

abstract：:Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structu...

journal_title：Scientific reports

authors： He X,Lin M,Sha B,Feng S,Shi X,Qu Z,Xu F

更新日期：2015-08-03 00:00:00

abstract：:The spreading of invasive species in new continents can vary from slow and limited diffusion to fast colonisations over vast new areas. We studied the sacred ibis Threskiornis aethiopicus along a 31-year period, from 1989 to 2019, with particular attention to the first area of release in NW Italy. We collected data on...

journal_title：Scientific reports

authors： Cucco M,Alessandria G,Bissacco M,Carpegna F,Fasola M,Gagliardi A,Gola L,Volponi S,Pellegrino I

更新日期：2021-01-08 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. T...

journal_title：Scientific reports

authors： Carvajal S,Perramón M,Oró D,Casals E,Fernández-Varo G,Casals G,Parra M,González de la Presa B,Ribera J,Pastor Ó,Morales-Ruíz M,Puntes V,Jiménez W

更新日期：2019-09-06 00:00:00

abstract：:The present work aimed to find out the effect of different levels of hydrolysable tannin (HT) on serum hormonal profile, biochemical indices, lipid profile, apparent digestibility of nutrients and body weight gain in healthy female rats. Forty five adult healthy female rats of 8 weeks old were randomly divided into fi...

journal_title：Scientific reports

authors： Manzoor F,Nisa MU,Hussain HA,Ahmad N,Umbreen H

更新日期：2020-11-26 00:00:00

abstract：:Interaction between polycyclic aromatic hydrocarbon (PAH) molecule and energetic ion is a subject of interest in different areas of modern physics. Here, we present measurements of energy and angular distributions of absolute double differential electron emission cross section for coronene (C24H12) and fluorene (C13H1...

journal_title：Scientific reports

authors： Biswas S,Champion C,Weck PF,Tribedi LC

更新日期：2017-07-17 00:00:00

abstract：:LiYF4:Eu nanophosphors with a single tetragonal phase are synthesized, and various strategies to enhance the Eu(3+) emission from the nanophosphors are investigated. The optimized Eu(3+) concentration is 35 mol%, and the red emission peaks due to the (5)D0 →(7)FJ (J = 1 and 2) transitions of Eu(3+) ions are further en...

journal_title：Scientific reports

authors： Kim SY,Won YH,Jang HS

更新日期：2015-01-19 00:00:00

abstract：:We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseas...

journal_title：Scientific reports

authors： Perenc L,Guzik A,Podgórska-Bednarz J,Drużbicki M

更新日期：2019-11-11 00:00:00

abstract：:Elevated prostaglandin E2 (PGE2) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogen...

journal_title：Scientific reports

authors： Monteleone NJ,Moore AE,Iacona JR,Lutz CS,Dixon DA

更新日期：2019-04-01 00:00:00

abstract：:A highly sensitive bismuth/silver nanoparticles/Nafion-modified screen-printed graphene electrode was fabricated and was utilized for the detection of trace lead (Pb) concentrations in river water samples prior to and after remediation using calamansi (Citrofortunella Microcarpa) rinds in different forms viz., ground ...

journal_title：Scientific reports

authors： Palisoc ST,Vitto RIM,Noel MG,Palisoc KT,Natividad MT

更新日期：2021-01-14 00:00:00

abstract：:Oxygen tolerance of selenium-containing [NiFeSe] hydrogenases (Hases) is attributable to the high reducing power of the selenocysteine residue, which sustains the bimetallic Ni-Fe catalytic center in the large subunit. Genes encoding [NiFeSe] Hases are inherited by few sulphate-reducing δ-proteobacteria globally distr...

journal_title：Scientific reports

authors： Tamura T,Tsunekawa N,Nemoto M,Inagaki K,Hirano T,Sato F

更新日期：2016-01-28 00:00:00

abstract：:Nanoscale wavelength-converted optical components are promising components for communication and optical information processing in integrated photonic system. In this work, we report a facile strategy for realizing continuously tunable wavelength-converted wave-guiding in dye-doped nanofibers. The nanofibers with diam...

journal_title：Scientific reports

authors： Yu H,Li B

更新日期：2013-01-01 00:00:00

abstract：:The current assessment of corneal vascularisation (CV) relies on slit-lamp examination, which may be subjective. Dye-based angiographies, like indocyanine green angiography (ICGA), allows for good visualisation of anterior segment blood vessels. However, ICGA is invasive and can be associated with systemic adverse eff...

journal_title：Scientific reports

authors： Ong HS,Tey KY,Ke M,Tan B,Chua J,Schmetterer L,Mehta JS,Ang M

更新日期：2021-01-13 00:00:00

abstract：:Adipocytes play a central role in maintaining metabolic homeostasis in the body. Differentiation of adipocyte precursor cells requires the transcriptional activity of peroxisome proliferator-activated receptor-γ (Pparγ) and CCAAT/enhancer binding proteins (C/Ebps). Transcriptional activity is regulated by signaling mo...

journal_title：Scientific reports

authors： Cai K,El-Merahbi R,Loeffler M,Mayer AE,Sumara G

更新日期：2017-08-03 00:00:00

abstract：:Our understanding of innate immune responses in human rectal mucosal tissues (RM) and their contributions to promoting or restricting HIV transmission is limited. We defined the RM composition of innate and innate-like cell subsets, including plasmacytoid dendritic cells; CD1c + myeloid DCs; neutrophils; macrophages; ...

journal_title：Scientific reports

authors： Smith SA,Murray PM,Amancha PK,Ackerley CG,Hu YJ,Amara RR,Kelley CF

更新日期：2020-11-19 00:00:00

abstract：:Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in response to arenavirus infection during cholestasis using bile duct ligation (BDL). We monitored T cell responses,...

journal_title：Scientific reports

authors： Lang E,Pozdeev VI,Shinde PV,Xu HC,Sundaram B,Zhuang Y,Poschmann G,Huang J,Stühler K,Pandyra AA,Keitel V,Häussinger D,Lang KS,Lang PA

更新日期：2018-08-15 00:00:00

abstract：:It is urgent to find an optimised therapy regimen for the control of MDR-TB globally. This study aimed to evaluate the efficiacy and safety of a combined regimen of rhIL-2 injection and standard chemotherapy within 18-month duration in a randomized controlled trial conducted in 14 centres in eastern China. From Jan. 2...

journal_title：Scientific reports

authors： Tan Q,Min R,Dai GQ,Wang YL,Nan L,Yang Z,Xia J,Pan SY,Mao H,Xie WP,Wang H

更新日期：2017-12-19 00:00:00