Abstract：
:Adipocytes play a central role in maintaining metabolic homeostasis in the body. Differentiation of adipocyte precursor cells requires the transcriptional activity of peroxisome proliferator-activated receptor-γ (Pparγ) and CCAAT/enhancer binding proteins (C/Ebps). Transcriptional activity is regulated by signaling modules activated by a plethora of hormones and nutrients. Mechanistic target of rapamacin complexes (mTORC) 1 and 2 are central for the coordination of hormonal and nutritional inputs in cells and are essential for adipogenesis. Serum glucocorticoid kinase 1 (Sgk1)-dependent phosphorylation of N-Myc downstream-regulated gene 1 (Ndrg1) is a hallmark of mTORC2 activation in cells. Moreover, Pparγ activation promotes Ndrg1 expression. However, the impact of Ndrg1 on adipocyte differentiation and function has not yet been defined. Here, we show that Ndrg1 expression and its Sgk1-dependent phosphorylation are induced during adipogenesis. Consistently, we demonstrate that Ndrg1 promotes adipocyte differentiation and function by inducing Pparγ expression. Additionally, our results indicate that Ndrg1 is required for C/Ebpα phosphorylation. Moreover, we found that Ndrg1 phosphorylation by Sgk1 promotes adipocyte formation. Taken together, we show that induction of Ndrg1 expression by Pparγ and its phosphorylation by Sgk1 kinase are required for the acquisition of adipocyte characteristics by precursor cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Cai K,El-Merahbi R,Loeffler M,Mayer AE,Sumara Gdoi
10.1038/s41598-017-07497-xsubject
Has Abstractpub_date
2017-08-03 00:00:00pages
7191issue
1issn
2045-2322pii
10.1038/s41598-017-07497-xjournal_volume
7pub_type
杂志文章abstract：:Myopia is the commonest eye disorder in the world. High myopes are predisposed to ocular pathologies. The vasoactive intestinal peptide receptor 2 (VIPR2) gene was identified as a myopia susceptibility locus by our group and another group. We continued to fine-map this locus. A case-control study was performed in 4 se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54619-8
更新日期：2019-12-03 00:00:00
abstract：:Multidomain proteins account for 70% of the eukaryotic proteome. In genetic disease, multidomain proteins are often affected by numerous mutations, but the effects of these mutations on protein stability and their roles in genetic disease are not well understood. Here, we analyzed protein globular domains to understan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39905-9
更新日期：2019-03-06 00:00:00
abstract：:We performed two phase I trials of the histone deacetylase inhibitor vorinostat combined with either the vascular endothelial growth factor inhibitor pazopanib (NCT01339871) or the proteasome inhibitor ixazomib (NCT02042989) in patients with metastatic TP53 mutant solid tumors. Both trials followed a 3 + 3 dose-escala...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58366-z
更新日期：2020-02-20 00:00:00
abstract：:We have investigated the valley Chern number and gapless edge states in wide-gap semiconductor SiC and BN monolayers by using the density functional theory calculations. We found that while SiC monolayer has a non-quantized valley Chern number due to a partial mixing of the Berry curvature peaks pertaining to the oppo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61906-2
更新日期：2020-03-19 00:00:00
abstract：:Juvenile hormone (JH) plays crucial roles in many aspects of the insect life. All the JH actions are initiated by transport of JH in the hemolymph as a complex with JH-binding protein (JHBP) to target tissues. Here, we report structural mechanism of JH delivery by JHBP based upon the crystal and solution structures of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00133
更新日期：2011-01-01 00:00:00
abstract：:We have investigated the rotating magnetocaloric effect (R-MCE) of TmB4 - an anisotropic magnetic system with geometrical frustration of Shastry-Sutherland type. The R-MCE was obtained from detailed temperature dependencies of heat capacity in various magnetic fields of a single crystalline sample for crystal axes ori...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29399-2
更新日期：2018-07-19 00:00:00
abstract：:Fire-induced permafrost degradation is well documented in boreal forests, but the role of fires in initiating thermokarst development in Arctic tundra is less well understood. Here we show that Arctic tundra fires may induce widespread thaw subsidence of permafrost terrain in the first seven years following the distur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15865
更新日期：2015-10-29 00:00:00
abstract：:Here we present the first report of a carbon-γ-Fe₂O₃ nanoparticle composite of mesoporous carbon, bearing COOH- and phenolic OH- functional groups on its surface, a remarkable and magnetically separable adsorbent, for the radioactive material emitted by the Fukushima Daiichi nuclear power plant accident. Contaminated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06053
更新日期：2014-08-13 00:00:00
abstract：:The pearl oyster is one of the rare animal models that support two distinct genomes, through the surgical graft process operated for culture pearl production. This grafted organism is assimilated to a chimera whose physiological functioning remains poorly known. The question of the energy expenditure comparison betwee...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25360-5
更新日期：2018-05-14 00:00:00
abstract：:Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5'-phosphatase SHIP1 are central posit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33769-1
更新日期：2018-10-19 00:00:00
abstract：:In this paper, a multi-band metal-insulator-metal (MIM) perfect absorber with refractive index sensing capability has been investigated in near-infrared region. The proposed structure has been studied for biomedical applications such as detection of solution of glucose in water, diagnosis of different stages of malari...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63459-w
更新日期：2020-04-14 00:00:00
abstract：:Although giant proximity effect (GPE) can shed important information on understanding superconducting pairing mechanisms and superconducting electronics, reports on the GPE are few because the fabrication of the junctions with GPE is technologically difficult. Here, we report a GPE in the single-crystalline MgB2 bilay...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40263-9
更新日期：2019-03-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-69600-z
更新日期：2020-07-22 00:00:00
abstract：:Amyloids are cross-β-sheet fibrillar aggregates, associated with various human diseases and native functions such as protein/peptide hormone storage inside secretory granules of neuroendocrine cells. In the current study, using amyloid detecting agents, we show that growth hormone (GH) could be stored as amyloid in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23370
更新日期：2016-03-23 00:00:00
abstract：:During anaerobic digestion (AD) process, process parameters e.g., VFA, pH, COD removal … and kinetic parameters e.g., hydrolysis rate, lag phase and methane production potential… are the important indicator for illustrating AD process performance, however, the AD process performance based on these parameters remains p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09977-6
更新日期：2017-08-24 00:00:00
abstract：:In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47077-9
更新日期：2019-07-24 00:00:00
abstract：:Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have been discovered so far. In particular it is well established that neurons can emit photons, which prompts the question whether these biophoto...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36508
更新日期：2016-11-07 00:00:00
abstract：:Plant litter is an important component in wetland ecosystems, and the role of plant litter decomposition is considered to be important for wetland ecosystem functions and services. However, the consequences of litter inputs have seldom been experimentally tested in real ecosystems such as constructed wetlands (CWs). T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50161-9
更新日期：2019-09-25 00:00:00
abstract：:Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular carcinoma. We examined...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19658-7
更新日期：2018-02-05 00:00:00
abstract：:Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43756-9
更新日期：2019-05-13 00:00:00
abstract：:Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associated neurocognitive disorders. HIV-1 Tat protein increases synaptic dopamine (DA) levels by directly inhibiting DA transporter (DAT) activity, ultimately leading to dopaminergic neuron damage. Through integrated computational m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39048
更新日期：2016-12-14 00:00:00
abstract：:In the dominant livestock systems of Sahelian countries herds have to move across territories. Their mobility is often a source of conflict with farmers in the areas crossed, and helps spread diseases such as Rift Valley Fever. Knowledge of the routes followed by herds is therefore core to guiding the implementation o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65132-8
更新日期：2020-05-20 00:00:00
abstract：:For historic individuals, the outward appearance and other phenotypic characteristics remain often non-resolved. Unfortunately, images or detailed written sources are only scarcely available in many cases. Attempts to study historic individuals with genetic data so far focused on hypervariable regions of mitochondrial...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20180-z
更新日期：2018-02-01 00:00:00
abstract：:The proinflammatory cytokine Interleukin 17A (hereafter named IL-17A) or IL-17A producing cells are elevated in breast tumors environment and correlate with poor prognosis. Increased IL-17A is associated with ER(-) or triple negative tumors and reduced Disease Free Survival. However, the pathophysiological role of IL-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03456
更新日期：2013-12-09 00:00:00
abstract：:Intrahepatic cholestasis induced by drug toxicity, bile salt export pump (BSEP) deficiency, or pregnancy frequently causes cholestatic liver damage, which ultimately may lead to liver fibrosis and cirrhosis. Here, the preventive and therapeutic effects of peroxisome proliferator-activated receptor α (PPARα) signaling ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10524-6
更新日期：2017-08-30 00:00:00
abstract：:Hydrophilic polymers have garnered much attention due to their critical roles in various applications such as molecular separation membranes, bio-interfaces, and surface engineering. However, a long-standing problem is that their mechanical properties usually deteriorate at high relative humidity (RH). Through the sim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07782
更新日期：2015-01-14 00:00:00
abstract：:Mast Cells (MCs) are one of the first immune cells encountered by invading pathogens. Their presence in large numbers in the superficial dermis, where Leishmania is encountered, suggests that they may play a critical role in immune responses to Leishmania. In this study the interactions of Leishmania donovani, the cau...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12753-1
更新日期：2017-10-16 00:00:00
abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11713-z
更新日期：2017-09-12 00:00:00
abstract：:The oral microflora is composed of both health-promoting as well as disease-initiating bacteria. Many of the disease-initiating bacteria are anaerobic and include organisms such as Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Tannerella forsythia. Here we investigated a novel therapeut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09616-0
更新日期：2017-09-05 00:00:00
abstract：:The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases. The release of EVs by Trypanosoma cruzi, the causative agent of Chagas disease, has recently been described, with different protein cargoes including the MA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44451
更新日期：2017-03-15 00:00:00
