Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

abstract：:We have systematically investigated the influence of oxygen vacancy defects on the structural, electronic and magnetic properties of La(1-x)Sr(x)MnO3 (x = 1/3) film by means of ab initio calculations using bare GGA as well as GGA+U formalism, in the latter of which, the on-site Coulombic repulsion parameter U for Mn 3...

journal_title：Scientific reports

authors： Li J

更新日期：2016-03-01 00:00:00

abstract：:Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...

journal_title：Scientific reports

authors： Xue H,Jiang Y,Yuan K,Yang T,Hou J,Cao C,Feng K,Wang X

更新日期：2016-07-19 00:00:00

abstract：:Equine athletes have a pattern of exercise which is analogous to human athletes and the cardiovascular risks in both species are similar. Both species have a propensity for atrial fibrillation (AF), which is challenging to detect by ECG analysis when in paroxysmal form. We hypothesised that the proarrhythmic backgroun...

journal_title：Scientific reports

authors： Alexeenko V,Fraser JA,Bowen M,Huang CL,Marr CM,Jeevaratnam K

更新日期：2020-04-22 00:00:00

abstract：:Understanding and manipulating the dynamic properties of the magnetic vortices stabilized in patterned ferromagnetic structures are of great interest owing to the superior resonant features with the high thermal stability and their flexible tunability. So far, numerous methods for investigating the dynamic properties ...

journal_title：Scientific reports

authors： Cui X,Hu S,Hidegara M,Yakata S,Kimura T

更新日期：2015-12-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： An T,Fan T,Zhang XQ,Liu YF,Huang J,Liang C,Lv BH,Wang YQ,Zhao XG,Liu JX,Fu YH,Jiang GJ

更新日期：2020-04-22 00:00:00

abstract：:We report a multi-channel optical frequency synthesizer developed to generate extremely stable continuous-wave lasers directly out of the optical comb of an Er-doped fiber oscillator. Being stabilized to a high-finesse cavity with a fractional frequency stability of 3.8 × 10-15 at 0.1 s, the comb-rooted synthesizer pr...

journal_title：Scientific reports

authors： Jang H,Kim BS,Chun BJ,Kang HJ,Jang YS,Kim YW,Kim YJ,Kim SW

更新日期：2019-05-21 00:00:00

abstract：:We performed two phase I trials of the histone deacetylase inhibitor vorinostat combined with either the vascular endothelial growth factor inhibitor pazopanib (NCT01339871) or the proteasome inhibitor ixazomib (NCT02042989) in patients with metastatic TP53 mutant solid tumors. Both trials followed a 3 + 3 dose-escala...

journal_title：Scientific reports

authors： Wang Y,Janku F,Piha-Paul S,Hess K,Broaddus R,Liu L,Shi N,Overman M,Kopetz S,Subbiah V,Naing A,Hong D,Tsimberidou AM,Karp D,Yao J,Fu S

更新日期：2020-02-20 00:00:00

abstract：:Control of pathogens arising from humans, livestock and wild animals can be enhanced by genome-based investigation. Phylogenetically classifying and optimal construction of these genomes using short sequence reads are key to this process. We examined the mammal-infecting unicellular parasite Leishmania adleri belongin...

journal_title：Scientific reports

authors： Coughlan S,Mulhair P,Sanders M,Schonian G,Cotton JA,Downing T

更新日期：2017-03-03 00:00:00

abstract：:The 14-3-3-related protein SMG7 plays critical roles in regulation of DNA damage response and nonsense-mediated mRNA decay (NMD). Like 14-3-3, SMG7 engages phosphoserine-dependent protein interactions; however, the precise role of phosphorylation-mediated SMG7 binding remains unknown. Here, we show that DNA damage-ind...

journal_title：Scientific reports

authors： Cowen LE,Luo H,Tang Y

更新日期：2019-09-11 00:00:00

abstract：:Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...

journal_title：Scientific reports

authors： Jessel HR,Chen S,Osovski S,Efroni S,Rittel D,Bachelet I

更新日期：2019-03-18 00:00:00

abstract：:Hesperiidae is one of the largest families of butterflies. Our knowledge of the higher systematics on hesperiids from China is still very limited. We infer the phylogenetic relationships of the subfamilies of Chinese skippers based on three mitochondrial genes (cytochrome b (Cytb), the NADH dehydrogenase subunit 1 (ND...

journal_title：Scientific reports

authors： Yuan X,Gao K,Yuan F,Wang P,Zhang Y

更新日期：2015-06-10 00:00:00

abstract：:The accurate diagnosis of malignant cervical lymphadenopathy remains challenging. In this study, we determined the value of quantitative parameters derived from dual-energy computed tomography (DECT) for differentiating malignant cervical lymphadenopathy caused by thyroid carcinoma (TC), salivary gland carcinoma (SC),...

journal_title：Scientific reports

authors： Yang L,Luo D,Li L,Zhao Y,Lin M,Guo W,Zhou C

更新日期：2016-08-08 00:00:00

abstract：:The classical view of nerve growth factor (NGF) action in the nervous system is linked to its retrograde axonal transport. However, almost nothing is known on the trafficking properties of its unprocessed precursor proNGF, characterized by different and generally opposite biological functions with respect to its matur...

journal_title：Scientific reports

authors： De Nadai T,Marchetti L,Di Rienzo C,Calvello M,Signore G,Di Matteo P,Gobbo F,Turturro S,Meucci S,Viegi A,Beltram F,Luin S,Cattaneo A

更新日期：2016-02-01 00:00:00

abstract：:In this article, we describe the electro-hydrodynamics of non-Newtonian fluid in narrow fluidic channel with solvent permeable and ion-penetrable polyelectrolyte layer (PEL) grafted on channel surface with an interaction of non-overlapping electric double layer (EDL) phenomenon. In this analysis, we integrate power-la...

journal_title：Scientific reports

authors： Gaikwad HS,Mondal PK,Wongwises S

更新日期：2018-05-18 00:00:00

abstract：:Fully elucidating the molecular mechanisms of non-coding RNAs (ncRNAs), including micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), underlying hepatocarcinogenesis is challenging. We characterized the expression profiles of ncRNAs and constructed a regulatory mRNA-lncRNA-miRNA (MLMI) network based on transcripto...

journal_title：Scientific reports

authors： Tang X,Feng D,Li M,Zhou J,Li X,Zhao D,Hao B,Li D,Ding K

更新日期：2019-11-06 00:00:00

abstract：:Ebola virus disease (EVD) is a contagious, severe and often lethal form of hemorrhagic fever in humans. The association of EVD outbreaks with forest clearance has been suggested previously but many aspects remained uncharacterized. We used remote sensing techniques to investigate the association between deforestation ...

journal_title：Scientific reports

authors： Olivero J,Fa JE,Real R,Márquez AL,Farfán MA,Vargas JM,Gaveau D,Salim MA,Park D,Suter J,King S,Leendertz SA,Sheil D,Nasi R

更新日期：2017-10-30 00:00:00

abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...

journal_title：Scientific reports

authors： Law BY,Chan WK,Xu SW,Wang JR,Bai LP,Liu L,Wong VK

更新日期：2014-07-01 00:00:00

abstract：:Dibutyl phthalate (DBP) is recognized as an environmental endocrine disruptor that has been detected in fetal and postnatal samples. Recent evidence found that in utero DBP exposure was associated with an increase of adipose tissue weight and serum lipids in offspring, but the precise mechanism is unknown. Here we aim...

journal_title：Scientific reports

authors： Li H,Li J,Qu Z,Qian H,Zhang J,Wang H,Xu X,Liu S

更新日期：2020-10-01 00:00:00

abstract：:This article aims to develop a generalized model calculation model to be applicable to the general theory of interaction potentials with reference to the stoichiometric elpasolite type crystals. In this study, we have chosen to report both a theoretical model and a calculation strategy to undertake semi empirical calc...

journal_title：Scientific reports

authors： Soto A,Shajahan S,Acevedo R

更新日期：2019-12-13 00:00:00

abstract：:Carbonic anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in vertebrates. While several carbonic anhydrase isoforms have been identified in numerous vertebrate species, basal lineages such as the cyclostomes have remained largely unexamined. Here we investigate the repe...

journal_title：Scientific reports

authors： Ferreira-Martins D,McCormick SD,Campos A,Lopes-Marques M,Osório H,Coimbra J,Castro LF,Wilson JM

更新日期：2016-10-05 00:00:00

abstract：:Accurately segmenting foods from optical images is a challenging task, yet becoming possible with the help of recent advances in Deep Learning based solutions. Automated identification of food items opens up possibilities of useful applications like nutrition intake monitoring. Given large variations in food choices, ...

journal_title：Scientific reports

authors： Siemon MSN,Shihavuddin ASM,Ravn-Haren G

更新日期：2021-01-12 00:00:00

abstract：:As an important method for building blocks synthesis, whole cell biocatalysis is hindered by some shortcomings such as unpredictability of reactions, utilization of opportunistic pathogen, and side reactions. Due to its biological and extensively studied genetic background, Pseudomonas putida KT2440 is viewed as a pro...

journal_title：Scientific reports

authors： Wang Y,Lv M,Zhang Y,Xiao X,Jiang T,Zhang W,Hu C,Gao C,Ma C,Xu P

更新日期：2014-11-06 00:00:00

abstract：:Ischemia-reperfusion (I/R) injury model has been widely applied to the study of microcirculation disturbance. In this work, we used laser oblique scanning optical microscopy (LOSOM) to observe the microcirculation system in the mesentery of rat model. Utilizing a localized point-scanning detection scheme, high-contras...

journal_title：Scientific reports

authors： Ding Y,Zhang Y,Peng T,Lu Y,Jin D,Ren Q,Liu Y,Han J,Xi P

更新日期：2013-01-01 00:00:00

abstract：:The design and fabrication of intricate hollow architectures as cost-effective and dual-function electrocatalyst for water and urea electrolysis is of vital importance to the energy and environment issues. Herein, a facile solvothermal strategy for construction of Prussian-blue analogue (PBA) hollow cages with an open...

journal_title：Scientific reports

authors： Feng Y,Wang X,Dong P,Li J,Feng L,Huang J,Cao L,Feng L,Kajiyoshi K,Wang C

更新日期：2019-11-04 00:00:00

abstract：:This study investigates the association between an index of mesozooplankton biomass, derived from the Continuous Plankton Recorder survey and satellite-derived productivity fronts in the North Atlantic. While chlorophyll-a content (CHL) is commonly described as a proxy for phytoplankton biomass, the size of productivi...

journal_title：Scientific reports

authors： Druon JN,Hélaouët P,Beaugrand G,Fromentin JM,Palialexis A,Hoepffner N

更新日期：2019-03-18 00:00:00

abstract：:Contest behaviour, and in particular the propensity to attack an unfamiliar conspecific, is influenced by an individual's aggressiveness, as well as by experience of winning and losing (so called 'winner-loser effects'). Individuals vary in aggressiveness and susceptibility to winner-loser effects but the relationship...

journal_title：Scientific reports

authors： Oldham L,Camerlink I,Arnott G,Doeschl-Wilson A,Farish M,Turner SP

更新日期：2020-08-07 00:00:00

abstract：:Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...

journal_title：Scientific reports

authors： Huang K,Li YF,Li DZ,Chen LM,Tao MZ,Ma Y,Zhao JR,Li MH,Chen M,Mirzaie M,Hafz N,Sokollik T,Sheng ZM,Zhang J

更新日期：2016-06-08 00:00:00

abstract：:Interleukin-36 (IL-36) represents three cytokines, IL-36α, IL-36β and IL-36γ, which bind to the same receptor, IL-1RL2; however, their physiological function(s) remain poorly understood. Here, the role of IL-36 in immunity against HSV-1 was examined using the flank skin infection mouse model. Expression analyses revea...

journal_title：Scientific reports

authors： Milora KA,Uppalapati SR,Sanmiguel JC,Zou W,Jensen LE

更新日期：2017-07-19 00:00:00

abstract：:The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

journal_title：Scientific reports

authors： Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

更新日期：2016-07-05 00:00:00

abstract：:Fibrosis with excessive amounts of type I collagen is a hallmark of many solid tumours, and fibrosis is a promising target in cancer therapy, but tools for its non-invasive quantification are missing. Here we used magnetic resonance imaging with a gadolinium-based probe targeted to type I collagen (EP-3533) to image a...

journal_title：Scientific reports

authors： Polasek M,Yang Y,Schühle DT,Yaseen MA,Kim YR,Sung YS,Guimaraes AR,Caravan P

更新日期：2017-08-14 00:00:00