Clinical and Immunological Effects of rhIL-2 Therapy in Eastern Chinese Patients with Multidrug-resistant Tuberculosis.

abstract：:The raccoon dog (Nyctereutes procyonoides) is an important canid fur-bearing animal species worldwide. Chinese raccoon dogs that present a white mutation, especially those with a white coat. Exploring melanin biosynthesis in the hair and skin of raccoon dogs is important for understanding the survival and evolutionary...

journal_title：Scientific reports

authors： Du Z,Huang K,Zhao J,Song X,Xing X,Wu Q,Zhang L,Xu C

更新日期：2017-01-18 00:00:00

abstract：:There have been no large nationwide birth cohort studies examining for the effects of maternal alcohol use during pregnancy on placental abnormality. This study searched for associations between alcohol consumption and the placental abnormalities of placenta previa, placental abruption, and placenta accreta using the ...

journal_title：Scientific reports

authors： Ohira S,Motoki N,Shibazaki T,Misawa Y,Inaba Y,Kanai M,Kurita H,Shiozawa T,Nakazawa Y,Tsukahara T,Nomiyama T,Japan Environment & Children’s Study (JECS) Group.

更新日期：2019-07-16 00:00:00

abstract：:The physical mechanism of the anthropogenic triggering of large earthquakes on active faults is studied on the basis of experimental phenomenology, i.e., that earthquakes occur on active tectonic faults, that crustal stress values are those measured in situ and, on active faults, comply to the values of the stress dro...

journal_title：Scientific reports

authors： Mulargia F,Bizzarri A

更新日期：2014-08-26 00:00:00

abstract：:Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...

journal_title：Scientific reports

authors： Cecchetto C,Rumiati RI,Aiello M

更新日期：2017-10-26 00:00:00

abstract：:Muscle specific receptor tyrosine kinase (MuSK) is an essential postsynaptic transmembrane molecule that mediates clustering of acetylcholine receptors (AChR). MUSK exon 10 is alternatively skipped in human, but not in mouse. Skipping of this exon disrupts a cysteine-rich region (Fz-CRD), which is essential for Wnt-me...

journal_title：Scientific reports

authors： Nasrin F,Rahman MA,Masuda A,Ohe K,Takeda J,Ohno K

更新日期：2014-10-30 00:00:00

abstract：:There is a growing need for low-cost, portable technologies for the detection of threats to the environment and human health. Here we propose a label-free, optical whole-cell Escherichia coli biosensor for the detection of 3-phenoxybenzoic acid (3-PBA), a biomarker for monitoring human exposure to synthetic pyrethroid...

journal_title：Scientific reports

authors： Riangrungroj P,Bever CS,Hammock BD,Polizzi KM

更新日期：2019-08-28 00:00:00

abstract：:Endovascular methods have been increasingly applied in treating cervicocranial artery dissection (CCAD). Anti-thrombotic therapy, which is used in non-interventional care of CCAD patients, has differential effects in East Asian patients. Therefore, we aimed to compare the clinical outcomes of endovascular versus non-i...

journal_title：Scientific reports

authors： Huang R,Niu L,Wang Y,Jia G,Jia L,Wang Y,Jiang W,Sun Y,Yu L

更新日期：2015-05-20 00:00:00

abstract：:Multiple approaches utilizing viral and DNA vectors have shown promise in the development of an effective vaccine against HIV. In this study, an alternative replication-defective flavivirus vector, RepliVax (RV), was evaluated for the delivery of HIV-1 immunogens. Recombinant RV-HIV viruses were engineered to stably e...

journal_title：Scientific reports

authors： Giel-Moloney M,Esteban M,Oakes BH,Vaine M,Asbach B,Wagner R,Mize GJ,Spies AG,McElrath J,Perreau M,Roger T,Ives A,Calandra T,Weiss D,Perdiguero B,Kibler KV,Jacobs B,Ding S,Tomaras GD,Montefiori DC,Ferrari G,Yates

更新日期：2019-12-27 00:00:00

abstract：:Urinary tract infections (UTIs) are the third most common types of infection in human medicine worldwide. There is increasing appreciation for the pathogenic role of Gram-positive cocci (GPC) in UTIs, as they have a plethora of virulence factors, maintaining their pathogenicity and high affinity for the epithelial cel...

journal_title：Scientific reports

authors： Gajdács M,Ábrók M,Lázár A,Burián K

更新日期：2020-10-19 00:00:00

abstract：:The Late Pleistocene Campanian Ignimbrite (CI) super-eruption (Southern Italy) is the largest known volcanic event in the Mediterranean area. The CI tephra is widely dispersed through western Eurasia and occurs in close stratigraphic association with significant palaeoclimatic and Palaeolithic cultural events. Here we...

journal_title：Scientific reports

authors： Giaccio B,Hajdas I,Isaia R,Deino A,Nomade S

更新日期：2017-04-06 00:00:00

abstract：:In typical numerical simulations, the space-charge force is calculated by slicing a beam into many longitudinal segments and by solving the two-dimensional Poisson equation in each segment. This method neglects longitudinal leakage of the space-charge force to nearby segments owing to its longitudinal spread over 1/γ....

journal_title：Scientific reports

authors： Shobuda Y,Chin YH

更新日期：2018-08-24 00:00:00

abstract：:There is widespread transcriptional dysregulation in Huntington's disease (HD) brain, but analysis is inevitably limited by advanced disease and postmortem changes. However, mutant HTT is ubiquitously expressed and acts systemically, meaning blood, which is readily available and contains cells that are dysfunctional i...

journal_title：Scientific reports

authors： Hensman Moss DJ,Flower MD,Lo KK,Miller JR,van Ommen GB,'t Hoen PA,Stone TC,Guinee A,Langbehn DR,Jones L,Plagnol V,van Roon-Mom WM,Holmans P,Tabrizi SJ

更新日期：2017-03-21 00:00:00

abstract：:Optical thermometry has been widely studied to achieve an inaccessible temperature measurement in submicron scale and it has been reported that the temperature sensitivity depends mainly on host types. In this work, we propose a new method to improve the optical temperature sensitivity of Yb3+-Er3+ co-doped CaWO4 phos...

journal_title：Scientific reports

authors： Wang X,Wang Y,Bu Y,Yan X,Wang J,Cai P,Vu T,Seo HJ

更新日期：2017-02-27 00:00:00

abstract：:Circadian disruption resulting from exposure to irregular light-dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer's disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to in...

journal_title：Scientific reports

authors： Nagare R,Possidente B,Lagalwar S,Figueiro MG

更新日期：2020-07-10 00:00:00

abstract：:A topical medication combining calcipotriol (Cal) and betamethasone dipropionate (BDP) has proven effective in a number of randomized controlled trials performed in patients with psoriasis, but its mechanism of action has not been fully elucidated. We investigated whether the combination of Cal and BDP (Cal/BDP) in th...

journal_title：Scientific reports

authors： Satake K,Amano T,Okamoto T

更新日期：2019-11-08 00:00:00

abstract：:CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions. In this study we examined the role of...

journal_title：Scientific reports

authors： Alisson-Silva F,Mantuano NR,Lopes AL,Vasconcelos-Dos-Santos A,Vale AM,Costa MM,Cannon JL,Oliveira AC,Todeschini AR

更新日期：2019-06-13 00:00:00

abstract：:Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine en...

journal_title：Scientific reports

authors： Salker MS,Singh Y,Zeng N,Chen H,Zhang S,Umbach AT,Fakhri H,Kohlhofer U,Quintanilla-Martinez L,Durairaj RRP,Barros FSV,Vrljicak P,Ott S,Brucker SY,Wallwiener D,Vrhovac Madunić I,Breljak D,Sabolić I,Koepsell H,Brosens

更新日期：2017-10-03 00:00:00

abstract：:Measuring toxicity is one of the main steps in drug development. Hence, there is a high demand for computational models to predict the toxicity effects of the potential drugs. In this study, we used a dataset, which consists of four toxicity effects:mutagenic, tumorigenic, irritant and reproductive effects. The propos...

journal_title：Scientific reports

authors： Tharwat A,Moemen YS,Hassanien AE

更新日期：2016-12-09 00:00:00

abstract：:Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most conventional alginate microencapsulation systems are associated with low mechanical stability and protrusion of cells which is associated with...

journal_title：Scientific reports

authors： Bhujbal SV,de Haan B,Niclou SP,de Vos P

更新日期：2014-10-31 00:00:00

abstract：:The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of the same clade, includ...

journal_title：Scientific reports

authors： Örd M,Faustova I,Loog M

更新日期：2020-10-09 00:00:00

abstract：:Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infan...

journal_title：Scientific reports

authors： Kim YH,Shin HJ,Sol IS,Kim SY,Kim JD,Yoon H,Kim KW,Kim MJ,Lee MJ,Sohn MH

更新日期：2017-11-09 00:00:00

abstract：:We evaluated the best methods for predicting various infarct core thresholds for endovascular treatment of ischemic stroke using parameters obtained by multiphase computed tomographic angiography (mCTA). Consecutive patients evaluated for endovascular treatment who concomitantly underwent mCTA and stroke magnetic reso...

journal_title：Scientific reports

authors： Lee SJ,Jung WS,Choi MH,Hong JM,Lee JS,Choi JW

更新日期：2019-10-23 00:00:00

abstract：:A major translational challenge in the fields of therapeutic angiogenesis and regenerative medicine is the need to create functional microvasculature. The purpose of this study was to assess whether a potentially autologous endothelial cell (EC) source derived from human induced pluripotent stem cells (iPSC-ECs) can f...

journal_title：Scientific reports

authors： Bezenah JR,Kong YP,Putnam AJ

更新日期：2018-02-08 00:00:00

abstract：:Islet transplantation is a novel promising strategy to cure type 1 diabetes. However, the long-term outcome is still poor, because both function and survival of the transplant decline over-time. Non-invasive imaging methods have the potential to enable monitoring of islet survival after transplantation and the effects...

journal_title：Scientific reports

authors： Eter WA,Bos D,Frielink C,Boerman OC,Brom M,Gotthardt M

更新日期：2015-10-22 00:00:00

abstract：:The chicken egg resists most environmental microbes suggesting that it potentially contains efficient antimicrobial molecules. Considering that some heparin-binding proteins in mammals are antibacterial, we investigated the presence and the antimicrobial activity of heparin-binding proteins from chicken egg white. Mas...

journal_title：Scientific reports

authors： Guyot N,Labas V,Harichaux G,Chessé M,Poirier JC,Nys Y,Réhault-Godbert S

更新日期：2016-06-13 00:00:00

abstract：:The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic calculations revea...

journal_title：Scientific reports

authors： Farkas SL,Marton S,Dandár E,Kugler R,Gál B,Jakab F,Bálint Á,Kecskeméti S,Bányai K

更新日期：2016-11-10 00:00:00

abstract：:The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antigen on cancer biology is unclear. We tested a potential role of HORMAD1...

journal_title：Scientific reports

authors： Gao Y,Kardos J,Yang Y,Tamir TY,Mutter-Rottmayer E,Weissman B,Major MB,Kim WY,Vaziri C

更新日期：2018-10-17 00:00:00

abstract：:In this article, we describe the electro-hydrodynamics of non-Newtonian fluid in narrow fluidic channel with solvent permeable and ion-penetrable polyelectrolyte layer (PEL) grafted on channel surface with an interaction of non-overlapping electric double layer (EDL) phenomenon. In this analysis, we integrate power-la...

journal_title：Scientific reports

authors： Gaikwad HS,Mondal PK,Wongwises S

更新日期：2018-05-18 00:00:00

abstract：:The oral environment affects not only oral health, but also general health, and the importance of oral self-care has recently been recognised. Although toothbrushes are the most important self-care product, there are few toothbrushes that have an inhibitory effect on oral bacteria. In the present study, monofilaments ...

journal_title：Scientific reports

authors： Matayoshi S,Nomura R,Kitamura T,Okawa R,Nakano K

更新日期：2021-01-08 00:00:00

abstract：:In this paper, we propose a strategy for the control of mobile chaotic oscillators by adaptively rewiring connections between nearby agents with local information. In contrast to the dominant adaptive control schemes where coupling strength is adjusted continuously according to the states of the oscillators, our metho...

journal_title：Scientific reports

authors： Zhou J,Zou Y,Guan S,Liu Z,Xiao G,Boccaletti S

更新日期：2017-11-22 00:00:00