Abstract：
:Elevated prostaglandin E2 (PGE2) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH, HPGD), in colonic tumors contributes to increased prostaglandin levels and poor patient survival. While loss of 15-PGDH can occur through transcriptional mechanisms, we demonstrate that 15-PGDH can be additionally regulated by a miRNA-mediated mechanism. We show that 15-PGDH and miR-21 are inversely correlated in CRC patients, with increased miR-21 levels associating with low 15-PGDH expression. 15-PGDH can be directly regulated by miR-21 through distinct sites in its 3' untranslated region (3'UTR), and miR-21 expression in CRC cells attenuates 15-PGDH and promotes increased PGE2 levels. Additionally, epithelial growth factor (EGF) signaling suppresses 15-PGDH expression while simultaneously enhancing miR-21 levels. miR-21 inhibition represses CRC cell proliferation, which is enhanced with EGF receptor (EGFR) inhibition. These findings present a novel regulatory mechanism of 15-PGDH by miR-21, and how dysregulated expression of miR-21 may contribute to loss of 15-PGDH expression and promote CRC progression via increased accumulation of PGE2.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Monteleone NJ,Moore AE,Iacona JR,Lutz CS,Dixon DAdoi
10.1038/s41598-019-41862-2subject
Has Abstractpub_date
2019-04-01 00:00:00pages
5405issue
1issn
2045-2322pii
10.1038/s41598-019-41862-2journal_volume
9pub_type
杂志文章abstract：:The current theories of antimalarial mechanism of artemisinin are inadequate to fully explain the observed effects. In our study, "organism-like" formation of Schistosoma hemozoin granules by attaching to and utilizing erythrocytes to form new ones was observed. This indicates that heme iron is transferred from erythr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34463
更新日期：2016-10-03 00:00:00
abstract：:We successfully realised plasmon-driven selective reduction reactions of 2-amino-5-nitrobenzenethiol (2A-5-NBT) to 3,3'-dimercapto-4,4'-diaminoazobenzene , an azobenzene derivative, using surface-enhanced Raman scattering (SERS) spectroscopy, and supported by the theoretical calculations. The SERS spectra demonstrated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10269
更新日期：2015-06-01 00:00:00
abstract：:The ratio of ω-6 to ω-3 polyunsaturated fatty acids (PUFAs) appears to be critical in the regulation of various pathophysiological processes and to maintain cellular homeostasis. While a high proportion of dietary intake of ω-6 PUFAs is associated with various inflammatory disorders, higher intake of ω-3 PUFAs is know...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31649
更新日期：2016-08-18 00:00:00
abstract：:Belgian Malinois (BM), one of the excellent military dog breeds in South Korea, is usually castrated before sexual maturation. Therefore, the transfer of their genetic features to the next generation is difficult. To overcome this, testicular cells from 4-month-old BMs were frozen. Testicular cells were thawed after 3...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21919
更新日期：2016-02-24 00:00:00
abstract：:The small intestine plays an essential role in the health and well-being of animals. Previous studies have shown that Lactobacillus has a protective effect on intestinal morphology, intestinal epithelium integrity and appropriate maturation of gut-associated tissues. Here, gene expression in jejunum tissue of weaned p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16158-y
更新日期：2017-11-17 00:00:00
abstract：:The global loss of biodiversity can be attributed to numerous threats. While pioneer studies have investigated their relative importance, the majority of those studies are restricted to specific geographic regions and/or taxonomic groups and only consider a small subset of threats, generally in isolation despite their...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24733-0
更新日期：2018-04-23 00:00:00
abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host. The virus is widely distributed throughout southeastern Europe, the Middle East, Africa, and Asia. Disease management has proven difficult and there are no bro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44210-6
更新日期：2019-05-23 00:00:00
abstract：:A Maxwell fisheye lens using parallel plate index grading is presented in this study to develop a passive retrodirective antenna array. As a proof-of-concept a design frequency of 10 GHz was selected for fabrication and experiment. The design principals of the lens are discussed, which enables 85% energy flow at the d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52779-1
更新日期：2019-11-07 00:00:00
abstract：:Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32833
更新日期：2016-10-07 00:00:00
abstract：:Conventional solid lubricants such as MoS2, graphite, or diamond-like carbon films demonstrate excellent tribological performance but only in specific environments due to their inherent materials properties. This limitation prohibits using these solid lubricants in environments that change dynamically. This study pres...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72666-4
更新日期：2020-09-21 00:00:00
abstract：:Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41262
更新日期：2017-02-01 00:00:00
abstract：:Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64094-1
更新日期：2020-04-30 00:00:00
abstract：:The plant hormone abscisic acid (ABA) and the jasmonic acid related-compound 12-oxo-phytodienoic acid (OPDA) play crucial roles in seed development, dormancy, and germination. However, a lack of suitable techniques for visualising plant hormones has restricted the investigation of their biological mechanisms. In the p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42977
更新日期：2017-02-17 00:00:00
abstract：:Exposure to light at night (LAN) is associated with insomnia in humans. Light provides the main input to the master clock in the hypothalamic suprachiasmatic nucleus (SCN) that coordinates the sleep-wake cycle. We aimed to develop a rodent model for the effects of LAN on sleep. Therefore, we exposed male Wistar rats t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35662
更新日期：2016-10-20 00:00:00
abstract：:The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42503
更新日期：2017-02-13 00:00:00
abstract：:Multifocal multiphoton microscopy (MMM) achieves fast imaging by simultaneously scanning multiple foci across different regions of specimen. The use of imaging detectors in MMM, such as CCD or CMOS, results in degradation of image signal-to-noise-ratio (SNR) due to the scattering of emitted photons. SNR can be partly ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05153
更新日期：2014-06-05 00:00:00
abstract：:Sense of body ownership and body representation are fundamental parts of human consciousness, but the contribution of the visual modality to their development remains unclear. We tested congenitally and late blind adults on a somatosensory version of the rubber hand illusion, and on the Aristotle illusion, in which si...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06622
更新日期：2014-10-23 00:00:00
abstract：:Primary human hepatocytes are necessary to evaluate cytotoxicity, drug metabolism, and drug-drug interactions for candidate compounds in early-phase drug discovery and development. However, these analyses are often hampered by limited resources and functional or genetic variation among lots. HepaRG human hepatocellula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03146-5
更新日期：2017-06-06 00:00:00
abstract：:Environmental cycles often influence the presence of animals, creating patterns at different temporal scales, which may mean that their effects overlap and/or interact. Interactions between diel and seasonal cycles have been reported to influence fish behaviour but little is known about such interactions in marine top...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38900-4
更新日期：2019-02-22 00:00:00
abstract：:We study propagation in a cyclic symmetric multicore fiber where the core radii randomly fluctuate along the propagation direction. We propose a hybrid analytic-numerical method to optimize the amplitude and frequency of the fluctuations that suppress power transfer between outer and inner cores. This framework allows...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51854-x
更新日期：2019-10-31 00:00:00
abstract：:Revisiting threat-related scenes elicits fear and activates a brain network related to cognitive-affective processing. Prior experience may contribute to the present fearful experience. We aimed to investigate (a) patterns of brain activation associated with individual differences in past fearful experiences (pFear) a...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-22805-9
更新日期：2018-03-23 00:00:00
abstract：:Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22792
更新日期：2016-03-10 00:00:00
abstract：:The performance and emission affected by piston catalytic coating have been analyzed in this study. The main contributing factors for improving performance such as load, fuel and speed have been preferred to reduce the emission and improve the performance of an IC engine. These specific standard parameters have been m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57129-9
更新日期：2020-02-07 00:00:00
abstract：:Rivers are an important aquatic conduit that connects terrestrial sources of dissolved inorganic carbon (DIC) and other elements with oceanic reservoirs. The Mekong River, one of the world's largest rivers, is firstly examined to explore inter-annual fluxes of dissolved and particulate constituents during 1923-2011 an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16005
更新日期：2015-11-02 00:00:00
abstract：:Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of signalling. Here we investigated the interactions of arrestin-1 with two functionally distinct forms of the dim-light photoreceptor rhodopsin. Using unbiased scanning mutagenesis we probed the individual contribution of each arrestin res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28686
更新日期：2016-06-28 00:00:00
abstract：:The initiation of polymorphic ventricular tachycardia in long QT syndrome type 2 (LQT2) has been associated with a characteristic ECG pattern of short-long RR intervals. We hypothesize that this characteristic pattern increases APD dispersion in LQT2, thereby promoting arrhythmia. We investigated APD dispersion and it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51230-9
更新日期：2019-10-16 00:00:00
abstract：:Deformable elastomeric spheres are evaluated experimentally as they skip multiple times over a lake surface. Some spheres are embedded with small inertial measurement units to measure the acceleration experienced during water surface impact. A model for multiple impact events shows good agreement between measured acce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42453-x
更新日期：2019-04-15 00:00:00
abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11792
更新日期：2015-07-07 00:00:00
abstract：:Infantile spasms (ISs) is a devastating form of an early infantile epileptic encephalopathy. The patterns of response of multiple regimens, and the difference in response rates for the cases who receive first-line therapies on time versus those who receive them after non-first-line therapies are unknown. We performed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68403-6
更新日期：2020-07-13 00:00:00
abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77801-9
更新日期：2020-11-26 00:00:00
