Urinary profiles of luteinizing hormone, estrogen and progestagen during the estrous and gestational periods in giant pandas (Ailuropda melanoleuca).

abstract：:Gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is an activatable fluorescent probe that can be activated by γ-glutamyltranspeptidase (GGT). The expression of GGT in the kidney, which is one of the major organs exhibiting enhanced GGT expression, is exclusively localised to the cortex. Here, we aimed to inves...

journal_title：Scientific reports

authors： Iyama T,Takata T,Yamada K,Mae Y,Taniguchi S,Ida A,Ogawa M,Yamamoto M,Hamada S,Fukuda S,Kanda T,Sugihara T,Isomoto H,Urano Y

更新日期：2020-07-21 00:00:00

abstract：:Early life overfeeding is associated with cognitive decline and anxiety-like behaviors in later life. It is not clear whether there are individual differences in the effects of early life overfeeding and what the underlying mechanistic pathways are. We investigated the long-lasting effects of small litter size, an exp...

journal_title：Scientific reports

authors： Salari AA,Samadi H,Homberg JR,Kosari-Nasab M

更新日期：2018-07-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Pedretti G,Milo V,Ambrogio S,Carboni R,Bianchi S,Calderoni A,Ramaswamy N,Spinelli AS,Ielmini D

更新日期：2018-06-18 00:00:00

abstract：:Plutella xylostella has become the major lepidopteran pest of Brassica owing to its strong ability of resistance development to a wide range of insecticides. Destruxin A, a mycotoxin of entomopathogenic fungus, Metarhizium anisopliae, has broad-spectrum insecticidal effects. However, the interaction mechanism of destr...

journal_title：Scientific reports

authors： Shakeel M,Xu X,Xu J,Zhu X,Li S,Zhou X,Yu J,Xu X,Hu Q,Yu X,Jin F

更新日期：2017-09-08 00:00:00

abstract：:Annually averaged solar radiation in the McMurdo Dry Valleys, Antarctica has varied by over 20 W m-2 during the past three decades; however, the drivers of this variability are unknown. Because small differences in radiation are important to water availability and ecosystem functioning in polar deserts, determining th...

journal_title：Scientific reports

authors： Obryk MK,Fountain AG,Doran PT,Lyons WB,Eastman R

更新日期：2018-03-22 00:00:00

abstract：:Coronin7 (CRN7) stabilizes F-actin and is a regulator of processes associated with the actin cytoskeleton. Its loss leads to defects in phagocytosis, motility and development. It harbors a CRIB (Cdc42- and Rac-interactive binding) domain in each of its WD repeat domains which bind to Rac GTPases preferably in their GD...

journal_title：Scientific reports

authors： Swaminathan K,Stumpf M,Müller R,Horn AC,Schmidbauer J,Eichinger L,Müller-Taubenberger A,Faix J,Noegel AA

更新日期：2015-09-28 00:00:00

abstract：:Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal stem cells (MSCs) can suppress immune rejection. To determine whether MSC co-transplantation can reduce immune rejection after allogeneic iPSC-CM transplantation, ...

journal_title：Scientific reports

authors： Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

更新日期：2020-03-12 00:00:00

abstract：:Polarization of macrophages is regulated through complex signaling networks. Correlating miRNA and mRNA expression over time after macrophage polarization has not yet been investigated. We used paired RNA-Seq and miRNA-Seq experiments to measure the mRNA and miRNA expression in bone marrow-derived macrophages over a t...

journal_title：Scientific reports

authors： Lu L,McCurdy S,Huang S,Zhu X,Peplowska K,Tiirikainen M,Boisvert WA,Garmire LX

更新日期：2016-12-16 00:00:00

abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

journal_title：Scientific reports

authors： Lin IF,Yamada T,Komine Y,Kato N,Kashino M

更新日期：2015-05-22 00:00:00

abstract：:Caffeine is a globally consumed psychostimulant but can be fatal to cells at overdose exposures. Although caspase-dependent apoptosis plays a role in caffeine-induced cell death, the responsible intracellular signalling cascade remains incompletely understood. The cellular slime mould, Dictyostelium discoideum, does n...

journal_title：Scientific reports

authors： Kuwayama H

更新日期：2012-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD regression in severely obese p...

journal_title：Scientific reports

authors： Chaim FDM,Pascoal LB,Chaim FHM,Palma BB,Damázio TA,da Costa LBE,Carvalho R,Cazzo E,Gestic MA,Utrini MP,Milanski M,Chaim EA,Leal RF

更新日期：2020-05-22 00:00:00

abstract：:Laser heating of gold nanospheres (GNS) is increasingly prevalent in biomedical applications due to tunable optical properties that determine heating efficiency. Although many geometric parameters (i.e. size, morphology) can affect optical properties of individual GNS and their heating, no specific studies of how GNS ...

journal_title：Scientific reports

authors： Wang Y,Gao Z,Han Z,Liu Y,Yang H,Akkin T,Hogan CJ,Bischof JC

更新日期：2021-01-13 00:00:00

abstract：:Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder, and the exact causal mechanism is unknown. Dysregulated allele-specific expression (ASE) has been identified in persons with ASD; however, a comprehensive analysis of ASE has not been conducted in a family quartet with ASD. To fill this ...

journal_title：Scientific reports

authors： Lin CY,Chang KW,Lin CY,Wu JY,Coon H,Huang PH,Ho HN,Akbarian S,Gau SS,Huang HS

更新日期：2018-03-09 00:00:00

abstract：:Food and beverage consumption has a great impact on the environment, although there is a lack of information concerning the whole diet. The environmental impact of 153 Italian adults (51 omnivores, 51 ovo-lacto-vegetarians, 51 vegans) and the inter-individual variability within dietary groups were assessed in a real-l...

journal_title：Scientific reports

authors： Rosi A,Mena P,Pellegrini N,Turroni S,Neviani E,Ferrocino I,Di Cagno R,Ruini L,Ciati R,Angelino D,Maddock J,Gobbetti M,Brighenti F,Del Rio D,Scazzina F

更新日期：2017-07-21 00:00:00

abstract：:Active deep-sea hydrothermal vents harbor abundant thermophilic and hyperthermophilic microorganisms. However, microbial communities in inactive hydrothermal vents have not been well documented. Here, we investigated bacterial and archaeal communities in the two deep-sea sediments (named as TVG4 and TVG11) collected f...

journal_title：Scientific reports

authors： Zhang L,Kang M,Xu J,Xu J,Shuai Y,Zhou X,Yang Z,Ma K

更新日期：2016-05-12 00:00:00

abstract：:Recently, we reported that chemokine (C-X-C motif) receptor (CXCR)4 and atypical chemokine receptor 3 regulate α1-adrenergic receptors (α1-AR) through the formation of hetero-oligomeric complexes. Whether α1-ARs also regulate chemokine receptor function within such heteromeric receptor complexes is unknown. We observe...

journal_title：Scientific reports

authors： Gao X,Albee LJ,Volkman BF,Gaponenko V,Majetschak M

更新日期：2018-02-09 00:00:00

abstract：:Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. ...

journal_title：Scientific reports

authors： Mani N,Bhandari S,Moreno R,Hu L,Prasad BVV,Suguna K

更新日期：2016-04-07 00:00:00

abstract：:The promising ability of a plasma wiggler based on laser wakefield acceleration to produce betatron X-rays with photon energies of a few keV to hundreds of keV and a peak brilliance of 10(22)-10(23) photons/s/mm(2)/mrad(2)/0.1%BW has been demonstrated, providing an alternative to large-scale synchrotron light sources....

journal_title：Scientific reports

authors： Ma Y,Chen L,Li D,Yan W,Huang K,Chen M,Sheng Z,Nakajima K,Tajima T,Zhang J

更新日期：2016-07-26 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is not sensitive to radiotherapy and chemotherapy and experiences postoperative relapse extremely easy, which is the major cause of the high mortality rate. The Notch signaling pathway is expected to become a new target for the biological treatment of HCC. We searched databases for studi...

journal_title：Scientific reports

authors： Zhang Y,Li D,Feng F,An L,Hui F,Dang D,Zhao Q

更新日期：2017-11-01 00:00:00

abstract：:Lactobacilli are thought to be beneficial for human health, with lactobacilli-associated infections being confined to immune-compromised individuals. However, Lactobacillus fermentum AGR1487 negatively affects barrier integrity in vitro so we hypothesized that it caused a pro-inflammatory response in the host. We comp...

journal_title：Scientific reports

authors： Anderson RC,Ulluwishewa D,Young W,Ryan LJ,Henderson G,Meijerink M,Maier E,Wells JM,Roy NC

更新日期：2016-02-04 00:00:00

abstract：:Genome editing has emerged as a technology with a potential to revolutionize plant breeding. In this study, we report on generating, in less than ten months, Tomelo, a non-transgenic tomato variety resistant to the powdery mildew fungal pathogen using the CRISPR/Cas9 technology. We used whole-genome sequencing to show...

journal_title：Scientific reports

authors： Nekrasov V,Wang C,Win J,Lanz C,Weigel D,Kamoun S

更新日期：2017-03-28 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast,...

journal_title：Scientific reports

authors： Sinigaglia L,Gracias S,Décembre E,Fritz M,Bruni D,Smith N,Herbeuval JP,Martin A,Dreux M,Tangy F,Jouvenet N

更新日期：2018-07-18 00:00:00

abstract：:Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested the hypothesis that hybridization can lead ...

journal_title：Scientific reports

authors： Mastrantonio V,Urbanelli S,Porretta D

更新日期：2019-12-16 00:00:00

abstract：:Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involve...

journal_title：Scientific reports

authors： Serrano-Candelas E,Martínez-Aranguren R,Vega O,Gastaminza G,Bartra J,Audicana MT,Núñez-Córdoba JM,Algorta J,Valero A,Martin M,Ferrer M

更新日期：2017-08-21 00:00:00

abstract：:Sunflower see/ds (Helianthus annuus L.) were roasted in an electric forced air oven for 15, 30, 45, and 60 min at 125, 135 and 145 °C. The effect of temperature and time on the flavor profile of the samples were evaluated by headspace solid-phase microextraction coupled with gas chromatography-mass spectroscopy (HS-SP...

journal_title：Scientific reports

authors： Guo S,Na Jom K,Ge Y

更新日期：2019-08-05 00:00:00

abstract：:Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bact...

journal_title：Scientific reports

authors： Kao WA,Pětrošová H,Ebady R,Lithgow KV,Rojas P,Zhang Y,Kim YE,Kim YR,Odisho T,Gupta N,Moter A,Cameron CE,Moriarty TJ

更新日期：2017-05-08 00:00:00

abstract：:To investigate the role of the altered activation of the immune system in the prognosis of patients affected by laryngeal squamous cell carcinoma (LSCC). We analyzed 56 patients with advanced LSCC divided into two groups according to their prognosis: the first group relapsed within 24 months after treatment, the secon...

journal_title：Scientific reports

authors： Tagliabue M,Maffini F,Fumagalli C,Gandini S,Lepanto D,Corso F,Cacciola S,Ranghiero A,Rappa A,Vacirca D,Cossu Rocca M,Alterio D,Guerini Rocco E,Cattaneo A,Chu F,Zorzi S,Curigliano G,Chiocca S,Barberis M,Viale G,Ans

更新日期：2020-10-27 00:00:00

abstract：:A novel approach of chemical mechanical polishing (CMP) is developed for cadmium zinc telluride (CdZnTe or CZT) wafers. The approach uses environment-friendly slurry that consists of mainly silica, hydrogen peroxide, and citric acid. This is different from the previously reported slurries that are usually composed of ...

journal_title：Scientific reports

authors： Zhang Z,Wang B,Zhou P,Kang R,Zhang B,Guo D

更新日期：2016-05-26 00:00:00

abstract：:Nowadays, one of the main challenges is moving towards an eco-sustainable agriculture, able to preserve the food production through a reduced use of pesticides. Current global food sustenance by intensive agriculture is mainly based on economic crop monocultures and drastically reduces the biodiversity, increasing the...

journal_title：Scientific reports

authors： Zambon Y,Contaldo N,Laurita R,Várallyay E,Canel A,Gherardi M,Colombo V,Bertaccini A

更新日期：2020-11-05 00:00:00

abstract：:Wolfram syndrome (WS) is a rare neurodegenerative disorder that is mainly characterized by diabetes mellitus, optic nerve atrophy, deafness, and progressive brainstem degeneration. Treatment with GLP-1 receptor agonists has shown a promising anti-diabetic effect in WS treatment in both animal models and in human patie...

journal_title：Scientific reports

authors： Seppa K,Toots M,Reimets R,Jagomäe T,Koppel T,Pallase M,Hasselholt S,Krogsbæk Mikkelsen M,Randel Nyengaard J,Vasar E,Terasmaa A,Plaas M

更新日期：2019-10-31 00:00:00