Abstract：
:Hepatocellular carcinoma (HCC) is not sensitive to radiotherapy and chemotherapy and experiences postoperative relapse extremely easy, which is the major cause of the high mortality rate. The Notch signaling pathway is expected to become a new target for the biological treatment of HCC. We searched databases for studies that evaluated the expression of Notch receptors and/or ligands in human HCC tissue. The search yielded 15 studies that enrolled 1643 patients. Compared with non-HCC tissues, Notch 1 was associated with a higher expression level (odds risk 1.59, 95% confidence interval 0.34 to 7.45), as well as Notch 3 (2.63, 0.69 to 10.02), Notch 4 (1.33, 0.74 to 2.38) and Jagged 1 (1.47, 0.23 to 9.53); however, Notch 2 showed the opposite result (0.60, 0.30 to 1.20). Larger tumor size (>5 cm), metastasis positive, and micro vascular invasion positive were features that were associated with over-expression in Notch 1 according to the clinicopathological features. The expression levels of Notch 1, 3, 4 and Jagged 1 were associated with higher expression in HCC tissues, while Notch 2 had the opposite result. This study is registered with PROSPERO (CRD42017055782).
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang Y,Li D,Feng F,An L,Hui F,Dang D,Zhao Qdoi
10.1038/s41598-017-14897-6subject
Has Abstractpub_date
2017-11-01 00:00:00pages
14809issue
1issn
2045-2322pii
10.1038/s41598-017-14897-6journal_volume
7pub_type
杂志文章,meta分析abstract：:Two essential key events in acrylamide (ACR) acute neurotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of selected proteins in the synaptic terminals and the depletion of the glutathione (GSx) stores in neural tissue. The use of N-acetylcysteine (NAC) has been recently p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53154-w
更新日期：2019-11-11 00:00:00
abstract：:Identifying similarities and differences in choice behavior across species is informative about how basic mechanisms give rise to more complex processes. In the present study, we compared pre- and post-choice latencies between rats and humans under two paradigms. In Experiment 1, we used a cued choice paradigm where s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20583
更新日期：2016-02-10 00:00:00
abstract：:Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07720
更新日期：2015-01-12 00:00:00
abstract：:GDP-mannose pyrophosphorylase (GMP) catalyzed the formation of GDP-mannose, which serves as a donor for the biosynthesis of mannose-containing polysaccharides. In this study, three GMP genes from Dendrobium officinale (i.e., DoGMPs) were cloned and analyzed. The putative 1000 bp upstream regulatory region of these DoG...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41010
更新日期：2017-02-08 00:00:00
abstract：:A delicate balance between proliferating and differentiating signals is necessary to ensure proper growth and neuronal specification. By studying the developing zebrafish brain, we observed a specific and dynamic expression of a microtubule destabilizer gene, stathmin-like 4 (stmn4), in the dorsal midbrain region. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36188
更新日期：2016-11-07 00:00:00
abstract：:Investigation of quantum spin Hall states in 1T' phase of the monolayer transition metal dichalcogenides has recently attracted the attention for its potential in nanoelectronic applications. While most of the theoretical findings in this regard deal with infinitely periodic crystal structures, here we employ density ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63450-5
更新日期：2020-04-21 00:00:00
abstract：:Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in response to arenavirus infection during cholestasis using bile duct ligation (BDL). We monitored T cell responses,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30627-y
更新日期：2018-08-15 00:00:00
abstract：:We collected Solidago altissima clones to explore their leaf damage resistance, and as a result identified five accessions that exhibited variable defense abilities against the generalist herbivore Spodoptera litura. In order to characterize molecules involved in such natural variation, we focused on ethylene response...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62142-4
更新日期：2020-03-24 00:00:00
abstract：:We found that the most suitable flooding disturbance model for regenerating Populus euphratica forest was two to three times per year with a duration of 15-20 days and an intensity of 25-30 m(3)/s. The flooding should take place during the seed emergence to young tree growth stages, and should be based on flooding exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15418
更新日期：2015-10-20 00:00:00
abstract：:The transport properties of films assembled from metal nanoclusters can be significantly different from the metals in their bulk or thin film forms due to quantum confinement effects and several competing energy and length scales. For a film composed of metal nanoclusters as its building blocks, the cluster size and t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07685
更新日期：2015-01-08 00:00:00
abstract：:Primates are now known to possess well-developed olfactory sensitivity and discrimination capacities that can play a substantial role in many aspects of their interaction with conspecifics and the environment. Several studies have demonstrated that olfactory cues may be useful in fruit selection. Here, using a conditi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14895
更新日期：2015-10-06 00:00:00
abstract：:Forest fragmentation threatens the ecosystem carbon (C) storage. The distribution patterns of ecosystem C density are poorly documented for fragmented forests of differing patch size. The objectives of this study were to examine C density in these forest ecosystems and the influence of edge effects on C density. Allom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13598-4
更新日期：2017-10-13 00:00:00
abstract：:A novel linear polarization converter operating in C- and X-bands with high polarization conversion ratio is described and demonstrated based on frequency selective surface. The building element is a planar-dipole pair, which is orthogonally printed on a double-layer substrate and vertically connected by a pair of thr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22092-4
更新日期：2018-02-28 00:00:00
abstract：:In situ reduction of selenite to elemental selenium (Se(0)), by microorganisms in sediments and soils is an important process and greatly affects the environmental distribution and the biological effects of selenium. However, the mechanism behind such a biological process remains unrevealed yet. Here we use Shewanella...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03735
更新日期：2014-01-17 00:00:00
abstract：:Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label, one arm, dose-escalation, exploratory study is to evaluate the ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12371-x
更新日期：2017-09-22 00:00:00
abstract：:The spread of multidrug resistance via mobile genetic elements is a major clinical and veterinary concern. Pathogenic Escherichia coli harbour antibiotic resistance and virulence genes mainly on plasmids, but also bacteriophages and hybrid phage-like plasmids. In this study, the genomes of three E. coli phage-like pla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54895-4
更新日期：2019-12-11 00:00:00
abstract：:In the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81632-7
更新日期：2021-01-22 00:00:00
abstract：:Electrostatic gates are of paramount importance for the physics of devices based on high-mobility two-dimensional electron gas (2DEG) since they allow depletion of electrons in selected areas. This field-effect gating enables the fabrication of a wide range of devices such as, for example, quantum point contacts (QPC)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13494
更新日期：2015-09-22 00:00:00
abstract：:Spherical radioactive caesium (Cs)-bearing microparticles (CsMPs) were emitted during the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident in March, 2011. The emission source (timing) and formation process of these particles remain unclear. In this study, the isotopic ratios of uranium (235U and 238U) and caesi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59933-0
更新日期：2020-02-24 00:00:00
abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68106-y
更新日期：2020-07-14 00:00:00
abstract：:We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13289
更新日期：2015-08-21 00:00:00
abstract：:The extent to which the details of past experiences are retained or forgotten remains controversial. Some studies suggest massive storage while others describe memories as fallible summary recreations of original events. The discrepancy can be ascribed to the content of memories and how memories are evaluated. Many st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33792-2
更新日期：2018-11-12 00:00:00
abstract：:We report on the magnetic field control of a bipolar resistive switching in Ag/TiO2/FTO based resistive random access memory device through I-V characteristics. Essentially, in the presence of magnetic field and in the low resistance state, an abrupt change in the resistance of the device demands higher voltage, hinti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17607-4
更新日期：2017-12-08 00:00:00
abstract：:Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease in which the abnormalities in alveolar surfactant accumulation are caused by impairments of GM-CSF pathway attributing to defects in a variety of genes. However, hereditary PAP is extremely uncommon and a detailed understanding in the genetic inheritance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43469
更新日期：2017-02-24 00:00:00
abstract：:There is a significant need to develop antibacterial materials that could be applied locally and directly to the places surrounded by large amount of bacteria, in order to address the problems of bacterial antibiotic-resistance or irreversible biofilm formation. Hydrogels are thought to be suitable candidates due to t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07753
更新日期：2015-01-13 00:00:00
abstract：:The effects of transcranial direct current stimulation (tDCS) on motor cortical excitability are highly variable between individuals. Inter-individual differences in the electric fields generated in the brain by tDCS might play a role in the variability. Here, we explored whether these fields are related to excitabili...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-37226-x
更新日期：2019-01-24 00:00:00
abstract：:Polymer electrolyte membranes (PEM) and Pt-based catalysts are two crucial components which determine the properties and price of fuel cells. Even though, PEM faces problem of fuel crossover in liquid fuel cells such as direct methanol fuel cell (DMFC) and direct borohydride fuel cell (DBFC), which lowers power output...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00567
更新日期：2012-01-01 00:00:00
abstract：:Facio-Scapulo Humeral dystrophy (FSHD) is the third most common myopathy, affecting 1 amongst 10,000 individuals (FSHD1, OMIM #158900). This autosomal dominant pathology is associated in 95% of cases with genetic and epigenetic alterations in the subtelomeric region at the extremity of the long arm of chromosome 4 (q ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46861-x
更新日期：2019-07-17 00:00:00
abstract：:The corrosion of steel in concrete is mainly due to the chemical reaction between the chloride ions and iron ions. Indeed, this is a serious threaten for reinforced concrete structure, especially for the reinforced concrete structure in the sea. So it is urgent and important to protect concrete against chloride ions c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03359
更新日期：2013-11-28 00:00:00
abstract：:This work reports the first study of current-driven magnetization noise in a single, nanometerscale, ferromagnetic (Co) particle, attached to normal metal leads by high-resistance tunneling junctions. As the tunnel current increases at low temperature, the magnetic switching field decreases, its probability distributi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01200
更新日期：2013-01-01 00:00:00
