Time Series miRNA-mRNA integrated analysis reveals critical miRNAs and targets in macrophage polarization.

abstract：:Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylcholine receptor (α7...

journal_title：Scientific reports

authors： Cortes M,Cao M,Liu HL,Moore CS,Durosier LD,Burns P,Fecteau G,Desrochers A,Barreiro LB,Antel JP,Frasch MG

更新日期：2017-09-06 00:00:00

abstract：:The structures, stabilities, and electronic properties of monolayer black phosphorus (M-BP) with different kinds of defects are investigated within the frame of density-functional theory. All the possible configurations of defects in M-BP are explored, and the calculated results suggest that the stabilities of the con...

journal_title：Scientific reports

authors： Li XB,Guo P,Cao TF,Liu H,Lau WM,Liu LM

更新日期：2015-06-02 00:00:00

abstract：:Method for production of alpha emitter 149Tb by irradiation of 151Eu with 70 MeV 3He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152Tb were measured experimentally using a stack foil technique in the 3He particles energy range 70 → 12 MeV. The thick target yield...

journal_title：Scientific reports

authors： Moiseeva AN,Aliev RA,Unezhev VN,Zagryadskiy VA,Latushkin ST,Aksenov NV,Gustova NS,Voronuk MG,Starodub GY,Ogloblin AA

更新日期：2020-01-16 00:00:00

abstract：:Plasma free amino acid (PFAA) profile is highlighted in its association with visceral obesity and hyperinsulinemia, and future diabetes. Indeed PFAA profiling potentially can evaluate individuals' future risks of developing lifestyle-related diseases, in addition to diabetes. However, few studies have been performed e...

journal_title：Scientific reports

authors： Yamakado M,Nagao K,Imaizumi A,Tani M,Toda A,Tanaka T,Jinzu H,Miyano H,Yamamoto H,Daimon T,Horimoto K,Ishizaka Y

更新日期：2015-07-09 00:00:00

abstract：:Downstream analysis of genomic and transcriptomic sequence data is often executed by functional annotation that can be performed by various bioinformatics tools and biological databases. However, a full fast integrated tool is not available for such analysis. Besides, the current available software is not able to prod...

journal_title：Scientific reports

authors： Araujo FA,Barh D,Silva A,Guimarães L,Ramos RTJ

更新日期：2018-01-29 00:00:00

abstract：:Cervical carcinoma is the fourth most common cause of death in woman, caused by human papillomavirus (HPV) infections and arising from the cervix. Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated protein, has been linked to tumorigenic effects. In the present study, we s...

journal_title：Scientific reports

authors： Guo QS,Song Y,Hua KQ,Gao SJ

更新日期：2017-05-18 00:00:00

abstract：:Mobility of people and goods during the Upper Paleolithic has proven difficult to reconstruct given the relative rareness of remains. Nevertheless, archaeological contexts like the Late Pleistocene horizon of Borsuka Cave (Southern Poland) represent a unique opportunity to explore patterns of objects' transportation a...

journal_title：Scientific reports

authors： Kowalik N,Anczkiewicz R,Wilczyński J,Wojtal P,Müller W,Bondioli L,Nava A,Gasparik M

更新日期：2020-06-25 00:00:00

abstract：:Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understan...

journal_title：Scientific reports

authors： Cheung DH,Ho ST,Lau KF,Jin R,Wang YN,Kung HF,Huang JJ,Shaw PC

更新日期：2017-03-03 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squ...

journal_title：Scientific reports

authors： Wu CH,Hsu CL,Lu PC,Lin WC,Juan HF,Huang HC

更新日期：2016-10-27 00:00:00

abstract：:We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese...

journal_title：Scientific reports

authors： Badraiq H,Cvoro A,Galleu A,Simon M,Miere C,Hobbs C,Schulz R,Siow R,Dazzi F,Ilic D

更新日期：2017-12-14 00:00:00

abstract：:K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D ...

journal_title：Scientific reports

authors： Vatansever S,Erman B,Gümüş ZH

更新日期：2019-08-13 00:00:00

abstract：:Entropy-stabilized materials are stabilized by the configurational entropy of the constituents, rather than the enthalpy of formation of the compound. A unique benefit to entropy-stabilized materials is the increased solubility of elements, which opens a broad compositional space, with subsequent local chemical and st...

journal_title：Scientific reports

authors： Meisenheimer PB,Kratofil TJ,Heron JT

更新日期：2017-10-17 00:00:00

abstract：:Neuroprotective strategies in the treatment of stroke have been attracting a great deal of attentions. Our previous clinical and basic studies have demonstrated that protopanaxadiol ginsenoside-Rd (Rd), a monomer compound extracted from Panax ginseng or Panax notoginseng, has neuroprotective effects against ischemic s...

journal_title：Scientific reports

authors： Zhang C,Liu X,Xu H,Hu G,Zhang X,Xie Z,Feng D,Wu R,Zhao G,Shi M

更新日期：2020-05-15 00:00:00

abstract：:Light chain (AL) amyloidosis, caused by deposition of amyloidogenic immunoglobulin light chains (LCs), is the most common systemic form in industrialized countries. Still open questions, and premises for developing targeted therapies, concern the mechanisms of amyloid formation in vivo and the bases of organ targeting...

journal_title：Scientific reports

authors： Ami D,Lavatelli F,Rognoni P,Palladini G,Raimondi S,Giorgetti S,Monti L,Doglia SM,Natalello A,Merlini G

更新日期：2016-07-04 00:00:00

abstract：:Root damage due to aluminum (Al) toxicity restricts crop production on acidic soils, which are extensive in the tropics. The sorghum root Al-activated citrate transporter, SbMATE, underlies the Al tolerance locus, AltSB, and increases grain yield under Al toxicity. Here, AltSB loci associated with Al tolerance were co...

journal_title：Scientific reports

authors： Hufnagel B,Guimaraes CT,Craft EJ,Shaff JE,Schaffert RE,Kochian LV,Magalhaes JV

更新日期：2018-07-04 00:00:00

abstract：:Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...

journal_title：Scientific reports

authors： Ueda Y,Saegusa J,Okano T,Sendo S,Yamada H,Nishimura K,Morinobu A

更新日期：2019-04-23 00:00:00

abstract：:Elevated prostaglandin E2 (PGE2) levels are observed in colorectal cancer (CRC) patients, and this increase is associated with poor prognosis. Increased synthesis of PGE2 in CRC has been shown to occur through COX-2-dependent mechanisms; however, loss of the PGE2-catabolizing enzyme, 15-hydroxyprostaglandin dehydrogen...

journal_title：Scientific reports

authors： Monteleone NJ,Moore AE,Iacona JR,Lutz CS,Dixon DA

更新日期：2019-04-01 00:00:00

abstract：:Invasive alien species are regarded a nuisance. This extends into a lack of conservation efforts in their native range. As a consequence, conservation of e.g. range-edge populations is neglected. Gobiidae have many representatives of alien species in European freshwaters, and therefore they have a bad reputation. Obje...

journal_title：Scientific reports

authors： Kukuła K,Ortyl B,Bylak A

更新日期：2019-12-23 00:00:00

abstract：:CaWRKY40 is a positive regulator of pepper (Capsicum annum) response to Ralstonia solanacearum inoculation (RSI), but the underlying mechanism remains largely unknown. Here, we functionally characterize CaCDPK15 in the defense signaling mediated by CaWRKY40. Pathogen-responsive TGA, W, and ERE boxes were identified in...

journal_title：Scientific reports

authors： Shen L,Yang S,Yang T,Liang J,Cheng W,Wen J,Liu Y,Li J,Shi L,Tang Q,Shi W,Hu J,Liu C,Zhang Y,Mou S,Liu Z,Cai H,He L,Guan D,Wu Y,He S

更新日期：2016-03-01 00:00:00

abstract：:We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...

journal_title：Scientific reports

authors： Feng X,Liu H,Huang N,Wang Z,Zhang Y

更新日期：2019-03-08 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a...

journal_title：Scientific reports

authors： Yu Z,Chen X,Han F,Qin S,Li M,Wu Y,Su Y,Ge J

更新日期：2017-03-10 00:00:00

abstract：:Refracture of cemented vertebrae occurs commonly after vertebroplasty (VP) for osteoporotic vertebral compression fracture (OVCF). It can result in severe pain or neurological deficit, but no preventive medication is available. Owing to the bone anabolic benefits of teriparatide (TP), this study was aimed to compare t...

journal_title：Scientific reports

authors： Yang YS,Tsou YS,Lo WC,Chiang YH,Lin JH

更新日期：2020-04-07 00:00:00

abstract：:It is well established that CD8(+) T cells play an important role in protective immunity against protozoan infections. However, their role in the course of Neospora caninum infection has not been fully elucidated. Here we report that CD8-deficient mice infected with N. caninum presented higher parasitic loads in the b...

journal_title：Scientific reports

authors： Correia A,Ferreirinha P,Botelho S,Belinha A,Leitão C,Caramalho Í,Teixeira L,González-Fernandéz Á,Appelberg R,Vilanova M

更新日期：2015-10-09 00:00:00

abstract：:Clonal cell analysis defines the potential of single cells and the diversity they can produce. To achieve this, we have developed a novel adaptation of the genetic tracing strategy, UbC-StarTrack, which attributes a specific and unique color-code to single neural precursors, allowing all their progeny to be tracked. W...

journal_title：Scientific reports

authors： Figueres-Oñate M,García-Marqués J,López-Mascaraque L

更新日期：2016-09-22 00:00:00

abstract：:Even after years of experiencing malaria, caused by infection with Plasmodium species, individuals still have incomplete immunity and develop low-density parasitemia on re-infection. Previous studies using the P. chabaudi (Pch) mouse model to understand the reason for chronic malaria, found that mice with a deletion o...

journal_title：Scientific reports

authors： Horne-Debets JM,Karunarathne DS,Faleiro RJ,Poh CM,Renia L,Wykes MN

更新日期：2016-05-24 00:00:00

abstract：:A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep ...

journal_title：Scientific reports

authors： Jung Y,Park H,Park JA,Noh J,Choi Y,Jung M,Jung K,Pyo M,Chen K,Javey A,Cho G

更新日期：2015-01-29 00:00:00

abstract：:Two polar vessels, Akademik Shokalskiy and Xuelong, were trapped by thick sea ice in the Antarctic coastal region just to the west of 144°E and between 66.5°S and 67°S in late December 2013. This event demonstrated the rapid establishment of extreme Antarctic sea ice conditions on synoptic time scales. The event was a...

journal_title：Scientific reports

authors： Wang Z,Turner J,Sun B,Li B,Liu C

更新日期：2014-06-17 00:00:00

abstract：:Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...

journal_title：Scientific reports

authors： Wallensten J,Nager A,Åsberg M,Borg K,Beser A,Wilczek A,Mobarrez F

更新日期：2021-01-21 00:00:00

abstract：:Thyroid nodules can be classified into benign and malignant tumors. However, distinguishing between these two types of tumors can be challenging in clinics. Since malignant nodules require surgical intervention whereas asymptomatic benign tumors do not, there is an urgent need for new techniques that enable accurate d...

journal_title：Scientific reports

authors： Tian Y,Nie X,Xu S,Li Y,Huang T,Tang H,Wang Y

更新日期：2015-10-21 00:00:00

abstract：:The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study...

journal_title：Scientific reports

authors： Mita T,Katakami N,Shiraiwa T,Yoshii H,Kuribayashi N,Osonoi T,Kaneto H,Kosugi K,Umayahara Y,Gosho M,Shimomura I,Watada H

更新日期：2017-01-09 00:00:00