GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome.

abstract：:Understanding the neural basis of poor impulse control in Internet addiction (IA) is important for understanding the neurobiological mechanisms of this syndrome. The current study investigated how neuronal pathways implicated in response inhibition were affected in IA using a Go-Stop paradigm and functional magnetic r...

journal_title：Scientific reports

authors： Li B,Friston KJ,Liu J,Liu Y,Zhang G,Cao F,Su L,Yao S,Lu H,Hu D

更新日期：2014-05-22 00:00:00

abstract：:Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of this study was to investigate the differences in miRNA profiles of tissue-derived cells and cultur...

journal_title：Scientific reports

authors： Kuosmanen SM,Kansanen E,Sihvola V,Levonen AL

更新日期：2017-09-08 00:00:00

abstract：:The ubiquitin-proteasomal degradation mechanism has gained the attention over the past decade. The E2 ubiquitin conjugating enzymes are the crucial part of ubiquitination mechanism and they are believed to hold imperative association for plant development. It accepts ubiquitin from the E1 enzyme and interacts with the...

journal_title：Scientific reports

authors： Sharma B,Bhatt TK

更新日期：2017-08-17 00:00:00

abstract：:Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...

journal_title：Scientific reports

authors： Wang X,Cui H,Gong G,Fu Z,Zhou J,Gu J,Yin Y,Feng D

更新日期：2018-07-13 00:00:00

abstract：:Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an inherited disorder that causes progressive kidney damage and renal failure. Mutations in the UMOD gene, encoding uromodulin, lead to ADTKD-UMOD related. Uromodulin is a GPI-anchored protein exclusively produced by epithelial cells of the thick ascendin...

journal_title：Scientific reports

authors： Trudu M,Schaeffer C,Riba M,Ikehata M,Brambilla P,Messa P,Martinelli-Boneschi F,Rastaldi MP,Rampoldi L

更新日期：2017-08-07 00:00:00

abstract：:Here we report a method for improving the magnetic field sensitivity of an ensemble of Nitrogen-Vacancy (NV) centres in 12C-enriched diamond aligned along the [111] crystal axis. The preferentially-aligned NV centres are fabricated by a Plasma Enhanced Chemical Vapour Deposition (PECVD) process and their concentration...

journal_title：Scientific reports

authors： Osterkamp C,Mangold M,Lang J,Balasubramanian P,Teraji T,Naydenov B,Jelezko F

更新日期：2019-04-08 00:00:00

abstract：:We demonstrate numerically and experimentally the enhancement of Surface Plasmon Resonance (SPR) sensing via dispersion engineering of the plasmonic response using plasmonic nanograting. Following their design and optimization, the plasmonic nanograting structures are fabricated using e-beam lithography and lift-off p...

journal_title：Scientific reports

authors： Arora P,Talker E,Mazurski N,Levy U

更新日期：2018-06-13 00:00:00

abstract：:This paper addresses the issue of the sorption process on coal concerning propylene released from the source of coal heating in the deposit. In this study, the interaction between Polish coals and propylene molecules, as well as three other hydrocarbons (ethylene, ethane, and propane) with the application of a fixed-b...

journal_title：Scientific reports

authors： Wojtacha-Rychter K,Howaniec N,Smoliński A

更新日期：2020-07-09 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...

journal_title：Scientific reports

authors： Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

更新日期：2019-07-16 00:00:00

abstract：:Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-handling in the cardiomyocyte. Previously, missense variants in JPH2 have been linked to hypertrophic cardiomyopathy; however, pathogenic "loss of function" (LOF) variants have not been described. Family-based genetic analysis ...

journal_title：Scientific reports

authors： Jones EG,Mazaheri N,Maroofian R,Zamani M,Seifi T,Sedaghat A,Shariati G,Jamshidi Y,Allen HD,Wehrens XHT,Galehdari H,Landstrom AP

更新日期：2019-06-21 00:00:00

abstract：:The study of the preparation phase of large earthquakes is essential to understand the physical processes involved, and potentially useful also to develop a future reliable short-term warning system. Here we analyse electron density and magnetic field data measured by Swarm three-satellite constellation for 4.7 years,...

journal_title：Scientific reports

authors： De Santis A,Marchetti D,Pavón-Carrasco FJ,Cianchini G,Perrone L,Abbattista C,Alfonsi L,Amoruso L,Campuzano SA,Carbone M,Cesaroni C,De Franceschi G,De Santis A,Di Giovambattista R,Ippolito A,Piscini A,Sabbagh D,Soldani M

更新日期：2019-12-30 00:00:00

abstract：:In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replaci...

journal_title：Scientific reports

authors： Boulet-Audet M,Kazarian SG,Byrne B

更新日期：2016-07-29 00:00:00

abstract：:Immune cell infiltrates in melanoma have important prognostic value. Gene expression analysis may simultaneously quantify numbers and function of multiple immune cell subtypes in formalin-fixed paraffin-embedded (FFPE) tissues. Prior studies report single gene expression can represent individual immune cell subtypes, ...

journal_title：Scientific reports

authors： Kwak M,Erdag G,Slingluff CL Jr

更新日期：2020-10-27 00:00:00

abstract：:There is growing evidence that hydrogen sulfide (H2S) is involved in many physiological processes in plants, but the role of H2S in dark-induced leaf senescence remains unknown. In this work, we found that H2S not only inhibited chlorophyll degradation but also caused the accumulation of photoreactive pheide a in deta...

journal_title：Scientific reports

authors： Wei B,Zhang W,Chao J,Zhang T,Zhao T,Noctor G,Liu Y,Han Y

更新日期：2017-06-01 00:00:00

abstract：:Near-infrared sensitization of monolayer MoS2 is here achieved via the covalent attachment of a novel heteroleptic nickel bis-dithiolene complex into sulfur vacancies in the MoS2 structure. Photocurrent action spectroscopy of the sensitized films reveals a discreet contribution from the sensitizer dye centred around 1...

journal_title：Scientific reports

authors： Dalgleish S,Reissig L,Shuku Y,Ligorio G,Awaga K,List-Kratochvil EJW

更新日期：2019-11-13 00:00:00

abstract：:Although biophysical yield responses to local warming have been studied, we know little about how crop yield growth-a function of climate and technology-responds to global temperature and socioeconomic changes. Here, we present the yield growth of major crops under warming conditions from preindustrial levels as simul...

journal_title：Scientific reports

authors： Iizumi T,Furuya J,Shen Z,Kim W,Okada M,Fujimori S,Hasegawa T,Nishimori M

更新日期：2017-08-10 00:00:00

abstract：:As mammalian herbivores feed, they often encounter noxious insects on plants. It is unknown how they handle such insects. We experimentally examined the behavioural responses of goats to the noxious spring-webworm (Ocnogyna loewii), and manipulated their sensory perception to reveal the process of insect detection. Go...

journal_title：Scientific reports

authors： Berman TS,Ben-Ari M,Glasser TA,Gish M,Inbar M

更新日期：2017-11-01 00:00:00

abstract：:To relieve the environmental issues of sewage sludge (SS) disposal and greenhouse gas (GHG) emission in China, we proposed an integrated method for the first time to simultaneously deal with these two problems. The hot slags below 920 °C could act as a good heat carrier for sludge gasification and the increasing CO2 c...

journal_title：Scientific reports

authors： Sun Y,Nakano J,Liu L,Wang X,Zhang Z

更新日期：2015-06-15 00:00:00

abstract：:Nature provides remarkable examples of mass-produced microscale particles with structures and chemistries optimized by evolution for particular functions. Synthetic chemical tailoring of such sustainable biogenic particles may be used to generate new multifunctional materials. Herein, we report a facile method for the...

journal_title：Scientific reports

authors： Ávila-Avilés RD,Torres-Gómez N,Camacho-López MA,Vilchis-Nestor AR

更新日期：2020-10-06 00:00:00

abstract：:Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving initiation, elongation and differentiation. Genetic basis solely for distal reproductive tract development is largely unknown. Lhfpl2 (lipom...

journal_title：Scientific reports

authors： Zhao F,Zhou J,Li R,Dudley EA,Ye X

更新日期：2016-03-11 00:00:00

abstract：:In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics...

journal_title：Scientific reports

authors： Giddey AD,de Kock E,Nakedi KC,Garnett S,Nel AJ,Soares NC,Blackburn JM

更新日期：2017-03-06 00:00:00

abstract：:The queens of eusocial bees, ants and wasps mate only during a very short period early in life and males therefore produce ejaculates consisting of large numbers of high quality sperm. Such extreme selection for high fecundity resulted in males investing minimally into their somatic survival, including their immune sy...

journal_title：Scientific reports

authors： Peng Y,Baer-Imhoof B,Millar AH,Baer B

更新日期：2015-06-30 00:00:00

abstract：:We explore the spectral dependence of fluorescence enhancement and the associated lifetime modification of fluorescent molecules coupled to single metal nanoparticles. Fluorescence lifetime imaging microscopy and single-particle dark-field spectroscopy are combined to correlate the dependence of fluorescence lifetime ...

journal_title：Scientific reports

authors： Li J,Krasavin AV,Webster L,Segovia P,Zayats AV,Richards D

更新日期：2016-02-15 00:00:00

abstract：:Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...

journal_title：Scientific reports

authors： Kim MS,Kim MK,Jo SE,Joo C,Kim YJ

更新日期：2016-06-10 00:00:00

abstract：:Monitoring of disease/therapeutic conditions is an important application of circulating tumor DNA (ctDNA). We devised numerical indices, based on ctDNA dynamics, for therapeutic response and disease progression. 52 lung cancer patients subjected to the EGFR-TKI treatment were prospectively collected, and ctDNA levels ...

journal_title：Scientific reports

authors： Kato K,Uchida J,Kukita Y,Kumagai T,Nishino K,Inoue T,Kimura M,Oba S,Imamura F

更新日期：2016-07-06 00:00:00

abstract：:Next generation sequencing (NGS) of DNAs amplified by rolling circle amplification from 6 tomato (Solanum lycopersicum) plants with leaf curl symptoms identified a number of monopartite begomoviruses, including Tomato yellow leaf curl virus (TYLCV), and a betasatellite (Tomato leaf curl betasatellite [ToLCB]). Both TY...

journal_title：Scientific reports

authors： Shahid MS,Shafiq M,Ilyas M,Raza A,Al-Sadrani MN,Al-Sadi AM,Briddon RW

更新日期：2019-11-12 00:00:00

abstract：:Solid-state spin-based qubits offer good prospects for scaling based on their long coherence times and nexus to large-scale electronic scale-up technologies. However, high-threshold quantum error correction requires a two-dimensional qubit array operating in parallel, posing significant challenges in fabrication and c...

journal_title：Scientific reports

authors： Nguyen T,Hill CD,Hollenberg LCL,James MR

更新日期：2017-10-17 00:00:00

abstract：:Graphene plasmonics has become a highlighted research area due to the outstanding properties of deep-subwavelength plasmon excitation, long relaxation time, and electro-optical tunability. Although the giant conductivity of a graphene layer enables the low-dimensional confinement of light, the atomic scale of the laye...

journal_title：Scientific reports

authors： Kim Y,Yu S,Park N

更新日期：2017-02-27 00:00:00

abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

journal_title：Scientific reports

authors： Wang L,Zhuang X,Zhuang G,Jing C

更新日期：2016-12-14 00:00:00

abstract：:Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free recognition of cells and organelles, and quantifies their number-density that, thermodynamically, is more representative of metabolism than size. Here, we report the fusion of these two imagin...

journal_title：Scientific reports

authors： Subedi NR,Jung PS,Bredeweg EL,Nemati S,Baker SE,Christodoulides DN,Vasdekis AE

更新日期：2020-11-19 00:00:00