Abstract：
:Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involvement is not clear, suggesting the involvement of additional mechanisms of action. In this study, we sought to investigate the ability of OmAb to inhibit mast cell and basophil degranulation induced by sera from CSU patients. For this purpose, we performed a comparison between the in vitro incubation of sera from CSU patients treated with OmAb and the in vivo administration of OmAb in a clinical trial. We found that OmAb added in vitro to sera from CSU patients did not modify the ability of the sera to induce cell degranulation. Similarly, the sera from patients treated with OmAb in the context of the clinical trial who had a good clinical outcome maintained the capacity to activate mast cells and basophils. Thus, we conclude that the beneficial activity of OmAb does not correlate with the ability of patient sera to induce cell degranulation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Serrano-Candelas E,Martínez-Aranguren R,Vega O,Gastaminza G,Bartra J,Audicana MT,Núñez-Córdoba JM,Algorta J,Valero A,Martin M,Ferrer Mdoi
10.1038/s41598-017-09361-4subject
Has Abstractpub_date
2017-08-21 00:00:00pages
8985issue
1issn
2045-2322pii
10.1038/s41598-017-09361-4journal_volume
7pub_type
杂志文章abstract：:Protein analysis using high-performance thin-layer chromatography (HPTLC) is not commonly used but can complement traditional electrophoretic and mass spectrometric approaches in a unique way. Due to various detection protocols and possibilities for hyphenation, HPTLC protein analysis is a promising alternative for e....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26665
更新日期：2016-05-25 00:00:00
abstract：:Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42360-1
更新日期：2019-04-17 00:00:00
abstract：:Medicinal plants are considered as one of the ideal sources for cancer therapy due to their bioactive contents and low toxicity to humans. Vernonia genus is one of the common medicinal plants, which has wide spread usage in food and medicine. However, there are limited studies to explore its anticancer properties. In ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23255
更新日期：2016-03-24 00:00:00
abstract：:Cuprizone-induced demyelination in mice is a frequently used model in preclinical multiple sclerosis research. A recent quantitative clinically-targeted MRI method, fast macromolecular proton fraction (MPF) mapping demonstrated a promise as a myelin biomarker in human and animal studies with a particular advantage of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46686
更新日期：2017-04-24 00:00:00
abstract：:Predation has driven the evolution of diverse adaptations for defence among prey, and one striking example is the deimatic display. While such displays can resemble, or indeed co-occur with, aposematic 'warning' signals, theory suggests deimatic displays may function independently of predator learning. The survival va...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36995-9
更新日期：2019-01-24 00:00:00
abstract：:Saliva has immense potential as a diagnostic fluid for identification and monitoring of several systemic diseases. Composition of the microbiome and inflammation has been associated and reflective of oral and overall health. In addition, the relative ease of collection of saliva further strengthens large-scale diagnos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81420-3
更新日期：2021-01-29 00:00:00
abstract：:Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13930-y
更新日期：2017-10-25 00:00:00
abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68978-0
更新日期：2020-07-27 00:00:00
abstract：:The establishment of the infant gut microbiota is a highly dynamic process dependent on extrinsic and intrinsic factors. We characterized the faecal microbiota of 4 breastfed infants and 4 formula-fed infants at 17 consecutive time points during the first 12 weeks of life. Microbiota composition was analysed by a comb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08268-4
更新日期：2017-08-21 00:00:00
abstract：:We report here that CYB5D2 is associated with tumor suppression function in breast cancer (BC). CYB5D2 expression was significantly reduced in tamoxifen resistant MCF7 cells and in MCF7 cell-derived xenografts treated with TAM. CYB5D2 overexpression induced apoptosis in MCF7 cells; CYB5D2 knockdown enhanced MCF7 cell ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43006-y
更新日期：2019-04-29 00:00:00
abstract：:Our understanding of innate immune responses in human rectal mucosal tissues (RM) and their contributions to promoting or restricting HIV transmission is limited. We defined the RM composition of innate and innate-like cell subsets, including plasmacytoid dendritic cells; CD1c + myeloid DCs; neutrophils; macrophages; ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76976-5
更新日期：2020-11-19 00:00:00
abstract：:The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15218-7
更新日期：2017-11-13 00:00:00
abstract：:Rice (Oryza sativa L.) is one of the essential staple food crops and tillering, panicle branching and grain filling are three important traits determining the grain yield. Although miRNAs have been reported being regulating yield, no study has systematically investigated how miRNAs differentially function in high and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26438-w
更新日期：2018-05-31 00:00:00
abstract：:We developed hybrid slot antenna structures for microbial sensing in the THz frequency range, where silver nanowires (AgNWs) were employed to increase the sensitivity. In order to fabricate the hybrid devices, we partially etched the AgNW in the slot antenna region, where we can expect the field enhancement effect at ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33617-2
更新日期：2018-10-19 00:00:00
abstract：:Denitrification in coastal sediments can provide resilience to eutrophication in estuarine ecosystems, but this key ecosystem function is impacted directly and indirectly by increasing stressors. The erosion and loading of fine sediments from land, resulting in sedimentation and elevated sediment muddiness, presents a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54192-0
更新日期：2019-11-26 00:00:00
abstract：:High-grade gliomas are the most aggressive malignant brain tumors. Accurate pre-operative prognosis for this cohort can lead to better treatment planning. Conventional survival prediction based on clinical information is subjective and could be inaccurate. Recent radiomics studies have shown better prognosis by using ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37387-9
更新日期：2019-01-31 00:00:00
abstract：:A detailed molecular understanding of botulinum neurotoxin (BoNT)/host-cell-receptor interactions is fundamental both for developing strategies against botulism and for generating improved BoNT variants for medical applications. The X-ray crystal structure of the receptor-binding domain (HC) of BoNT/A1 in complex with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43588
更新日期：2017-03-02 00:00:00
abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been known as a promising agent for cancer therapy due to its specific apoptosis-inducing effect on tumor cells rather than most normal cells. However, systemically delivered TRAIL suffers from a rapid clearance from the body with an extremely short h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41904
更新日期：2017-02-22 00:00:00
abstract：:China has one of the highest rates of cesarean sections in the world. However, limited epidemiological studies have evaluated the risk factors for cesarean section among Chinese women. Thus, the aim of this cohort study was to investigate the associations between pre-pregnancy BMI, gestational weight gain (GWG) and th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37168
更新日期：2016-11-22 00:00:00
abstract：:Photoluminescence and photomodulated reflectivity measurements of ZnOSe alloys are used to demonstrate a splitting of the valence band due to the band anticrossing interaction between localized Se states and the extended valence band states of the host ZnO matrix. A strong multiband emission associated with optical tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44214
更新日期：2017-03-13 00:00:00
abstract：:We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40676-6
更新日期：2019-03-08 00:00:00
abstract：:Five different weed plants viz. Convulvulus arvensis, Chenopodium murale, Tribulus terrestris, Trianthema portulacastrum, and Achyranthes aspera were investigated for their entomocidal and genotoxic effects against Culex quinquefasciatus mosquitoes. High mortality was observed at 72 hours in a dose dependent manner. A...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63815-w
更新日期：2020-04-22 00:00:00
abstract：:The unique capacity of localized surface plasmon resonance (LSPR) offers a new opportunity to overcome the limited efficiency of semiconductor photocatalyst. Here we unravel that LSPR, which usually occurs in noble metal nanoparticles, can be realized by hydrogen doping in noble-metal-free semiconductor using TiO2 as ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03986
更新日期：2014-02-05 00:00:00
abstract：:Blueberry juice is a healthy and nutritious food that has become increasingly popular worldwide. However, little is known about the microbial groups of this juice that can cause its spoilage. This study aimed to identify the main spoilage microorganisms in blueberry juice and explore whether a microchip pulsed electri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26513-2
更新日期：2018-05-25 00:00:00
abstract：:Serial 3-dimensional dental model superimposition provides a risk-free, detailed evaluation of morphological alterations on a patient's mouth. Here, we evaluated accuracy and precision of five palatal areas, used for superimposition of maxillary 3D digital dental casts. Sixteen pre- and post-orthodontic treatment dent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06013-5
更新日期：2017-07-19 00:00:00
abstract：:Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12990
更新日期：2015-08-10 00:00:00
abstract：:Imputation is a computational method based on the principle of haplotype sharing allowing enrichment of genome-wide association study datasets. It depends on the haplotype structure of the population and density of the genotype data. The 1000 Genomes Project led to the generation of imputation reference panels which h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06905-6
更新日期：2017-07-27 00:00:00
abstract：:Annual reduction rate of corneal endothelial cell density (ECD) varies among etiologies, however, the cause of chronic endothelial cell loss is still unknown. We recently reported the elevation of inflammatory cytokines in the aqueous humor (AqH) in eyes with bullous keratopathy and low ECD. To evaluate the associatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14131-3
更新日期：2017-10-19 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-61010-5
更新日期：2020-03-03 00:00:00
abstract：:Quantum information technologies harness the intrinsic nature of quantum theory to beat the limitations of the classical methods for information processing and communication. Recently, the application of quantum features to metrology has attracted much attention. Quantum optical coherence tomography (QOCT), which util...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18042
更新日期：2015-12-14 00:00:00
