当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.

Abstract：

:Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only convex, but also singular at the origin, which is a necessary condition for sparsity. Thus most SCCA methods impose [Formula: see text]-norm onto the individual feature or the structure level of features to pursuit corresponding sparsity. However, the [Formula: see text]-norm penalty over-penalizes large coefficients and may incurs estimation bias. A number of non-convex penalties are proposed to reduce the estimation bias in regression tasks. But using them in SCCA remains largely unexplored. In this paper, we design a unified non-convex SCCA model, based on seven non-convex functions, for unbiased estimation and stable feature selection simultaneously. We also propose an efficient optimization algorithm. The proposed method obtains both higher correlation coefficients and better canonical loading patterns. Specifically, these SCCA methods with non-convex penalties discover a strong association between the APOE e4 rs429358 SNP and the hippocampus region of the brain. They both are Alzheimer's disease related biomarkers, indicating the potential and power of the non-convex methods in brain imaging genetics.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Du L,Liu K,Yao X,Yan J,Risacher SL,Han J,Guo L,Saykin AJ,Shen L,Alzheimer’s Disease Neuroimaging Initiative.

doi

10.1038/s41598-017-13930-y

subject

Has Abstract

pub_date

2017-10-25 00:00:00

pages

14052

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13930-y

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • A common protocol for the simultaneous processing of multiple clinically relevant bacterial species for whole genome sequencing.

    abstract：:Whole-genome sequencing is likely to become increasingly used by local clinical microbiology laboratories, where sequencing volume is low compared with national reference laboratories. Here, we describe a universal protocol for simultaneous DNA extraction and sequencing of numerous different bacterial species, allowin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80031-8

    authors： Raven KE,Girgis ST,Akram A,Blane B,Leek D,Brown N,Peacock SJ

    更新日期：2021-01-08 00:00:00

  • Electronic Structure of Oxide Interfaces: A Comparative Analysis of GdTiO3/SrTiO3 and LaAlO3/SrTiO3 Interfaces.

    abstract：:Emergent phases in the two-dimensional electron gas (2DEG) formed at the interface between two insulating oxides have attracted great attention in the past decade. We present ab-initio electronic structure calculations for the interface between a Mott insulator GdTiO3 (GTO) and a band insulator SrTiO3 (STO) and compar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18647

    authors： Banerjee H,Banerjee S,Randeria M,Saha-Dasgupta T

    更新日期：2015-12-22 00:00:00

  • Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age.

    abstract：:The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the pres...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62195-5

    authors： Chaudhari DS,Dhotre DP,Agarwal DM,Gaike AH,Bhalerao D,Jadhav P,Mongad D,Lubree H,Sinkar VP,Patil UK,Salvi S,Bavdekar A,Juvekar SK,Shouche YS

    更新日期：2020-03-30 00:00:00

  • Collagen morphology and texture analysis: from statistics to classification.

    abstract：:In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. Texture analysis based on first-order statistics (FOS) and second-order statistics such as gray level co-occurrence matrix (GLCM) was explored to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02190

    authors： Mostaço-Guidolin LB,Ko AC,Wang F,Xiang B,Hewko M,Tian G,Major A,Shiomi M,Sowa MG

    更新日期：2013-01-01 00:00:00

  • Glycol Derived Carbon- TiO2 as Low Cost and High Performance Anode Material for Sodium-Ion Batteries.

    abstract：:Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43895

    authors： Tao H,Zhou M,Wang K,Cheng S,Jiang K

    更新日期：2017-03-03 00:00:00

  • Studying the role of axon fasciculation during development in a computational model of the Xenopus tadpole spinal cord.

    abstract：:During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13804-3

    authors： Davis O,Merrison-Hort R,Soffe SR,Borisyuk R

    更新日期：2017-10-19 00:00:00

  • Ultra-short laser-accelerated proton pulses have similar DNA-damaging effectiveness but produce less immediate nitroxidative stress than conventional proton beams.

    abstract：:Ultra-short proton pulses originating from laser-plasma accelerators can provide instantaneous dose rates at least 10(7)-fold in excess of conventional, continuous proton beams. The impact of such extremely high proton dose rates on A549 human lung cancer cells was compared with conventionally accelerated protons and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32441

    authors： Raschke S,Spickermann S,Toncian T,Swantusch M,Boeker J,Giesen U,Iliakis G,Willi O,Boege F

    更新日期：2016-08-31 00:00:00

  • Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer.

    abstract：:No consensus currently exist on the optimal treatment of patients with high-risk nonmuscle invasive (HGT1) micropapillary variant of bladder cancer (MPBC). Transcripsome analysis may allow stratification of MPBC-HGT1 enabling prediction of recurrence and guide therapeutic management for individual patients. Whole tran...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76904-7

    authors： Bowden M,Nadal R,Zhou CW,Werner L,Barletta J,Juanpere N,Lloreta J,Hernandez-Llodrà S,Morote J,de Torres I,Orsola A,Cejas P,Long H,Bellmunt J

    更新日期：2020-11-18 00:00:00

  • Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea.

    abstract：:Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavior, the intra-regional functional connectivity (FC) in the hub regions of the sy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24543

    authors： Wu TH,Tu CH,Chao HT,Li WC,Low I,Chuang CY,Yeh TC,Cheng CM,Chou CC,Chen LF,Hsieh JC

    更新日期：2016-04-19 00:00:00

  • Genetic architecture and mechanism of seed number per pod in rapeseed: elucidated through linkage and near-isogenic line analysis.

    abstract：:Seed number per pod (SNPP) is one of the major yield components and breeding targets in rapeseed that shows great variation and is invaluable for genetic improvement. To elucidate the genetic architecture and uncover the mechanism of SNPP, we identified five quantitative trait loci (QTLs) using the BnaZNRIL population...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24124

    authors： Yang Y,Shi J,Wang X,Liu G,Wang H

    更新日期：2016-04-12 00:00:00

  • Magma fragmentation and particle size distributions in low intensity mafic explosions: the July/August 2015 Piton de la Fournaise eruption.

    abstract：:Understanding magma fragmentation mechanisms in explosive eruptions is a key requirement for volcanic hazard assessment, eruption management and risk mitigation. This paper focuses on a type case small explosivity eruption (July-August 2015 eruption of Piton de la Fournaise). These eruptions, despite being often overl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-69976-y

    authors： Edwards MJ,Pioli L,Harris AJL,Gurioli L,Thivet S

    更新日期：2020-08-18 00:00:00

  • Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice.

    abstract：:Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04946-5

    authors： Sasayama D,Sugiyama N,Yonekubo S,Pawlak A,Murasawa H,Nakamura M,Hayashi M,Ogawa T,Moro M,Washizuka S,Amano N,Hongo K,Ohnota H

    更新日期：2017-07-05 00:00:00

  • Genetic diversity of Nile tilapia (Oreochromis niloticus) throughout West Africa.

    abstract：:Nile tilapia (Oreochromis niloticus) is a globally significant aquaculture species rapidly gaining status as a farmed commodity. In West Africa, wild Nile tilapia genetic resources are abundant yet knowledge of fine-scale population structure and patterns of natural genetic variation are limited. Coinciding with this ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53295-y

    authors： Lind CE,Agyakwah SK,Attipoe FY,Nugent C,Crooijmans RPMA,Toguyeni A

    更新日期：2019-11-14 00:00:00

  • Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation.

    abstract：:Mitochondrial disorders are among the most prevalent inborn errors of metabolism but largely lack treatments and have poor outcomes. High-fat, low-carbohydrate ketogenic diets (KDs) have shown beneficial effects in mouse models of mitochondrial myopathies, with induction of mitochondrial biogenesis as the suggested ma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01109-4

    authors： Purhonen J,Rajendran J,Mörgelin M,Uusi-Rauva K,Katayama S,Krjutskov K,Einarsdottir E,Velagapudi V,Kere J,Jauhiainen M,Fellman V,Kallijärvi J

    更新日期：2017-04-19 00:00:00

  • Three-dimensional structure analysis and percolation properties of a barrier marine coating.

    abstract：:Artificially structured coatings are widely employed to minimize materials deterioration and corrosion, the annual direct cost of which is over 3% of the gross domestic product (GDP) for industrial countries. Manufacturing higher performance anticorrosive coatings is one of the most efficient approaches to reduce this...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01177

    authors： Chen B,Guizar-Sicairos M,Xiong G,Shemilt L,Diaz A,Nutter J,Burdet N,Huo S,Mancuso J,Monteith A,Vergeer F,Burgess A,Robinson I

    更新日期：2013-01-01 00:00:00

  • The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia.

    abstract：:Multiple factors help shape the infant intestinal microbiota early in life. Environmental conditions such as the presence of bioactive molecules from breast milk dictate gut microbial growth and survival. Infants also receive distinct, personalized, bacterial exposures leading to differential colonization. Microbial e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40932

    authors： Lewis ZT,Sidamonidze K,Tsaturyan V,Tsereteli D,Khachidze N,Pepoyan A,Zhgenti E,Tevzadze L,Manvelyan A,Balayan M,Imnadze P,Torok T,Lemay DG,Mills DA

    更新日期：2017-02-02 00:00:00

  • Can electric fields explain inter-individual variability in transcranial direct current stimulation of the motor cortex?

    abstract：:The effects of transcranial direct current stimulation (tDCS) on motor cortical excitability are highly variable between individuals. Inter-individual differences in the electric fields generated in the brain by tDCS might play a role in the variability. Here, we explored whether these fields are related to excitabili...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-37226-x

    authors： Laakso I,Mikkonen M,Koyama S,Hirata A,Tanaka S

    更新日期：2019-01-24 00:00:00

  • HCMV-encoded miR-UL112-3p promotes glioblastoma progression via tumour suppressor candidate 3.

    abstract：:Glioblastoma (GBM) is the most prevalent and lethal type of primary malignant brain tumour. Recent studies suggest that the discovery of human cytomegalovirus (HCMV)-encoded microRNAs (miRNAs) might play a role in the pathogenesis of diseases, including GBM. In this study, we aimed to analyse the expression and functi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44705

    authors： Liang Q,Wang K,Wang B,Cai Q

    更新日期：2017-03-17 00:00:00

  • Lattice topology dictates photon statistics.

    abstract：:Propagation of coherent light through a disordered network is accompanied by randomization and possible conversion into thermal light. Here, we show that network topology plays a decisive role in determining the statistics of the emerging field if the underlying lattice is endowed with chiral symmetry. In such lattice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09236-8

    authors： Kondakci HE,Abouraddy AF,Saleh BEA

    更新日期：2017-08-21 00:00:00

  • Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties.

    abstract：:Macular edema due to neovascular age-related macular degeneration, diabetes or retinal vein occlusion can cause central vision loss. Intravitreal treatment with antibody-based biopharmaceutical compounds designed to neutralize vascular endothelial growth factor (VEGF) has proven to be an efficient strategy to ameliora...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20525-8

    authors： Sivertsen MS,Jørstad ØK,Grevys A,Foss S,Moe MC,Andersen JT

    更新日期：2018-02-01 00:00:00

  • Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus.

    abstract：:Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10839-4

    authors： Li Z,Mao R,Teng D,Hao Y,Chen H,Wang X,Wang X,Yang N,Wang J

    更新日期：2017-09-21 00:00:00

  • Complete genome sequence of the cellulose-producing strain Komagataeibacter nataicola RZS01.

    abstract：:Komagataeibacter nataicola is an acetic acid bacterium (AAB) that can produce abundant bacterial cellulose and tolerate high concentrations of acetic acid. To globally understand its fermentation characteristics, we present a high-quality complete genome sequence of K. nataicola RZS01. The genome consists of a 3,485,1...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04589-6

    authors： Zhang H,Xu X,Chen X,Yuan F,Sun B,Xu Y,Yang J,Sun D

    更新日期：2017-06-30 00:00:00

  • Tunable high-order sideband spectra generation using a photonic molecule optomechanical system.

    abstract：:A tunable high-order sideband spectra generation scheme is presented by using a photonic molecule optomechanical system coupled to a waveguide beyond the perturbation regime. The system is coherently driven by a two-tone laser consisting of a continuous-wave control field and a pulsed driving field which propagates th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22920

    authors： Cao C,Mi SC,Gao YP,He LY,Yang D,Wang TJ,Zhang R,Wang C

    更新日期：2016-03-10 00:00:00

  • White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging.

    abstract：:Supported by histological and genetic evidence implicating myelin, neuroinflammation and oligodendrocyte dysfunction in schizophrenia spectrum disorders (SZ), diffusion tensor imaging (DTI) studies have consistently shown white matter (WM) abnormalities when compared to healthy controls (HC). The diagnostic specificit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32355-9

    authors： Tønnesen S,Kaufmann T,Doan NT,Alnæs D,Córdova-Palomera A,Meer DV,Rokicki J,Moberget T,Gurholt TP,Haukvik UK,Ueland T,Lagerberg TV,Agartz I,Andreassen OA,Westlye LT

    更新日期：2018-09-20 00:00:00

  • Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway.

    abstract：:Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35023-0

    authors： Upadhyay R,Sanchez-Hidalgo A,Wilusz CJ,Lenaerts AJ,Arab J,Yeh J,Stefanisko K,Tarasova NI,Gonzalez-Juarrero M

    更新日期：2018-11-09 00:00:00

  • Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models.

    abstract：:Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological consequences of cardiovascular and renal damage. We aimed to design chemical NGAL inhibitors and investigate its effects in experimental models of myocardial infar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-82279-0

    authors： Bonnard B,Martínez-Martínez E,Fernández-Celis A,Pieronne-Deperrois M,Do QT,Ramos I,Rossignol P,Zannad F,Mulder P,Ouvrard-Pascaud A,López-Andrés N,Jaisser F

    更新日期：2021-01-28 00:00:00

  • Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.

    abstract：:Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-handling in the cardiomyocyte. Previously, missense variants in JPH2 have been linked to hypertrophic cardiomyopathy; however, pathogenic "loss of function" (LOF) variants have not been described. Family-based genetic analysis ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44987-6

    authors： Jones EG,Mazaheri N,Maroofian R,Zamani M,Seifi T,Sedaghat A,Shariati G,Jamshidi Y,Allen HD,Wehrens XHT,Galehdari H,Landstrom AP

    更新日期：2019-06-21 00:00:00

  • NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape.

    abstract：:Glioblastoma (grade IV glioma) is the most common and aggressive adult brain tumor. A better understanding of the biology of glioblastoma cells is crucial to identify molecular targets stimulating cell death. NPM1 (nucleophosmin) is a multifunctional chaperone that plays an important role in cancer development. Herein...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16495

    authors： Holmberg Olausson K,Elsir T,Moazemi Goudarzi K,Nistér M,Lindström MS

    更新日期：2015-11-12 00:00:00

  • Proteomic analysis of egg white heparin-binding proteins: towards the identification of natural antibacterial molecules.

    abstract：:The chicken egg resists most environmental microbes suggesting that it potentially contains efficient antimicrobial molecules. Considering that some heparin-binding proteins in mammals are antibacterial, we investigated the presence and the antimicrobial activity of heparin-binding proteins from chicken egg white. Mas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27974

    authors： Guyot N,Labas V,Harichaux G,Chessé M,Poirier JC,Nys Y,Réhault-Godbert S

    更新日期：2016-06-13 00:00:00

  • Characterisation of the Cyanate Inhibited State of Cytochrome c Oxidase.

    abstract：:Heme-copper oxygen reductases are terminal respiratory enzymes, catalyzing the reduction of dioxygen to water and the translocation of protons across the membrane. Oxygen consumption is inhibited by various substances. Here we tested the relatively unknown inhibition of cytochrome c oxidase (CcO) with isocyanate. In c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60801-0

    authors： Kruse F,Nguyen AD,Dragelj J,Schlesinger R,Heberle J,Mroginski MA,Weidinger IM

    更新日期：2020-03-02 00:00:00