当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.

Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.

Abstract：

:Avoiding immune rejection after allogeneic induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) transplantation is a concern. However, mesenchymal stem cells (MSCs) can suppress immune rejection. To determine whether MSC co-transplantation can reduce immune rejection after allogeneic iPSC-CM transplantation, the latter cell type, harbouring a luciferase transgene, was subcutaneously transplanted alone or together with syngeneic MSCs into BALB/c mice. Bioluminescence imaging revealed that MSC co-transplantation significantly improved graft survival (day 7: iPSC-CMs alone 34 ± 5%; iPSC-CMs with MSCs, 61 ± 7%; P = 0.008). MSC co-transplantation increased CD4 + CD25 + FOXP3 + regulatory T cell numbers, apoptotic CD8-positive T cells, and IL-10 and TGF-beta expression at the implantation site. Analysis using a regulatory T cell depletion model indicated that enhanced regulatory T cell populations in the iPSC-CM with MSC group partially contributed to the extended iPSC-CM survival. Further, MSCs affected activated lymphocytes directly through cell-cell contact, which reduced the CD8/CD4 ratio, the proportion of Th1-positive cells among CD4-positive cells, and the secretion of several inflammation-related cytokines. Syngeneic MSC co-transplantation might thus control allogeneic iPSC-CM rejection by mediating immune tolerance via regulatory T cells and cell-cell contact with activated lymphocytes; this approach has promise for cardiomyogenesis-based therapy using allogeneic iPSC-CMs for severe heart failure.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yoshida S,Miyagawa S,Toyofuku T,Fukushima S,Kawamura T,Kawamura A,Kashiyama N,Nakamura Y,Toda K,Sawa Y

doi

10.1038/s41598-020-58126-z

subject

Has Abstract

pub_date

2020-03-12 00:00:00

pages

4593

issue

1

issn

2045-2322

pii

10.1038/s41598-020-58126-z

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Functional Genome Screening to Elucidate the Colistin Resistance Mechanism.

    abstract：:Antibiogram profile of 1590 clinical bacterial isolates based on thirteen different antimicrobial compounds showed that 1.6% of the bacterial isolates are multidrug resistant. Distribution pattern based on 16S rRNA sequence analysis showed that Pseudomonas aeruginosa constituted the largest group (83.6%) followed by B...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23156

    authors： Kumar M,Gupta A,Sahoo RK,Jena J,Debata NK,Subudhi E

    更新日期：2016-03-18 00:00:00

  • Topographical interrogation of the living cell surface reveals its role in rapid cell shape changes during phagocytosis and spreading.

    abstract：:Dramatic and rapid changes in cell shape are perhaps best exemplified by phagocytes, such as neutrophils. These cells complete the processes of spreading onto surfaces, and phagocytosis within 100 s of stimulation. Although these cell shape changes are accompanied by an apparent large increase in cell surface area, th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09761-6

    authors： Jumaa MAA,Dewitt S,Hallett MB

    更新日期：2017-08-29 00:00:00

  • Effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichtys molitrix revealed by hepatic RNA-seq and miRNA-seq.

    abstract：:High-throughput sequencing was applied to analyze the effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichthys molitrix. Silver carps were exposed to two cyanobacteria species (toxic and non-toxic) for RNA-seq and miRNA-seq analysis. RNA-seq revealed that the liver tissue contained 105,379 unigene...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10335-9

    authors： Hu M,Qu X,Pan L,Fu C,Jia P,Liu Q,Wang Y

    更新日期：2017-09-05 00:00:00

  • Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy.

    abstract：:Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain cell death and syste...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46488-y

    authors： Martinello KA,Meehan C,Avdic-Belltheus A,Lingam I,Ragab S,Hristova M,Tann CJ,Peebles D,Hagberg H,Wolfs TGAM,Klein N,Tachtsidis I,Golay X,Kramer BW,Fleiss B,Gressens P,Robertson NJ

    更新日期：2019-07-15 00:00:00

  • Potential modulations in flatland: near-infrared sensitization of MoS2 phototransistors by a solvatochromic dye directly tethered to sulfur vacancies.

    abstract：:Near-infrared sensitization of monolayer MoS2 is here achieved via the covalent attachment of a novel heteroleptic nickel bis-dithiolene complex into sulfur vacancies in the MoS2 structure. Photocurrent action spectroscopy of the sensitized films reveals a discreet contribution from the sensitizer dye centred around 1...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53186-2

    authors： Dalgleish S,Reissig L,Shuku Y,Ligorio G,Awaga K,List-Kratochvil EJW

    更新日期：2019-11-13 00:00:00

  • Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice.

    abstract：:Traumatic brain injury (TBI) has been associated with atherosclerosis and cardiovascular mortality in humans. However the causal relationship between TBI and vascular disease is unclear. This study investigated the direct role of TBI on vascular disease using a murine model of atherosclerosis. Apolipoprotein E deficie...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23959-2

    authors： Wang J,Su E,Wang H,Guo C,Lawrence DA,Eitzman DT

    更新日期：2018-04-04 00:00:00

  • Identification of a periodontal pathogen and bihormonal cells in pancreatic islets of humans and a mouse model of periodontitis.

    abstract：:Results from epidemiological and prospective studies indicate a close association between periodontitis and diabetes. However the mechanisms by which periodontal pathogens influence the development of prediabetes/diabetes are not clear. We previously reported that oral administration of a periodontal pathogen, Porphyr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65828-x

    authors： Ilievski V,Toth PT,Valyi-Nagy K,Valyi-Nagy T,Green SJ,Marattil RS,Aljewari HW,Wicksteed B,O'Brien-Simpson NM,Reynolds EC,Layden BT,Unterman TG,Watanabe K

    更新日期：2020-06-19 00:00:00

  • Elevated temperature altered photosynthetic products in wheat seedlings and organic compounds and biological activity in rhizopshere soil under cadmium stress.

    abstract：:The objective of this study was to investigate the effects of slightly elevated atmospheric temperature in the spring on photosynthetic products in wheat seedlings and on organic compounds and biological activity in rhizosphere soil under cadmium (Cd) stress. Elevated temperature was associated with increased soluble ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14426

    authors： Jia X,Zhao Y,Wang W,He Y

    更新日期：2015-09-23 00:00:00

  • Four-dimensional in vivo X-ray microscopy with projection-guided gating.

    abstract：:Visualizing fast micrometer scale internal movements of small animals is a key challenge for functional anatomy, physiology and biomechanics. We combine phase contrast tomographic microscopy (down to 3.3 μm voxel size) with retrospective, projection-based gating (in the order of hundreds of microseconds) to improve th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08727

    authors： Mokso R,Schwyn DA,Walker SM,Doube M,Wicklein M,Müller T,Stampanoni M,Taylor GK,Krapp HG

    更新日期：2015-03-12 00:00:00

  • Dynamic scaling for the growth of non-equilibrium fluctuations during thermophoretic diffusion in microgravity.

    abstract：:Diffusion processes are widespread in biological and chemical systems, where they play a fundamental role in the exchange of substances at the cellular level and in determining the rate of chemical reactions. Recently, the classical picture that portrays diffusion as random uncorrelated motion of molecules has been re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14486

    authors： Cerbino R,Sun Y,Donev A,Vailati A

    更新日期：2015-09-30 00:00:00

  • A framework to identify structured behavioral patterns within rodent spatial trajectories.

    abstract：:Animal behavior is highly structured. Yet, structured behavioral patterns-or "statistical ethograms"-are not immediately apparent from the full spatiotemporal data that behavioral scientists usually collect. Here, we introduce a framework to quantitatively characterize rodent behavior during spatial (e.g., maze) navig...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79744-7

    authors： Donnarumma F,Prevete R,Maisto D,Fuscone S,Irvine EM,van der Meer MAA,Kemere C,Pezzulo G

    更新日期：2021-01-11 00:00:00

  • Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes.

    abstract：:Cartilage tissue is avascular and hypoxic which regulates chondrocyte phenotype via stabilization of HIFs. Here, we investigated the role of hypoxia and HIFs in regulation of Rho and canonical Wnt signaling in chondrocytes. Our data demonstrates that hypoxia controls the expression of RhoA in chondrocytes in a context...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09505-6

    authors： Öztürk E,Hobiger S,Despot-Slade E,Pichler M,Zenobi-Wong M

    更新日期：2017-08-22 00:00:00

  • Rapid and reversible lithiation of doped biogenous iron oxide nanoparticles.

    abstract：:Certain bacteria produce iron oxide material assembled with nanoparticles (NPs) that are doped with silicon (Fe:Si ~ 3:1) in ambient environment. Such biogenous iron oxides (BIOX) proved to be an excellent electrode material for lithium-ion batteries, but underlying atomistic mechanisms remain elusive. Here, quantum m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-38540-8

    authors： Misawa M,Hashimoto H,Kalia RK,Matsumoto S,Nakano A,Shimojo F,Takada J,Tiwari S,Tsuruta K,Vashishta P

    更新日期：2019-02-12 00:00:00

  • Phosphorus (P) use efficiency in rice is linked to tissue-specific biomass and P allocation patterns.

    abstract：:Phosphorus (P) is a non-renewable resource which may be depleted within next few decades; hence high P use efficiency is need of time. Plants have evolved an array of adaptive mechanisms to enhance external P acquisition and reprioritize internal utilization under P deficiency. Tissue specific biomass and P allocation...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61147-3

    authors： Irfan M,Aziz T,Maqsood MA,Bilal HM,Siddique KHM,Xu M

    更新日期：2020-03-09 00:00:00

  • Quantum state transfer via Bloch oscillations.

    abstract：:The realization of reliable quantum channels, able to transfer a quantum state with high fidelity, is a fundamental step in the construction of scalable quantum devices. In this paper we describe a transmission scheme based on the genuinely quantum effect known as Bloch oscillations. The proposed protocol makes it pos...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26054

    authors： Tamascelli D,Olivares S,Rossotti S,Osellame R,Paris MG

    更新日期：2016-05-18 00:00:00

  • A convolutional neural network-based system to prevent patient misidentification in FDG-PET examinations.

    abstract：:Patient misidentification in imaging examinations has become a serious problem in clinical settings. Such misidentification could be prevented if patient characteristics such as sex, age, and body weight could be predicted based on an image of the patient, with an alert issued when a mismatch between the predicted and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43656-y

    authors： Kawauchi K,Hirata K,Katoh C,Ichikawa S,Manabe O,Kobayashi K,Watanabe S,Furuya S,Shiga T

    更新日期：2019-05-10 00:00:00

  • Antibiotic stewardship in the PICU: Impact of ward rounds led by paediatric infectious diseases specialists on antibiotic consumption.

    abstract：:Antimicrobial stewardship programmes (ASP) are aimed at optimising antimicrobial utilization. However, only few studies have focused on paediatric intensive care units (PICU), where inappropriate antibiotic use occurs frequently. We assessed the effect and safety of a once weekly paediatric infectious disease (PID) wa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65671-0

    authors： Renk H,Sarmisak E,Spott C,Kumpf M,Hofbeck M,Hölzl F

    更新日期：2020-06-01 00:00:00

  • Target contact and exploration strategies in haptic search.

    abstract：:In a haptic search task, one has to detect the presence of a target among distractors using the sense of touch. A salient target can be detected faster than a non-salient target. However, little is known about the exploration strategies that are used, especially in 3D search tasks where items are held in the hand. In ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06254

    authors： van Polanen V,Bergmann Tiest WM,Kappers AM

    更新日期：2014-09-03 00:00:00

  • A thin-film microprocessor with inkjet print-programmable memory.

    abstract：:The Internet of Things is driving extensive efforts to develop intelligent everyday objects. This requires seamless integration of relatively simple electronics, for example through 'stick-on' electronics labels. We believe the future evolution of this technology will be governed by Wright's Law, which was first propo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep07398

    authors： Myny K,Smout S,Rockelé M,Bhoolokam A,Ke TH,Steudel S,Cobb B,Gulati A,Gonzalez Rodriguez F,Obata K,Marinkovic M,Pham DV,Hoppe A,Gelinck GH,Genoe J,Dehaene W,Heremans P

    更新日期：2014-12-10 00:00:00

  • Magnetoelectric Spin Wave Modulator Based On Synthetic Multiferroic Structure.

    abstract：:We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28878-w

    authors： Balinskiy M,Chavez AC,Barra A,Chiang H,Carman GP,Khitun A

    更新日期：2018-07-18 00:00:00

  • Accuracy assessment of a novel semiautomatic method evaluating bone grafts around the dental implant: an in vitro and ex vivo study.

    abstract：:The present study aimed to evaluate the accuracy and repeatability of morphological contour interpolation (MCI)-based semiautomatic segmentation method for volumetric measurements of bone grafts around dental implants. Three in vitro (one with a cylinder and two with a geometrically complex form) and four ex vivo mode...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71651-1

    authors： Shi JY,Li Y,Zhuang LF,Zhang X,Fan LF,Lai HC

    更新日期：2020-09-10 00:00:00

  • Risk Factors for Ischemic Stroke in Atrial Fibrillation Patients Undergoing Radiofrequency Catheter Ablation.

    abstract：:Ischemic stroke after radiofrequency catheter ablation (RFCA) in atrial fibrillation (AF) patients is a great challenge for electrophysiologists. We performed this retrospective study to evaluate clinical and echocardiographic characteristics associated with increased risk of ischemic stroke following RFCA. A total of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43566-z

    authors： Kim YG,Shim J,Oh SK,Lee KN,Choi JI,Kim YH

    更新日期：2019-05-07 00:00:00

  • Interleukin-1β induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes.

    abstract：:Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in IL-1β-stimulated OA chondrocytes but the synthesis of protein found significantly delayed. Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27611

    authors： Ansari MY,Haqqi TM

    更新日期：2016-06-08 00:00:00

  • Surface Characteristics of Silicon Nanowires/Nanowalls Subjected to Octadecyltrichlorosilane Deposition and n-octadecane Coating.

    abstract：:In this study, nanowires/nanowalls were generated on a silicon wafer through a chemical etching method. Octadecyltrichlorosilane (OTS) was deposited onto the nanowire/nanowall surfaces to alter their hydrophobicity. The hydrophobic characteristics of the surfaces were further modified via a 1.5-μm-thick layer of n-oct...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38678

    authors： Yilbas BS,Salhi B,Yousaf MR,Al-Sulaiman F,Ali H,Al-Aqeeli N

    更新日期：2016-12-09 00:00:00

  • The effect of pulsatile motion and cardiac-gating on reconstruction and diffusion tensor properties of the corticospinal tract.

    abstract：:Pulsatile motion occurs in the cardiac systolic period and leads to significantly larger displacement of water molecules as it is observed during diffusion weighted image acquisition. Obvious pulsatile motion arises in the brain stem and basal ganglia and might affect the corticospinal tract. So far there is no consen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29525-0

    authors： Bopp MHA,Yang J,Nimsky C,Carl B

    更新日期：2018-07-25 00:00:00

  • Hypertension and breast cancer risk: a systematic review and meta-analysis.

    abstract：:Observational studies examining the relationship between hypertension and breast cancer risk have reported conflicting findings. We conducted this systematic review and meta-analysis to summarize the evidence regarding the association between hypertension and risk of breast cancer. Eligible studies were identified thr...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/srep44877

    authors： Han H,Guo W,Shi W,Yu Y,Zhang Y,Ye X,He J

    更新日期：2017-03-20 00:00:00

  • Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance.

    abstract：:Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68987-z

    authors： Sakano D,Inoue A,Enomoto T,Imasaka M,Okada S,Yokota M,Koike M,Araki K,Kume S

    更新日期：2020-07-22 00:00:00

  • Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia.

    abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42480

    authors： Katagiri S,Nishina S,Yokoi T,Mikami M,Nakayama Y,Tanaka M,Azuma N

    更新日期：2017-02-16 00:00:00

  • Prediction of Steam Burns Severity using Raman Spectroscopy on ex vivo Porcine Skin.

    abstract：:Skin burns due to accidental exposure to hot steam have often been reported to be more severe than the ones occurring from dry heat. While skin burns due to flames or radiant heat have been thoroughly characterized, the mechanisms leading to steam burns are not well understood and a conundrum still exists: can second ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24647-x

    authors： Zhai L,Adlhart C,Spano F,Innocenti Malini R,Piątek AK,Li J,Rossi RM

    更新日期：2018-05-02 00:00:00

  • YebC, a putative transcriptional factor involved in the regulation of the proteolytic system of Lactobacillus.

    abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09124-1

    authors： Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

    更新日期：2017-08-17 00:00:00