Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes.

abstract：:Transient gene expression approaches are valuable tools for rapid introduction of genes of interest and characterization of their functions in plants. Although agroinfiltration is the most effectively and routinely used method for transient expression of multiple genes in various plant species, this approach has been ...

journal_title：Scientific reports

authors： Seo JK,Choi HS,Kim KH

更新日期：2016-02-29 00:00:00

abstract：:Ordered/disordered phase separation occurring in bio-membranes has piqued researchers' interest because these ordered domains, called lipid rafts, regulate important biological functions. The structure of the ordered domain has been examined with artificial membranes, which undergo macroscopic ordered/disordered phase...

journal_title：Scientific reports

authors： Kinoshita M,Yamaguchi S,Matsumori N

更新日期：2020-12-21 00:00:00

abstract：:Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...

journal_title：Scientific reports

authors： Jessel HR,Chen S,Osovski S,Efroni S,Rittel D,Bachelet I

更新日期：2019-03-18 00:00:00

abstract：:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...

journal_title：Scientific reports

authors： Chang WM,Lin YF,Su CY,Peng HY,Chang YC,Hsiao JR,Chen CL,Chang JY,Shieh YS,Hsiao M,Shiah SG

更新日期：2017-01-25 00:00:00

abstract：:Marine blue holes are precious geological heritages with high scientific research values. Their physical and chemical characteristics are unique because of the steep-walled structure and isolated water column which create isolated ecosystems in geographically restricted areas. The Sansha Yongle Blue Hole (SYBH) is the...

journal_title：Scientific reports

authors： Li Q,Lei Y,Morard R,Li T,Wang B

更新日期：2020-06-24 00:00:00

abstract：:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation...

journal_title：Scientific reports

authors： Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

更新日期：2014-07-28 00:00:00

abstract：:Endothelium-dependent flow-mediated dilation (ED-FMD), a biophysical marker of endothelial dysfunction, is apparently impaired in patients with systemic lupus erythematosus (SLE) but such observation is inconsistent. Here, we assessed and compared the brachial artery ED-FMD (baED-FMD) using ultrasonography between SLE...

journal_title：Scientific reports

authors： Mak A,Kow NY,Schwarz H,Gong L,Tay SH,Ling LH

更新日期：2017-08-04 00:00:00

abstract：:Pluripotency can be induced in vitro from adult somatic mammalian cells by enforced expression of defined transcription factors regulating and initiating the pluripotency network. Despite the substantial advances over the last decade to improve the efficiency of direct reprogramming, exact mechanisms underlying the co...

journal_title：Scientific reports

authors： Raab S,Klingenstein M,Möller A,Illing A,Tosic J,Breunig M,Kuales G,Linta L,Seufferlein T,Arnold SJ,Kleger A,Liebau S

更新日期：2017-11-29 00:00:00

abstract：:Interactions between diverse species that coexist in nature are of utmost interest in the field of ecology. Recent theoretical studies have shown that spatiality plays a key role in maintaining complex systems with multiple differing species. In these models, however, organisms move among habitats randomly, implying t...

journal_title：Scientific reports

authors： Mougi A

更新日期：2019-09-02 00:00:00

abstract：:Three-dimensional (3D) remote imaging attracts increasing attentions in capturing a target's characteristics. Although great progress for 3D remote imaging has been made with methods such as scanning imaging lidar and pulsed floodlight-illumination imaging lidar, either the detection range or application mode are limi...

journal_title：Scientific reports

authors： Gong W,Zhao C,Yu H,Chen M,Xu W,Han S

更新日期：2016-05-17 00:00:00

abstract：:n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs are reported to have immunomodulatory effects, but few studies have examined these functions. Thus, we examined whether dietary n-3 and n-6 PUFAs are associated with the risk of gastric cancer and further investigated whether fatty acid desaturases 1 and 2 (FADS1 a...

journal_title：Scientific reports

authors： Lee S,Lee J,Choi IJ,Kim YW,Ryu KW,Kim YI,Kim J

更新日期：2018-02-28 00:00:00

abstract：:The 8th edition of TNM staging system has been released and it incorporates many changes to the T and N classifications for pancreatic cancer. Comparative study between the 7th and 8th edition of TNM staging system from Asian population has not been reported yet. This study aimed to compare the 7th and 8th edition of ...

journal_title：Scientific reports

authors： Cong L,Liu Q,Zhang R,Cui M,Zhang X,Gao X,Guo J,Dai M,Zhang T,Liao Q,Zhao Y

更新日期：2018-07-10 00:00:00

abstract：:Tail-anchored (TA) proteins are post-translationally inserted into membranes. The TRC40 pathway targets TA proteins to the endoplasmic reticulum via a receptor comprised of WRB and CAML. TRC40 pathway clients have been identified using in vitro assays, however, the relevance of the TRC40 pathway in vivo remains unknow...

journal_title：Scientific reports

authors： Rivera-Monroy J,Musiol L,Unthan-Fechner K,Farkas Á,Clancy A,Coy-Vergara J,Weill U,Gockel S,Lin SY,Corey DP,Kohl T,Ströbel P,Schuldiner M,Schwappach B,Vilardi F

更新日期：2016-12-21 00:00:00

abstract：:Carbon nanofibers were widely utilized to improve microwave absorption properties since they are a promising lightweight candidate. Adjustable conductive nanostructures of carbon nanofibers were synthesized by electrospinning technique. The conductive network is controlled by the polyvinyl pyrrolidone (PVP) content du...

journal_title：Scientific reports

authors： Lv J,Gu W,Cui X,Dai S,Zhang B,Ji G

更新日期：2019-03-12 00:00:00

abstract：:The ryanodine receptor 1 is a large calcium ion channel found in mammalian skeletal muscle. The ion channel gained a lot of attention recently, after multiple independent authors published near-atomic cryo electron microscopy data. Taking advantage of the unprecedented quality of structural data, we performed molecula...

journal_title：Scientific reports

authors： Heinz LP,Kopec W,de Groot BL,Fink RHA

更新日期：2018-05-02 00:00:00

abstract：:Quantification of stillbirth risk has potential to support clinical decision-making. Studies that have attempted to quantify stillbirth risk have been hampered by small event rates, a limited range of predictors that typically exclude obstetric history, lack of validation, and restriction to a single classifier (logis...

journal_title：Scientific reports

authors： Malacova E,Tippaya S,Bailey HD,Chai K,Farrant BM,Gebremedhin AT,Leonard H,Marinovich ML,Nassar N,Phatak A,Raynes-Greenow C,Regan AK,Shand AW,Shepherd CCJ,Srinivasjois R,Tessema GA,Pereira G

更新日期：2020-03-24 00:00:00

abstract：:A novel characterization technique using both in situ reflection high-energy electron diffraction (RHEED) transmission mode and transmission electron microscopy (TEM) has been developed to investigate the growth behaviour of semiconductor nanostructures. RHEED employed in transmission mode enables the acquisition of s...

journal_title：Scientific reports

authors： Jo J,Tchoe Y,Yi GC,Kim M

更新日期：2018-01-26 00:00:00

abstract：:Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...

journal_title：Scientific reports

authors： Wang M,Sun Z,Yu T,Ding F,Li L,Wang X,Fu M,Wang H,Huang J,Li N,Dai Y

更新日期：2017-09-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ezewudo M,Borens A,Chiner-Oms Á,Miotto P,Chindelevitch L,Starks AM,Hanna D,Liwski R,Zignol M,Gilpin C,Niemann S,Kohl TA,Warren RM,Crook D,Gagneux S,Hoffner S,Rodrigues C,Comas I,Engelthaler DM,Alland D,Rigouts L,

更新日期：2020-02-21 00:00:00

abstract：:The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex formed between activated Sos and Ras at the point of the functional cycle where the nucleotide exchange is completed has not been described to date. Here we show th...

journal_title：Scientific reports

authors： Vo U,Vajpai N,Embrey KJ,Golovanov AP

更新日期：2016-07-14 00:00:00

abstract：:Among the bacterial symbionts harbored by the model organism Paramecium, many still lack a recent investigation that includes a molecular characterization. The genus Lyticum consists of two species of large-sized bacteria displaying numerous flagella, despite their inability to move inside their hosts' cytoplasm. We p...

journal_title：Scientific reports

authors： Boscaro V,Schrallhammer M,Benken KA,Krenek S,Szokoli F,Berendonk TU,Schweikert M,Verni F,Sabaneyeva EV,Petroni G

更新日期：2013-11-22 00:00:00

abstract：:In this work, we demonstrate theoretically and experimentally the possibility of tuning the electromagnetic properties of metamaterials with magnetic fields by incorporating amorphous magnetic microwires. The large permeability of these wires at microwave frequencies allows tuning the resonance of the metamaterial by ...

journal_title：Scientific reports

authors： Lopez-Dominguez V,Garcia MA,Marin P,Hernando A

更新日期：2017-08-24 00:00:00

abstract：:Plasma dipeptidyl-peptidase-4 activity (DPP4a) is inversely associated with left ventricular function in patients with heart failure (HF) or diabetes. However, the association between DPP4a and left ventricular function in ST-segment elevation myocardial infarction (STEMI) patients has not been reported. We studied th...

journal_title：Scientific reports

authors： Li JW,Chen YD,Liu YQ,Wang JD,Chen WR,Zhang YQ,Ma Q

更新日期：2017-07-21 00:00:00

abstract：:The immature phenotype of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) is a major limitation to the use of these valuable cells for pre-clinical toxicity testing and for disease modeling. Here we tested the hypothesis that human perinatal stem cell derived extracellular matrix (ECM) promotes ...

journal_title：Scientific reports

authors： Block T,Creech J,da Rocha AM,Marinkovic M,Ponce-Balbuena D,Jiménez-Vázquez EN,Griffey S,Herron TJ

更新日期：2020-11-04 00:00:00

abstract：:GlgE, an enzyme of the pathway that converts trehalose to α-glucans, is essential for Mycobacterium tuberculosis. Inhibition of GlgE, which transfers maltose from a maltose-1-phosphate donor to α-glucan/maltooligosaccharide chain acceptor, leads to a toxic accumulation of maltose-1-phosphate that culminates in cellula...

journal_title：Scientific reports

authors： Mendes V,Blaszczyk M,Maranha A,Empadinhas N,Blundell TL

更新日期：2015-11-30 00:00:00

abstract：:Evidence indicates that astronauts experience significant bone loss in space. We previously showed that simulated microgravity (μXg) using the NASA developed rotary cell culture system (RCCS) enhanced bone resorbing osteoclast (OCL) differentiation. However, the mechanism by which μXg increases OCL formation is unclea...

journal_title：Scientific reports

authors： Sambandam Y,Baird KL,Stroebel M,Kowal E,Balasubramanian S,Reddy SV

更新日期：2016-05-04 00:00:00

abstract：:Single photons are of paramount importance to future quantum technologies, including quantum communication and computation. Nonlinear photonic devices using parametric processes offer a straightforward route to generating photons, however additional nonlinear processes may come into play and interfere with these sourc...

journal_title：Scientific reports

authors： Husko CA,Clark AS,Collins MJ,De Rossi A,Combrié S,Lehoucq G,Rey IH,Krauss TF,Xiong C,Eggleton BJ

更新日期：2013-11-04 00:00:00

abstract：:This multi-disciplinary work provides an updated assessment of possible future eruptive scenarios for the city of Rome. Seven new 40Ar/39Ar ages from selected products of the Monti Sabatini and Vulsini volcanic districts, along with a compilation of all the literature ages on the Colli Albani and Vico products, are us...

journal_title：Scientific reports

authors： Marra F,Castellano C,Cucci L,Florindo F,Gaeta M,Jicha BR,Palladino DM,Sottili G,Tertulliani A,Tolomei C

更新日期：2020-05-26 00:00:00

abstract：:Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases. In most animal cell types, the dynein motor complex is anchored at the cell cortex and exerts pulling forces on astral microtubules to position...

journal_title：Scientific reports

authors： Vodicska B,Cerikan B,Schiebel E,Hoffmann I

更新日期：2018-04-20 00:00:00

abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...

journal_title：Scientific reports

authors： Tokita M,Kennedy SR,Risques RA,Chun SG,Pritchard C,Oshima J,Liu Y,Bryant-Greenwood PK,Welcsh P,Monnat RJ

更新日期：2016-08-25 00:00:00